Sarah Ades

Associate Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School

Sarah Ades

Research Summary

Signal transduction and antibiotic-induced stress responses in bacteria.

Huck Affiliations

Links

Publication Tags

Escherichia Coli Proteins Sigma Factor Membrane Proteins Rna Holoenzymes Dna Directed Rna Polymerases Anti Bacterial Agents Cyclic Peptides Membranes Binding Sites Virulence Genes In Vitro Techniques Bordetella Bronchiseptica Messenger Rna High Throughput Screening Assays Initiator Codon Infection Starvation Open Reading Frames Sporulation Specific Sigma Factors Gels Growth Operon

Most Recent Papers

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah Ellen Ades, Katsuhiko Murakami, 2018, Molecular cell on p. 828-839.e5

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of bacteriology

Teaching broader impacts of science with undergraduate research.

Kenneth Keiler, Kathy Jackson, L Jaworski, D Lopatto, Sarah Ades, 2017, PLoS biology on p. e2001318

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of bacteriology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial agents and chemotherapy on p. 193-205

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

S El-Mowafi, E Sineva, J Alumasa, H Nicoloff, J Tomsho, Sarah Ades, Kenneth Keiler, 2014,

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial agents and chemotherapy on p. 5500-5509

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah Ellen Ades, 2014, Molecular Microbiology on p. 479-493

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric T. Harvill, Sarah E. Ades, 2012, BMC microbiology

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah E. Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Most-Cited Papers

Physiological response to membrane protein overexpression in E. coli

Francesca Gubellini, Grégory Verdon, Nathan K. Karpowich, Jon D. Luff, Grégory Boël, Nils Gauthier, Samuel K. Handelman, Sarah E. Ades, John F. Hunt, 2011, Molecular and Cellular Proteomics

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah Ellen Ades, Katsuhiko Murakami, 2018, Molecular cell on p. 828-839.e5

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial agents and chemotherapy on p. 5500-5509

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes

Saumya Gopalkrishnan, Herve Nicoloff, Sarah Ellen Ades, 2014, Molecular Microbiology on p. 479-493

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial agents and chemotherapy on p. 193-205

SigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Sarah E. Barchinger, Xuqing Zhang, Sara E. Hester, Maria E. Rodriguez, Eric T. Harvill, Sarah E. Ades, 2012, BMC microbiology

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Helen Yakhnin, Robert Aichele, Sarah E. Ades, Tony Romeo, Paul Babitzke, 2017, Journal of bacteriology

Appropriate regulation of the σ<sup>E</sup>d-ependent envelope stress response is necessary to maintain cell envelope integrity and stationary-phase survival in Escherichia coli

Hervé Nicoloff, Saumya Gopalkrishnan, Sarah E. Ades, 2017, Journal of bacteriology

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

S El-Mowafi, E Sineva, J Alumasa, H Nicoloff, J Tomsho, Sarah Ades, Kenneth Keiler, 2014,

Teaching broader impacts of science with undergraduate research.

Kenneth Keiler, Kathy Jackson, L Jaworski, D Lopatto, Sarah Ades, 2017, PLoS biology on p. e2001318