Shantu Amin

Professor of Pharmacology

Shantu Amin

Publication Tags

Aryl Hydrocarbon Receptors Antineoplastic Agents Ligands Pharmaceutical Preparations Therapeutics Apoptosis Human Ahr Protein Neoplasms Dna Anti Inflammatory Agents Quinoxalines Glycine Chemical Activation Proteins Stem Cells Genes Fluorouracil Protein Isoforms Intestines Microbiota Carcinogens Oxaliplatin Aldehyde Dehydrogenase Transducers Muricholic Acid

Most Recent Papers

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Saketh S. Dinavahi, Raghavendra Gowda, Christopher G. Bazewicz, Madhu Babu Battu, Jyh Ming Lin, Robert J. Chitren, Manoj K. Pandey, Shantu Amin, Gavin P. Robertson, Krishne Gowda, 2020, European Journal of Medicinal Chemistry

Effects of the Tobacco Carcinogens N′-Nitrosonornicotine and Dibenzo[ a, l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue

Joseph B. Guttenplan, Kun-Ming Chen, Yuan-Wan Sun, Nora A.E. Shalaby, Wieslawa Kosinska, Dhimant Desai, Krishne Gowda, Shantu Amin, Karam El-Bayoumy, 2019, Chemical research in toxicology on p. 1893-1899

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Emily E. Frieben, Shantu Amin, Arun Sharma, 2019, Journal of Medicinal Chemistry on p. 5261-5275

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Dhimant Desai, Matthew Lauver, Alexandria Ostman, Linda Cruz, Kevin Ferguson, Ge Jin, Brianne Roper, Daniel Brosius, Aron Lukacher, Shantu Amin, Nicholas Buchkovich, 2019, Bioorganic and Medicinal Chemistry on p. 1795-1803

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Troy D. Hubbard, Qing Liu, Iain A. Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew D. Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Verónica Alcolea, Deepkamal N. Karelia, Manoj K. Pandey, Daniel Plano, Parvesh Singh, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun K. Sharma, 2019, International journal of molecular sciences

Leishmanicidal activity of isoselenocyanate derivatives

Celia Fernández-Rubio, Esther Larrea, José Peña Guerrero, Eduardo Sesma Herrero, Iñigo Gamboa, Carlos Berrio, Daniel Plano, Shantu Amin, Arun K. Sharma, Paul A. Nguewa, 2019, Antimicrobial agents and chemotherapy

Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

Vladimir Shafirovich, Marina Kolbanovskiy, Konstantin Kropachev, Zhi Liu, Yuquin Cai, Michael A. Terzidis, Annalisa Masi, Chryssostomos Chatgilialoglu, Shantu Amin, Alexander Dadali, Suse Broyde, Nicholas E. Geacintov, 2019, Biochemistry

ASR352, A potent anticancer agent

Satya Narayan, Srinivasa Ramisetti, Aruna S. Jaiswal, Brian K. Law, Ashona Singh-Pillay, Parvesh Singh, Shantu Amin, Arun Sharma, 2019, European Journal of Medicinal Chemistry on p. 456-467

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Su Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, 2019, Journal of Lipid Research on p. 1078-1086

Most-Cited Papers

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature communications

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain A. Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh Ming Lin, Stephen C. Strom, Curtis J. Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific reports

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Iain A. Murray, Jose L. Morales, Colin A. Flaveny, Brett C. DiNatale, Chris Chiaro, Krishnegowda Gowdahalli, Shantu Amin, Gary H. Perdew, 2010, Molecular pharmacology on p. 247-254

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

Iain A. Murray, Gowdahalli Krishnegowda, Brett C. Dinatale, Colin Flaveny, Chris Chiaro, Jyh Ming Lin, Arun K. Sharma, Shantu Amin, Gary H. Perdew, 2010, Chemical research in toxicology on p. 955-966

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959