Spencer Szczesny
Associate Professor of Biomedical Engineering
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425 Chemical and Biomedical Engineering
University Park, PA - ses297@psu.edu
- 814-865-3284
Research Summary
Mechanobiology focusing on how mechanical stimuli influence tendon cell behavior in their native microenvironment with the ultimate goal of understanding tendon pathology and identifying novel therapeutic options.
Huck Affiliations
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Publication Tags
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Tendons Mechanics Tissue Collagen Strain Hydrogels Plasticity Microstructure Fibers Stem Cells Shear Stress Mesenchymal Stem Cells Bioreactors Shear Recovery Biocompatible Materials Cell Nucleus Plastics Mechanical Properties Cells Hyaluronic Acid Biomaterials Hydrogel Pathology SubstratesMost Recent Publications
Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation
Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition
Incorporating an Education Module on Diversity, Equity, and Inclusion into Undergraduate and Graduate Curricula Has No Positive Effect on Women's Perception of Biomedical Engineering
Spencer Szczesny, Alyssa Salazar, Ann Cameron Casasanta, 2023, ASEE Annual Conference and Exposition, Conference Proceedings
Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure
Krishna Pedaprolu, Spencer E. Szczesny, 2023, Journal of Biomechanics
Mouse Achilles Tendons are Resistant to Collagen Denaturation during Cyclic and Monotonic Loading to Failure
Krishna Pedaprolu, Spencer Szczesny, 2023, Journal of Biomechanics
Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
Stanton Godshall, Krishna Pedaprolu, Erica Vasti, Faezeh Eskandari, Spencer E. Szczesny, 2023, Journal of Visualized Experiments
Tendon cell and tissue culture: Perspectives and recommendations
Spencer E. Szczesny, David T. Corr, 2023, Journal of Orthopaedic Research
Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner
Lauren Paschall, Sabrina Carrozzi, Erdem Tabdanov, Aman Dhawan, Spencer E. Szczesny, 2023, Journal of Orthopaedic Research on p. 267-276
A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants
Krishna Pedaprolu, Spencer E. Szczesny, 2022, Journal of Biomechanical Engineering
The Elephant in the Cell: Nuclear Mechanics and Mechanobiology
Michelle L. Jones, Kris Noel Dahl, Tanmay P. Lele, Daniel E. Conway, Vivek Shenoy, Soham Ghosh, Spencer E. Szczesny, 2022, Journal of Biomechanical Engineering
Mechanical Stimulation as Both the Cause and the Cure of Tendon and Ligament Injuries
Lauren Paschall, Krishna Pedaprolu, Sabrina Carrozzi, A Dhawan, Spencer Szczesny, 2022,
Most-Cited Papers
Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates
Ze Gong, Spencer E. Szczesny, Steven R. Caliari, Elisabeth E. Charrier, Ovijit Chaudhuri, Xuan Cao, Yuan Lin, Robert L. Mauck, Paul A. Janmey, Jason A. Burdick, Vivek B. Shenoy, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E2686-E2695
Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon
Spencer E. Szczesny, Dawn M. Elliott, 2014, Acta Biomaterialia on p. 2582-2590
Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior
Claudia Loebel, Spencer E. Szczesny, Brian D. Cosgrove, Mauro Alini, Marcy Zenobi-Wong, Robert L. Mauck, David Eglin, 2017, Biomacromolecules on p. 855-864
Quantification of interfibrillar shear stress in aligned soft collagenous tissues via notch tension testing
Spencer E. Szczesny, Jeffrey L. Caplan, Pal Pedersen, Dawn M. Elliott, 2015, Scientific Reports
The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction
Spencer E. Szczesny, Robert L. Mauck, 2017, Journal of Biomechanical Engineering
Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells
Su Jin Heo, Woojin M. Han, Spencer E. Szczesny, Brian D. Cosgrove, Dawn M. Elliott, David A. Lee, Randall L. Duncan, Robert L. Mauck, 2016, Biophysical Journal on p. 864-874
Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection
Elena Tous Kichula, Hua Wang, Shauna M. Dorsey, Spencer E. Szczesny, Dawn M. Elliott, Jason A. Burdick, Jonathan F. Wenk, 2014, Annals of Biomedical Engineering on p. 1546-1556
Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles
Spencer E. Szczesny, Dawn M. Elliott, 2014, Journal of the Mechanical Behavior of Biomedical Materials on p. 325-338
Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading
Andrea H. Lee, Spencer E. Szczesny, Michael H. Santare, Dawn M. Elliott, 2017, Acta Biomaterialia on p. 363-372
Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells
Spencer E. Szczesny, Tristan P. Driscoll, Hsiao Yun Tseng, Pang Ching Liu, Su Jin Heo, Robert L. Mauck, Pen Hsiu G. Chao, 2017, ACS Biomaterials Science and Engineering on p. 2869-2876
News Articles Featuring Spencer Szczesny
Oct 13, 2023
Females less likely to heal from ACL injuries than males
A study using an animal model is the first to examine tissue healing following chronic overuse injuries of the anterior cruciate ligament. Females also are less able to heal from these microtraumas than males.
Full Article
Jun 12, 2023
Penn State announces tenure-line faculty promotions, effective July 1, 2023
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.
Full Article