Sarah Ades

Associate Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School

Sarah Ades

Research Summary

Signal transduction and antibiotic-induced stress responses in bacteria.

Huck Institutes Affiliations

Links

Publication Tags

Escherichia Coli Proteins Sigma Factor Holoenzymes Membrane Proteins Membranes Virulence Dna Directed Rna Polymerases Anti Bacterial Agents Rna Regulon Cyclic Peptides Genes Students Porins Starvation Bacteria Binding Sites High Throughput Screening Assays Infection Teaching Salmonella Enterica Bordetella Bronchiseptica In Vitro Techniques Gram Negative Bacteria

Most Recent Papers

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of Bacteriology

Teaching broader impacts of science with undergraduate research

Kenneth C. Keiler, Kathy L. Jackson, Leslie Jaworski, David Lopatto, Sarah E. Ades, 2017, PLoS Biology

Circuitry linking the global Csr- and σ<sup>E</sup>-dependent cell envelope stress response systems

Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of Bacteriology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric T. Harvill, Sarah E. Ades, 2012, BMC Microbiology

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah E. Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica

Vivek K. Mutalik, Gen Nonaka, Sarah E. Ades, Virgil A. Rhodius, Carol A. Gross, 2009, Journal of Bacteriology on p. 7279-7287

High-Impact Papers

The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistance

Mary E. Laubacher, Sarah E. Ades, 2008, Journal of Bacteriology on p. 2065-2074

The extracytoplasmic stress factor, σ<sup>E</sup>, is required to maintain cell envelope integrity in Escherichia coli

Jennifer D. Hayden, Sarah E. Ades, 2008, PLoS One

ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor ς<sup>E</sup> in Escherichia coli by both direct and indirect mechanisms

Alessandra Costanzo, Herve Nicoloff, Sarah E. Barchinger, Amy B. Banta, Richard L. Gourse, Sarah E. Ades, 2008, Molecular Microbiology on p. 619-632

Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica

Vivek K. Mutalik, Gen Nonaka, Sarah E. Ades, Virgil A. Rhodius, Carol A. Gross, 2009, Journal of Bacteriology on p. 7279-7287

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah E. Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah E. Ades, 2014, Molecular Microbiology on p. 479-493

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial Agents and Chemotherapy on p. 193-205

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric T. Harvill, Sarah E. Ades, 2012, BMC Microbiology

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami, 2018, Molecular Cell on p. 828-839.e5