Ross Hardison

Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology

Ross Hardison

Research Summary

Regulation of gene expression during development.

Huck Affiliations

Links

Publication Tags

Chromatin Genes Globins Acetylation Proteins Fetal Hemoglobin Gene Expression Histones Hemoglobinopathies Mitosis Mutation Gata1 Transcription Factor Thalassemia Transcription Transcription Factors Dna Databases Extrusion Erythroid Cells Gamma Globins Hemoglobin Subunits Beta Globins Human Genome Genome Chromosomes

Most Recent Papers

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells

Ross Hardison, Y Zhang, Cheryl Keller, G Xiang, E Heuston, L An, J Lichtenberg, B Giardine, D Bodine, Shaun Mahony, Q Li, F Yue, M Weiss, G Blobel, J Taylor, J Hughes, D Higgs, B Göttgens, 2020, IUBMB life on p. 27-38

OnTAD

Lin An, Tao Yang, Jiahao Yang, Johannes Nuebler, Guanjue Xiang, Ross C. Hardison, Qunhua Li, Yu Zhang, 2019, Genome biology on p. 1-16

Chromatin structure dynamics during the mitosis-to-G1 phase transition

Haoyue Zhang, Daniel J. Emerson, Thomas G. Gilgenast, Katelyn R. Titus, Yemin Lan, Peng Huang, Di Zhang, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Jennifer E. Phillips-Cremins, Gerd A. Blobel, 2019, Nature on p. 158-162

S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data

Guanjue Xiang, Cheryl Keller, Belinda Giardine, Lin An, Ross Hardison, Yu Zhang, 2019, bioRxiv on p. 506634

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

Guanjue Xiang, Cheryl Keller, Elisabeth Heuston, Belinda Giardine, Lin An, Alexander Wixom, Amber Miller, April Cockburn, Jens Lichtenberg, Berthold Gottgens, others, David Bodine, Shaun Mahony, James Taylor, Gerd Blobel, Mitchell Weiss, Yong Cheng, Feng Yue, Jim Hughes, Douglas Higgs, Yu Zhang, Ross Hardison, 2019, bioRxiv

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Xianjiang Lan, Eugene Khandros, Peng Huang, Scott A. Peslak, Saurabh K. Bhardwaj, Jeremy D. Grevet, Osheiza Abdulmalik, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Josue Baeza, Emily R. Duffner, Osama El Demerdash, Xiaoli S. Wu, Christopher R. Vakoc, Benjamin A. Garcia, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, 2019, Blood Advances on p. 1586-1597

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel, 2019, Cell Reports on p. 400-415.e5

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation

Caroline R. Bartman, Nicole Hamagami, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel, Arjun Raj, 2019, Molecular cell on p. 519-532.e4

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells

Ross Hardison, Yu Zhang, Cheryl Keller, Guanjue Xiang, Elisabeth Heuston, Lin An, Jens Lichtenberg, Belinda Giardine, David Bodine, Shaun Mahony, Qunhua Li, Feng Yue, Mitchell Weiss, Gerd Blobel, James Taylor, Jim Hughes, Douglas Higgs, Berthold Gottgens, 2019, IUBMB LIFE

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.

C Bartman, N Hamagami, C Keller, B Giardine, Ross Hardison, G Blobel, A Raj, 2018, Molecular Cell

Most-Cited Papers

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham, Anshul Kundaje, Shelley F. Aldred, Patrick J. Collins, Carrie A. Davis, Francis Doyle, Charles B. Epstein, Seth Frietze, Jennifer Harrow, Rajinder Kaul, Jainab Khatun, Bryan R. Lajoie, Stephen G. Landt, Bum Kyu Lee, Florencia Pauli, Kate R. Rosenbloom, Peter Sabo, Alexias Safi, Amartya Sanyal, Noam Shoresh, Jeremy M. Simon, Lingyun Song, Nathan D. Trinklein, Robert C. Altshuler, Ewan Birney, James B. Brown, Chao Cheng, Sarah Djebali, Xianjun Dong, Jason Ernst, Terrence S. Furey, Mark Gerstein, Belinda Giardine, Melissa Greven, Ross C. Hardison, Robert S. Harris, Javier Herrero, Michael M. Hoffman, Sowmya Iyer, Manolis Kellis, Pouya Kheradpour, Timo Lassmann, Qunhua Li, Xinying Lin, Georgi K. Marinov, Angelika Merkel, Ali Mortazavi, Ross Cameron Hardison, Robert Scott Harris, Qunhua Li, 2012, Nature on p. 57-74

