Associate Professor of Biomedical Engineering
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.
Huck Graduate Students
Publication TagsPeptides Peptide Cells Hydrogels Gels Amino Acids Proteins Membranes Ligands Tumors Dendrimers Adhesives Acid Biocompatible Materials Hydrogel Heparin Enzymes Liposomes Dna Nanoconjugates Macrophages Protein Gel Antigen Surface
Most Recent Publications
Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions
Nicole A. Crowley, Scott H. Medina, 2023, Neuropsychopharmacology on p. 253-254
Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies
Macy M. Hale, Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4453-4465
Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics
Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4392
Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168
Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation
Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small
Janna N. Sloand, Janna Sloand^, Tyler Culp, Nichole M. Wonderling, Enrique D. Gomez, Scott Medina*, 2021, Advanced Functional Materials
Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis
Janna Sloand^, Janna Sloand, Eric Rokni, Connor Watson, Keefe Manning, Michael A. Miller, Michael Miller^, Keefe , Julianna Simon, , S Medina, Scott Medina*, 2021, Advanced healthcare materials
Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina, 2021, Biomaterials
Janna N. Sloand, Michael A. Miller, Scott H. Medina, 2021, Peptide Science
Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell, 2021, APL Bioengineering
Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications
Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells
Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666
Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372
Rapid fabrication of precise high-throughput filters from membrane protein nanosheets
Yu-Ming Tu, Y Yu, Woochul Song, Tingwei Ren, Yue-xiao Shen, Ratul Chowdhury, Prasangi Rajapaksha, Tyler Culp, Laxmicharan Samineni, Chao Lang, L Chao, Alina Thokkadam, Drew Carson, Yuxuan Dai, Arwa Mukthar, Miaoci Zhang, Andrey Parshin, Janna Sloand, J Sloand^, Scott Medina, Mariusz Grzelakowski, Dibakar Bhattacharya, William Phillip, Enrique D. Gomez, Robert J. Hickey, Yinai Wei, Manish Kumar, M Kumar*, 2020, Nature Materials on p. 347-354
Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553
Christopher M. Micklitsch, Scott Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, Joel Schneider*, 2015, Macromolecules on p. 1281-1288
Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands
Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350
Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles
Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101
Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer
Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11
News Articles Featuring Scott Medina
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Apr 06, 2022
First round of funded projects announced from the Benkovic Research Initiative
Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.
Mar 17, 2022
Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission
An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.
Jul 15, 2021
Engineers find imaging technique could become treatment for deep vein thrombosis
Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.
Jan 06, 2021
Smart Antibacterial Avoids Collateral Damage, Potential Blowback
Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.
Jan 06, 2021
Resist the resistance: Fighting the good fight against bacteria
In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.