Associate Professor of Biomedical Engineering
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.
Publication TagsPeptides Peptide Cells Hydrogels Gels Amino Acids Ultrasonics Ligands Surface Tumors Dendrimers Adhesives Neoplasms Hydrogel Drug Nanoconjugates Dna Enzymes Liposomes Nanoparticles Macrophages Therapeutics Antigen Pharmaceutical Preparations Water
Most Recent Publications
Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168
Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions
Nicole A. Crowley, Scott H. Medina, 2022, Neuropsychopharmacology
Janna N. Sloand, Janna Sloand^, Tyler Culp, Nichole M. Wonderling, Enrique D. Gomez, Scott Medina*, 2021, Advanced Functional Materials
Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina, 2021, Biomaterials
Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell, 2021, APL Bioengineering
Janna N. Sloand, Michael A. Miller, Scott H. Medina, 2021, Peptide Science
Atip Lawanprasert, Alda Chau, Janna N. Sloand, Sean Hannifin, Scott H. Medina, 2021, ACS applied materials & interfaces on p. 5989-5998
Fluorinated Peptide Biomaterials
Janna Sloand^, Michael Miller^, Scott Medina*, 2020, Peptide Science on p. e24184
Supramolecular Peptide Assemblies as Antimicrobial Scaffolds
Andrew Simonson^, Matthew Aronson^, Scott Medina*, 2020, Molecules on p. 2751
Andrew W. Simonson, Matthew R. Aronson, Scott H. Medina, Scott H. Medina, 2020, Molecules
Michael C. Giano, Zuhaib Ibrahim, Scott H. Medina, Karim A. Sarhane, Joani M. Christensen, Yuji Yamada, Gerald Brandacher, Joel P. Schneider, 2014, Nature Communications
Daniel J. Smith, Gabriel A. Brat, Scott H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J. Furtmüller, Byoung Chol Oh, Katelyn J. Nagy-Smith, Piotr Walczak, Gerald Brandacher, Joel P. Schneider, 2016, Nature Nanotechnology on p. 95-102
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells
Scott H. Medina, Maxim V. Chevliakov, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Sibu P. Kuruvilla, Mohamed E.H. ElSayed, 2013, Biomaterials on p. 4655-4666
Scott H. Medina, Stephen E. Miller, Allison I. Keim, Alexander P. Gorka, Martin J. Schnermann, Joel P. Schneider, 2016, Angewandte Chemie - International Edition on p. 3369-3372
Scott H. Medina, Sandra Li, O. M.Zack Howard, Micah Dunlap, Anna Trivett, Joel P. Schneider, Joost J. Oppenheim, 2015, Biomaterials on p. 545-553
Targeting hepatic cancer cells with pegylated dendrimers displaying N-Acetylgalactosamine and SP94 peptide ligands
Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach, Mohamed E.H. Elsayed, 2013, Advanced healthcare materials on p. 1337-1350
Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles
Souvik Biswas, Scott H. Medina, Joseph J. Barchi, 2015, Carbohydrate Research on p. 93-101
Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer
Scott H. Medina, Brian Bush, Maggie Cam, Emily Sevcik, Frank W. DelRio, Kaustav Nandy, Joel P. Schneider, 2019, Biomaterials on p. 1-11
Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery
Scott H. Medina, Megan S. Michie, Stephen E. Miller, Martin J. Schnermann, Joel P. Schneider, 2017, Angewandte Chemie - International Edition on p. 11404-11408
Scott H. Medina, Joel P. Schneider, 2015, Journal of Controlled Release on p. 317-326
News Articles Featuring Scott Medina
Apr 06, 2022
First round of funded projects announced from the Benkovic Research Initiative
Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.
Mar 17, 2022
Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission
An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.
Jul 15, 2021
Engineers find imaging technique could become treatment for deep vein thrombosis
Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.
Jan 06, 2021
Smart Antibacterial Avoids Collateral Damage, Potential Blowback
Calling for the use of broad-spectrum antibiotics can be as indiscriminate as saying, “Kill them all; let God sort them out.” Either way, one may eliminate the good along with the bad, courting blowback, that is, repercussions that are as unwelcome as they are unpredictable.
Jan 06, 2021
Resist the resistance: Fighting the good fight against bacteria
In an effort to reduce the potential infection-caused 10 million deaths worldwide, Penn State researcher Scott Medina has developed a peptide, or small protein, that can target a specific pathogen without damaging the good bacteria that bolsters the immune system.