Sally Mackenzie

Director of the Plant Institute; Huck Chair of Functional Genomics; Professor of Biology and of Plant Science

Sally Mackenzie

Research Summary

Organelle biology and cellular specializations. Plant epigenetics, memory and phenotypic plasticity. Crop epigenetic breeding.

Huck Graduate Students

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Arabidopsis Methylation Genes Phenotype Breeding Rna Growth Epigenome Transgenes Dna Methylation Epigenomics Epigenetics Plastids Gene Expression Signal Transduction Memory Viscosity Nanotechnology Rna Interference Genome Mitochondria Dna Proteins Mutation Organelles

Most Recent Publications

Plant environmental sensing relies on specialized plastids

Sally Mackenzie, Phillip Mullineaux, 2022, Journal of Experimental Botany on p. 7155

Methylome decoding of RdDM-mediated reprogramming effects in the Arabidopsis MSH1 system

Hardik Kundariya, Robersy Sanchez, Xiaodong Yang, Alenka Hafner, Sally A. Mackenzie, 2022, Genome Biology

Exploiting sterility and fertility variation in cytoplasmic male sterile vegetable crops

F Xu, X Yang, N Zhao, Z Hu, Sally Mackenzie, M Zhang, J Yang, 2022, Horticultural Research

Exploiting sterility and fertility variation in cytoplasmic male sterile vegetable crops

Fengyuan Xu, Xiaodong Yang, Na Zhao, Zhongyuan Hu, Sally A. MacKenzie, Mingfang Zhang, Jinghua Yang, 2022, Horticulture Research

A new take on organelle-mediated stress sensing in plants

Isaac J. Dopp, Xiaodong Yang, Sally A. Mackenzie, 2021, New Phytologist on p. 2148-2153

MutS HOMOLOG1 mediates fertility reversion from cytoplasmic male sterile Brassica juncea in response to environment

Na Zhao, Zhangping Li, Lili Zhang, Xiaodong Yang, Sally A. Mackenzie, Zhongyuan Hu, Mingfang Zhang, Jinghua Yang, 2021, Plant, Cell and Environment on p. 234-246

Implementation of Epigenetic Variation in Sorghum Selection and Implications for Crop Resilience Breeding

Dikungwa Ketumile, Xiaodong Yang, Robersy Sanchez Rodriguez, R Sanchez, Hardik Kundariya, John Rajewski, Ismail Dweikat, Sally Mackenzie, 2021, Frontiers in Plant Science

Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming

Xiaodong Yang, Robersy Sanchez, Hardik Kundariya, Tom Maher, Isaac Dopp, Rosemary Schwegel, Kamaldeep Virdi, Michael J. Axtell, Sally A. Mackenzie, 2020, Nature Communications

Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia

Robersy Sanchez, Sally A. Mackenzie, 2020, Scientific Reports

Plant science decadal vision 2020–2030: Reimagining the potential of plants for a healthy and sustainable future

Natalie Henkhaus, Madelaine Bartlett, David Gang, Rebecca Grumet, Ingrid Jordon-Thaden, Argelia Lorence, Eric Lyons, Samantha Miller, Seth Murray, Andrew Nelson, Chelsea Specht, Brett Tyler, Thomas Wentworth, David Ackerly, David Baltensperger, Philip Benfey, James Birchler, Sreekala Chellamma, Roslyn Crowder, Michael Donoghue, Jose Pablo Dundore-Arias, Jacqueline Fletcher, Valerie Fraser, Kelly Gillespie, Lonnie Guralnick, Elizabeth Haswell, Mitchell Hunter, Shawn Kaeppler, Stefan Kepinski, Fay Wei Li, Sally Mackenzie, Lucinda McDade, Ya Min, Jennifer Nemhauser, Brian Pearson, Peter Petracek, Katie Rogers, Ann Sakai, Delanie Sickler, Crispin Taylor, Laura Wayne, Ole Wendroth, Felipe Zapata, David Stern, 2020, Plant Direct

Most-Cited Papers

The genome sequence of allopolyploid Brassica juncea and analysis of differential homoeolog gene expression influencing selection

Jinghua Yang, Dongyuan Liu, Xiaowu Wang, Changmian Ji, Feng Cheng, Baoning Liu, Zhongyuan Hu, Sheng Chen, Deepak Pental, Youhui Ju, Pu Yao, Xuming Li, Kun Xie, Jianhui Zhang, Jianlin Wang, Fan Liu, Weiwei Ma, Jannat Shopan, Hongkun Zheng, Sally A. Mackenzie, Mingfang Zhang, 2016, Nature Genetics on p. 1225-1232

Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth

Kamaldeep S. Virdi, John D. Laurie, Ying Zhi Xu, Jiantao Yu, Mon Ray Shao, Robersy Sanchez, Hardik Kundariya, Dong Wang, Jean Jack M. Riethoven, Yashitola Wamboldt, Maria P. Arrieta-Montiel, Vikas Shedge, Sally A. Mackenzie, 2015, Nature Communications on p. 6386

The origin and biosynthesis of the benzenoid moiety of ubiquinone (Coenzyme Q) in Arabidopsis

Anna Block, Joshua R. Widhalm, Abdelhak Fatihi, Rebecca E. Cahoon, Yashitola Wamboldt, Christian Elowsky, Sally A. Mackenzie, Edgar B. Cahoon, Clint Chapple, Natalia Dudareva, Gilles J. Basset, 2014, Plant Cell on p. 1938-1948

