Sergei Koshkin
Assistant Research Professor
-
323 Huck Life Sciences
University Park, PA - He/His
- sqk6348@psu.edu
- 814-863-2533
Research Summary
The application and development of mass spectrometry methods for analysis of biomolecules for identification of prognostic/diagnostic/predictive biomarkers and research of mechanisms and regulations of normal and pathological processes in living systems.
Huck Affiliations
Most Recent Publications
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
Hung Chun Tung, Jong Won Kim, Junjie Zhu, Sihan Li, Jiong Yan, Qing Liu, Imhoi Koo, Sergei Koshkin, Fuhua Hao, Guo Zhong, Meishu Xu, Zehua Wang, Jingyuan Wang, Yixian Huang, Yue Xi, Xinran Cai, Pengfei Xu, Songrong Ren, Takanobu Higashiyama, Frank J. Gonzalez, Song Li, Nina Isoherranen, Da Yang, Xiaochao Ma, Andrew D. Patterson, Wen Xie, 2024, Science Translational Medicine
Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice
Yuan Tian, Bipin Rimal, Jordan E. Bisanz, Wei Gui, Trenton M. Wolfe, Imhoi Koo, Iain Alexander Murray, Shaneice K. Nettleford, Shigetoshi Yokoyama, Fangcong Dong, Sergei Koshkin, K. Sandeep Prabhu, Peter J. Turnbaugh, Seth T. Walk, Gary H. Perdew, Andrew D. Patterson, 2024, Environmental Health Perspectives
Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System
Valery G. Shtyrlin, Valery A. Borissenok, Nikita Yu Serov, Vladimir G. Simakov, Vyacheslav A. Bragunets, Ivan R. Trunin, Irina A. Tereshkina, Sergey A. Koshkin, Mikhail S. Bukharov, Edward M. Gilyazetdinov, Evgeny E. Shestakov, Anna G. Sirotkina, Alexey V. Zakharov, 2019, Origins of Life and Evolution of Biospheres on p. 1-18
C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies
Konstantin Petrov, Irina Zueva, Irina Kovyazina, Igor Sedov, Sofya Lushchekina, Alexandra Kharlamova, Oksana Lenina, Sergei Koshkin, Yurii Shtyrlin, Evgeny Nikolsky, Patrick Masson, 2018, Neuropharmacology on p. 304-315
Synthesis of lipophilic N-phosphorylmethylated amino acids and their membrane-transport properties towards some organic acids
Rafael A. Cherkasov, Sergey A. Koshkin, Airat R. Garifzyanov, Natal'ya V. Davletshina, 2016, Phosphorus, Sulfur and Silicon and the Related Elements on p. 1650-1651
Synthesis of silyl esters of phosphorylated derivatives of sarcosine
R. R. Davletshin, N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, R. A. Cherkasov, 2016, Russian Journal of General Chemistry on p. 2562-2563
Synthesis of a new quaternary phosphonium salt: NMR study of the conformational structure and dynamics
Oksana V. Aganova, Leysan F. Galiullina, Albert V. Aganov, Nikita V. Shtyrlin, Mikhail V. Pugachev, Alexey D. Strel'nik, Sergey A. Koshkin, Yurii G. Shtyrlin, Vladimir V. Klochkov, 2016, Magnetic Resonance in Chemistry on p. 320-327
Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine
R. S. Pavelyev, R. R. Khairullina, S. A. Koshkin, A. G. Iksanova, O. A. Lodochnikova, N. N. Khaertdinov, G. F. Sitdikova, A. F. Safina, E. G. Aleksandrova, L. E. Ziganshina, Yu G. Shtyrlin, 2016, Bulletin of the Academy of Sciences of the USSR Division of Chemical Science on p. 519-531
Synthesis and structure of complexes of N-(diphenylphosphoryl)methyl-N-methylaminoacetic acid with ions of cooper(II) and nickel(II)
A. R. Garifzyanov, S. A. Koshkin, N. V. Davletshina, Ye O. Chibirev, D. R. Islamov, O. N. Kataeva, R. A. Cherkasov, 2015, Russian Journal of Organic Chemistry on p. 1659-1661
Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives
