Spencer Szczesny

Assistant Professor of Bioengineering

Spencer Szczesny

Research Summary

Mechanobiology focusing on how mechanical stimuli influence tendon cell behavior in their native microenvironment with the ultimate goal of understanding tendon pathology and identifying novel therapeutic options.

Huck Affiliations

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Publication Tags

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Tendons Mechanics Collagen Tissue Hydrogels Stem Cells Strain Plasticity Length Shear Mesenchymal Stem Cells Stiffness Gages Atomic Force Microscopy Recovery Bioreactors Shear Stress Fatigue Pathology Mechanical Properties Fatigue Of Materials Plastics Cells Hyaluronic Acid Biomechanical Phenomena

Most Recent Publications

Mouse Achilles Tendons are Resistant to Collagen Denaturation during Cyclic and Monotonic Loading to Failure

Krishna Pedaprolu, Spencer Szczesny, 2023, Journal of Biomechanics

Tendon Cell and Tissue Culture: Perspectives and Recommendations

Spencer Szczesny, David Corr, 2023, Journal of Orthopaedic Research

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Stanton Godshall, Krishna Pedaprolu, Erica Vasti, Faezeh Eskandari, Spencer E. Szczesny, 2023, Journal of Visualized Experiments

The Elephant in the Cell: Nuclear Mechanics and Mechanobiology

Michelle L. Jones, Kris Noel Dahl, Tanmay P. Lele, Daniel E. Conway, Vivek Shenoy, Soham Ghosh, Spencer E. Szczesny, 2022, Journal of Biomechanical Engineering

A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants

Krishna Pedaprolu, Spencer E. Szczesny, 2022, Journal of Biomechanical Engineering

Mechanical Stimulation as Both the Cause and the Cure of Tendon and Ligament Injuries

Lauren Paschall, Krishna Pedaprolu, Sabrina Carrozzi, A Dhawan, Spencer Szczesny, 2022,

Mechanical Stimulation via Muscle Activity Is Necessary for the Maturation of Tendon Multiscale Mechanics During Embryonic Development

Benjamin E. Peterson, Rebecca A. Rolfe, Allen Kunselman, Paula Murphy, Spencer E. Szczesny, 2021, Frontiers in Cell and Developmental Biology

Dependence of tendon multiscale mechanics on sample gauge length is consistent with discontinuous collagen fibrils

Benjamin E. Peterson, Spencer E. Szczesny, 2020, Acta Biomaterialia on p. 302-309

Ex vivo models of musculoskeletal tissues

Spencer E. Szczesny, 2020, Connective Tissue Research on p. 245-247

Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics

Spencer E. Szczesny, Céline Aeppli, Alexander David, Robert L. Mauck, 2018, Journal of Biomechanics on p. 251-256

Most-Cited Papers

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

Ze Gong, Spencer E. Szczesny, Steven R. Caliari, Elisabeth E. Charrier, Ovijit Chaudhuri, Xuan Cao, Yuan Lin, Robert L. Mauck, Paul A. Janmey, Jason A. Burdick, Vivek B. Shenoy, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E2686-E2695

Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon

Spencer E. Szczesny, Dawn M. Elliott, 2014, Acta Biomaterialia on p. 2582-2590

Quantification of interfibrillar shear stress in aligned soft collagenous tissues via notch tension testing

Spencer E. Szczesny, Jeffrey L. Caplan, Pal Pedersen, Dawn M. Elliott, 2015, Scientific Reports

Biaxial mechanics and inter-lamellar shearing of stem-cell seeded electrospun angle-ply laminates for annulus fibrosus tissue engineering

Tristan P. Driscoll, Ryan H. Nakasone, Spencer E. Szczesny, Dawn M. Elliott, Robert L. Mauck, 2013, Journal of Orthopaedic Research on p. 864-870

Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles

Spencer E. Szczesny, Dawn M. Elliott, 2014, Journal of the Mechanical Behavior of Biomedical Materials on p. 325-338

The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction

Spencer E. Szczesny, Robert L. Mauck, 2017, Journal of Biomechanical Engineering

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

Su Jin Heo, Woojin M. Han, Spencer E. Szczesny, Brian D. Cosgrove, Dawn M. Elliott, David A. Lee, Randall L. Duncan, Robert L. Mauck, 2016, Biophysical Journal on p. 864-874

Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior

Claudia Loebel, Spencer E. Szczesny, Brian D. Cosgrove, Mauro Alini, Marcy Zenobi-Wong, Robert L. Mauck, David Eglin, 2017, Biomacromolecules on p. 855-864

Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading

Andrea H. Lee, Spencer E. Szczesny, Michael H. Santare, Dawn M. Elliott, 2017, Acta Biomaterialia on p. 363-372

Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection

Elena Tous Kichula, Hua Wang, Shauna M. Dorsey, Spencer E. Szczesny, Dawn M. Elliott, Jason A. Burdick, Jonathan F. Wenk, 2014, Annals of Biomedical Engineering on p. 1546-1556