Sarah Ades
Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School

-
408 Althouse Lab
University Park, PA - sea10@psu.edu
- 814-863-1088
Research Summary
Signal transduction and antibiotic-induced stress responses in bacteria.
Huck Affiliations
Links
Publication Tags
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Escherichia Coli Sigma Factor Genes Crowdsourcing Proteins Students Gene Ontology Teaching Rna Ontology Membranes Holoenzymes Dna Directed Rna Polymerases Gene College Students Cyclic Peptides Education Binding Sites Anti Bacterial Agents Learning Environment Messenger Rna Proteolysis In Vitro Techniques AnnotationMost Recent Publications
Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO)
Jolene Ramsey, Brenley McIntosh, Daniel Renfro, Suzanne A. Aleksander, Sandra LaBonte, Curtis Ross, Adrienne E. Zweifel, Nathan Liles, Shabnam Farrar, Jason J. Gill, Ivan Erill, Sarah Ades, Tanya Z. Berardini, Jennifer A. Bennett, Siobhan Brady, Robert Britton, Seth Carbon, Steven M. Caruso, Dave Clements, Ritu Dalia, Meredith Defelice, Erin L. Doyle, Iddo Friedberg, Susan M.R. Gurney, Lee Hughes, Allison Johnson, Jason M. Kowalski, Donghui Li, Ruth C. Lovering, Tamara L. Mans, Fiona McCarthy, Sean D. Moore, Rebecca Murphy, Timothy D. Paustian, Sarah Perdue, Celeste N. Peterson, Birgit M. Prüß, Margaret S. Saha, Robert R. Sheehy, John T. Tansey, Louise Temple, Alexander William Thorman, Saul Trevino, Amy Cheng Vollmer, Virginia Walbot, Joanne Willey, Deborah A. Siegele, James C. Hu, 2021, PLoS Computational Biology
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA
Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5
Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli
Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of Bacteriology
Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors
Elena Sineva, Maria Savkina, Sarah E. Ades, 2017, Current Opinion in Microbiology on p. 128-137
Teaching broader impacts of science with undergraduate research
Kenneth C. Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah E. Ades, 2017, PLoS Biology on p. e2001318
Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems
Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of Bacteriology
Why you should dispense with antibacterial soaps
Sarah Ades, K Keiler, 2016, The Conversation
Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay
S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509
Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes
Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493
Most-Cited Papers
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA
Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5
Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors
Elena Sineva, Maria Savkina, Sarah E. Ades, 2017, Current Opinion in Microbiology on p. 128-137
Regulated proteolysis: Control of the Escherichia coli σ <sup>E</sup> -dependent cell envelope stress response
Sarah E. Barchinger, Sarah E. Ades, 2013, Sub-Cellular Biochemistry on p. 129-160
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509
Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes
Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493
Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems
Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of Bacteriology
Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay
S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205
Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli
Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of Bacteriology
Teaching broader impacts of science with undergraduate research
Kenneth C. Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah E. Ades, 2017, PLoS Biology on p. e2001318
Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO)
Jolene Ramsey, Brenley McIntosh, Daniel Renfro, Suzanne A. Aleksander, Sandra LaBonte, Curtis Ross, Adrienne E. Zweifel, Nathan Liles, Shabnam Farrar, Jason J. Gill, Ivan Erill, Sarah Ades, Tanya Z. Berardini, Jennifer A. Bennett, Siobhan Brady, Robert Britton, Seth Carbon, Steven M. Caruso, Dave Clements, Ritu Dalia, Meredith Defelice, Erin L. Doyle, Iddo Friedberg, Susan M.R. Gurney, Lee Hughes, Allison Johnson, Jason M. Kowalski, Donghui Li, Ruth C. Lovering, Tamara L. Mans, Fiona McCarthy, Sean D. Moore, Rebecca Murphy, Timothy D. Paustian, Sarah Perdue, Celeste N. Peterson, Birgit M. Prüß, Margaret S. Saha, Robert R. Sheehy, John T. Tansey, Louise Temple, Alexander William Thorman, Saul Trevino, Amy Cheng Vollmer, Virginia Walbot, Joanne Willey, Deborah A. Siegele, James C. Hu, 2021, PLoS Computational Biology