Scott Medina

Assistant Professor of Biomedical Engineering

Scott Medina

Research Summary

Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.

Huck Affiliations

Links

Publication Tags

Peptides Cells Proteins Hydrogels Dendrimers Gels Neoplasms Amino Acids Ultrasonics Acetylgalactosamine Tumors Ligands Membranes Adhesives Lectins Therapeutics Drug Delivery Systems Hepatocytes Nanoconjugates Liver Neoplasms Liposomes Masks Enzymes Dna Polysaccharides

Most Recent Papers

Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis

Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina, 2021, Biomaterials

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480

Peptide functionalized liposomes for receptor targeted cancer therapy

Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell, 2021, APL Bioengineering

Fluorinated peptide biomaterials

Janna N. Sloand, Michael A. Miller, Scott H. Medina, 2021, Peptide Science

Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

Atip Lawanprasert, Alda Chau, Janna N. Sloand, Sean Hannifin, Scott H. Medina, 2021, ACS applied materials & interfaces on p. 5989-5998

Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

Janna N. Sloand, Eric Rokni, Connor T. Watson, Michael A. Miller, Keefe B. Manning, Julianna C. Simon, Scott H. Medina, 2021, Advanced healthcare materials

Re-engineering antimicrobial peptides into oncolytics targeting drug-resistant ovarian cancers

Matthew R. Aronson, Erika S. Dahl, Jacob A. Halle, Andrew W. Simonson, Rose A. Gogal, Adam B. Glick, Katherine M. Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461

Antimicrobial Scaffolds

Andrew W. Simonson, Matthew R. Aronson, Scott H. Medina, Scott H. Medina, 2020, Molecules

Ultrasound-guided cytosolic protein delivery via transient fluorous masks

Janna N. Sloand, Theodore T. Nguyen, Scott A. Zinck, Erik C. Cook, Tawanda Zimudzi, Scott A. Showalter, Adam B. Glick, Julianna Simon, Scott H. Medina, 2020, ACS Nano on p. 4061-4073

Discovery of antitumor lectins from rainforest tree root transcriptomes

Atip Lawanprasert, Caitlin A. Guinan, Erica A. Langford, Carly E. Hawkins, Janna N. Sloand, Howard W. Fescemyer, Matthew R. Aronson, Jacob A. Halle, James H. Marden, Scott H. Medina, 2020, PLoS One

Most-Cited Papers

Injectable bioadhesive hydrogels with innate antibacterial properties

Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102

N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

Scott H. Medina, Venkatesh Tekumalla, Maxim V. Chevliakov, Donna S. Shewach, William D. Ensminger, Mohamed E.H. El-Sayed, 2011, Biomaterials on p. 4118-4129

Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells

Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372

Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands

Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels

Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553

Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles

Christopher M. Micklitsch, Scott H. Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, 2015, Macromolecules on p. 1281-1288

Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles

Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101

Cancer cell surface induced peptide folding allows intracellular translocation of drug

Scott H. Medina, Joel P. Schneider, 2015, Journal of Controlled Release on p. 317-326