Shantu Amin

Professor of Pharmacology

Shantu Amin

Publication Tags

Apoptosis Aryl Hydrocarbon Receptors Neoplasms Dna Ligands Human Ahr Protein Quinoxalines Reactive Oxygen Species Sulforafan Cells Glycine Proteins Antineoplastic Agents Therapeutics Membranes Chemical Activation Stem Cells Intestines Microbiota Melanoma Prostatic Neoplasms Abt 737 Viruses 2,8 Dihydroxyquinoline Oxaliplatin

Most Recent Papers

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Dhimant Desai, Matthew Lauver, Alexandria Ostman, Linda Cruz, Kevin Ferguson, Ge Jin, Brianne Roper, Daniel Brosius, Aron Lukacher, Shantu Amin, Nicholas Buchkovich, 2019, Bioorganic and Medicinal Chemistry on p. 1795-1803

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain Alexander Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Leishmanicidal activity of isoselenocyanate derivatives

Celia Fernández-Rubio, Esther Larrea, José Peña Guerrero, Eduardo Sesma Herrero, Iñigo Gamboa, Carlos Berrio, Daniel Plano, Shantu Amin, Arun Sharma, Paul A. Nguewa, 2019, Antimicrobial agents and chemotherapy

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Verónica Alcolea, Deepkamal N. Karelia, Manoj K. Pandey, Daniel Plano, Parvesh Singh, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun Sharma, 2019, International journal of molecular sciences

Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

Vladimir Shafirovich, Marina Kolbanovskiy, Konstantin Kropachev, Zhi Liu, Yuquin Cai, Michael A. Terzidis, Annalisa Masi, Chryssostomos Chatgilialoglu, Shantu Amin, Alexander Dadali, Suse Broyde, Nicholas E. Geacintov, 2019, Biochemistry

ASR352, A potent anticancer agent

Satya Narayan, Srinivasa Ramisetti, Aruna S. Jaiswal, Brian K. Law, Ashona Singh-Pillay, Parvesh Singh, Shantu Amin, Arun Sharma, 2019, European Journal of Medicinal Chemistry on p. 456-467

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Emily E. Frieben, Shantu Amin, Arun Sharma, 2019, Journal of Medicinal Chemistry

Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary

Kun-Ming Chen, Yuan-Wan Sun, Timothy K. Cooper, Gabrielle Benitez, Cesar Aliaga, Junjia Zhu, Krishne Gowda, Shantu Amin, Karam El-Bayoumy, 2018, Chemical Research in Toxicology on p. 1111-1118

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Marcin Dyba, Brandon Da Silva, Heidi Coia, Yanqi Hou, Sumire Noguchi, Jishen Pan, Deborah Berry, Karen Creswell, Jacek Krzeminski, Dhimant Desai, Shantu Amin, David Yang, Fung Lung Chung, 2018, Chemical Research in Toxicology on p. 772-783

Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells

Wei Wu, Deepkamal Karelia, Kartick Pramanik, Shantu Amin, Arun Sharma, Cheng Jiang, Junxuan Lu, 2018, Molecular Carcinogenesis on p. 1055-1066

High-Impact Papers

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu Amin, Istvan Albert, Andrew David Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong-Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells

Shivendra V. Singh, Renaud Warin, Dong Xiao, A. Anna Powolny, Silvia D. Stan, Jlie A. Arlotti, Yan Zeng, Eun Ryeong Hahm, Stanley W. Marynowski, Ajay Bommareddy, Dhimant Desai, Shantu Amin, Robert A. Parise, Jan H. Beumer, William H. Chambers, 2009, Cancer Research on p. 2117-2125

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain Alexander Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh ming Lin, Stephen C. Strom, Curtis John Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew David Patterson, Frank J. Gonzalez, 2015, Nature communications

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen-shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Krishne Gowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong-Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

Arati Sharma, Arun Sharma, Subbarao V. Madhunapantula, Dhimant Desai, Sung Jin Huh, Paul Mosca, Shantu Amin, Gavin Robertson, 2009, Clinical Cancer Research on p. 1674-1685

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain Alexander Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu Amin, Andrew David Patterson, Gary H. Perdew, 2015, Scientific reports

Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species

Dong Xiao, Anna A. Powolny, Jedrzej Antosiewicz, Eun Ryeong Hahm, Ajay Bommareddy, Yan Zeng, Dhimant Desai, Shantu Amin, Anna Herman-Antosiewicz, Shivendra V. Singh, 2009, Pharmaceutical Research on p. 1729-1738

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Iain Alexander Murray, Jose L. Morales, Colin A. Flaveny, Brett C. DiNatale, Chris Chiaro, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2010, Molecular Pharmacology on p. 247-254