Ross Hardison

Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology

Ross Hardison

Research Summary

Regulation of gene expression during development.

Huck Affiliations

Links

Publication Tags

Dna Genome Chromatin Genes Human Genome Fetal Hemoglobin Binding Sites Globins Mutation Encyclopedias Transcription Factors Ccctc Binding Factor Thalassemia Databases Hemoglobinopathies Hemoglobins Sickle Cell Anemia Genomics Hemoglobin Subunits Erythroid Cells Beta Globins Gamma Globins Dna Methylation Rna Gene Editing

Most Recent Papers

Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis

Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng, 2021, Blood on p. 1327-1339

Distinct properties and functions of CTCF revealed by a rapidly inducible degron system

Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel, 2021, Cell Reports

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.

X Lan, R Ren, R Feng, L Ly, Y Lan, Z Zhang, N Aboreden, K Qin, J Horton, J Grevet, T Mayuranathan, O Abdulmalik, Cheryl Keller, B Giardine, Ross Hardison, M Crossley, M Weiss, X Cheng, J Shi, G Blobel, 2021, Molecular cell on p. 239-254.e8

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, Zhe Zhang, Nicholas Aboreden, Kunhua Qin, John R. Horton, Jeremy D. Grevet, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Merlin Crossley, Mitchell J. Weiss, Xiaodong Cheng, Junwei Shi, Gerd A. Blobel, 2021, Molecular Cell on p. 239-254.e8

Clinically relevant updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Belinda M. Giardine, Philippe Joly, Serge Pissard, Henri Wajcman, David H. K Chui, Ross C. Hardison, George P. Patrinos, 2021, Nucleic Acids Research on p. D1192-D1196

A map of cis-regulatory elements and 3D genome structures in zebrafish

Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N.K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith Cheng, Feng Yue, 2020, Nature on p. 337-343

Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis.

Q Qi, L Cheng, X Tang, Y He, Y Li, T Yee, D Shrestha, R Feng, P Xu, X Zhou, S Pruett-Miller, Ross Hardison, M Weiss, Y Cheng, 2020, Blood

Alteration of genome folding via contact domain boundary insertion

Di Zhang, Peng Huang, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Haoyue Zhang, Thomas G. Gilgenast, Jennifer E. Phillips-Cremins, Ross C. Hardison, Gerd A. Blobel, 2020, Nature Genetics on p. 1076-1087

HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation

Scott A. Peslak, Eugene Khandros, Peng Huang, Xianjiang Lan, Carly L. Geronimo, Jeremy D. Grevet, Osheiza Abdulmalik, Zhe Zhang, Belinda M. Giardine, Cheryl A. Keller, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, 2020, Blood advances on p. 4560-4572

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian, Veena Afzal, Bronwen Aken, Jennifer A. Akiyama, Omar Al Jammal, Henry Amrhein, Stacie M. Anderson, Gregory R. Andrews, Igor Antoshechkin, Kristin G. Ardlie, Joel Armstrong, Matthew Astley, Budhaditya Banerjee, Amira A. Barkal, If H.A. Barnes, Iros Barozzi, Daniel Barrell, Gemma Barson, Daniel Bates, Ulugbek K. Baymuradov, Cassandra Bazile, Michael A. Beer, Samantha Beik, M. A. Bender, Ruth Bennett, Louis Philip Benoit Bouvrette, Bradley E. Bernstein, Andrew Berry, Anand Bhaskar, Alexandra Bignell, Steven M. Blue, David M. Bodine, Carles Boix, Nathan Boley, Tyler Borrman, Beatrice Borsari, Alan P. Boyle, Laurel A. Brandsmeier, Alessandra Breschi, Emery H. Bresnick, Jason A. Brooks, Michael Buckley, Lingling Cai, Ross C. Hardison, Cheryl A. Keller, Feng Yue, Lijun Zhang, 2020, Nature on p. 699-710

