Sinisa Dovat

Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology

Sinisa Dovat

Research Summary

Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Huck Affiliations

Links

Most Recent Publications

Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia

Yali Ding, Bing He, Daniel Bogush, Joseph Schramm, Chingakham Singh, Katarina Dovat, Julia Randazzo, Diwakar Tukaramrao, Jeremy Hengst, Charyguly Annageldiyev, Avinash Kudva, Dhimant Desai, Arati Sharma, Vladimir S. Spiegelman, Suming Huang, Chi T. Viet, Glenn Dorsam, Giselle Saulnier Scholler, James Broach, Feng Yue, Sinisa Dovat, 2025, Leukemia on p. 2010-2020

CK2α Deletion in the Hematopoietic Compartment Shows a Mild Alteration in Terminally Differentiated Cells and the Expansion of Stem Cells

Rajesh Rajaiah, Muhammad Daniyal, Marudhu Pandiyan Shanmugam, Hannah Valensi, Koby Duke, Katherine Mercer, Morgann Klink, Matthew Lanza, Yasin Uzun, Suming Huang, Sinisa Dovat, Chandrika Gowda Behura, 2025, Cells

Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL

Qi Han, Yan Gu, Huimin Xiang, Linyao Zhang, Yan Wang, Chan Yang, Jun Li, Chelsea Steiner, Rosa Lapalombella, Jennifer A. Woyach, Yiping Yang, Sinisa Dovat, Chunhua Song, Zheng Ge, 2025, Blood on p. 1407-1421

New precision medicine weapons for targeted treatment of high-risk B-cell precursor acute lymphoblastic leukemia

Sinisa Dovat, Joseph Schramm, 2024, Haematologica on p. 3835-3837

Upregulation of nuclear protein Hemgn by transcriptional repressor Gfi1 through repressing PU.1 contributes to the anti-apoptotic activity of Gfi1

Binod G C, Laney Jia Hoyt, Sinisa Dovat, Fan Dong, 2024, Journal of Biological Chemistry

From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies

Upendarrao Golla, Satyam Patel, Nyah Shah, Stella Talamo, Riya Bhalodia, David Claxton, Sinisa Dovat, Arati Sharma, 2024, Cancers

Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma

Minh Phuong Dong, Neeraja Dharmaraj, Estela Kaminagakura, Jianfei Xue, David G. Leach, Jeffrey D. Hartgerink, Michael Zhang, Hana Joy Hanks, Yi Ye, Bradley E. Aouizerat, Kyle Vining, Carissa M. Thomas, Sinisa Dovat, Simon Young, Chi T. Viet, 2024, Biomedicines

Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

William A. Chen, Terry G. Williams, Leena So, Natalie Drew, Jie Fang, Pedro Ochoa, Nhi Nguyen, Yasmeen Jawhar, Jide Otiji, Penelope J. Duerksen-Hughes, Mark E. Reeves, Carlos A. Casiano, Hongjian Jin, Sinisa Dovat, Jun Yang, Kristopher E. Boyle, Olivia L. Francis-Boyle, 2024, International Journal of Molecular Sciences

Integrating Optical Genome Mapping and Whole Genome Sequencing in Somatic Structural Variant Detection

Laura Budurlean, Diwakar Bastihalli Tukaramrao, Lijun Zhang, Sinisa Dovat, James Broach, 2024, Journal of Personalized Medicine

Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Siyu Gu, Yue Hou, Katarina Dovat, Sinisa Dovat, Chunhua Song, Zheng Ge, 2023, Experimental Hematology and Oncology

Most-Cited Papers

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Irina Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, V Singh, Chethana Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, others, Stefan A. Muljo, Vladimir S. Spiegelman, 2020, Leukemia on p. 1354--1363

Subtype-specific 3D genome alteration in acute myeloid leukaemia

J Xu, Fan Song, Huijue Lyu, Mikoto Kobayashi, Baozhen Zhang, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Josiah Wong, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Hongbo Yang, Ross C. Hardison, Sinisa Dovat, Leonidas Platanias, Yarui Diao, Yue Yang, Tomoko Yamada, Aaron Viny, Ross Levine, David Claxton, James R. Broach, Hong Zheng, Feng Yue, 2022, Nature on p. 387-398

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2016, Journal of Biological Chemistry on p. 24449-24464

WDR5 high expression and its effect on tumorigenesis in leukemia

Zheng Ge, Evelyn J. Song, Yuka Imamura Kawasawa, Jianyong Li, Sinisa Dovat, Chunhua Song, 2016, Oncotarget on p. 37740-37754

Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia

Haijun Wang, Chunhua Song, Yali Ding, Xiaokang Pan, Zheng Ge, Bi Hua Tan, Chandrika Gowda, Mansi Sachdev, Sunil Muthusami, Hongsheng Ouyang, Liangxue Lai, Olivia L. Francis, Christopher L. Morris, Hisham Abdel-Azim, Glenn Dorsam, Meixian Xiang, Kimberly J. Payne, Sinisa Dovat, 2016, Journal of Biological Chemistry on p. 4004-4018

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen, Lei Bao, Kerry Keefer, Santhanam Shanmughapriya, Longgui Chen, John Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Salim Merali, Carmen Merali, Yuka Imamura, Sinisa Dovat, Muniswamy Madesh, Joseph Y. Cheung, Hong Gang Wang, Barbara A. Miller, 2020, Cell Death and Disease

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, 2015, Oncotarget on p. 42300-42311

Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia

Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge, 2015, PLoS One

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

N. Yoshida, H. Sakaguchi, H. Muramatsu, Y. Okuno, C. Song, S. Dovat, A. Shimada, M. Ozeki, H. Ohnishi, T. Teramoto, T. Fukao, N. Kondo, Y. Takahashi, K. Matsumoto, K. Kato, S. Kojima, 2017, Leukemia on p. 1221-1223