Ross Hardison
Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology
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304 Wartik Lab
University Park, PA - rch8@psu.edu
- 814-863-0113
Research Summary
Regulation of gene expression during development.
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Genome Sciences Institute
Links
Publication Tags
Chromatin Genes Gene Expression Genome Fetal Hemoglobin Transcription Factors Erythroid Cells Mitosis Histones Proteins Acetylation Population Amino Acid Motifs Megakaryocytes Mutation Globins Thalassemia Histone Code Extrusion Nucleic Acid Regulatory Sequences Dna Messenger Rna Hemoglobinopathies Therapeutics DatabasesMost Recent Papers
OnTAD
Lin An, Tao Yang, Jiahao Yang, Johannes Nuebler, Guanjue Xiang, Ross C. Hardison, Qunhua Li, Yu Zhang, 2019, Genome biology on p. 1-16
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Haoyue Zhang, Daniel J. Emerson, Thomas G. Gilgenast, Katelyn R. Titus, Yemin Lan, Peng Huang, Di Zhang, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Jennifer E. Phillips-Cremins, Gerd A. Blobel, 2019, Nature on p. 158-162
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells
Xianjiang Lan, Eugene Khandros, Peng Huang, Scott A. Peslak, Saurabh K. Bhardwaj, Jeremy D. Grevet, Osheiza Abdulmalik, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Josue Baeza, Emily R. Duffner, Osama El Demerdash, Xiaoli S. Wu, Christopher R. Vakoc, Benjamin A. Garcia, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, 2019, Blood Advances on p. 1586-1597
Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel, 2019, Cell Reports on p. 400-415.e5
Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation
Caroline R. Bartman, Nicole Hamagami, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel, Arjun Raj, 2019, Molecular cell on p. 519-532.e4
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Jeremy D. Grevet, Xianjiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, Xinjun Ji, Saurabh K. Bhardwaj, Carolyne J. Face, David F. Posocco, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Ben A. Garcia, Stella T. Chou, Stephen A. Liebhaber, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, 2018, Science on p. 285-290
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points
Elisabeth F. Heuston, Cheryl A. Keller Capone, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, Ross Cameron Hardison, David M. Bodine, 2018, Epigenetics and Chromatin
Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element
Peng Huang, Cheryl A. Keller, Belinda Giardine, Jeremy D. Grevet, James O.J. Davies, Jim R. Hughes, Ryo Kurita, Yukio Nakamura, Ross C. Hardison, Gerd A. Blobel, 2017, Genes and Development on p. 1704-1713
The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries
Sarah C. Hsu, Thomas G. Gilgenast, Caroline R. Bartman, Christopher R. Edwards, Aaron J. Stonestrom, Peng Huang, Daniel J. Emerson, Perry Evans, Michael T. Werner, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Arjun Raj, Jennifer E. Phillips-Cremins, Gerd A. Blobel, 2017, Molecular cell on p. 102-116.e7
A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition
C. C.S. Hsiung, Caroline R. Bartman, Peng Huang, Paul Ginart, Aaron J. Stonestrom, Cheryl A. Keller, Carolyne Face, Kristen S. Jahn, Perry Evans, Laavanya Sankaranarayanan, Belinda Giardine, Ross C. Hardison, Arjun Raj, Gerd A. Blobel, 2016, Genes and Development on p. 1423-1439
Most-Cited Papers
Complete Khoisan and Bantu genomes from southern Africa
Stephan C. Schuster, Webb Miller, Aakrosh Ratan, Lynn P. Tomsho, Belinda Giardine, Lindsay R. Kasson, Robert S. Harris, Desiree C. Petersen, Fangqing Zhao, Ji Qi, Can Alkan, Jeffrey M. Kidd, Yazhou Sun, Daniela I. Drautz, Pascal Bouffard, Donna M. Muzny, Jeffrey G. Reid, Lynne V. Nazareth, Qingyu Wang, Richard Burhans, Cathy Riemer, Nicola E. Wittekindt, Priya Moorjani, Elizabeth A. Tindall, Charles G. Danko, Wee Siang Teo, Anne M. Buboltz, Zhenhai Zhang, Qianyi Ma, Arno Oosthuysen, Abraham W. Steenkamp, Hermann Oostuisen, Philippus Venter, John Gajewski, Yu Zhang, B. Franklin Pugh, Kateryna D. Makova, Anton Nekrutenko, Elaine R. Mardis, Nick Patterson, Tom H. Pringle, Francesca Chiaromonte, James C. Mullikin, Evan E. Eichler, Ross C. Hardison, Richard A. Gibbs, Timothy T. Harkins, Vanessa M. Hayes, 2010, Nature on p. 943-947
Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
Belinda Giardine, Joseph Borg, Emmanouil Viennas, Cristiana Pavlidis, Kamran Moradkhani, Philippe Joly, Marina Bartsakoulia, Cathy Riemer, Webb Miller, Giannis Tzimas, Henri Wajcman, Ross C. Hardison, George P. Patrinos, 2014, Nucleic acids research on p. D1063-D1069
Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility
Nergiz Dogan, Weisheng Wu, Christapher S. Morrissey, Kuan Bei Chen, Aaron Stonestrom, Maria Long, Cheryl A. Keller, Yong Cheng, Deepti Jain, Axel Visel, Len A. Pennacchio, Mitchell J. Weiss, Gerd A. Blobel, Ross C. Hardison, 2015, Epigenetics and Chromatin
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Maxim Pimkin, Andrew V. Kossenkov, Tejaswini Mishra, Christapher S. Morrissey, Weisheng Wu, Cheryl A. Keller, Gerd A. Blobel, Dongwon Lee, Michael A. Beer, Ross C. Hardison, Mitchell J. Weiss, 2014, Genome research on p. 1932-1944
Identification of biologically relevant enhancers in human erythroid cells
MacK Y. Su, Laurie A. Steiner, Hannah Bogardus, Tejaswini Mishra, Vincent P. Schulz, Ross C. Hardison, Patrick G. Gallagher, 2013, Journal of Biological Chemistry on p. 8433-8444
A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition
C. C.S. Hsiung, Caroline R. Bartman, Peng Huang, Paul Ginart, Aaron J. Stonestrom, Cheryl A. Keller, Carolyne Face, Kristen S. Jahn, Perry Evans, Laavanya Sankaranarayanan, Belinda Giardine, Ross C. Hardison, Arjun Raj, Gerd A. Blobel, 2016, Genes and Development on p. 1423-1439
Genome-wide comparative analysis reveals human-mouse regulatory landscape and evolution
Olgert Denas, Richard Sandstrom, Yong Cheng, Kathryn Beal, Javier Herrero, Ross C. Hardison, James Taylor, 2015, BMC genomics
The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries
Sarah C. Hsu, Thomas G. Gilgenast, Caroline R. Bartman, Christopher R. Edwards, Aaron J. Stonestrom, Peng Huang, Daniel J. Emerson, Perry Evans, Michael T. Werner, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Arjun Raj, Jennifer E. Phillips-Cremins, Gerd A. Blobel, 2017, Molecular cell on p. 102-116.e7
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus
Marta Byrska-Bishop, Daniel VanDorn, Amy E. Campbell, Marisol Betensky, Philip R. Arca, Yu Yao, Paul Gadue, Fernando F. Costa, Richard L. Nemiroff, Gerd A. Blobel, Deborah L. French, Ross C. Hardison, Mitchell J. Weiss, Stella T. Chou, 2015, Journal of Clinical Investigation on p. 993-1005
Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element
Peng Huang, Cheryl A. Keller, Belinda Giardine, Jeremy D. Grevet, James O.J. Davies, Jim R. Hughes, Ryo Kurita, Yukio Nakamura, Ross C. Hardison, Gerd A. Blobel, 2017, Genes and Development on p. 1704-1713
News Articles Featuring Ross Hardison
Dec 17, 2019
New tool reveals DNA structures that influence disease
Disruption of certain DNA structures — called topologically associating domains, or TADs — is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps elucidate the complex functions of TADs, an international team of researchers is making it easier to study these important structures and help prevent disease.
Full Article
May 06, 2019
Icefish Study Adds Another Color to the Story of Blood
The rainbow of pigments that animals use for blood illustrates a central truth about evolution
Full Article
Apr 22, 2019
Icefish Study Adds Another Color to the Story of Blood
The Antarctic blackfin icefish is the only known vertebrate animal that lacks red blood cells containing hemoglobin. But the use of hemoglobin to transport oxygen through the body is actually a rarity among invertebrates, which rely on a variety of other pigments in their versions of blood.
Full Article
Mar 26, 2019
CBIOS Trainee Hillary Koch Awarded NIH Fellowship
Koch's dissertation proposal, "Statistical Methods for Differential Peak Detection in Hi-C Data," was funded upon its first submission to the National Human Genome Research Institute.
Full Article