Huck Chair of Functional Genomics; Professor of Biology and of Plant Science
Organelle biology and cellular specializations. Plant epigenetics, memory and phenotypic plasticity. Crop epigenetic breeding.
Huck Graduate Students
- Bioinformatics and Genomics
- Plant Biology
- Molecular, Cellular, and Integrative Biosciences
- Plant Institute
Publication TagsArabidopsis Genes Methylation Phenotype Dna Methylation Mitochondria Proteins Rna Interference Transgenes Plastids Epigenomics Genetically Modified Plants Biochemistry Mutation Growth Biosynthesis Epigenome Arabidopsis Proteins Genetic Complementation Test Chloroplasts Breeding Ubiquinone Gene Regulatory Networks Genome Gene Expression
Most Recent Papers
A new take on organelle-mediated stress sensing in plants
Isaac J. Dopp, Xiaodong Yang, Sally A. Mackenzie, 2021, New Phytologist on p. 2148-2153
MutS HOMOLOG1 mediates fertility reversion from cytoplasmic male sterile Brassica juncea in response to environment
Na Zhao, Zhangping Li, Lili Zhang, Xiaodong Yang, Sally A. Mackenzie, Zhongyuan Hu, Mingfang Zhang, Jinghua Yang, 2021, Plant, Cell and Environment on p. 234-246
Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming
Xiaodong Yang, Robersy Sanchez, Hardik Kundariya, Tom Maher, Isaac Dopp, Rosemary Schwegel, Kamaldeep Virdi, Michael J. Axtell, Sally A. Mackenzie, 2020, Nature Communications
MSH1-induced heritable enhanced growth vigor through grafting is associated with the RdDM pathway in plants
Hardik Kundariya, Xiaodong Yang, Kyla Morton, Robersy Sanchez, Michael J. Axtell, Samuel F. Hutton, Michael Fromm, Sally A. Mackenzie, 2020, Nature Communications
Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia
Robersy Sanchez, Sally A. Mackenzie, 2020, Scientific Reports
Plant science decadal vision 2020–2030: Reimagining the potential of plants for a healthy and sustainable future
Natalie Henkhaus, Madelaine Bartlett, David Gang, Rebecca Grumet, Ingrid Jordon-Thaden, Argelia Lorence, Eric Lyons, Samantha Miller, Seth Murray, Andrew Nelson, Chelsea Specht, Brett Tyler, Thomas Wentworth, David Ackerly, David Baltensperger, Philip Benfey, James Birchler, Sreekala Chellamma, Roslyn Crowder, Michael Donoghue, Jose Pablo Dundore-Arias, Jacqueline Fletcher, Valerie Fraser, Kelly Gillespie, Lonnie Guralnick, Elizabeth Haswell, Mitchell Hunter, Shawn Kaeppler, Stefan Kepinski, Fay Wei Li, Sally Mackenzie, Lucinda McDade, Ya Min, Jennifer Nemhauser, Brian Pearson, Peter Petracek, Katie Rogers, Ann Sakai, Delanie Sickler, Crispin Taylor, Laura Wayne, Ole Wendroth, Felipe Zapata, David Stern, 2020, Plant Direct
Approaches to Whole-Genome Methylome Analysis in Plants
Xiaodong Yang, Sally A. Mackenzie, 2020, on p. 15-31
Organellar protein multi-functionality and phenotypic plasticity in plants
Sally A. MacKenzie, Hardik Kundariya, 2020, Philosophical Transactions of the Royal Society B: Biological Sciences
Discrimination of DNA methylation signal from background variation for clinical diagnostics
Robersy Sanchez, Xiaodong Yang, Thomas Maher, Sally A. Mackenzie, 2019, International Journal of Molecular Sciences
Many facets of dynamic plasticity in plants
Xiaodong Yang, Sally A. Mackenzie, 2019, Cold Spring Harbor perspectives in biology
The genome sequence of allopolyploid Brassica juncea and analysis of differential homoeolog gene expression influencing selection
Jinghua Yang, Dongyuan Liu, Xiaowu Wang, Changmian Ji, Feng Cheng, Baoning Liu, Zhongyuan Hu, Sheng Chen, Deepak Pental, Youhui Ju, Pu Yao, Xuming Li, Kun Xie, Jianhui Zhang, Jianlin Wang, Fan Liu, Weiwei Ma, Jannat Shopan, Hongkun Zheng, Sally A. Mackenzie, Mingfang Zhang, 2016, Nature Genetics on p. 1225-1232
Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth
Kamaldeep S. Virdi, John D. Laurie, Ying Zhi Xu, Jiantao Yu, Mon Ray Shao, Robersy Sanchez, Hardik Kundariya, Dong Wang, Jean Jack M. Riethoven, Yashitola Wamboldt, Maria P. Arrieta-Montiel, Vikas Shedge, Sally A. Mackenzie, 2015, Nature Communications
The origin and biosynthesis of the benzenoid moiety of ubiquinone (Coenzyme Q) in Arabidopsis
Anna Block, Joshua R. Widhalm, Abdelhak Fatihi, Rebecca E. Cahoon, Yashitola Wamboldt, Christian Elowsky, Sally A. Mackenzie, Edgar B. Cahoon, Clint Chapple, Natalia Dudareva, Gilles J. Basset, 2014, Plant Cell on p. 1938-1948
In vivo extraction of Arabidopsis cell turgor pressure using nanoindentation in conjunction with finite element modeling
Elham Forouzesh, Ashwani Goel, Sally A. MacKenzie, Joseph A. Turner, 2013, Plant Journal on p. 509-520