Topologically associating domains are stable units of replication-timing regulation

Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross Cameron Hardison, Tamer Kahveci, Bing Ren, David M. Gilbert, 2014, Nature on p. 402-405

Integrative annotation of chromatin elements from ENCODE data

Michael M. Hoffman, Jason Ernst, Steven P. Wilder, Anshul Kundaje, Robert Scott Harris, Max Libbrecht, Belinda Giardine, Paul M. Ellenbogen, Jeffrey A. Bilmes, Ewan Birney, Ross Cameron Hardison, Ian Dunham, Manolis Kellis, William Stafford Noble, 2013, Nucleic acids research on p. 827-841

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Belinda Giardine, Joseph Borg, Emmanouil Viennas, Cristiana Pavlidis, Kamran Moradkhani, Philippe Joly, Marina Bartsakoulia, Cathy Riemer, Webb Miller, Giannis Tzimas, Henri Wajcman, Ross C. Hardison, George P. Patrinos, 2014, Nucleic acids research on p. D1063-D1069

Principles of regulatory information conservation between mouse and human

Yong Cheng, Zhihai Ma, Bong Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller Capone, Belinda Giardine, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross Cameron Hardison, Michael P. Snyder, 2014, Nature on p. 371-375

Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1

Stephan Kadauke, Maheshi I. Udugama, Jan M. Pawlicki, Jordan C. Achtman, Deepti P. Jain, Yong Cheng, Ross Cameron Hardison, Gerd A. Blobel, 2012, Cell on p. 725-737

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

Janine M. Lamonica, Wulan Deng, Stephan Kadauke, Amy E. Campbell, Roland Gamsjaeger, Hongxin Wang, Yong Cheng, Andrew N. Billin, Ross Cameron Hardison, Joel P. Mackay, Gerd A. Blobel, 2011, Proceedings of the National Academy of Sciences of the United States of America

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Elizabeth A. Traxler, Yu Yao, Yong Dong Wang, Kaitly J. Woodard, Ryo Kurita, Yukio Nakamura, Jim R. Hughes, Ross Cameron Hardison, Gerd A. Blobel, Chunliang Li, Mitchell J. Weiss, 2016, Nature Medicine on p. 987-990

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

Belinda Giardine, Joseph Borg, Douglas R. Higgs, Kenneth R. Peterson, Sjaak Philipsen, Donna Maglott, Belinda K. Singleton, David J. Anstee, A. Nazli Basak, Barnaby Clark, Flavia C. Costa, Paula Faustino, Halyna Fedosyuk, Alex E. Felice, Alain Francina, Renzo Galanello, Monica V.E. Gallivan, Marianthi Georgitsi, Richard J. Gibbons, Piero C. Giordano, Cornelis L. Harteveld, James D. Hoyer, Martin Jarvis, Philippe Joly, Emmanuel Kanavakis, Panagoula Kollia, Stephan Menzel, Webb Miller, Kamran Moradkhani, John Old, Adamantia Papachatzopoulou, Manoussos N. Papadakis, Petros Papadopoulos, Sonja Pavlovic, Lucia Perseu, Milena Radmilovic, Cathy Riemer, Stefania Satta, Iris Schrijver, Maja Stojiljkovic, Swee Lay Thein, Jan Traeger-Synodinos, Ray Tully, Takahito Wada, John S. Waye, Claudia Wiemann, Branka Zukic, David H.K. Chui, Henri Wajcman, Ross Cameron Hardison, George P. Patrinos, 2011, Nature Genetics on p. 295-302

Unlinking an lncRNA from Its Associated cis Element

Vikram R. Paralkar, Cristian C. Taborda, Peng Huang, Yu Yao, Andrew V. Kossenkov, Rishi Prasad, Jing Luan, James O.J. Davies, Jim R. Hughes, Ross Cameron Hardison, Gerd A. Blobel, Mitchell J. Weiss, 2016, Molecular Cell on p. 104-110