Shantu Amin

Professor of Pharmacology

Shantu Amin

Huck Affiliations

Publication Tags

Neoplasms Therapeutics Cholesterol Selenium Proteins Tumors Glycine Genes Metabolism Molecule Protein Apoptosis Peroxisome Proliferator Activated Receptors Intestines Ligand Chemistry Vorinostat Muricholic Acid Caspase 8 Abt 737 Peroxisome Proliferator Activated Receptor Agonist Membranes Colorectal Neoplasms Aryl Hydrocarbon Receptors Histone Deacetylases

Most Recent Papers

Influence of ceramide on lipid domain stability studied with small-angle neutron scattering

Mitchell DiPasquale, Tye G. Deering, Dhimant Desai, Arun K. Sharma, Shantu Amin, Todd E. Fox, Mark Kester, John Katsaras, Drew Marquardt, Frederick A. Heberle, 2022, Chemistry and Physics of Lipids

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development

Saketh S. Dinavahi, Yu Chi Chen, Raghavendra Gowda, Pavan Kumar Dhanyamraju, Kishore Punnath, Dhimant Desai, Arthur Berg, Scot R. Kimball, Shantu Amin, Jin Ming Yang, Gavin P. Robertson, 2022, International Journal of Molecular Sciences

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma, 2022, Molecules

Selenium-Based Novel Epigenetic Regulators Offer Effective Chemotherapeutic Alternative with Wider Safety Margins in Experimental Colorectal Cancer

Preety Ghanghas, Monika Sharma, Dhimant Desai, Kaisar Raza, Aman Bhalla, Pramod Kumar, Dipika Narula, Shantu Amin, Sankar Nath Sanyal, Naveen Kaushal, 2022, Biological Trace Element Research on p. 635-646

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

Carmen S. Tellez, Maria A. Picchi, Daniel Juri, Kieu Do, Dhimant H. Desai, Shantu G. Amin, Julie A. Hutt, Piotr T. Filipczak, Steven A. Belinsky, 2021, Clinical Epigenetics

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Kun Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy, 2021, Scientific Reports

Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia

Upendarrao Golla, Melanie A. Ehudin, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Abhijit A. Date, Irina Elcheva, Arthur Berg, Shantu Amin, Thomas P. Loughran, Mark Kester, Dhimant Desai, Sinisa Dovat, David Claxton, Arati Sharma, 2021, Cancers

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80

Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Yu Chi Chen, Saketh S. Dinavahi, Qilong Feng, Raghavendra Gowda, Srinivasa Ramisetti, Xinghai Xia, Kyle B. LaPenna, Venkat R. Chirasani, Sung Hyun Cho, Susan L. Hafenstein, Madhu Babu Battu, Arthur Berg, Arun K. Sharma, Tom Kirchhausen, Nikolay V. Dokholyan, Shantu Amin, Pingnian He, Gavin P. Robertson, 2021, Cancer Letters on p. 107-119

Most-Cited Papers

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Chunhua Song, Chandrika Gowda, Xiaokang Pan, Yali Ding, Yongqing Tong, Bi Hua Tan, Haijun Wang, Sunil Muthusami, Zheng Ge, Mansi Sachdev, Shantu G. Amin, Dhimant Desai, Krishne Gowda, Raghavendra Gowda, Gavin P. Robertson, Hilde Schjerven, Markus Muschen, Kimberly J. Payne, Sinisa Dovat, 2015, Blood on p. 1813-1822

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

Crucial role of macrophage selenoproteins in experimental colitis

Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692