Ross Hardison
Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology

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304 Wartik Lab
University Park, PA - rch8@psu.edu
- 814-863-0113
Research Summary
Regulation of gene expression during development.
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Genome Sciences Institute
Links
Publication Tags
Genome Chromatin Genes Dna Mutation Globins Human Genome Encyclopedias Transcription Factors Fetal Hemoglobin Gene Editing Hemoglobins Computational Biology Erythroid Cells Thalassemia Hemoglobinopathies Epigenomics Datasets Hemoglobin Subunits Gamma Globins Beta Globins Hemoglobin Sickle Cell Anemia Population RnaMost Recent Publications
CLIMB: High-dimensional association detection in large scale genomic data
Hillary Koch, Cheryl A. Keller, Guanjue Xiang, Belinda Giardine, Feipeng Zhang, Yicheng Wang, Ross C. Hardison, Qunhua Li, 2022, Nature Communications
Subtype-specific 3D genome alteration in acute myeloid leukaemia
Jie Xu, Fan Song, Huijue Lyu, Mikoto Kobayashi, Baozhen Zhang, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Josiah Hiu yuen Wong, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Hongbo Yang, Ross C. Hardison, Sinisa Dovat, Leonidas C. Platanias, Yarui Diao, Yue Yang, Tomoko Yamada, Aaron D. Viny, Ross L. Levine, David Claxton, James R. Broach, Hong Zheng, Feng Yue, 2022, Nature on p. 387-398
CTCF blocks antisense transcription initiation at divergent promoters
Jing Luan, Marit W. Vermunt, Camille M. Syrett, Allison Coté, Jacob M. Tome, Haoyue Zhang, Anran Huang, Jennifer M. Luppino, Cheryl A. Keller Capone, Belinda M. Giardine, Shiping Zhang, Margaret C. Dunagin, Zhe Zhang, Eric F. Joyce, John T. Lis, Arjun Raj, Ross C. Hardison, Gerd A. Blobel, 2022, Nature Structural Biology on p. 1136-1144
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
Peng Huang, Scott A. Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A. Keller, Belinda Giardine, Henry W. Bell, Xianjiang Lan, Malini Sharma, John R. Horton, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Merlin Crossley, Ross C. Hardison, Xiaodong Cheng, Gerd A. Blobel, 2022, Nature Genetics on p. 1417-1426
Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells (Nature Genetics, (2022), 54, 6, (874-884), 10.1038/s41588-022-01076-1)
Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A. Keller, Scott A. Peslak, Eugene Khandros, Megan S. Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Osheiza Abdulmalik, Belinda Giardine, Stella T. Chou, Junwei Shi, Ross C. Hardison, Mitchell J. Weiss, Gerd A. Blobel, 2022, Nature Genetics on p. 906
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A. Keller, Scott A. Peslak, Eugene Khandros, Megan S. Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Osheiza Abdulmalik, Belinda Giardine, Stella T. Chou, Junwei Shi, Ross C. Hardison, Mitchell J. Weiss, Gerd A. Blobel, 2022, Nature Genetics on p. 874-884
Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia
Hee Jin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, 2022, Blood on p. 3058-3072
Author Correction: Perspectives on ENCODE (Nature, (2020), 583, 7818, (693-698), 10.1038/s41586-020-2449-8)
