Ross Hardison
Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology
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304 Wartik Lab
University Park, PA - rch8@psu.edu
- 814-863-0113
Research Summary
Regulation of gene expression during development.
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Genome Sciences Institute
Links
Publication Tags
Chromatin Genes Globins Acetylation Proteins Fetal Hemoglobin Gene Expression Histones Hemoglobinopathies Mitosis Mutation Gata1 Transcription Factor Thalassemia Transcription Transcription Factors Dna Databases Extrusion Erythroid Cells Gamma Globins Hemoglobin Subunits Beta Globins Human Genome Genome ChromosomesMost Recent Papers
Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells
Ross Hardison, Y Zhang, Cheryl Keller, G Xiang, E Heuston, L An, J Lichtenberg, B Giardine, D Bodine, Shaun Mahony, Q Li, F Yue, M Weiss, G Blobel, J Taylor, J Hughes, D Higgs, B Göttgens, 2020, IUBMB life on p. 27-38
OnTAD
Lin An, Tao Yang, Jiahao Yang, Johannes Nuebler, Guanjue Xiang, Ross C. Hardison, Qunhua Li, Yu Zhang, 2019, Genome biology on p. 1-16
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Haoyue Zhang, Daniel J. Emerson, Thomas G. Gilgenast, Katelyn R. Titus, Yemin Lan, Peng Huang, Di Zhang, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Jennifer E. Phillips-Cremins, Gerd A. Blobel, 2019, Nature on p. 158-162
S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data
Guanjue Xiang, Cheryl Keller, Belinda Giardine, Lin An, Ross Hardison, Yu Zhang, 2019, bioRxiv on p. 506634
An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis
Guanjue Xiang, Cheryl Keller, Elisabeth Heuston, Belinda Giardine, Lin An, Alexander Wixom, Amber Miller, April Cockburn, Jens Lichtenberg, Berthold Gottgens, others, David Bodine, Shaun Mahony, James Taylor, Gerd Blobel, Mitchell Weiss, Yong Cheng, Feng Yue, Jim Hughes, Douglas Higgs, Yu Zhang, Ross Hardison, 2019, bioRxiv
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells
Xianjiang Lan, Eugene Khandros, Peng Huang, Scott A. Peslak, Saurabh K. Bhardwaj, Jeremy D. Grevet, Osheiza Abdulmalik, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Josue Baeza, Emily R. Duffner, Osama El Demerdash, Xiaoli S. Wu, Christopher R. Vakoc, Benjamin A. Garcia, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, 2019, Blood Advances on p. 1586-1597
Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel, 2019, Cell Reports on p. 400-415.e5
Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation
Caroline R. Bartman, Nicole Hamagami, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel, Arjun Raj, 2019, Molecular cell on p. 519-532.e4
Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells
Ross Hardison, Yu Zhang, Cheryl Keller, Guanjue Xiang, Elisabeth Heuston, Lin An, Jens Lichtenberg, Belinda Giardine, David Bodine, Shaun Mahony, Qunhua Li, Feng Yue, Mitchell Weiss, Gerd Blobel, James Taylor, Jim Hughes, Douglas Higgs, Berthold Gottgens, 2019, IUBMB LIFE
Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.
C Bartman, N Hamagami, C Keller, B Giardine, Ross Hardison, G Blobel, A Raj, 2018, Molecular Cell
Most-Cited Papers
An integrated encyclopedia of DNA elements in the human genome
Ian Dunham, Anshul Kundaje, Shelley F. Aldred, Patrick J. Collins, Carrie A. Davis, Francis Doyle, Charles B. Epstein, Seth Frietze, Jennifer Harrow, Rajinder Kaul, Jainab Khatun, Bryan R. Lajoie, Stephen G. Landt, Bum Kyu Lee, Florencia Pauli, Kate R. Rosenbloom, Peter Sabo, Alexias Safi, Amartya Sanyal, Noam Shoresh, Jeremy M. Simon, Lingyun Song, Nathan D. Trinklein, Robert C. Altshuler, Ewan Birney, James B. Brown, Chao Cheng, Sarah Djebali, Xianjun Dong, Jason Ernst, Terrence S. Furey, Mark Gerstein, Belinda Giardine, Melissa Greven, Ross C. Hardison, Robert S. Harris, Javier Herrero, Michael M. Hoffman, Sowmya Iyer, Manolis Kellis, Pouya Kheradpour, Timo Lassmann, Qunhua Li, Xinying Lin, Georgi K. Marinov, Angelika Merkel, Ali Mortazavi, Ross Cameron Hardison, Robert Scott Harris, Qunhua Li, 2012, Nature on p. 57-74
Topologically associating domains are stable units of replication-timing regulation
Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross Cameron Hardison, Tamer Kahveci, Bing Ren, David M. Gilbert, 2014, Nature on p. 402-405