Most-Cited Papers

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham, Anshul Kundaje, Shelley F. Aldred, Patrick J. Collins, Carrie A. Davis, Francis Doyle, Charles B. Epstein, Seth Frietze, Jennifer Harrow, Rajinder Kaul, Jainab Khatun, Bryan R. Lajoie, Stephen G. Landt, Bum Kyu Lee, Florencia Pauli, Kate R. Rosenbloom, Peter Sabo, Alexias Safi, Amartya Sanyal, Noam Shoresh, Jeremy M. Simon, Lingyun Song, Nathan D. Trinklein, Robert C. Altshuler, Ewan Birney, James B. Brown, Chao Cheng, Sarah Djebali, Xianjun Dong, Jason Ernst, Terrence S. Furey, Mark Gerstein, Belinda Giardine, Melissa Greven, Ross C. Hardison, Robert S. Harris, Javier Herrero, Michael M. Hoffman, Sowmya Iyer, Manolis Kellis, Pouya Kheradpour, Timo Lassmann, Qunhua Li, Xinying Lin, Georgi K. Marinov, Angelika Merkel, Ali Mortazavi, Ross Cameron Hardison, Robert Scott Harris, Qunhua Li, 2012, Nature on p. 57-74

A user's guide to the Encyclopedia of DNA elements (ENCODE)