Michael P. Snyder, Federi Bronwen co Abascal, Thomas R. Gingeras, Reyes Acosta, Jill E. Moore, Nicholas J. Addleman, Jessika Adrian, Zhiping Weng, Mark B. Gerstein, Veena Afzal, Bing Ren, Bronwen Aken, Rizi Ai, Jennifer A. Akiyama, John A. Stamatoyannopoulos, Omar Al Jammal, Brenton R. Graveley, Henry Amrhein, Elise A. Feingold, Michael J. Pazin, Stacie M. Anderson, Michael Pagan, Gregory R. Andrews, Daniel A. Gilchrist, Igor Antoshechkin, Kristin G. Ardlie, Benjamin C. Hitz, J. Michael Cherry, Joel Armstrong, Matthew Astley, Bradley E. Bernstein, Eric M. Mendenhall, Budhaditya Banerjee, Amira A. Barkal, Daniel R. Zerbino, If H.A. Barnes, Adam Frankish, Paul Flicek, Iros Barozzi, Richard M. Myers, Daniel Barrell, Gemma Barson, Daniel Bates, Ulugbek K. Baymuradov, Cassandra Bazile, Michael A. Beer, Samantha Beik, M. A. Bender, Ruth Bennett, Louis Philip Benoit Bouvrette, Bradley E. Bernstein, Andrew Berry, Anand Bhaskar, Alexandra Bignell, Steven M. Blue, David M. Bodine, Carles Boix, Nathan Boley, Tyler Borrman, Beatrice Borsari, Alan P. Boyle, Laurel A. Brandsmeier, Alessandra Breschi, Emery H. Bresnick, Jason A. Brooks, Michael Buckley, Ross C. Hardison, Cheryl A. Keller, Hongbo Yang, Feng Yue, 2022, Nature on p. E4
Erratum: Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes (Nature (2020) 583 7818 (699-710))
Federico Abascal, Jill E. Moore, Michael J. Purcaro, Reyes Acosta, Henry E. Pratt, Nicholas J. Addleman, Jessika Adrian, Charles B. Epstein, Veena Afzal, Noam Shoresh, Jessika Adrian, Bronwen Aken, Jennifer A. Akiyama, Trupti Kawli, Carrie A. Davis, Omar Al Jammal, Henry Amrhein, Alexander Dobin, Stacie M. Anderson, Rajinder Kaul, Jessica Halow, Gregory R. Andrews, Eric L. Van Nostrand, Igor Antoshechkin, Peter Freese, Kristin G. Ardlie, David U. Gorkin, Joel Armstrong, Yin Shen, Matthew Astley, Budhaditya Banerjee, Yupeng He, Mark Mackiewicz, Amira A. Barkal, If H.A. Barnes, Florencia Pauli-Behn, Brian A. Williams, Iros Barozzi, Ali Mortazavi, Daniel Barrell, Gemma Barson, Cheryl A. Keller, Xiao Ou Zhang, Daniel Bates, Shaimae I. Elhajjajy, Ulugbek K. Baymuradov, Cassandra Bazile, Jack Huey, Michael A. Beer, Diane E. Dickel, Samantha Beik, Valentina Snetkova, M. A. Bender, Xintao Wei, Xiaofeng Wang, Ruth Bennett, Louis Philip Benoit Bouvrette, Juan Carlos Rivera-Mulia, Bradley E. Bernstein, Joel Rozowsky, Jing Zhang, Andrew Berry, Surya B. Chhetri, Anand Bhaskar, Jialing Zhang, Alexandra Bignell, Steven M. Blue, Alec Victorsen, David M. Bodine, Kevin P. White, Axel Visel, Carles Boix, Nathan Boley, Gene W. Yeo, Christopher B. Burge, Tyler Borrman, Beatrice Borsari, Eric Lécuyer, David M. Gilbert, Alan P. Boyle, Laurel A. Brandsmeier, Job Dekker, Alessandra Breschi, John Rinn, Eric M. Mendenhall, Emery H. Bresnick, Joseph R. Ecker, Jason A. Brooks, Manolis Kellis, Michael Buckley, Christopher B. Burge, Robert J. Klein, William S. Noble, Hongbo Yang, Anshul Kundaje, Feng Yue, Roderic Guigó, Ross C. Hardison, 2022, Nature on p. E3
Systematic Integration of Epigenomic Landscapes in Human and Mouse Blood Cells to Predict Activity and Targets of Regulatory Elements
Ross C. Hardison, Guanjue Xiang, Camden Jansen, Cheryl A. Keller, Belinda M. Giardine, April Cockburn, Xi He, Michael E. Sauria, Kathryn Weaver, Qunhua Li, Yu Zhang, 2022, FASEB Journal
Most-Cited Papers
A comparative encyclopedia of DNA elements in the mouse genome
