Sinisa Dovat

Associate Professor of Pediatric Hematology and Oncology

Sinisa Dovat

Research Summary

Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Huck Affiliations

Publication Tags

Precursor Cell Lymphoblastic Leukemia Lymphoma Genes Leukemia Neoplasms Casein Kinase Ii Cells Mutation B Lymphocytes Dna Gene Expression Chromatin Phosphorylation Cell Proliferation Ikaros Transcription Factor Clustered Regularly Interspaced Short Palindromic Repeats Therapeutics Phosphotransferases Lymphoid Enhancer Binding Factor 1 Screening Protein Phosphatase 1 Pre B Cell Receptors Ion Channels Multiple Myeloma Osteogenesis Histone Deacetylase 1

Most Recent Papers

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

Nathália Moreno Cury, Tobias Mühlethaler, Angelo Brunelli Albertoni Laranjeira, Rafael Renatino Canevarolo, Priscila Pini Zenatti, Daniel Lucena-Agell, Isabel Barasoain, Chunhua Song, Dongxiao Sun, Sinisa Dovat, Rosendo Augusto Yunes, Andrea Enrico Prota, Michel Olivier Steinmetz, José Fernando Díaz, José Andrés Yunes, 2019, iScience on p. 95-109

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Yali Ding, Bo Zhang, Jonathon L. Payne, Chunhua Song, Zheng Ge, Chandrika Gowda, Soumya Iyer, Pavan K. Dhanyamraju, Glenn Dorsam, Mark E. Reeves, Dhimant Desai, Suming Huang, Kimberly J. Payne, Feng Yue, Sinisa Dovat, 2019, Leukemia on p. 2720-2731

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells

Claudia Nicolae, Michael J. O’Connor, Emily M. Schleicher, Chunhua Song, Raghavendra Gowda, Gavin Robertson, Sinisa Dovat, George-Lucian Moldovan, 2019, Oncogene on p. 5530-5540

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Huacheng Luo, Amin Sobh, Christopher D. Vulpe, Edmond Brewer, Sinisa Dovat, Yi Qiu, Suming Huang, 2019, Journal of visualized experiments : JoVE

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Irina A. Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, Vikash Singh, Chethana P. Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, Stefan A. Muljo, Vladimir S. Spiegelman, 2019, Leukemia

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia

Qi Han, Jinlong Ma, Yan Gu, Huihui Song, Malika Kapadia, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, Zheng Ge, 2019, Journal of Cancer on p. 3842-3850

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia

Zheng Ge, Qi Han, Yan Gu, Qinyu Ge, Jinlong Ma, Justin Sloane, Guofeng Gao, Kimberly J. Payne, Laszlo Szekely, Chunhua Song, Sinisa Dovat, 2018, Oncogenesis

New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time

Yong Qing Tong, Zhi Jun Zhao, Bei Liu, An Yu Bao, Hong Yun Zheng, Jian Gu, Ying Xia, Mary McGrath, Sinisa Dovat, Chunhua Song, Yan Li, 2018, Leukemia Research on p. 47-53

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Zheng Ge, Yan Gu, Qi Han, Justin Sloane, Qinyu Ge, Goufeng Gao, Jinlong Ma, Huihui Song, Jiaojiao Hu, Baoan Chen, Sinisa Dovat, Chunhua Song, 2018, Epigenomics on p. 59-69

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Manoj K. Pandey, Krishne Gowda, Shen shu Sung, Thomas Abraham, Tulin Budak-Alpdogan, Giampolo Talamo, Sinisa Dovat, Shantu Amin, 2017, Experimental Hematology on p. 31-42

Most-Cited Papers

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene

Frederick D. Goldman, Zafer Gurel, Duha Al-Zubeidi, Ari J. Fried, Michael Icardi, Chunhua Song, Sinisa Dovat, 2012, Pediatric Blood and Cancer on p. 591-597

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Rahul Nahar, Parham Ramezani-Rad, Maximilian Mossner, Cihangir Duy, Leandro Cerchietti, Huimin Geng, Sinisa Dovat, Hassan Jumaa, B. Hilda Ye, Ari Melnick, Markus Müschen, 2011, Blood on p. 4174-4178

Ikaros, CK2 kinase, and the road to leukemia

Sinisa Dovat, Chunhua Song, Kimberly J. Payne, Zhanjun Li, 2011, Molecular and Cellular Biochemistry on p. 201-207

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Fatih M. Uckun, Hong Ma, Jian Zhang, Zahide Ozer, Sinisa Dovat, Cheney Mao, Rita Ishkhanian, Patricia Goodman, Sanjive Qazi, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 18072-18077

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, 2015, Oncotarget on p. 42300-42311

Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways

Manoj K. Pandey, Vijay P. Kale, Chunhua Song, Shen shu Sung, Arun K. Sharma, Giampaolo Talamo, Sinisa Dovat, Shantu G. Amin, 2014, Experimental Hematology on p. 883-896

Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia

Haijun Wang, Chunhua Song, Yali Ding, Xiaokang Pan, Zheng Ge, Bihua Tan, Chandrika Gowda, Mansi Sachdev, Sunil Muthusami, Hongsheng Ouyang, Liangxue Lai, Olivia L. Francis, Christopher L. Morris, Hisham Abdel-Azim, Glenn Dorsam, Meixian Xiang, Kimberly J. Payne, Sinisa Dovat, 2016, Journal of Biological Chemistry on p. 4004-4018

Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia

Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge, 2015, PloS one

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2016, Journal of Biological Chemistry on p. 24449-24464