Sarah Ades

Associate Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School

Sarah Ades

Research Summary

Signal transduction and antibiotic-induced stress responses in bacteria.

Huck Affiliations

Links

Publication Tags

Escherichia Coli Sigma Factor Proteins Membranes Rna Proteolysis Genes Membrane Proteins Holoenzymes Peptide Hydrolases Dna Directed Rna Polymerases Signal Transduction Cyclic Peptides Protein Anti Bacterial Agents Virulence Binding Sites Students Starvation Messenger Rna High Throughput Screening Assays Initiator Codon Teaching Open Reading Frames In Vitro Techniques

Most Recent Papers

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of Bacteriology

Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors

Elena Sineva, Maria Savkina, Sarah E. Ades, 2017, Current Opinion in Microbiology on p. 128-137

Teaching broader impacts of science with undergraduate research.

Kenneth C. Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah E. Ades, 2017, PLoS Biology on p. e2001318

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of Bacteriology

Why you should dispense with antibacterial soaps

Sarah Ades, K Keiler, 2016, The Conversation

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493

Regulated proteolysis: Control of the Escherichia coli σ <sup>E</sup> -dependent cell envelope stress response

Sarah E. Barchinger, Sarah E. Ades, 2013, Sub-Cellular Biochemistry on p. 129-160

Most-Cited Papers

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah E. Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5

Regulated proteolysis: Control of the Escherichia coli σ <sup>E</sup> -dependent cell envelope stress response

Sarah E. Barchinger, Sarah E. Ades, 2013, Sub-Cellular Biochemistry on p. 129-160

Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors

Elena Sineva, Maria Savkina, Sarah E. Ades, 2017, Current Opinion in Microbiology on p. 128-137

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of Bacteriology

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of Bacteriology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric T. Harvill, Sarah E. Ades, 2012, BMC Microbiology