Scott Selleck
Professor of Biochemistry and Molecular Biology

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206D Huck Life Sciences
University Park, PA - sbs24@psu.edu
- 814-867-3274
Huck Affiliations
Most Recent Publications
Impaired mitophagy in Sanfilippo A mice causes hypertriglyceridemia and brown adipose tissue activation
Miguel TilloUC, William Lamanna, Chrissa Dwyer, Daniel Sandoval, Ariane Pennetheiner, Norah Al-Azzam, Stephane Sarrazin, Jon Gonzalex, Shih-Hsin Kan, Alexander Andreyev, Nicholas Schultheis, Bryan Thacker, Charles Glass, Patricia Dickson, Raymond Wang, Scott Selleck, Jeff Esko, Philip Gordts, Journal of Biological Chemistry on p. 15
Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease
Nicholas Schultheis, Alyssa Connell, Alexander Kapral, Robert J. Becker, Richard Mueller, Shalini Shah, Mackenzie O'Donnell, Matthew Roseman, Lindsey Swanson, Sophia DeGuara, Weihua Wang, Fei Yin, Tripti Saini, Ryan J. Weiss, Scott B. Selleck, 2024, iScience
Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans
Nicholas Schultheis, Robert Becker, Gelila Berhanu, Alexander Kapral, Matthew Roseman, Shalini Shah, Alyssa Connell, Scott Selleck, 2023, Frontiers in Genetics
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stéphane Sarrazin, Jon C. Gonzales, Shih Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L.S.M. Gordts, 2022, Journal of Biological Chemistry
Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control
Nicholas Schultheis, Mei Jiang, Scott B. Selleck, 2021, Collagen and Related Research on p. 173-181
Heparan sulfate structure affects autophagy, lifespan, responses to oxidative stress, and cell degeneration in Drosophila parkin mutants
Claire Reynolds-Peterson, Jie Xu, Na Zhao, Casey Cruse, Brandon Yonel, Claire Trasorras, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Jennifer Dobson, Nicholas Schultheis, Mei Jiang, Scott Selleck, 2020, G3: Genes, Genomes, Genetics on p. 129-141
The joint effect of air pollution exposure and copy number variation on risk for autism
Dokyoon Kim, Heather Volk, Santhosh Girirajan, Sarah Pendergrass, Molly A. Hall, Shefali S. Verma, Rebecca J. Schmidt, Robin L. Hansen, Debashis Ghosh, Yunin Ludena-Rodriguez, Kyoungmi Kim, Marylyn D. Ritchie, Irva Hertz-Picciotto, Scott B. Selleck, 2017, Autism Research on p. 1470-1480
Heparan sulfate proteoglycans regulate autophagy in Drosophila
Claire E. Reynolds-Peterson, Na Zhao, Jie Xu, Taryn M. Serman, Jielin Xu, Scott B. Selleck, 2017, Autophagy on p. 1262-1279
Diverse convergent evidence in the genetic analysis of complex disease: Coordinating omic, informatic, and experimental evidence to better identify and validate risk factors
Timothy H. Ciesielski, Sarah A. Pendergrass, Marquitta J. White, Nuri Kodaman, Rafal S. Sobota, Minjun Huang, Jacquelaine Bartlett, Jing Li, Qinxin Pan, Jiang Gui, Scott B. Selleck, Christopher I. Amos, Marylyn D. Ritchie, Jason H. Moore, Scott M. Williams, 2014, BioData Mining
Most-Cited Papers
The joint effect of air pollution exposure and copy number variation on risk for autism
Dokyoon Kim, Heather Volk, Santhosh Girirajan, Sarah Pendergrass, Molly A. Hall, Shefali S. Verma, Rebecca J. Schmidt, Robin L. Hansen, Debashis Ghosh, Yunin Ludena-Rodriguez, Kyoungmi Kim, Marylyn D. Ritchie, Irva Hertz-Picciotto, Scott B. Selleck, 2017, Autism Research on p. 1470-1480
Heparan sulfate proteoglycans regulate autophagy in Drosophila
Claire E. Reynolds-Peterson, Na Zhao, Jie Xu, Taryn M. Serman, Jielin Xu, Scott B. Selleck, 2017, Autophagy on p. 1262-1279
Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control
Nicholas Schultheis, Mei Jiang, Scott B. Selleck, 2021, Collagen and Related Research on p. 173-181
Heparan sulfate structure affects autophagy, lifespan, responses to oxidative stress, and cell degeneration in Drosophila parkin mutants
Claire Reynolds-Peterson, Jie Xu, Na Zhao, Casey Cruse, Brandon Yonel, Claire Trasorras, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Jennifer Dobson, Nicholas Schultheis, Mei Jiang, Scott Selleck, 2020, G3: Genes, Genomes, Genetics on p. 129-141
Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans
Nicholas Schultheis, Robert Becker, Gelila Berhanu, Alexander Kapral, Matthew Roseman, Shalini Shah, Alyssa Connell, Scott Selleck, 2023, Frontiers in Genetics
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stéphane Sarrazin, Jon C. Gonzales, Shih Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L.S.M. Gordts, 2022, Journal of Biological Chemistry
Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease
Nicholas Schultheis, Alyssa Connell, Alexander Kapral, Robert J. Becker, Richard Mueller, Shalini Shah, Mackenzie O'Donnell, Matthew Roseman, Lindsey Swanson, Sophia DeGuara, Weihua Wang, Fei Yin, Tripti Saini, Ryan J. Weiss, Scott B. Selleck, 2024, iScience
News Articles Featuring Scott Selleck
Sep 11, 2024
Reversing Alzheimer’s Early Defects? Scientists Discover Key Treatment Target
A new study from Penn State researchers suggests that targeting a specific group of proteins involved in regulating cell repair and boosting cell growth could offer a new avenue for treating Alzheimer’s and similar neurodegenerative diseases.
Full Article
Jul 02, 2024
Potential new target for early treatment of Alzheimer's disease
A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.
Full Article
Feb 05, 2020
DNA Damage Linked to Brain Overgrowth in Autism
Cell lines from individuals with macrocephalic autism spectrum disorder have an increased number of double-strand breaks in the DNA of long neural genes.
Full Article