Integrative annotation of chromatin elements from ENCODE data
Michael M. Hoffman, Jason Ernst, Steven P. Wilder, Anshul Kundaje, Robert Scott Harris, Max Libbrecht, Belinda Giardine, Paul M. Ellenbogen, Jeffrey A. Bilmes, Ewan Birney, Ross Cameron Hardison, Ian Dunham, Manolis Kellis, William Stafford Noble, 2013, Nucleic acids research on p. 827-841
Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
Belinda Giardine, Joseph Borg, Emmanouil Viennas, Cristiana Pavlidis, Kamran Moradkhani, Philippe Joly, Marina Bartsakoulia, Cathy Riemer, Webb Miller, Giannis Tzimas, Henri Wajcman, Ross C. Hardison, George P. Patrinos, 2014, Nucleic acids research on p. D1063-D1069
Principles of regulatory information conservation between mouse and human
Yong Cheng, Zhihai Ma, Bong Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller Capone, Belinda Giardine, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross Cameron Hardison, Michael P. Snyder, 2014, Nature on p. 371-375
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1
Stephan Kadauke, Maheshi I. Udugama, Jan M. Pawlicki, Jordan C. Achtman, Deepti P. Jain, Yong Cheng, Ross Cameron Hardison, Gerd A. Blobel, 2012, Cell on p. 725-737
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes
Janine M. Lamonica, Wulan Deng, Stephan Kadauke, Amy E. Campbell, Roland Gamsjaeger, Hongxin Wang, Yong Cheng, Andrew N. Billin, Ross Cameron Hardison, Joel P. Mackay, Gerd A. Blobel, 2011, Proceedings of the National Academy of Sciences of the United States of America
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
Elizabeth A. Traxler, Yu Yao, Yong Dong Wang, Kaitly J. Woodard, Ryo Kurita, Yukio Nakamura, Jim R. Hughes, Ross Cameron Hardison, Gerd A. Blobel, Chunliang Li, Mitchell J. Weiss, 2016, Nature Medicine on p. 987-990
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
Belinda Giardine, Joseph Borg, Douglas R. Higgs, Kenneth R. Peterson, Sjaak Philipsen, Donna Maglott, Belinda K. Singleton, David J. Anstee, A. Nazli Basak, Barnaby Clark, Flavia C. Costa, Paula Faustino, Halyna Fedosyuk, Alex E. Felice, Alain Francina, Renzo Galanello, Monica V.E. Gallivan, Marianthi Georgitsi, Richard J. Gibbons, Piero C. Giordano, Cornelis L. Harteveld, James D. Hoyer, Martin Jarvis, Philippe Joly, Emmanuel Kanavakis, Panagoula Kollia, Stephan Menzel, Webb Miller, Kamran Moradkhani, John Old, Adamantia Papachatzopoulou, Manoussos N. Papadakis, Petros Papadopoulos, Sonja Pavlovic, Lucia Perseu, Milena Radmilovic, Cathy Riemer, Stefania Satta, Iris Schrijver, Maja Stojiljkovic, Swee Lay Thein, Jan Traeger-Synodinos, Ray Tully, Takahito Wada, John S. Waye, Claudia Wiemann, Branka Zukic, David H.K. Chui, Henri Wajcman, Ross Cameron Hardison, George P. Patrinos, 2011, Nature Genetics on p. 295-302
Unlinking an lncRNA from Its Associated cis Element
Vikram R. Paralkar, Cristian C. Taborda, Peng Huang, Yu Yao, Andrew V. Kossenkov, Rishi Prasad, Jing Luan, James O.J. Davies, Jim R. Hughes, Ross Cameron Hardison, Gerd A. Blobel, Mitchell J. Weiss, 2016, Molecular Cell on p. 104-110
News Articles Featuring Ross Hardison
Dec 17, 2019
New tool reveals DNA structures that influence disease
Disruption of certain DNA structures — called topologically associating domains, or TADs — is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps elucidate the complex functions of TADs, an international team of researchers is making it easier to study these important structures and help prevent disease.
Full Article
May 06, 2019
Icefish Study Adds Another Color to the Story of Blood
The rainbow of pigments that animals use for blood illustrates a central truth about evolution
Full Article
Apr 22, 2019
Icefish Study Adds Another Color to the Story of Blood
The Antarctic blackfin icefish is the only known vertebrate animal that lacks red blood cells containing hemoglobin. But the use of hemoglobin to transport oxygen through the body is actually a rarity among invertebrates, which rely on a variety of other pigments in their versions of blood.
Full Article
Mar 26, 2019
CBIOS Trainee Hillary Koch Awarded NIH Fellowship
Koch's dissertation proposal, "Statistical Methods for Differential Peak Detection in Hi-C Data," was funded upon its first submission to the National Human Genome Research Institute.
Full Article