Rosalyn Irby
Associate Professor of Cancer Research

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H072 Cancer Center
Hershey, PA - rbi2@psu.edu
- 717-531-1050
Huck Affiliations
Publication Tags
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Neoplasms Fluorouracil Colonic Neoplasms Prostate Apoptosis Response 4 Protein Apoptosis Therapeutics Cells Proteins Cetuximab Protein Phosphorylation Protein Tyrosine Kinases Tumor Suppressor Protein Colorectal Neoplasms Apoptosis Regulatory Proteins Isatin Pancreatic Neoplasms Resistance Tubulin Modulators Protein Kinase B Inhibitor Antineoplastic Agent Cell Line Neoplasm Cells Genes ColonMost Recent Publications
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25
Intra-cellular tyrosine kinase
Rosalyn Irby, Timothy J. Yeatman, 2015, on p. 231-242
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PLoS One
Par-4 as a potential target for cancer therapy
Rosalyn B. Irby, Christina Lb Kline, 2013, Expert Opinion on Therapeutic Targets on p. 77-87
Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study
Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn B. Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jason Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran, 2012, Leukemia Research on p. 581-587
The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU
Christina Leah B. Kline, Rosalyn B. Irby, 2011, Apoptosis : an international journal on programmed cell death on p. 1285-1294
Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway
Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014
The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
Arun K. Sharma, Christina L. Kline, Arthur Berg, Shantu Amin, Rosalyn B. Irby, 2011, Clinical Cancer Research on p. 4474-4483
Tyrosine kinase update: Role and response in cancer therapy
Rosalyn B. Irby, Yixing Jiang, 2011, Current Cancer Therapy Reviews on p. 155-166
Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network
Bi-Dar Wang, Christina Kline, Danielle Pastor, Thomas Olson, Bryan Frank, Truong Luu, Arun Sharma, G Robertson, Matthew Weirauch, Steven Patierno, Joshua Stuart, R Irby, Norman Lee, 2010, Molecular Cancer
Most-Cited Papers
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PLoS One
Par-4 as a potential target for cancer therapy
Rosalyn B. Irby, Christina Lb Kline, 2013, Expert Opinion on Therapeutic Targets on p. 77-87
Intra-cellular tyrosine kinase
Rosalyn Irby, Timothy J. Yeatman, 2015, on p. 231-242