Scott Medina
Assistant Professor of Biomedical Engineering
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223 Hallowell
University Park, PA 16802 - shm126@psu.edu
- 814-863-4758
Research Summary
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.
Huck Affiliations
Links
Publication Tags
Peptides Cells Proteins Hydrogels Dendrimers Gels Neoplasms Amino Acids Ultrasonics Acetylgalactosamine Tumors Ligands Membranes Adhesives Lectins Therapeutics Drug Delivery Systems Hepatocytes Nanoconjugates Liver Neoplasms Liposomes Masks Enzymes Dna PolysaccharidesMost Recent Papers
Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis
Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina, 2021, Biomaterials
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480
Peptide functionalized liposomes for receptor targeted cancer therapy
Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell, 2021, APL Bioengineering
Fluorinated peptide biomaterials
Janna N. Sloand, Michael A. Miller, Scott H. Medina, 2021, Peptide Science
Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity
Atip Lawanprasert, Alda Chau, Janna N. Sloand, Sean Hannifin, Scott H. Medina, 2021, ACS applied materials & interfaces on p. 5989-5998
Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis
Janna N. Sloand, Eric Rokni, Connor T. Watson, Michael A. Miller, Keefe B. Manning, Julianna C. Simon, Scott H. Medina, 2021, Advanced healthcare materials
Re-engineering antimicrobial peptides into oncolytics targeting drug-resistant ovarian cancers
Matthew R. Aronson, Erika S. Dahl, Jacob A. Halle, Andrew W. Simonson, Rose A. Gogal, Adam B. Glick, Katherine M. Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461
Antimicrobial Scaffolds
Andrew W. Simonson, Matthew R. Aronson, Scott H. Medina, Scott H. Medina, 2020, Molecules
Ultrasound-guided cytosolic protein delivery via transient fluorous masks
Janna N. Sloand, Theodore T. Nguyen, Scott A. Zinck, Erik C. Cook, Tawanda Zimudzi, Scott A. Showalter, Adam B. Glick, Julianna Simon, Scott H. Medina, 2020, ACS Nano on p. 4061-4073
Discovery of antitumor lectins from rainforest tree root transcriptomes
Atip Lawanprasert, Caitlin A. Guinan, Erica A. Langford, Carly E. Hawkins, Janna N. Sloand, Howard W. Fescemyer, Matthew R. Aronson, Jacob A. Halle, James H. Marden, Scott H. Medina, 2020, PLoS One
Most-Cited Papers
Injectable bioadhesive hydrogels with innate antibacterial properties
Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications
A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels
Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102
N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers
Scott H. Medina, Venkatesh Tekumalla, Maxim V. Chevliakov, Donna S. Shewach, William D. Ensminger, Mohamed E.H. El-Sayed, 2011, Biomaterials on p. 4118-4129
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells
Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666
An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry
Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372
Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands
Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350
Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels
Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553
Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles
Christopher M. Micklitsch, Scott H. Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, 2015, Macromolecules on p. 1281-1288
Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles
Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101
Cancer cell surface induced peptide folding allows intracellular translocation of drug
Scott H. Medina, Joel P. Schneider, 2015, Journal of Controlled Release on p. 317-326
News Articles Featuring Scott Medina
Jul 15, 2021
Engineers find imaging technique could become treatment for deep vein thrombosis
Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.
Full Article
Jan 06, 2021
Smart Antibacterial Avoids Collateral Damage, Potential Blowback
Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.
Full Article
Jan 06, 2021
Resist the resistance: Fighting the good fight against bacteria
In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.
Full Article