Nikita V. Shtyrlin, Sergey V. Sapozhnikov, Sergey A. Koshkin, Alfiya G. Iksanova, Arthur H. Sabirov, Airat R. Kayumov, Aliya A. Nureeva, Marina I. Zeldi, Yurii G. Shtyrlin, 2015, Medicinal Chemistry on p. 656-665
Most-Cited Papers
Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives
Nikita V. Shtyrlin, Sergey V. Sapozhnikov, Sergey A. Koshkin, Alfiya G. Iksanova, Arthur H. Sabirov, Airat R. Kayumov, Aliya A. Nureeva, Marina I. Zeldi, Yurii G. Shtyrlin, 2015, Medicinal Chemistry on p. 656-665
C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies
Konstantin Petrov, Irina Zueva, Irina Kovyazina, Igor Sedov, Sofya Lushchekina, Alexandra Kharlamova, Oksana Lenina, Sergei Koshkin, Yurii Shtyrlin, Evgeny Nikolsky, Patrick Masson, 2018, Neuropharmacology on p. 304-315
Synthesis of new lipophilic phosphine oxide derivatives of natural amino acids and their membrane transport properties toward carboxylic acids
S. A. Koshkin, A. R. Garifzyanov, N. V. Davletshina, O. N. Kataeva, D. R. Islamov, R. A. Cherkasov, 2015, Russian Journal of Organic Chemistry on p. 1232-1244
Antagonistic properties of new non-phosphorylated derivatives of nitrogen-containing heterocycles towards P2 receptors
Ayrat U. Ziganshin, Olga S. Kalinina, Alexei D. Strelnik, Marsel R. Garipov, Sergey A. Koshkin, Liliya E. Ziganshina, Yurii G. Shtyrlin, 2015, International Journal of Pharmacology on p. 400-404
Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System
Valery G. Shtyrlin, Valery A. Borissenok, Nikita Yu Serov, Vladimir G. Simakov, Vyacheslav A. Bragunets, Ivan R. Trunin, Irina A. Tereshkina, Sergey A. Koshkin, Mikhail S. Bukharov, Edward M. Gilyazetdinov, Evgeny E. Shestakov, Anna G. Sirotkina, Alexey V. Zakharov, 2019, Origins of Life and Evolution of Biospheres on p. 1-18
Liquid extraction of metal ions with phosphonate derivatives of amino acids
S. A. Koshkin, A. R. Garifzyanov, N. V. Davletshina, R. R. Davletshin, E. O. Chibirev, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 1789-1790
Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine
R. S. Pavelyev, R. R. Khairullina, S. A. Koshkin, A. G. Iksanova, O. A. Lodochnikova, N. N. Khaertdinov, G. F. Sitdikova, A. F. Safina, E. G. Aleksandrova, L. E. Ziganshina, Yu G. Shtyrlin, 2016, Bulletin of the Academy of Sciences of the USSR Division of Chemical Science on p. 519-531
Synthesis and membrane-transport properties of new lithium-selective extracting agent, tris(O,O-diamylphosphorylmethyl)amine
N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, M. A. Filimonova, A. Z. Gainullin, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 2198-2199
Membrane transport of alkali metals with phosphorylmethyl derivatives of amino acids
N. V. Davletshina, S. A. Koshkin, A. R. Garifzyanov, R. R. Davletshin, M. A. Filimonova, R. A. Cherkasov, 2015, Russian Journal of General Chemistry on p. 1791-1792
Synthesis and structure of complexes of N-(diphenylphosphoryl)methyl-N-methylaminoacetic acid with ions of cooper(II) and nickel(II)
A. R. Garifzyanov, S. A. Koshkin, N. V. Davletshina, Ye O. Chibirev, D. R. Islamov, O. N. Kataeva, R. A. Cherkasov, 2015, Russian Journal of Organic Chemistry on p. 1659-1661
News Articles Featuring Sergei Koshkin
Aug 14, 2024
Early life exposure to common chemical permanently disrupts gut microbiome
Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.
Full Article
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Full Article