Richard M. Myers, John Stamatoyannopoulos, Michael Snyder, Ian Dunham, Ross Cameron Hardison, Bradley E. Bernstein, Thomas R. Gingeras, W. James Kent, Ewan Birney, Barbara Wold, Gregory E. Crawford, Charles B. Epstein, Noam Shoresh, Jason Ernst, Tarjei S. Mikkelsen, Pouya Kheradpour, Xiaolan Zhang, Li Wang, Robbyn Issner, Michael J. Coyne, Timothy Durham, Manching Ku, Thanh Truong, Lucas D. Ward, Robert C. Altshuler, Michael F. Lin, Manolis Kellis, Carrie A. Davis, Philipp Kapranov, Alexander Dobin, Christopher Zaleski, Felix Schlesinger, Philippe Batut, Sudipto Chakrabortty, Sonali Jha, Wei Lin, Jorg Drenkow, Huaien Wang, Kim Bell, Ian Bell, Hui Gao, Erica Dumais, Jacqueline Dumais, Stylianos E. Antonarakis, Catherine Ucla, Christelle Borel, Roderic Guigo, Sarah Djebali, Julien Lagarde, Colin Kingswood, Paolo Ribeca, Micha Sammeth, Tyler Alioto, Angelika Merkel, Hagen Tilgner, Piero Carninci, Yoshihide Hayashizaki, Timo Lassmann, Hazuki Takahashi, Rehab F. Abdelhamid, Gregory Hannon, Katalin Toth Fejes, Jonathan Preall, Assaf Gordon, Vihra Sotirova, Alexandre Reymond, Cedric Howald, Emilie Aït Yahya Graison, Jacqueline Chrast, Yijun Ruan, Xiaoan Ruan, Atif Shahab, Wan Ting Poh, Chia Lin Wei, Terrence S. Furey, Alan P. Boyle, Nathan C. Sheffield, Lingyun Song, Yoichiro Shibata, Teresa Vales, Deborah Winter, Zhancheng Zhang, Darin London, Tianyuan Wang, Damian Keefe, Vishwanath R. Iyer, Bum Kyu Lee, Ryan M. McDaniell, Zheng Liu, Anna Battenhouse, Akshay A. Bhinge, Jason D. Lieb, Linda L. Grasfeder, Kimberly A. Showers, Paul G. Giresi, Seul K.C. Kim, Christopher Shestak, Florencia Pauli, Timothy E. Reddy, Jason Gertz, E. Christopher Partridge, Preti Jain, Rebekka O. Sprouse, Anita Bansal, Barbara Pusey, Michael A. Muratet, Katherine E. Varley, Kevin M. Bowling, Kimberly M. Newberry, Amy S. Nesmith, Jason A. Dilocker, Stephanie L. Parker, Lindsay L. Waite, Krista Thibeault, Kevin Roberts, Devin M. Absher, Ali Mortazavi, Brian Williams, Georgi Marinov, Diane Trout, Brandon King, Kenneth McCue, Anthony Kirilusha, Gilberto DeSalvo, Katherine Aylor Fisher, Henry Amrhein, Shirley Pepke, Jost Vielmetter, Gavin Sherlock, Arend Sidow, Serafim Batzoglou, Rami Rauch, Anshul Kundaje, Max Libbrecht, Elliott H. Margulies, Stephen C.J. Parker, Laura Elnitski, Eric D. Green, Tim Hubbard, Jennifer Harrow, Stephen Searle, Felix Kokocinski, Browen Aken, Adam Frankish, Toby Hunt, Gloria Despacio-Reyes, Mike Kay, Gaurab Mukherjee, Alexandra Bignell, Gary Saunders, Veronika Boychenko, Michael Brent, M. J. van Baren, Randall H. Brown, Mark Gerstein, Ekta Khurana, Suganthi Balasubramanian, Hugo Lam, Philip Cayting, Rebecca Robilotto, Zhi Lu, Thomas Derrien, Andrea Tanzer, David G. Knowles, Marco Mariotti, David Haussler, Rachel Harte, Mark Diekhans, Mike Lin, Alfonso Valencia, Michael Tress, Stephen G. Landt, Debasish Raha, Minyi Shi, Ghia Euskirchen, Fabian Grubert, Maya Kasowski, Jin Lian, Phil Lacroute, Youhan Xu, Hannah Monahan, Dorrelyn Patacsil, Teri Slifer, Xinqiong Yang, Alexandra Charos, Brian Reed, Linfeng Wu, Raymond K. Auerbach, Lukas Habegger, Manoj Hariharan, Joel Rozowsky, Alexej Abyzov, Sherman M. Weissman, Kevin Struhl, Nathan Lamarre-Vincent, Marianne Lindahl-Allen, Benoit Miotto, Zarmik Moqtaderi, Joseph D. Fleming, Peter Newburger, Peggy J. Farnham, Seth Frietze, Henriette O'Geen, Xiaoqin Xu, Kim R. Blahnik, Alina R. Cao, Sushma Iyengar, Rajinder Kaul, Robert E. Thurman, Hao Wang, Patrick A. Navas, Richard Sandstrom, Peter J. Sabo, Molly Weaver, Theresa Canfield, Kristen Lee, Shane Neph, Vaughan Roach, Alex Reynolds, Audra Johnson, Eric Rynes, Erika Giste, Shinny Vong, Jun Neri, Tristan Frum, Eric D. Nguyen, Abigail K. Ebersol, Minerva E. Sanchez, Hadar H. Sheffer, Dimitra Lotakis, Eric Haugen, Richard Humbert, Tanya Kutyavin, Tony Shafer, William S. Noble, Job Dekker, Bryan R. Lajoie, Amartya Sanyal, Kate R. Rosenbloom, Timothy R. Dreszer, Brian J. Raney, Galt P. Barber, Laurence R. Meyer, Cricket A. Sloan, Venkat S. Malladi, Melissa S. Cline, Katrina Learned, Vanessa K. Swing, Ann S. Zweig, Brooke Rhead, Pauline A. Fujita, Krishna Roskin, Donna Karolchik, Robert M. Kuhn, Steven P. Wilder, Daniel Sobral, Javier Herrero, Kathryn Beal, Margus Lukk, Alvis Brazma, Juan M. Vaquerizas, Nicholas M. Luscombe, Peter J. Bickel, Nathan Boley, James B. Brown, Qunhua Li, Haiyan Huang, Andrea Sboner, Kevin Y. Yip, Chao Cheng, Koon Kiu Yan, Nitin Bhardwaj, Jing Wang, Lucas Lochovsky, Justin Jee, Theodore Gibson, Jing Leng, Jiang Du, Robert Scott Harris, Giltae Song, Webb Miller, Bernard Suh, Benedict Paten, Michael M. Hoffman, Orion J. Buske, Zhiping Weng, Xianjun Dong, Jie Wang, Hualin Xi, Scott A. Tenenbaum, Frank Doyle, Sridar Chittur, Luiz O. Penalva, Thomas D. Tullius, Kevin P. White, Subhradip Karmakar, Alec Victorsen, Nader Jameel, Nick Bild, Robert L. Grossman, Patrick J. Collins, Nathan D. Trinklein, Morgan C. Giddings, Jainab Khatun, Chris Maier, Ting Wang, Troy W. Whitfield, Xian Chen, Yanbao Yu, Harsha Gunawardena, Elise A. Feingold, Rebecca F. Lowdon, Laura A.L. Dillon, Peter J. Good, Brian Risk, 2011, PLoS Biology on p. e1001046

