Shantu Amin
Professor of Pharmacology
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Hershey Med Ctr
Hershey, - sga3@psu.edu
- 717-531-8285
Huck Affiliations
Most Recent Publications
Pharmacological agents targeting drug-tolerant persister cells in cancer
Yu Chi Chen, Krishne Gowda, Shantu Amin, Todd D. Schell, Arun K. Sharma, Gavin P. Robertson, 2024, Pharmacological Research
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew, 2023, Metabolites
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters, 2023, Metabolites
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Vijay Pralhad Kale, Jeremy A. Hengst, Arati K. Sharma, Upendarrao Golla, Sinisa Dovat, Shantu G. Amin, Jong K. Yun, Dhimant H. Desai, 2023, Pharmaceuticals
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew, 2023, FASEB Journal on p. e23010
Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis
Ramanpreet Kaur, Dhimant Desai, Shantu Amin, Kaisar Raza, Aman Bhalla, Pooja Yadav, Naveen Kaushal, 2023, Molecular and Cellular Biochemistry on p. 621-636
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2023, Laboratory Investigation on p. 100012
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
Ethan W. Morgan, Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Trenton Wolfe, Reece Erickson, Krishne Gowda, Shantu G. Amin, Kristina S. Petersen, Penny M. Kris-Etherton, Craig B. Marcus, Seth T. Walk, Andrew D. Patterson, Gary H. Perdew, 2023, International Journal of Tryptophan Research
Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity
Kun-Ming Chen, Yuan-Wan Sun, Jiafen Hu, Karla Balogh, Krishne Gowda, Cesar Aliaga, Dongxiao Sun, Neil Christensen, Shantu Amin, Karam El-Bayoumy, K El Bayoumy, 2023, ACS Omega
Most-Cited Papers
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa Tindall, Penny Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary Perdew, 2020, Gut Microbes on p. 1788899
Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents
Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328
Acid ceramidase is upregulated in AML and represents a novel therapeutic target
Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222
Targeting ion channels for cancer therapy by repurposing the approved drugs
Vijay Pralhad Kale, Shantu G. Amin, Manoj K. Pandey, 2015, Biochimica et Biophysica Acta - Biomembranes on p. 2747-2755
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
News Articles Featuring Shantu Amin
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article
Apr 06, 2023
Broccoli consumption protects gut lining, reduces disease, in mice
Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.
Full Article