Sinisa Dovat

Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology

Sinisa Dovat

Research Summary

Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Huck Affiliations

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Publication Tags

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Leukemia Precursor Cell Lymphoblastic Leukemia Lymphoma Cells Casein Kinase Ii Acute Myeloid Leukemia Ion Channels Reactive Oxygen Species Therapeutics Neoplasms Energy Metabolism Mutation Proteins B Lymphocytes Histone Deacetylase 1 Histone Demethylases Neuroblastoma Lymphoid Enhancer Binding Factor 1 Cell Survival Doxorubicin Messenger Rna Genes Apoptosis Histones Cell Viability Growth

Most Recent Publications

Integrating Optical Genome Mapping and Whole Genome Sequencing in Somatic Structural Variant Detection

Laura Budurlean, Diwakar Bastihalli Tukaramrao, Lijun Zhang, Sinisa Dovat, James Broach, 2024, Journal of Personalized Medicine

Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Siyu Gu, Yue Hou, Katarina Dovat, Sinisa Dovat, Chunhua Song, Zheng Ge, 2023, Experimental Hematology and Oncology

Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

Vijay Pralhad Kale, Jeremy A. Hengst, Arati K. Sharma, Upendarrao Golla, Sinisa Dovat, Shantu G. Amin, Jong K. Yun, Dhimant H. Desai, 2023, Pharmaceuticals

IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis

Mayura R. Dhamdhere, Chethana P. Gowda, Vikash Singh, Zhenqiu Liu, Nicholas Carruthers, Christa Grant, Arati Sharma, Sinisa Dovat, Jeffrey M. Sundstrom, Hong Gang Wang, Vladimir S. Spiegelman, 2023, Oncogene on p. 1558-1571

Signaling pathways and regulation of gene expression in hematopoietic cells

Daniel Bogush, Joseph Schramm, Yali Ding, Bing He, Chingakham Singh, Arati Sharma, Diwakar Bastihalli Tukaramrao, Soumya Iyer, Dhimant Desai, Gregory Nalesnik, Jeremy Hengst, Riya Bhalodia, Chandrika Gowda, Sinisa Dovat, 2023, Advances in Biological Regulation

IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell, Vladimir S. Spiegelman, 2023, Frontiers in Immunology

TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia

Hossam R. Alkashgari, Caleb Ruiz-Jimenez, Cornelia Stoian, Jacqueline S. Coats, Ineavely Baez, Evgeny Chirshev, Shannalee R. Martinez, Sinisa Dovat, Olivia L. Francis-Boyle, Carlos A. Casiano, Kimberly J. Payne, 2023, International Journal of Molecular Sciences

Subtype-specific 3D genome alteration in acute myeloid leukaemia

J Xu, Fan Song, Huijue Lyu, Mikoto Kobayashi, Baozhen Zhang, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Josiah Wong, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Hongbo Yang, Ross C. Hardison, Sinisa Dovat, Leonidas Platanias, Yarui Diao, Yue Yang, Tomoko Yamada, Aaron Viny, Ross Levine, David Claxton, James R. Broach, Hong Zheng, Feng Yue, 2022, Nature on p. 387-398

Novel Casein Kinase II (CK2) inhibitor BMS-135 shows significant in vivo anti-leukemia effect

C. Gowda, A. Purandare, K. Mercer, K. Duke, S. Dovat, 2022, European Journal of Cancer on p. S29

High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study

Jun Li, Qi Han, Yanqing Huang, Yanhui Wei, Jie Zi, Lidong Zhao, Zhimei Cai, Xuzhang Lu, Rong Xiao, Yanming Zhang, Xiaotian Yang, Hao Xu, Naitong Sun, Wanchuan Zhuang, Zhengdong Wu, Yuan Xia, Yanli Xu, Bin He, Wei Zhu, Fengling Min, Yongchun Chen, Banghe Ding, Peimin Shi, Jing Xie, Hua Tang, Zefa Liu, Bingzong Li, Yu Sun, Hongxia Qiu, Limin Duan, Elanora Dovat, Chunhua Song, Laszlo SzeKely, Sinisa Dovat, Zheng Ge, 2022, Blood Cancer Journal

Most-Cited Papers

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Irina A. Elcheva, Tyler Wood, Kathryn Chiarolanzio, Bryan Chim, Madeline Wong, Vikash Singh, Chethana P. Gowda, Qingli Lu, Markus Hafner, Sinisa Dovat, Zhenqiu Liu, Stefan A. Muljo, Vladimir S. Spiegelman, 2020, Leukemia on p. 1354-1363

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Lei Bao, Shu Jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2016, Journal of Biological Chemistry on p. 24449-24464

WDR5 high expression and its effect on tumorigenesis in leukemia

Zheng Ge, Evelyn J. Song, Yuka Imamura Kawasawa, Jianyong Li, Sinisa Dovat, Chunhua Song, 2016, Oncotarget on p. 37740-37754

Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia

Haijun Wang, Chunhua Song, Yali Ding, Xiaokang Pan, Zheng Ge, Bi Hua Tan, Chandrika Gowda, Mansi Sachdev, Sunil Muthusami, Hongsheng Ouyang, Liangxue Lai, Olivia L. Francis, Christopher L. Morris, Hisham Abdel-Azim, Glenn Dorsam, Meixian Xiang, Kimberly J. Payne, Sinisa Dovat, 2016, Journal of Biological Chemistry on p. 4004-4018

Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia

Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge, 2015, PLoS One

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen, Lei Bao, Kerry Keefer, Santhanam Shanmughapriya, Longgui Chen, John Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Salim Merali, Carmen Merali, Yuka Imamura, Sinisa Dovat, Muniswamy Madesh, Joseph Y. Cheung, Hong Gang Wang, Barbara A. Miller, 2020, Cell Death and Disease

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

N. Yoshida, H. Sakaguchi, H. Muramatsu, Y. Okuno, C. Song, S. Dovat, A. Shimada, M. Ozeki, H. Ohnishi, T. Teramoto, T. Fukao, N. Kondo, Y. Takahashi, K. Matsumoto, K. Kato, S. Kojima, 2017, Leukemia on p. 1221-1223

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, 2015, Oncotarget on p. 42300-42311

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

C. Song, X. Pan, Z. Ge, C. Gowda, Y. Ding, H. Li, Z. Li, G. Yochum, M. Muschen, Q. Li, K. J. Payne, S. Dovat, 2016, Leukemia on p. 1436-1440