Scott Medina
Associate Professor of Biomedical Engineering
-
223 Hallowell
University Park, PA 16802 - shm126@psu.edu
- 814-863-4758
Research Summary
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- One Health Microbiome Center
- Neuroscience Institute
Links
Most Recent Publications
Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids
Michael A. Miller, Scott Medina, 2024, Advanced Functional Materials
Decoupling Fluorous Protein Coatings Yield Heat-Stable and Intrinsically Sterile Bioformulations
Harminder Singh, Atip Lawanprasert, None Utkarsh, Sopida Pimcharoen, Arshiya Dewan, Dane Rahoi, Girish S. Kirimanjeswara, Scott H. Medina, 2024, ACS applied materials & interfaces on p. 38893-38904
Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly
Michael A. Miller, Scott Medina, 2024, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions
Inhye Kim, Inhye Kim^, Jacob Elliott, Atip Lawanprasert, Atip Lawanprasert^, Grace Wood, Julianna C. Simon, Scott Medina*, 2023, Small
The manifold role of octapeptide repeats in prion protein assembly
Amy H. Guadagno, Scott H. Medina, 2023, Peptide Science
Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions
Atip Lawanprasert, Janna Sloand, Gonz\'alez Vargas, Mariangely, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Michael Miller, Sopida Pimcharoen, Jian Wang, Scott Leighow, Justin R. Pritchard, Nikolay V. Dokholyan, others, Scott H. Medina, 2023, ChemBioChem on p. e202300159
Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics
Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4392
Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies
Macy M. Hale, Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4453-4465
Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions
Nikki Crowley*, Nicole A. Crowley, Scott Medina*, 2022, Neuropsychopharmacology on p. 253-254
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation
Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168
Most-Cited Papers
Injectable bioadhesive hydrogels with innate antibacterial properties
Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications
A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels
Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102
Rapid fabrication of precise high-throughput filters from membrane protein nanosheets
Yu-Ming Tu, Y Yu, Woochul Song, Tingwei Ren, Yue-xiao Shen, Ratul Chowdhury, Prasangi Rajapaksha, Tyler Culp, Laxmicharan Samineni, Chao Lang, L Chao, Alina Thokkadam, Drew Carson, Yuxuan Dai, Arwa Mukthar, Miaoci Zhang, Andrey Parshin, Janna Sloand, J Sloand^, Scott Medina, Mariusz Grzelakowski, Dibakar Bhattacharya, William Phillip, Enrique D. Gomez, Robert J. Hickey, Yinai Wei, Manish Kumar, M Kumar*, 2020, Nature Materials on p. 347-354
An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry
Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372
Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels
Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553
Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer
Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11
Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles
Christopher M. Micklitsch, Scott Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, Joel Schneider*, 2015, Macromolecules on p. 1281-1288
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Andrew Simonson^, Atip Lawanprasert, Atip Lawanprasert^, Tyler D.P. Goralski, Kenneth C. Keiler, Scott Medina*, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles
Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101
Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery
Scott H. Medina, Megan S. Michie, Stephen E. Miller, Martin J. Schnermann, Joel P. Schneider, 2017, Angewandte Chemie - International Edition on p. 11404-11408
News Articles Featuring Scott Medina
Dec 06, 2024
Tracking immune cell brain cancer therapies with ultrasound
National Cancer Institute awards biomedical engineering researchers $3.2M to study immune cell-based cancer treatment.
Full Article
Apr 15, 2024
Huck Leadership Fellows selected for 2024-25
For the 2024-2025 academic year, Huck Institutes of the Life Sciences has appointed Associate Professor of Biomedical Engineering Scott Medina, Professor of Statistics Lingzhou Xue, and Associate Professor of Surgery Dino Ravnic to be Huck Leadership Fellows.
Full Article
Mar 27, 2024
Synthetic material could improve ease and cut cost of gut microbiome research
A team of Penn State researchers has developed a new synthetic material that could enable scientists to more easily study how microorganisms interact with the gastrointestinal (GI) system.
Full Article
Sep 20, 2023
Tiny bubbles could reveal immune cell secrets and improve treatments
Penn State researchers are developing a novel bubble-based technique to watch immune cells at work.
Full Article
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Full Article
Apr 06, 2022
First round of funded projects announced from the Benkovic Research Initiative
Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.
Full Article
Mar 17, 2022
Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission
An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.
Full Article
Jul 15, 2021
Engineers find imaging technique could become treatment for deep vein thrombosis
Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.
Full Article
Jan 06, 2021
Smart Antibacterial Avoids Collateral Damage, Potential Blowback
Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.
Full Article
Jan 06, 2021
Resist the resistance: Fighting the good fight against bacteria
In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.
Full Article