Scott Medina

Assistant Professor of Biomedical Engineering

Scott Medina

Research Summary

Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.

Huck Affiliations

Links

Publication Tags

Peptides Cells Gels Membranes Hydrogels Dendrimers Dna Nanoparticles Neoplasms Acetylgalactosamine Amino Acids Gold Ligands Adhesives Polysaccharides Liver Neoplasms Nanoconjugates Hepatocytes Enzymes Amphiphiles Tumors Pharmaceutical Preparations Syringes Nanostructured Materials Proteins

Most Recent Papers

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400

Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide

Anshika Kapur, Scott H. Medina, Wentao Wang, Goutam Palui, Xin Ji, Joel P. Schneider, Hedi Mattoussi, 2018, ACS Omega on p. 17164-17172

Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide

Anshika Kapur, Scott H. Medina, Wentao Wang, Goutam Palui, Joel P. Schneider, Hedi Mattoussi, 2018, ACS Omega on p. 12754-12762

Lipopeptisomes

Matthew R. Aronson, Andrew W. Simonson, Lindsey M. Orchard, Manuel Llinás, Scott H. Medina, 2018, Acta Biomaterialia on p. 269-277

Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide

Ken Ishikawa, Scott H. Medina, Joel P. Schneider, Amar J.S. Klar, 2017, Cell Chemical Biology on p. 149-158

Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery

Scott H. Medina, Megan S. Michie, Stephen E. Miller, Martin J. Schnermann, Joel P. Schneider, 2017, Angewandte Chemie - International Edition on p. 11404-11408

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature nanotechnology on p. 95-102

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels

Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553

Most-Cited Papers

Injectable bioadhesive hydrogels with innate antibacterial properties

Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature communications

N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

Scott H. Medina, Venkatesh Tekumalla, Maxim V. Chevliakov, Donna S. Shewach, William D. Ensminger, Mohamed E.H. El-Sayed, 2011, Biomaterials on p. 4118-4129

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature nanotechnology on p. 95-102

Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells

Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666

Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands

Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced Healthcare Materials on p. 1337-1350

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372

Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles

Christopher M. Micklitsch, Scott H. Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, 2015, Macromolecules on p. 1281-1288

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels

Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553

Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles

Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101

Cancer cell surface induced peptide folding allows intracellular translocation of drug

Scott H. Medina, Joel P. Schneider, 2015, Journal of Controlled Release on p. 317-326