Feng Yue, Yong Cheng, Alessandra Breschi, Jeff Vierstra, Weisheng Wu, Tyrone Ryba, Richard Sandstrom, Zhihai Ma, Carrie Davis, Benjamin D. Pope, Yin Shen, Dmitri D. Pervouchine, Sarah Djebali, Robert E. Thurman, Rajinder Kaul, Eric Rynes, Anthony Kirilusha, Georgi K. Marinov, Brian A. Williams, Diane Trout, Henry Amrhein, Katherine Fisher-Aylor, Igor Antoshechkin, Gilberto DeSalvo, Lei Hoon See, Meagan Fastuca, Jorg Drenkow, Chris Zaleski, Alex Dobin, Pablo Prieto, Julien Lagarde, Giovanni Bussotti, Andrea Tanzer, Olgert Denas, Kanwei Li, M. A. Bender, Miaohua Zhang, Rachel Byron, Mark T. Groudine, David McCleary, Long Pham, Zhen Ye, Samantha Kuan, Lee Edsall, Yi Chieh Wu, Matthew D. Rasmussen, Mukul S. Bansal, Manolis Kellis, Cheryl A. Keller, Christapher S. Morrissey, Tejaswini Mishra, Deepti Jain, Nergiz Dogan, Robert S. Harris, Philip Cayting, Trupti Kawli, Alan P. Boyle, Ghia Euskirchen, Anshul Kundaje, Shin Lin, Yiing Lin, Camden Jansen, Venkat S. Malladi, Melissa S. Cline, Drew T. Erickson, Vanessa M. Kirkup, Katrina Learned, Cricket A. Sloan, Kate R. Rosenbloom, Beatriz Lacerda De Sousa, Kathryn Beal, Miguel Pignatelli, Paul Flicek, Jin Lian, Tamer Kahveci, Dongwon Lee, W. James Kent, Miguel Ramalho Santos, Javier Herrero, Cedric Notredame, Audra Johnson, Shinny Vong, Kristen Lee, Daniel Bates, Fidencio Neri, Morgan Diegel, Theresa Canfield, Peter J. Sabo, Matthew S. Wilken, Thomas A. Reh, Erika Giste, Anthony Shafer, Tanya Kutyavin, Eric Haugen, Douglas Dunn, Alex P. Reynolds, Shane Neph, Richard Humbert, R. Scott Hansen, Marella De Bruijn, Licia Selleri, Alexander Rudensky, Steven Josefowicz, Robert Samstein, Evan E. Eichler, Stuart H. Orkin, Dana Levasseur, Thalia Papayannopoulou, Kai Hsin Chang, Arthur Skoultchi, Srikanta Gosh, Christine Disteche, Piper Treuting, Yanli Wang, Mitchell J. Weiss, Gerd A. Blobel, Xiaoyi Cao, Sheng Zhong, Ting Wang, Peter J. Good, Rebecca F. Lowdon, Leslie B. Adams, Xiao Qiao Zhou, Michael J. Pazin, Elise A. Feingold, Barbara Wold, James Taylor, Ali Mortazavi, Sherman M. Weissman, John A. Stamatoyannopoulos, Michael P. Snyder, Roderic Guigo, Thomas R. Gingeras, David M. Gilbert, Ross C. Hardison, Michael A. Beer, Bing Ren, 2014, Nature on p. 355-64
Topologically associating domains are stable units of replication-timing regulation
Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross C. Hardison, Tamer Kahveci, Bing Ren, David M. Gilbert, 2014, Nature on p. 402-405
Expanded encyclopaedias of DNA elements in the human and mouse genomes
Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian, Veena Afzal, Bronwen Aken, Jennifer A. Akiyama, Omar Al Jammal, Henry Amrhein, Stacie M. Anderson, Gregory R. Andrews, Igor Antoshechkin, Kristin G. Ardlie, Joel Armstrong, Matthew Astley, Budhaditya Banerjee, Amira A. Barkal, If H.A. Barnes, Iros Barozzi, Daniel Barrell, Gemma Barson, Daniel Bates, Ulugbek K. Baymuradov, Cassandra Bazile, Michael A. Beer, Samantha Beik, M. A. Bender, Ruth Bennett, Louis Philip Benoit Bouvrette, Bradley E. Bernstein, Andrew Berry, Anand Bhaskar, Alexandra Bignell, Steven M. Blue, David M. Bodine, Carles Boix, Nathan Boley, Tyler Borrman, Beatrice Borsari, Alan P. Boyle, Laurel A. Brandsmeier, Alessandra Breschi, Emery H. Bresnick, Jason A. Brooks, Michael Buckley, Ross C. Hardison, Cheryl A. Keller, Hongbo Yang, Feng Yue, Lijun Zhang, 2020, Nature on p. 699-710
Defining functional DNA elements in the human genome
