Sinisa Dovat

Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology

Sinisa Dovat

Research Summary

Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Huck Affiliations

Links

Publication Tags

Precursor Cell Lymphoblastic Leukemia Lymphoma Cells Genes Leukemia Therapeutics B Lymphocytes Neoplasms Phosphorylation Casein Kinase Ii Dna Mutation Tumors Acute Myeloid Leukemia Doxorubicin Transcription Ion Channels Reactive Oxygen Species Phosphotransferases Energy Metabolism Chromatin Histone Deacetylase 1 Ikaros Transcription Factor Gene Expression Stem Cells Protein Phosphatase 1

Most Recent Papers

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity

Gordana Raca, Hisham Abdel-Azim, Feng Yue, James Broach, Jonathon L. Payne, Mark E. Reeves, Chandrika Gowda, Joseph Schramm, Dhimant Desai, Elanora Dovat, Tommy Hu, Arthur S. Berg, Deepa Bhojwani, Kimberly J. Payne, Sinisa Dovat, 2021, Leukemia

Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Zheng Ge, Chunhua Song, Yali Ding, Bihua Tan, Dhimant Desai, Arati Sharma, Raghavendra Gowda, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Soumya Iyer, Pavan Kumar Dhanyamraju, Yuka Imamura, Daniel Bogush, Yevgeniya Bamme, Yiping Yang, Mario Soliman, Shriya Kane, Elanora Dovat, Joseph Schramm, Tommy Hu, Mary McGrath, Zissis C. Chroneos, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat, 2021, Leukemia

Medulloblastoma

Pavan Kumar Dhanyamraju, Trupti N. Patel, Sinisa Dovat, 2020, Molecular Biology Reports on p. 9931-9937

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia

Chunhua Song, Zheng Ge, Yali Ding, Bi Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat, 2020, Blood on p. 1520-1534

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Irina A. Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, Vikash Singh, Chethana P. Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, Stefan A. Muljo, Vladimir S. Spiegelman, 2020, Leukemia on p. 1354-1363

Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis

Ying Li, Ziwei Liao, Huacheng Luo, Aissa Benyoucef, Yuanyuan Kang, Qian Lai, Sinisa Dovat, Barbara Miller, Iouri Chepelev, Yangqiu Li, Keji Zhao, Marjorie Brand, Suming Huang, 2020, Nucleic Acids Research on p. 3119-3133

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen, Lei Bao, Kerry Keefer, Santhanam Shanmughapriya, Longgui Chen, John Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Salim Merali, Carmen Merali, Yuka Imamura, Sinisa Dovat, Muniswamy Madesh, Joseph Y. Cheung, Hong Gang Wang, Barbara A. Miller, 2020, Cell Death and Disease

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Charyguly Annageldiyev, Su Fern Tan, Shreya Thakur, Pavan Kumar Dhanyamraju, Srinivasa R. Ramisetti, Preeti Bhadauria, Jacob Schick, Zheng Zeng, Varun Sharma, Wendy Dunton, Sinisa Dovat, Dhimant Desai, Hong Zheng, David J. Feith, Thomas P. Loughran, Shantu Amin, Arun K. Sharma, David Claxton, Arati Sharma, 2020, Frontiers in Oncology

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma, 2020, Haematologica on p. 687-696

Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

Jonathon L. Payne, Chunhua Song, Yali Ding, Pavan Kumar Dhanyamraju, Yevgeniya Bamme, Joseph W. Schramm, Dhimant Desai, Arati Sharma, Chandrika Gowda, Sinisa Dovat, 2020, International Journal of Molecular Sciences

Most-Cited Papers

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene

Frederick D. Goldman, Zafer Gurel, Duha Al-Zubeidi, Ari J. Fried, Michael Icardi, Chunhua Song, Sinisa Dovat, 2012, Pediatric Blood and Cancer on p. 591-597

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Rahul Nahar, Parham Ramezani-Rad, Maximilian Mossner, Cihangir Duy, Leandro Cerchietti, Huimin Geng, Sinisa Dovat, Hassan Jumaa, B. Hilda Ye, Ari Melnick, Markus Müschen, 2011, Blood on p. 4174-4178

Ikaros and tumor suppression in acute Lymphoblastic leukemia

Kimberly J. Payne, Sinisa Dovat, 2011, Critical Reviews in Oncogenesis on p. 3-12

Ikaros, CK2 kinase, and the road to leukemia

Sinisa Dovat, Chunhua Song, Kimberly J. Payne, Zhanjun Li, 2011, Molecular and Cellular Biochemistry on p. 201-207

Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia

Haijun Wang, Chunhua Song, Yali Ding, Xiaokang Pan, Zheng Ge, Bi Hua Tan, Chandrika Gowda, Mansi Sachdev, Sunil Muthusami, Hongsheng Ouyang, Liangxue Lai, Olivia L. Francis, Christopher L. Morris, Hisham Abdel-Azim, Glenn Dorsam, Meixian Xiang, Kimberly J. Payne, Sinisa Dovat, 2016, Journal of Biological Chemistry on p. 4004-4018

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Fatih M. Uckun, Hong Ma, Jian Zhang, Zahide Ozer, Sinisa Dovat, Cheney Mao, Rita Ishkhanian, Patricia Goodman, Sanjive Qazi, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 18072-18077

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2016, Journal of Biological Chemistry on p. 24449-24464

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, 2015, Oncotarget on p. 42300-42311

Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia

Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge, 2015, PLoS One