Scott Medina

Assistant Professor of Biomedical Engineering

Scott Medina

Research Summary

Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.

Huck Affiliations

Links

Publication Tags

Peptides Peptide Cells Hydrogels Amino Acids Gels Ultrasonics Tumors Ligands Proteins Membranes Dendrimers Adhesives Hydrogel Acid Bacteria Neoplasms Enzymes Dna Drug Delivery Systems Liposomes Nanoconjugates Nanoparticles Surface Macrophages

Most Recent Papers

Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation

Atip Lawanprasert, Andrew W. Simonson, Sarah E. Sumner, McKayla J. Nicol, Sopida Pimcharoen, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Biomacromolecules on p. 1158-1168

Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids

Janna N. Sloand, Tyler E. Culp, Nichole M. Wonderling, Enrique D. Gomez, Scott H. Medina, 2021, Advanced Functional Materials

Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

Janna N. Sloand, Eric Rokni, Connor T. Watson, Michael A. Miller, Keefe B. Manning, Julianna C. Simon, Scott H. Medina, 2021, Advanced healthcare materials

Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis

Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina, 2021, Biomaterials

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480

Peptide functionalized liposomes for receptor targeted cancer therapy

Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell, 2021, APL Bioengineering

Fluorinated peptide biomaterials

Janna N. Sloand, Michael A. Miller, Scott H. Medina, 2021, Peptide Science

Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity

Atip Lawanprasert, Alda Chau, Janna N. Sloand, Sean Hannifin, Scott H. Medina, 2021, ACS applied materials & interfaces on p. 5989-5998

Re-engineering antimicrobial peptides into oncolytics targeting drug-resistant ovarian cancers

Matthew R. Aronson, Erika S. Dahl, Jacob A. Halle, Andrew W. Simonson, Rose A. Gogal, Adam B. Glick, Katherine M. Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461

Antimicrobial Scaffolds

Andrew W. Simonson, Matthew R. Aronson, Scott H. Medina, Scott H. Medina, 2020, Molecules

Most-Cited Papers

Injectable bioadhesive hydrogels with innate antibacterial properties

Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102

Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells

Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels

Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553

Influence of hydrophobic face amino acids on the hydrogelation of -hairpin peptide amphiphiles

Christopher M. Micklitsch, Scott H. Medina, Tuna Yucel, Katelyn J. Nagy-Smith, Darrin J. Pochan, Joel P. Schneider, 2015, Macromolecules on p. 1281-1288

Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands

Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350

Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles

Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11

Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery

Scott H. Medina, Megan S. Michie, Stephen E. Miller, Martin J. Schnermann, Joel P. Schneider, 2017, Angewandte Chemie - International Edition on p. 11404-11408

News Articles Featuring Scott Medina

First round of funded projects announced from the Benkovic Research Initiative

Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.

Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission

An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.

Engineers find imaging technique could become treatment for deep vein thrombosis

Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.

Smart Antibacterial Avoids Collateral Damage, Potential Blowback

Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.

Resist the resistance: Fighting the good fight against bacteria

In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.