Rosalyn Irby

Associate Professor of Cancer Research

Rosalyn Irby

Huck Affiliations

Publication Tags

Colonic Neoplasms Fluorouracil Prostate Apoptosis Response 4 Protein Neoplasms Cells Apoptosis Cell Line Cetuximab Tubulin Modulators Apoptosis Regulatory Proteins Isatin Colorectal Neoplasms Lymphocytes Colon Proteins Therapeutics Large Granular Lymphocytic Leukemia Phosphorylation Micrornas Pharmaceutical Preparations Vinblastine Genes Gene Regulatory Networks Growth Nude Mice

Most Recent Papers

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PloS one

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria

Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jiangang (Jason) Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran, 2012, Leukemia Research on p. 581-587

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Christina Leah B. Kline, Rosalyn B. Irby, 2011, Apoptosis on p. 1285-1294

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014

The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model

Arun K. Sharma, Christina L. Kline, Arthur Berg, Shantu Amin, Rosalyn B. Irby, 2011, Clinical Cancer Research on p. 4474-4483

Tyrosine kinase update

Rosalyn B. Irby, Yixing Jiang, 2011, Current Cancer Therapy Reviews on p. 155-166

Voltage-gated Na<sup>+</sup> channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

Carrie D. House, Charles J. Vaske, Arnold M. Schwartz, Vincent Obias, Bryan Frank, Truong Luu, Narine Sarvazyan, Rosalyn Irby, Robert L. Strausberg, Tim G. Hales, Joshua M. Stuart, Norman H. Lee, 2010, Cancer Research on p. 6957-6967

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Bi Dar Wang, Christina L.B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby, Norman H. Lee, 2010, Molecular Cancer

Primary cell lines

Danielle M. Pastor, Lisa Poritz, Thomas L. Olson, Christina L. Kline, Leonard R. Harris, Walter Koltun, Vernon Chinchilli, Rosalyn Irby, 2010, International Journal of Clinical and Experimental Medicine on p. 69-83

Most-Cited Papers

Voltage-gated Na<sup>+</sup> channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

Carrie D. House, Charles J. Vaske, Arnold M. Schwartz, Vincent Obias, Bryan Frank, Truong Luu, Narine Sarvazyan, Rosalyn Irby, Robert L. Strausberg, Tim G. Hales, Joshua M. Stuart, Norman H. Lee, 2010, Cancer Research on p. 6957-6967

Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway

Jun Yang, Xin Liu, Susan B. Nyland, Ranran Zhang, Lindsay K. Ryland, Kathleen Broeg, Kendall Thomas Baab, Nancy Ruth Jarbadan, Rosalyn Irby, Thomas P. Loughran, 2010, Blood on p. 51-60

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Bi Dar Wang, Christina L.B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby, Norman H. Lee, 2010, Molecular Cancer

The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model

Arun K. Sharma, Christina L. Kline, Arthur Berg, Shantu Amin, Rosalyn B. Irby, 2011, Clinical Cancer Research on p. 4474-4483

Tumor necrosis factor α induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines

Danielle M. Pastor, Rosalyn Irby, Lisa Poritz, 2010, Diseases of the colon and rectum on p. 257-263

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria

Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jiangang (Jason) Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran, 2012, Leukemia Research on p. 581-587

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PloS one

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Christina Leah B. Kline, Rosalyn B. Irby, 2011, Apoptosis on p. 1285-1294