Sergei Koshkin

Assistant Research Professor

323 Huck Life Sciences
University Park, PA
He/His
sqk6348@psu.edu
814-863-2533

Research Summary

The application and development of mass spectrometry methods for analysis of biomolecules for identification of prognostic/diagnostic/predictive biomarkers and research of mechanisms and regulations of normal and pathological processes in living systems.

Huck Affiliations

Metabolomics Core Facility

Most Recent Publications

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose

Hung Chun Tung, Jong Won Kim, Junjie Zhu, Sihan Li, Jiong Yan, Qing Liu, Imhoi Koo, Sergei A. Koshkin, Fuhua Hao, Guo Zhong, Meishu Xu, Zehua Wang, Jingyuan Wang, Yixian Huang, Yue Xi, Xinran Cai, Pengfei Xu, Songrong Ren, Takanobu Higashiyama, Frank J. Gonzalez, Song Li, Nina Isoherranen, Da Yang, Xiaochao Ma, Andrew D. Patterson, Wen Xie, 2024, Science Translational Medicine

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice

Yuan Tian, Bipin Rimal, Jordan E. Bisanz, Wei Gui, Trenton M. Wolfe, Imhoi Koo, Iain Alexander Murray, Shaneice K. Nettleford, Shigetoshi Yokoyama, Fangcong Dong, Sergei Koshkin, K. Sandeep Prabhu, Peter J. Turnbaugh, Seth T. Walk, Gary H. Perdew, Andrew D. Patterson, 2024, Environmental Health Perspectives on p. 87005

Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System

Valery G. Shtyrlin, Valery A. Borissenok, Nikita Yu Serov, Vladimir G. Simakov, Vyacheslav A. Bragunets, Ivan R. Trunin, Irina A. Tereshkina, Sergey A. Koshkin, Mikhail S. Bukharov, Edward M. Gilyazetdinov, Evgeny E. Shestakov, Anna G. Sirotkina, Alexey V. Zakharov, 2019, Origins of Life and Evolution of Biospheres on p. 1-18

C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies

Konstantin Petrov, Irina Zueva, Irina Kovyazina, Igor Sedov, Sofya Lushchekina, Alexandra Kharlamova, Oksana Lenina, Sergei Koshkin, Yurii Shtyrlin, Evgeny Nikolsky, Patrick Masson, 2018, Neuropharmacology on p. 304-315

Synthesis of lipophilic N-phosphorylmethylated amino acids and their membrane-transport properties towards some organic acids

Rafael A. Cherkasov, Sergey A. Koshkin, Airat R. Garifzyanov, Natal'ya V. Davletshina, 2016, Phosphorus, Sulfur and Silicon and the Related Elements on p. 1650-1651

Synthesis of silyl esters of phosphorylated derivatives of sarcosine

R. R. Davletshin, N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, R. A. Cherkasov, 2016, Russian Journal of General Chemistry on p. 2562-2563

Synthesis of a new quaternary phosphonium salt: NMR study of the conformational structure and dynamics

Oksana V. Aganova, Leysan F. Galiullina, Albert V. Aganov, Nikita V. Shtyrlin, Mikhail V. Pugachev, Alexey D. Strel'nik, Sergey A. Koshkin, Yurii G. Shtyrlin, Vladimir V. Klochkov, 2016, Magnetic Resonance in Chemistry on p. 320-327

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev, R. R. Khairullina, S. A. Koshkin, A. G. Iksanova, O. A. Lodochnikova, N. N. Khaertdinov, G. F. Sitdikova, A. F. Safina, E. G. Aleksandrova, L. E. Ziganshina, Yu G. Shtyrlin, 2016, Bulletin of the Academy of Sciences of the USSR Division of Chemical Science on p. 519-531

Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

Nikita V. Shtyrlin, Sergey V. Sapozhnikov, Sergey A. Koshkin, Alfiya G. Iksanova, Arthur H. Sabirov, Airat R. Kayumov, Aliya A. Nureeva, Marina I. Zeldi, Yurii G. Shtyrlin, 2015, Medicinal Chemistry on p. 656-665

Synthesis and membrane-transport properties of new lithium-selective extracting agent, tris(O,O-diamylphosphorylmethyl)amine

N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, M. A. Filimonova, A. Z. Gainullin, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 2198-2199

Most-Cited Papers

Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies

Synthesis of new lipophilic phosphine oxide derivatives of natural amino acids and their membrane transport properties toward carboxylic acids

S. A. Koshkin, A. R. Garifzyanov, N. V. Davletshina, O. N. Kataeva, D. R. Islamov, R. A. Cherkasov, 2015, Russian Journal of Organic Chemistry on p. 1232-1244

Antagonistic properties of new non-phosphorylated derivatives of nitrogen-containing heterocycles towards P2 receptors

Ayrat U. Ziganshin, Olga S. Kalinina, Alexei D. Strelnik, Marsel R. Garipov, Sergey A. Koshkin, Liliya E. Ziganshina, Yurii G. Shtyrlin, 2015, International Journal of Pharmacology on p. 400-404

Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose

Liquid extraction of metal ions with phosphonate derivatives of amino acids

S. A. Koshkin, A. R. Garifzyanov, N. V. Davletshina, R. R. Davletshin, E. O. Chibirev, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 1789-1790

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

Membrane transport of alkali metals with phosphorylmethyl derivatives of amino acids

N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, R. R. Davletshin, M. A. Filimonova, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 1791-1792

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice

News Articles Featuring Sergei Koshkin

Aug 14, 2024

Early life exposure to common chemical permanently disrupts gut microbiome

Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.

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Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Full Article