Shaun Mahony

Associate Professor of Biochemistry & Molecular Biology

Shaun Mahony

Research Summary

We apply neural networks and other machine learning approaches to understand how transcription factors control cellular identity

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Transcription Factors Genome Chromatin Genomics Genes Proteins Dna Motor Neurons Chromatin Immunoprecipitation Sequencing Experiment Nucleosomes Embryonic Stem Cells Chip Gene Expression Biochemistry Quality Control Chromatin Assembly And Disassembly Experiments Fungal Proteins Modeling Analysis Cells Transcription Factor Heat Shock Response Saccharomycetales

Most Recent Papers

PEGR: a flexible management platform for reproducible epigenomic and genomic research

Danying Shao, G Kellogg, Ali Nematbakhsh, Prashant Kuntala, Shaun Mahony, B. Pugh, W Lai,

Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation

Sudarshan Pinglay, Milica Bulajić, Dylan Rahe, Emily Huang, Ran Brosh, Sergei German, John Cadley, Lila Rieber, Nicole Easo, Shaun Mahony, Matthew Maurano, Liam Holt, Esteban Mazzoni, Jef Boeke,

PEGR

Danying Shao, Gretta D. Kellogg, Ali Nematbakhsh, Prashant K. Kuntala, Shaun Mahony, B. Franklin Pugh, William K.M. Lai, 2022, Genome Biology

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes

Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Yingzhen Pei, Simon E. Vidal, Ana Paula Zen Petisco Fiore, Begüm Aydin, Matthias Stadtfeld, Uwe Ohler, Shaun Mahony, Neville E. Sanjana, Esteban O. Mazzoni, 2022, Cell Reports

Domain-adaptive neural networks improve cross-species prediction of transcription factor binding

Kelly Cochran, Divyanshi Srivastava, Avanti Shrikumar, Akshay Balsubramani, Ross C. Hardison, Anshul Kundaje, Shaun Mahony, 2022, Genome Research on p. 512-523

An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding

Divyanshi Srivastava, Begüm Aydin, Esteban O. Mazzoni, Shaun Mahony, 2021, Genome Biology

The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation

Suprita Singh, Joana M. Santos, Lindsey M. Orchard, Naomi Yamada, Riëtte van Biljon, Heather J. Painter, Shaun Mahony, Manuel Llinás, 2021, Molecular Microbiology on p. 1005-1024

A high-resolution protein architecture of the budding yeast genome

Matthew J. Rossi, Prashant K. Kuntala, William K.M. Lai, Naomi Yamada, Nitika Badjatia, Chitvan Mittal, Guray Kuzu, Kylie Bocklund, Nina P. Farrell, Thomas R. Blanda, Joshua D. Mairose, Ann V. Basting, Katelyn S. Mistretta, David J. Rocco, Emily S. Perkinson, Gretta D. Kellogg, Shaun Mahony, B. Franklin Pugh, 2021, Nature on p. 309-314

S3V2-IDEAS: a package for normalizing, denoising and integrating epigenomic datasets across different cell types.

G Xiang, B Giardine, S Mahony, Y Zhang, Ross Hardison, 2021, Bioinformatics (Oxford, England) on p. 3011-3013

Alignment and quantification of ChIP-exo crosslinking patterns reveal the spatial organization of protein-DNA complexes

Naomi Yamada, Matthew J. Rossi, Nina Farrell, B. Franklin Pugh, Shaun Mahony, 2020, Nucleic Acids Research on p. 11215-11226

Most-Cited Papers

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Makiko Iwafuchi-Doi, Greg Donahue, Akshay Kakumanu, Jason A. Watts, Shaun Mahony, B. Franklin Pugh, Dolim Lee, Klaus H. Kaestner, Kenneth S. Zaret, 2016, Molecular Cell on p. 79-91

High Resolution Genome Wide Binding Event Finding and Motif Discovery Reveals Transcription Factor Spatial Binding Constraints

Yuchun Guo, Shaun Mahony, David K. Gifford, 2012, PLoS Computational Biology

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

Esteban O. Mazzoni, Shaun Mahony, Michael Closser, Carolyn A. Morrison, Stephane Nedelec, Damian J. Williams, Disi An, David K. Gifford, Hynek Wichterle, 2013, Nature Neuroscience on p. 1219-1227

Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Esteban O. Mazzoni, Shaun Mahony, Mirza Peljto, Tulsi Patel, Seraphim R. Thornton, Scott McCuine, Christopher Reeder, Laurie A. Boyer, Richard A. Young, David K. Gifford, Hynek Wichterle, 2013, Nature Neuroscience on p. 1191-1198

Reprogrammed stomach tissue as a renewable source of functional β cells for blood glucose regulation

Chaiyaboot Ariyachet, Alessio Tovaglieri, Guanjue Xiang, Jiaqi Lu, Manasvi S. Shah, Camilla A. Richmond, Catia Verbeke, Douglas A. Melton, Ben Z. Stanger, David Mooney, Ramesh A. Shivdasani, Shaun Mahony, Qing Xia, David T. Breault, Qiao Zhou, 2016, Cell Stem Cell on p. 410-421

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons

Simona Lodato, Bradley J. Molyneaux, Emanuela Zuccaro, Loyal A. Goff, Hsu Hsin Chen, Wen Yuan, Alyssa Meleski, Emi Takahashi, Shaun Mahony, John L. Rinn, David K. Gifford, Paola Arlotta, 2014, Nature Neuroscience on p. 1046-1054

A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells

Silvia Velasco, Mahmoud M. Ibrahim, Akshay Kakumanu, Görkem Garipler, Begüm Aydin, Mohamed Ahmed Al-Sayegh, Antje Hirsekorn, Farah Abdul-Rahman, Rahul Satija, Uwe Ohler, Shaun Mahony, Esteban O. Mazzoni, 2017, Cell Stem Cell on p. 205-217.e8

An Integrated Model of Multiple-Condition ChIP-Seq Data Reveals Predeterminants of Cdx2 Binding

Shaun Mahony, Matthew D. Edwards, Esteban O. Mazzoni, Richard I. Sherwood, Akshay Kakumanu, Carolyn A. Morrison, Hynek Wichterle, David K. Gifford, 2014, PLoS Computational Biology

Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

Begüm Aydin, Akshay Kakumanu, Mary Rossillo, Mireia Moreno-Estellés, Görkem Garipler, Niels Ringstad, Nuria Flames, Shaun Mahony, Esteban O. Mazzoni, 2019, Nature Neuroscience on p. 897-908

Widespread and precise reprogramming of yeast protein-genome interactions in response to heat shock.

Vinesh Vinayachandran, Rohit Reja, Matthew J. Rossi, Bongsoo Park, Lila Rieber, Chitvan Mittal, Shaun Mahony, B. Franklin Pugh, 2018, Genome Research on p. 357-366