Ruobo Zhou

Assistant Professor of Chemistry

Ruobo Zhou

Research Summary

Quantitatively and functionally understanding the compartmentalization and spatiotemporal organization of protein-protein and protein-RNA interactions involved in fundamental cell functions as well as in cancer and neurodegenerative diseases.

Huck Affiliations

Links

Publication Tags

Membranes Dna Skeleton Spectrin Neurons Actins Axons Dendrites Messenger Rna Cellular Structures Time Animals Nucleosomes Single Stranded Dna Microscopy Carisoprodol Molecules Dichlorodimethylsilane Polysorbates Protein Proteins Brain Imaging Techniques Replication Protein A Neuroglia

Most Recent Papers

Developmental mechanism of the periodic membrane skeleton in axons

Guisheng Zhong, Jiang He, Ruobo Zhou, Damaris Lorenzo, Hazen Babcock, Vann Bennett, Xiaowei Zhuang, eLife

The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures

Neal Lue, Ruobo Zhou, Lidia Chico, Ninghui Mao, Olga Steinberg-Neifach, Taekjip Ha, PLoS Genetics on p. e1003145

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

Ruobo Zhou, Jichuan Zhang, Matthew Bochman, Virginia Zakian, Taekjip Ha, eLife

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1

Soo-Hyun Yang, Ruobo Zhou, Judith Campbell, Junjie Chen, Taekjip Ha, Tanya Paull, The EMBO Journal on p. 126-139

Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons

Ruobo Zhou, Boran Han, Chenglong Xia, Xiaowei Zhuang, 2019, Science on p. 929-934

βiI-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport

Damaris N. Lorenzo, Alexandra Badea, Ruobo Zhou, Peter J. Mohler, Xiaowei Zhuang, Vann Bennett, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 15686-15695

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Ruobo Zhou, Olivia Yang, Anne Cécile Déclais, Hyeonseok Jin, Gwang Hyeon Gwon, Alasdair D.J. Freeman, Yunje Cho, David M.J. Lilley, Taekjip Ha, 2019, Nature Chemical Biology on p. 269-275

Visualizing and discovering cellular structures with super-resolution microscopy

Yaron M. Sigal, Ruobo Zhou, Xiaowei Zhuang, 2018, Science on p. 880-887

Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

Boran Han, Ruobo Zhou, Chenglong Xia, Xiaowei Zhuang, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. E6678-E6685

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, Xiaowei Zhuang, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6029-6034

Most-Cited Papers

Visualizing and discovering cellular structures with super-resolution microscopy

Yaron M. Sigal, Ruobo Zhou, Xiaowei Zhuang, 2018, Science on p. 880-887

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells

Chong Wang, Boran Han, Ruobo Zhou, Xiaowei Zhuang, 2016, Cell on p. 990-1001

Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility

Thuy T.M. Ngo, Qiucen Zhang, Ruobo Zhou, Jaya G. Yodh, Taekjip Ha, 2015, Cell on p. 1135-1144

Developmental mechanism of the periodic membrane skeleton in axons

Guisheng Zhong, Jiang He, Ruobo Zhou, Damaris Lorenzo, Hazen P. Babcock, Vann Bennett, Xiaowei Zhuang, 2014, eLife

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

Ruobo Zhou, Jichuan Zhang, Matthew L. Bochman, Virginia A. Zakian, Taekjip Ha, 2014, eLife

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, Xiaowei Zhuang, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6029-6034

An improved surface passivation method for single-molecule studies

Boyang Hua, Kyu Young Han, Ruobo Zhou, Hajin Kim, Xinghua Shi, Sanjaya C. Abeysirigunawardena, Ankur Jain, Digvijay Singh, Vasudha Aggarwal, Sarah A. Woodson, Taekjip Ha, 2014, Nature Methods on p. 1233-1236

Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

Boran Han, Ruobo Zhou, Chenglong Xia, Xiaowei Zhuang, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. E6678-E6685

Structural mechanisms of PriA-mediated DNA replication restart

Basudeb Bhattacharyya, Nicholas P. George, Tiffany M. Thurmes, Ruobo Zhou, Niketa Jani, Sarah R. Wessel, Steven J. Sandler, Taekjip Ha, James L. Keck, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 1373-1378

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1

Soo Hyun Yang, Ruobo Zhou, Judith Campbell, Junjie Chen, Taekjip Ha, Tanya T. Paull, 2013, EMBO Journal on p. 126-139