Shantu Amin

Professor of Pharmacology

Shantu Amin

Huck Affiliations

Publication Tags

Therapeutics Neoplasms Apoptosis Aldehyde Dehydrogenase Cells Isatin Protein Isoforms Pharmaceutical Preparations Antineoplastic Agents Tobacco Dibenzo(A,L)Pyrene Smoke Acute Myeloid Leukemia Selenium Glycine Leukemia Casein Kinase Ii Ceramides Intestines Genes Environmental Pollutants Death Domain Receptor Signaling Adaptor Proteins Citrobacter Rodentium Muricholic Acid Marinopyrrole A

Most Recent Papers

The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections

Neil D. Christensen, Kun Ming Chen, Jiafen Hu, Douglas B. Stairs, Yuan Wan Sun, Cesar Aliaga, Karla K. Balogh, Hannah Atkins, Debra Shearer, Jingwei Li, Sarah A. Brendle, Krishne Gowda, Shantu Amin, Vonn Walter, Raphael Viscidi, Karam El-Bayoumy, 2021, Chemico-Biological Interactions

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia

Chunhua Song, Zheng Ge, Yali Ding, Bi Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat, 2020, Blood on p. 1520-1534

The essential role of selenoproteins in the resolution of citrobacter rodentium-induced intestinal inflammation

Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu, 2020, Frontiers in Nutrition

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Charyguly Annageldiyev, Su Fern Tan, Shreya Thakur, Pavan Kumar Dhanyamraju, Srinivasa R. Ramisetti, Preeti Bhadauria, Jacob Schick, Zheng Zeng, Varun Sharma, Wendy Dunton, Sinisa Dovat, Dhimant Desai, Hong Zheng, David J. Feith, Thomas P. Loughran, Shantu Amin, Arun K. Sharma, David Claxton, Arati Sharma, 2020, Frontiers in Oncology

Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations

Kun-Ming Chen, Yuan-Wan Sun, Yuka Kawasawa, Anna Salzberg, Junjia Zhu, Krishnegowda Gowdahalli, Cesar Aliaga, Shantu Amin, Hannah Atkins, Karam El Bayoumy, 2020, Cancer Prevention Research on p. 357-366

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma, 2020, Haematologica on p. 687-696

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Gulsum E. Muku, Ann Kusnadi, Guray Kuzu, Rachel Tanos, Iain A. Murray, Krishne Gowda, Shantu Amin, Gary H. Perdew, 2020, Laboratory Investigation on p. 250-264

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Saketh S. Dinavahi, Raghavendra Gowda, Krishne Gowda, Christopher G. Bazewicz, Venkat R. Chirasani, Madhu Babu Battu, Arthur Berg, Nikolay V. Dokholyan, Shantu Amin, Gavin P. Robertson, 2020, Molecular Cancer Therapeutics on p. 447-459

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Saketh S. Dinavahi, Raghavendra Gowda, Christopher G. Bazewicz, Madhu Babu Battu, Jyh Ming Lin, Robert J. Chitren, Manoj K. Pandey, Shantu Amin, Gavin P. Robertson, Krishne Gowda, 2020, European Journal of Medicinal Chemistry

Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

Jennifer M. Pearson, Su Fern Tan, Arati Sharma, Charyguly Annageldiyev, Todd E. Fox, Jose Luis Abad, Gemma Fabrias, Dhimant Desai, Shantu Amin, Hong Gang Wang, Myles C. Cabot, David F. Claxton, Mark Kester, David J. Feith, Thomas P. Loughran, 2020, Molecular Cancer Research on p. 352-363

Most-Cited Papers

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014

Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions

Dara A. Reeves, Hong Mu, Konstantin Kropachev, Yuqin Cai, Shuang Ding, Alexander Kolbanovskiy, Marina Kolbanovskiy, Ying Chen, Jacek Krzeminski, Shantu Amin, Dinshaw J. Patel, Suse Broyde, Nicholas E. Geacintov, 2011, Nucleic Acids Research on p. 8752-8764