Sinisa Dovat
Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology
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500 University Drive
Hershey, PA - sxd30@psu.edu
- 717-531-0003
Research Summary
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.
Huck Affiliations
Links
Publication Tags
Leukemia Precursor Cell Lymphoblastic Leukemia Lymphoma Therapeutics Casein Kinase Ii B Lymphocytes Genes Cells Neoplasms Doxorubicin Ion Channels Reactive Oxygen Species Mutation Energy Metabolism Messenger Rna Histone Deacetylase 1 Stem Cells Acute Myeloid Leukemia Rna Binding Proteins Lymphoid Enhancer Binding Factor 1 Insulin Like Growth Factor Binding Protein 2 Histone Demethylases 5 (3 Chlorophenylamino)Benzo(C)(2,6)Naphthyridine 8 Carboxylic A Tumors Phosphorylation ChromatinMost Recent Papers
Transcriptional regulation of Rab21 GTPase in leukemia
Sinisa Dovat, Yali Ding, Chunhua Song, Daniel Bogush, Diwakar Bastihali Tukaramrao, Arati Sharma, Dhimant Desai, 2022, FASEB Journal
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages
Eric Yau, Yan Chen, Chunhua Song, Jason Webb, Marykate Carillo, Yuka Imamura Kawasawa, Zhenyuan Tang, Yoshinori Takahashi, Todd M. Umstead, Sinisa Dovat, Zissis C. Chroneos, 2021, Zeitschrift für Immunitätsforschung und experimentelle Therapie
Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia
Upendarrao Golla, Melanie A. Ehudin, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Abhijit A. Date, Irina Elcheva, Arthur Berg, Shantu Amin, Thomas P. Loughran, Mark Kester, Dhimant Desai, Sinisa Dovat, David Claxton, Arati Sharma, 2021, Cancers
Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity
Gordana Raca, Hisham Abdel-Azim, Feng Yue, James Broach, Jonathon L. Payne, Mark E. Reeves, Chandrika Gowda, Joseph Schramm, Dhimant Desai, Elanora Dovat, Tommy Hu, Arthur S. Berg, Deepa Bhojwani, Kimberly J. Payne, Sinisa Dovat, 2021, Leukemia on p. 2399-2402
Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia
Zheng Ge, Chunhua Song, Yali Ding, Bi Hua Tan, Dhimant Desai, Arati Sharma, Raghavendra Gowda, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Soumya Iyer, Pavan Kumar Dhanyamraju, Yuka Imamura, Daniel Bogush, Yevgeniya Bamme, Yiping Yang, Mario Soliman, Shriya Kane, Elanora Dovat, Joseph Schramm, Tommy Hu, Mary McGrath, Zissis C. Chroneos, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat, 2021, Leukemia on p. 1267-1278
Medulloblastoma
Pavan Kumar Dhanyamraju, Trupti N. Patel, Sinisa Dovat, 2020, Molecular Biology Reports on p. 9931-9937
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia
Chunhua Song, Zheng Ge, Yali Ding, Bi Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat, 2020, Blood on p. 1520-1534
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1
Irina A. Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, Vikash Singh, Chethana P. Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, Stefan A. Muljo, Vladimir S. Spiegelman, 2020, Leukemia on p. 1354-1363
Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis
Ying Li, Ziwei Liao, Huacheng Luo, Aissa Benyoucef, Yuanyuan Kang, Qian Lai, Sinisa Dovat, Barbara Miller, Iouri Chepelev, Yangqiu Li, Keji Zhao, Marjorie Brand, Suming Huang, 2020, Nucleic Acids Research on p. 3119-3133
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
Shu jen Chen, Lei Bao, Kerry Keefer, Santhanam Shanmughapriya, Longgui Chen, John Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Salim Merali, Carmen Merali, Yuka Imamura, Sinisa Dovat, Muniswamy Madesh, Joseph Y. Cheung, Hong Gang Wang, Barbara A. Miller, 2020, Cell Death and Disease
Most-Cited Papers
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822
Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene
Frederick D. Goldman, Zafer Gurel, Duha Al-Zubeidi, Ari J. Fried, Michael Icardi, Chunhua Song, Sinisa Dovat, 2012, Medical and Pediatric Oncology on p. 591-597
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1
Irina A. Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, Vikash Singh, Chethana P. Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, Stefan A. Muljo, Vladimir S. Spiegelman, 2020, Leukemia on p. 1354-1363
Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics
Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2016, Journal of Biological Chemistry on p. 24449-24464
Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia
Haijun Wang, Chunhua Song, Yali Ding, Xiaokang Pan, Zheng Ge, Bi Hua Tan, Chandrika Gowda, Mansi Sachdev, Sunil Muthusami, Hongsheng Ouyang, Liangxue Lai, Olivia L. Francis, Christopher L. Morris, Hisham Abdel-Azim, Glenn Dorsam, Meixian Xiang, Kimberly J. Payne, Sinisa Dovat, 2016, Journal of Biological Chemistry on p. 4004-4018
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros
Fatih M. Uckun, Hong Ma, Jian Zhang, Zahide Ozer, Sinisa Dovat, Cheney Mao, Rita Ishkhanian, Patricia Goodman, Sanjive Qazi, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 18072-18077
WDR5 high expression and its effect on tumorigenesis in leukemia
Zheng Ge, Evelyn J. Song, Yuka Imamura Kawasawa, Jianyong Li, Sinisa Dovat, Chunhua Song, 2016, Oncotarget on p. 37740-37754
Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia
Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge, 2015, PLoS One
Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia
Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, 2015, Oncotarget on p. 42300-42311
High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement
Zheng Ge, Yan Gu, Gang Zhao, Jianyong Li, Baoan Chen, Qi Han, Xing Guo, Juan Liu, Hui Li, Michael D. Yu, Justin Olson, Sadie Steffens, Kimberly J. Payne, Chunhua Song, Sinisa Dovat, 2016, Oncotarget on p. 49722-49732