Sarah Ades

Associate Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School

Sarah Ades

Research Summary

Signal transduction and antibiotic-induced stress responses in bacteria.

Huck Affiliations

Links

Publication Tags

Escherichia Coli Proteins Sigma Factor Students Holoenzymes Rna Teaching Membrane Proteins Membranes Binding Sites Virulence Dna Directed Rna Polymerases Cyclic Peptides Anti Bacterial Agents Education Porins Regulon Learning Genes Messenger Rna High Throughput Screening Assays Research Initiator Codon Infection Starvation

Most Recent Papers

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah Ellen Ades, Katsuhiko Murakami, 2018, Molecular cell on p. 828-839.e5

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah Ellen Ades, 2017, Journal of Bacteriology

Teaching broader impacts of science with undergraduate research

Kenneth Charles Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah Ellen Ades, 2017, PLoS Biology

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Elena Borisovna Yakhnina, Robert Aichele, Sarah Ellen Ades, Tony Romeo, Paul Lee Babitzke, 2017, Journal of bacteriology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, Elena V. Sineva, John Alumasa, H. Nicoloff, J. W. Tomsho, Sarah Ellen Ades, Kenneth Charles Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah Ellen Ades, 2014, Molecular Microbiology on p. 479-493

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John Alumasa, Sarah Ellen Ades, Kenneth Charles Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric Thomas Harvill, Sarah Ellen Ades, 2012, BMC microbiology

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah Ellen Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica

Vivek K. Mutalik, Gen Nonaka, Sarah Ellen Ades, Virgil A. Rhodius, Carol A. Gross, 2009, Journal of Bacteriology on p. 7279-7287

High-Impact Papers

Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica

Vivek K. Mutalik, Gen Nonaka, Sarah Ellen Ades, Virgil A. Rhodius, Carol A. Gross, 2009, Journal of Bacteriology on p. 7279-7287

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah Ellen Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John Alumasa, Sarah Ellen Ades, Kenneth Charles Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah Ellen Ades, 2014, Molecular Microbiology on p. 479-493

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah Ellen Ades, Katsuhiko Murakami, 2018, Molecular cell on p. 828-839.e5

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric Thomas Harvill, Sarah Ellen Ades, 2012, BMC microbiology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, Elena V. Sineva, John Alumasa, H. Nicoloff, J. W. Tomsho, Sarah Ellen Ades, Kenneth Charles Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Elena Borisovna Yakhnina, Robert Aichele, Sarah Ellen Ades, Tony Romeo, Paul Lee Babitzke, 2017, Journal of bacteriology

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah Ellen Ades, 2017, Journal of Bacteriology

Teaching broader impacts of science with undergraduate research

Kenneth Charles Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah Ellen Ades, 2017, PLoS Biology