In vivo extraction of Arabidopsis cell turgor pressure using nanoindentation in conjunction with finite element modeling

Elham Forouzesh, Ashwani Goel, Sally A. MacKenzie, Joseph A. Turner, 2013, Plant Journal on p. 509-520

An epigenetic breeding system in soybean for increased yield and stability

Sunil K.Kenchanmane Raju, Mon Ray Shao, Robersy Sanchez, Ying Zhi Xu, Ajay Sandhu, George Graef, Sally Mackenzie, 2018, Plant Biotechnology Journal on p. 1836-1847

Muts HOMOLOG1-derived epigenetic breeding potential in tomato

Xiaodong Yang, Hardik Kundariya, Ying Zhi Xu, Ajay Sandhu, Jiantao Yu, Samuel F. Hutton, Mingfang Zhang, Sally A. Mackenzie, 2015, Plant Physiology on p. 222-232

MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development

Kamaldeep S S. Virdi, Yashitola Wamboldt, Hardik Kundariya, John D D. Laurie, Ido Keren, K. R. Sunil Kumar, Anna Block, Gilles Basset, Steve Luebker, Christian Elowsky, Philip M M. Day, Johnna L L. Roose, Terry M M. Bricker, Thomas Elthon, Sally A A. Mackenzie, 2016, Molecular Plant on p. 245-260

Functional modeling identifies paralogous solanesyl-diphosphate synthases that assemble the side chain of plastoquinone-9 in plastids

Anna Block, Rikard Fristedt, Sara Rogers, Jyothi Kumar, Brian Barnes, Joshua Barnes, Christian G. Elowsky, Yashitola Wamboldt, Sally A. Mackenzie, Kevin Redding, Sabeeha S. Merchant, Gilles J. Basset, 2013, Journal of Biological Chemistry on p. 27594-27606

MSH1-induced heritable enhanced growth vigor through grafting is associated with the RdDM pathway in plants

Haridik Kundariya, Xiaodong Yang, Kyla Morton, R Sanchez Rodriguez, Robersy Sanchez, Michael J. Axtell, Samuel Hutton, Michael Fromm, Sally A. Mackenzie, 2020, Nature Communications on p. 5345

Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming

Xiaodong Yang, Robersy Sanchez, Hardik Kundariya, Tom Maher, Isaac Dopp, Rosemary Schwegel, Kamaldeep Virdi, Michael J. Axtell, Sally A. Mackenzie, 2020, Nature Communications

News Articles Featuring Sally Mackenzie

Nov 22, 2022

New 'Life From All Angles' video features Sally Mackenzie’s epigenetics research

The latest episode of "Life From All Angles," a YouTube series from the Huck Institutes of the Life Sciences, features Penn State Plant Institute Director Sally Mackenzie and her groundbreaking research in the field of epigenetics.

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Aug 16, 2022

Plant molecular geneticists discover, and begin to crack, the epigenetic code

When plants sense environmental challenges such as drought or extended periods of extreme temperatures, they instinctively reprogram their genetic material to survive and even thrive.

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May 03, 2022

Entrepreneurs compete for better future at Tech Tournament

Illuminate Therapeutics, a game changer in the way head and neck cancers are treated, earned the grand prize cash award of $75,000 at the Invent Penn State Tech Tournament, held April 28-29 at the Penn Stater Hotel & Conference Center, during the 2022 Invent Penn State Venture & IP Conference.

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Sep 13, 2021

Eberly’s 2022 Lab Bench to Commercialization grant recipients announced

The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.

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Sep 02, 2021

Epigenetics: Conducting The Symphony Of Genetics

For all the hype, fear and misinformation that surrounds the application of gene editing, there is an equally powerful technology that offers much the same in potential benefit. This technology, epigenetics, is a natural process that has gone largely unremarked by consumers.

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Nov 09, 2020

High-yielding plants that survive temperature swings may be our next weapon against climate change

Sally Mackenzie spent her childhood summers walking through the vast fields of bright, red, ripe tomato crops: They grow best in the heat of her home state of California. Yet recent seasons prove it can get too hot for a tomato.

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Oct 23, 2020

Researchers graft tomato plants with epigenetically-modified rootstock

Progeny of novel combination is more vigorous and productive than parental plants. Novel grafted plants — consisting of rootstock epigenetically modified to “believe” it has been under stress — joined to an unmodified scion, or above-ground shoot, give rise to progeny that are more vigorous, productive, and resilient than the parental plants.

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Oct 22, 2020

Grafting with epigenetically-modified rootstock yields surprise

Novel grafted plants—consisting of rootstock epigenetically modified to “believe” it has been under stress joined to an unmodified scion, or above-ground shoot—give rise to progeny that are more vigorous, productive and resilient than the parent plants.

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Jul 01, 2020

As climate change makes growing seasons less predictable, scientists dig into a novel approach to boosting crop resilience

Epigenetic modification of plants shows promise for enhancing food security — but we still have a lot to learn.

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May 05, 2020

Plants pass on 'memory' of stress to some progeny, making them more resilient

By manipulating the expression of one gene, geneticists can induce a form of “stress memory” in plants that is inherited by some progeny, giving them the potential for more vigorous, hardy and productive growth, according to Penn State researchers, who suggest the discovery has significant implications for plant breeding.

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