A comparative encyclopedia of DNA elements in the mouse genome.

F Yue, Y Cheng, A Breschi, J Vierstra, W Wu, T Ryba, R Sandstrom, Z Ma, C Davis, B Pope, Y Shen, D Pervouchine, S Djebali, R Thurman, R Kaul, E Rynes, A Kirilusha, G Marinov, B Williams, D Trout, H Amrhein, K Fisher-Aylor, I Antoshechkin, G DeSalvo, L See, M Fastuca, J Drenkow, C Zaleski, A Dobin, P Prieto, J Lagarde, G Bussotti, A Tanzer, O Denas, K Li, M Bender, M Zhang, R Byron, M Groudine, D McCleary, L Pham, Z Ye, S Kuan, L Edsall, Y Wu, M Rasmussen, M Bansal, M Kellis, Cheryl Keller, C Morrissey, T Mishra, D Jain, Nergiz Dogan, Robert Harris, P Cayting, T Kawli, A Boyle, G Euskirchen, A Kundaje, S Lin, Y Lin, C Jansen, V Malladi, M Cline, D Erickson, V Kirkup, K Learned, C Sloan, K Rosenbloom, B de Lacerda Sousa, K Beal, M Pignatelli, P Flicek, J Lian, T Kahveci, D Lee, W Kent, M Ramalho Santos, J Herrero, C Notredame, A Johnson, S Vong, K Lee, D Bates, F Neri, M Diegel, T Canfield, P Sabo, M Wilken, T Reh, E Giste, A Shafer, T Kutyavin, E Haugen, D Dunn, A Reynolds, S Neph, R Humbert, R Hansen, M De Bruijn, L Selleri, A Rudensky, S Josefowicz, R Samstein, E Eichler, S Orkin, D Levasseur, T Papayannopoulou, K Chang, A Skoultchi, S Gosh, C Disteche, P Treuting, Y Wang, M Weiss, G Blobel, X Cao, S Zhong, T Wang, P Good, R Lowdon, L Adams, X Zhou, M Pazin, E Feingold, B Wold, J Taylor, A Mortazavi, S Weissman, J Stamatoyannopoulos, M Snyder, R Guigo, T Gingeras, D Gilbert, Ross Hardison, M Beer, B Ren, 2014, Nature on p. 355-64

Topologically associating domains are stable units of replication-timing regulation

Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross Cameron Hardison, Tamer Kahveci, Bing Ren, David M. Gilbert, 2014, Nature on p. 402-405

Defining functional DNA elements in the human genome

Manolis Kellis, Barbara Wold, Michael P. Snyder, Bradley E. Bernstein, Anshul Kundaje, Georgi K. Marinov, Lucas D. Ward, Ewan Birney, Gregory E. Crawford, Job Dekker, Ian Dunham, Laura L. Elnitski, Peggy J. Farnham, Elise A. Feingold, Mark Gerstein, Morgan C. Giddings, David M. Gilbert, Thomas R. Gingeras, Eric D. Green, Roderic Guigo, Tim Hubbard, Jim Kent, Jason D. Lieb, Richard M. Myers, Michael J. Pazin, Bing Ren, John A. Stamatoyannopoulos, Zhiping Weng, Kevin P. White, Ross C. Hardison, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 6131-6138