The chloroplast triggers developmental reprogramming when MutS HOMOLOG1 is suppressed in plants
Ying Zhi Xu, Roberto de la Rosa Santamaria, Kamaldeep S. Virdi, Maria P. Arrieta-Montiel, Fareha Razvi, Shaoqing Li, Guodong Ren, Bin Yu, Danny Alexander, Lining Guo, Xuehui Feng, Ismail M. Dweikat, Tom E. Clemente, Sally A. Mackenzie, 2012, Plant Physiology on p. 710-720
Muts HOMOLOG1-derived epigenetic breeding potential in tomato
Xiaodong Yang, Hardik Kundariya, Ying Zhi Xu, Ajay Sandhu, Jiantao Yu, Samuel F. Hutton, Mingfang Zhang, Sally A. Mackenzie, 2015, Plant Physiology on p. 222-232
Gene network reconstruction identifies the authentic trans-prenyl diphosphate synthase that makes the solanesyl moiety of ubiquinone-9 in Arabidopsis
Anne Lise Ducluzeau, Yashitola Wamboldt, Christian G. Elowsky, Sally A. MacKenzie, Robert C. Schuurink, Gilles J.C. Basset, 2012, Plant Journal on p. 366-375
An epigenetic breeding system in soybean for increased yield and stability
Sunil K.Kenchanmane Raju, Mon Ray Shao, Robersy Sanchez, Ying Zhi Xu, Ajay Sandhu, George Graef, Sally Mackenzie, 2018, Plant Biotechnology Journal on p. 1836-1847
Functional modeling identifies paralogous solanesyl-diphosphate synthases that assemble the side chain of plastoquinone-9 in plastids
Anna Block, Rikard Fristedt, Sara Rogers, Jyothi Kumar, Brian Barnes, Joshua Barnes, Christian G. Elowsky, Yashitola Wamboldt, Sally A. Mackenzie, Kevin Redding, Sabeeha S. Merchant, Gilles J. Basset, 2013, Journal of Biological Chemistry on p. 27594-27606
MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development
Kamaldeep S S. Virdi, Yashitola Wamboldt, Hardik Kundariya, John D D. Laurie, Ido Keren, K. R. Sunil Kumar, Anna Block, Gilles Basset, Steve Luebker, Christian Elowsky, Philip M M. Day, Johnna L L. Roose, Terry M M. Bricker, Thomas Elthon, Sally A A. Mackenzie, 2016, Molecular Plant on p. 245-260
News Articles Featuring Sally Mackenzie
Sep 13, 2021
Eberly’s 2022 Lab Bench to Commercialization grant recipients announced
The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.
Sep 02, 2021
Epigenetics: Conducting The Symphony Of Genetics
For all the hype, fear and misinformation that surrounds the application of gene editing, there is an equally powerful technology that offers much the same in potential benefit. This technology, epigenetics, is a natural process that has gone largely unremarked by consumers.
Nov 09, 2020
High-yielding plants that survive temperature swings may be our next weapon against climate change
Sally Mackenzie spent her childhood summers walking through the vast fields of bright, red, ripe tomato crops: They grow best in the heat of her home state of California. Yet recent seasons prove it can get too hot for a tomato.
Oct 23, 2020
Researchers graft tomato plants with epigenetically-modified rootstock
Progeny of novel combination is more vigorous and productive than parental plants. Novel grafted plants — consisting of rootstock epigenetically modified to “believe” it has been under stress — joined to an unmodified scion, or above-ground shoot, give rise to progeny that are more vigorous, productive, and resilient than the parental plants.
Oct 22, 2020
Grafting with epigenetically-modified rootstock yields surprise
Novel grafted plants—consisting of rootstock epigenetically modified to “believe” it has been under stress joined to an unmodified scion, or above-ground shoot—give rise to progeny that are more vigorous, productive and resilient than the parent plants.
Jul 01, 2020
As climate change makes growing seasons less predictable, scientists dig into a novel approach to boosting crop resilience
Epigenetic modification of plants shows promise for enhancing food security — but we still have a lot to learn.
May 05, 2020
Plants pass on 'memory' of stress to some progeny, making them more resilient
By manipulating the expression of one gene, geneticists can induce a form of “stress memory” in plants that is inherited by some progeny, giving them the potential for more vigorous, hardy and productive growth, according to Penn State researchers, who suggest the discovery has significant implications for plant breeding.
Oct 07, 2019
Mackenzie Named Inaugural Director of Plant Institute
Sally Mackenzie sees a unique opportunity for Penn State to address complex global challenges in an unprecedented way.
Feb 21, 2019
Can plants get scared? Or help fight depression? New research suggests 'yes'
New studies show that plants react to threats much in the way that fear motivates people and that plants can reduce depression and lead to longer life spans.