Spencer Szczesny

Associate Professor of Biomedical Engineering

Spencer Szczesny

Research Summary

Mechanobiology focusing on how mechanical stimuli influence tendon cell behavior in their native microenvironment with the ultimate goal of understanding tendon pathology and identifying novel therapeutic options.

Huck Affiliations

Links

Most Recent Publications

Embryo Movement is Required for Limb Tendon Maturation

Rebecca Rolfe, Ebru Busturkmen, Lauren Sliney, Grace Hayden, Nicholas Dunne, Niamh Buckley, Helen McCarthy, Spencer Szczesny, Paula Murphy, 2024, Frontiers in Cell and Developmental Biology on p. 1466872

Structural Determinants of Tendon Multiscale Mechanics and Their Sensitivity to Mechanical Stimulation During Development in an Embryonic Chick Model

Benjamin Peterson, Maria Laura Canonicco Castro, Helen McCarthy, Niamh Buckley, Nicholas Dunne, Rebecca Rolfe, Paula Murphy, Spencer Szczesny, 2024, Acta Biomaterialia

Incorporating an Education Module on Diversity, Equity, and Inclusion into Undergraduate and Graduate Curricula Has No Positive Effect on Women's Perception of Biomedical Engineering

Spencer Szczesny, Alyssa Salazar, Ann Cameron Casasanta, 2023, ASEE Annual Conference and Exposition, Conference Proceedings

Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure

Krishna Pedaprolu, Spencer E. Szczesny, 2023, Journal of Biomechanics

Mouse Achilles Tendons are Resistant to Collagen Denaturation during Cyclic and Monotonic Loading to Failure

Krishna Pedaprolu, Spencer Szczesny, 2023, Journal of Biomechanics

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Stanton Godshall, Krishna Pedaprolu, Erica Vasti, Faezeh Eskandari, Spencer E. Szczesny, 2023, Journal of Visualized Experiments

Tendon cell and tissue culture: Perspectives and recommendations

Spencer E. Szczesny, David T. Corr, 2023, Journal of Orthopaedic Research

Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner

Lauren Paschall, Sabrina Carrozzi, Sabrina Carozzi, Erdem Tabdanov, Spencer Szczesny, Aman Dhawan, Spencer E. Szczesny, 2023, Journal of Orthopaedic Research on p. 267-276

Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation

Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition on p. e202306583

A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants

Krishna Pedaprolu, Spencer E. Szczesny, 2022, Journal of Biomechanical Engineering

Most-Cited Papers

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

Ze Gong, Spencer E. Szczesny, Steven R. Caliari, Elisabeth E. Charrier, Ovijit Chaudhuri, Xuan Cao, Yuan Lin, Robert L. Mauck, Paul A. Janmey, Jason A. Burdick, Vivek B. Shenoy, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E2686-E2695

Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon

Spencer E. Szczesny, Dawn M. Elliott, 2014, Acta Biomaterialia on p. 2582-2590

Quantification of interfibrillar shear stress in aligned soft collagenous tissues via notch tension testing

Spencer E. Szczesny, Jeffrey L. Caplan, Pal Pedersen, Dawn M. Elliott, 2015, Scientific Reports

Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior

Claudia Loebel, Spencer E. Szczesny, Brian D. Cosgrove, Mauro Alini, Marcy Zenobi-Wong, Robert L. Mauck, David Eglin, 2017, Biomacromolecules on p. 855-864

The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction

Spencer E. Szczesny, Robert L. Mauck, 2017, Journal of Biomechanical Engineering

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

Su Jin Heo, Woojin M. Han, Spencer E. Szczesny, Brian D. Cosgrove, Dawn M. Elliott, David A. Lee, Randall L. Duncan, Robert L. Mauck, 2016, Biophysical Journal on p. 864-874

Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading

Andrea H. Lee, Spencer E. Szczesny, Michael H. Santare, Dawn M. Elliott, 2017, Acta Biomaterialia on p. 363-372

Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles

Spencer E. Szczesny, Dawn M. Elliott, 2014, Journal of the Mechanical Behavior of Biomedical Materials on p. 325-338

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

Spencer E. Szczesny, Tristan P. Driscoll, Hsiao Yun Tseng, Pang Ching Liu, Su Jin Heo, Robert L. Mauck, Pen Hsiu G. Chao, 2017, ACS Biomaterials Science and Engineering on p. 2869-2876

Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection

Elena Tous Kichula, Hua Wang, Shauna M. Dorsey, Spencer E. Szczesny, Dawn M. Elliott, Jason A. Burdick, Jonathan F. Wenk, 2014, Annals of Biomedical Engineering on p. 1546-1556