Manolis Kellis, Barbara Wold, Michael P. Snyder, Bradley E. Bernstein, Anshul Kundaje, Georgi K. Marinov, Lucas D. Ward, Ewan Birney, Gregory E. Crawford, Job Dekker, Ian Dunham, Laura L. Elnitski, Peggy J. Farnham, Elise A. Feingold, Mark Gerstein, Morgan C. Giddings, David M. Gilbert, Thomas R. Gingeras, Eric D. Green, Roderic Guigo, Tim Hubbard, Jim Kent, Jason D. Lieb, Richard M. Myers, Michael J. Pazin, Bing Ren, John A. Stamatoyannopoulos, Zhiping Weng, Kevin P. White, Ross C. Hardison, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 6131-6138
Integrative annotation of chromatin elements from ENCODE data
Michael M. Hoffman, Jason Ernst, Steven P. Wilder, Anshul Kundaje, Robert S. Harris, Max Libbrecht, Belinda Giardine, Paul M. Ellenbogen, Jeffrey A. Bilmes, Ewan Birney, Ross C. Hardison, Ian Dunham, Manolis Kellis, William Stafford Noble, 2013, Nucleic Acids Research on p. 827-841
Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
Belinda Giardine, Joseph Borg, Emmanouil Viennas, Cristiana Pavlidis, Kamran Moradkhani, Philippe Joly, Marina Bartsakoulia, Cathy Riemer, Webb Miller, Giannis Tzimas, Henri Wajcman, Ross C. Hardison, George P. Patrinos, 2014, Nucleic Acids Research on p. D1063-D1069
The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions
Yanli Wang, Fan Song, Bo Zhang, Lijun Zhang, Jie Xu, Da Kuang, Daofeng Li, Mayank N.K. Choudhary, Yun Li, Ming Hu, Ross Hardison, Ting Wang, Feng Yue, 2018, Genome Biology
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
Elizabeth A. Traxler, Yu Yao, Yong Dong Wang, Kaitly J. Woodard, Ryo Kurita, Yukio Nakamura, Jim R. Hughes, Ross C. Hardison, Gerd A. Blobel, Chunliang Li, Mitchell J. Weiss, 2016, Nature Medicine on p. 987-990
Principles of regulatory information conservation between mouse and human
Yong Cheng, Zhihai Ma, Bong Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller, Belinda Giardine, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross C. Hardison, Michael P. Snyder, 2014, Nature on p. 371-375
HiCRep: assessing the reproducibility of Hi-C data using a stratum-adjusted correlation coefficient
Tao Yang, Feipeng Zhang, Galip Gürkan Yardımci, Fan Song, Ross C. Hardison, William Stafford Noble, Feng Yue, Qunhua Li, 2017, Genome Research on p. 1939-1949
News Articles Featuring Ross Hardison
Nov 14, 2022
New statistical method improves genomic analyses
A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions — such as cell types or tissues.
Full Article
Dec 17, 2019
New tool reveals DNA structures that influence disease
Disruption of certain DNA structures — called topologically associating domains, or TADs — is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps elucidate the complex functions of TADs, an international team of researchers is making it easier to study these important structures and help prevent disease.
Full Article
May 06, 2019
Icefish Study Adds Another Color to the Story of Blood
The rainbow of pigments that animals use for blood illustrates a central truth about evolution
Full Article
Apr 22, 2019
Icefish Study Adds Another Color to the Story of Blood
The Antarctic blackfin icefish is the only known vertebrate animal that lacks red blood cells containing hemoglobin. But the use of hemoglobin to transport oxygen through the body is actually a rarity among invertebrates, which rely on a variety of other pigments in their versions of blood.
Full Article
Mar 26, 2019
CBIOS Trainee Hillary Koch Awarded NIH Fellowship
Koch's dissertation proposal, "Statistical Methods for Differential Peak Detection in Hi-C Data," was funded upon its first submission to the National Human Genome Research Institute.
Full Article