An encyclopedia of mouse DNA elements (Mouse ENCODE)

John A. Stamatoyannopoulos, Michael Snyder, Ross Hardison, Bing Ren, Thomas Gingeras, David M. Gilbert, Mark Groudine, Michael Bender, Rajinder Kaul, Theresa Canfield, Erica Giste, Audra Johnson, Mia Zhang, Gayathri Balasundaram, Rachel Byron, Vaughan Roach, Peter J. Sabo, Richard Sandstrom, A. Sandra Stehling, Robert E. Thurman, Sherman M. Weissman, Philip Cayting, Manoj Hariharan, Jin Lian, Yong Cheng, Stephen G. Landt, Zhihai Ma, Barbara J. Wold, Job Dekker, Gregory E. Crawford, Cheryl A. Keller, Weisheng Wu, Christopher Morrissey, Swathi A. Kumar, Tejaswini Mishra, Deepti Jain, Marta Byrska-Bishop, Daniel Blankenberg, Bryan R. Lajoiel, Gaurav Jain, Amartya Sanyal, Kaun Bei Chen, Olgert Denas, James Taylor, Gerd A. Blobel, Mitchell J. Weiss, Max Pimkin, Wulan Deng, Georgi K. Marinov, Brian A. Williams, Katherine I. Fisher-Aylor, Gilberto Desalvo, Anthony Kiralusha, Diane Trout, Henry Amrhein, Ali Mortazavi, Lee Edsall, David McCleary, Samantha Kuan, Yin Shen, Feng Yue, Zhen Ye, Carrie A. Davis, Chris Zaleski, Sonali Jha, Chenghai Xue, Alex Dobin, Wei Lin, Meagan Fastuca, Huaien Wang, Roderic Guigo, Sarah Djebali, Julien Lagarde, Tyrone Ryba, Takayo Sasaki, Venkat S. Malladi, Melissa S. Cline, Vanessa M. Kirkup, Katrina Learned, Kate R. Rosenbloom, W. James Kent, Elise A. Feingold, Peter J. Good, Michael Pazin, Rebecca F. Lowdon, Leslie B. Adams, 2012, Genome Biology

Integrative annotation of chromatin elements from ENCODE data

Michael M. Hoffman, Jason Ernst, Steven P. Wilder, Anshul Kundaje, Robert Scott Harris, Max Libbrecht, Belinda Giardine, Paul M. Ellenbogen, Jeffrey A. Bilmes, Ewan Birney, Ross Cameron Hardison, Ian Dunham, Manolis Kellis, William Stafford Noble, 2013, Nucleic Acids Research on p. 827-841

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Belinda Giardine, Joseph Borg, Emmanouil Viennas, Cristiana Pavlidis, Kamran Moradkhani, Philippe Joly, Marina Bartsakoulia, Cathy Riemer, Webb Miller, Giannis Tzimas, Henri Wajcman, Ross C. Hardison, George P. Patrinos, 2014, Nucleic Acids Research on p. D1063-D1069

Principles of regulatory information conservation between mouse and human

Yong Cheng, Zhihai Ma, Bong Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller Capone, Belinda Giardine, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross Cameron Hardison, Michael P. Snyder, 2014, Nature on p. 371-375

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Elizabeth A. Traxler, Yu Yao, Yong Dong Wang, Kaitly J. Woodard, Ryo Kurita, Yukio Nakamura, Jim R. Hughes, Ross Cameron Hardison, Gerd A. Blobel, Chunliang Li, Mitchell J. Weiss, 2016, Nature Medicine on p. 987-990