Scott Medina

Associate Professor of Biomedical Engineering

Scott Medina

Research Summary

Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.

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Publication Tags

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Peptides Cells Peptide Hydrogels Gels Amino Acids Membranes Dendrimers Adhesives Dna Nanoconjugates Heparin Acid Hydrogel Enzymes Ligands Gel Antigen Proteins Thrombosis Surface Water Drug Permeability Fabrication

Most Recent Publications

Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions

Inhye Kim, Jacob C. Elliott, Atip Lawanprasert, Grace M. Wood, Julianna C. Simon, Scott H. Medina, 2023, Small

Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions

Atip Lawanprasert, Janna N. Sloand, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Michael A. Miller, Sopida Pimcharoen, Jian Wang, Scott M. Leighow, Justin R. Pritchard, Nikolay V. Dokholyan, Scott H. Medina, 2023, ChemBioChem

The manifold role of octapeptide repeats in prion protein assembly

Amy H. Guadagno, Scott H. Medina, 2023, Peptide Science

Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies

Macy M. Hale, Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4453-4465

Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics

Scott H. Medina, 2022, Molecular Pharmaceutics on p. 4392

Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions

Nikki Crowley*, Nicole A. Crowley, Scott Medina*, 2022, Neuropsychopharmacology on p. 253-254

Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation

Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168

Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation

Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small

Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids

Janna N. Sloand, Janna Sloand^, Tyler Culp, Nichole M. Wonderling, Enrique D. Gomez, Scott Medina*, 2021, Advanced Functional Materials

Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

Janna Sloand^, Janna Sloand, Eric Rokni, Connor Watson, Keefe Manning, Michael A. Miller, Michael Miller^, Keefe , Julianna Simon, , S Medina, Scott Medina*, 2021, Advanced healthcare materials

Most-Cited Papers

Injectable bioadhesive hydrogels with innate antibacterial properties

Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102

Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells

Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666

Rapid fabrication of precise high-throughput filters from membrane protein nanosheets

Yu-Ming Tu, Y Yu, Woochul Song, Tingwei Ren, Yue-xiao Shen, Ratul Chowdhury, Prasangi Rajapaksha, Tyler Culp, Laxmicharan Samineni, Chao Lang, L Chao, Alina Thokkadam, Drew Carson, Yuxuan Dai, Arwa Mukthar, Miaoci Zhang, Andrey Parshin, Janna Sloand, J Sloand^, Scott Medina, Mariusz Grzelakowski, Dibakar Bhattacharya, William Phillip, Enrique D. Gomez, Robert J. Hickey, Yinai Wei, Manish Kumar, M Kumar*, 2020, Nature Materials on p. 347-354

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels

Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553

Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles

Christopher M. Micklitsch, Scott Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, Joel Schneider*, 2015, Macromolecules on p. 1281-1288

Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands

Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350

Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles

Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101

News Articles Featuring Scott Medina

Sep 20, 2023

Tiny bubbles could reveal immune cell secrets and improve treatments

Penn State researchers are developing a novel bubble-based technique to watch immune cells at work.

Full Article

Jan 05, 2023

Controlled, localized delivery of blood thinner may improve blood clot treatment

Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.

Full Article

Apr 06, 2022

First round of funded projects announced from the Benkovic Research Initiative

Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.

Full Article

Mar 17, 2022

Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission

An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.

Full Article

Jul 15, 2021

Engineers find imaging technique could become treatment for deep vein thrombosis

Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.

Full Article

Jan 06, 2021

Smart Antibacterial Avoids Collateral Damage, Potential Blowback

Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.

Full Article

Jan 06, 2021

Resist the resistance: Fighting the good fight against bacteria

In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.

Full Article