Rosalyn Irby
Associate Professor of Cancer Research
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H072 Cancer Center
Hershey, PA - rbi2@psu.edu
- 717-531-1050
Huck Affiliations
Publication Tags
Neoplasms Colonic Neoplasms Fluorouracil Apoptosis Prostate Apoptosis Response 4 Protein Therapeutics Cells Proteins Cetuximab Protein Phosphorylation Protein Tyrosine Kinases Colorectal Neoplasms Large Granular Lymphocytic Leukemia Apoptosis Regulatory Proteins Isatin Resistance Aplastic Anemia Pancreatic Neoplasms Epitopes Lymphocytes Tubulin Modulators Aplastic Anaemia Protein Kinase B Inhibitor Paroxysmal HemoglobinuriaMost Recent Papers
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25
Intra-cellular tyrosine kinase
Rosalyn Irby, Timothy J. Yeatman, 2015, on p. 231-242
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PLoS One
Par-4 as a potential target for cancer therapy
Rosalyn B. Irby, Christina Lb Kline, 2013, Expert Opinion on Therapeutic Targets on p. 77-87
Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria
Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn B. Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jason Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran, 2012, Leukemia Research on p. 581-587
The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU
Christina Leah B. Kline, Rosalyn B. Irby, 2011, Apoptosis : an international journal on programmed cell death on p. 1285-1294
Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway
Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014
The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
Arun K. Sharma, Christina L. Kline, Arthur Berg, Shantu Amin, Rosalyn B. Irby, 2011, Clinical Cancer Research on p. 4474-4483
Tyrosine kinase update
Rosalyn B. Irby, Yixing Jiang, 2011, Current Cancer Therapy Reviews on p. 155-166
Voltage-gated Na<sup>+</sup> channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion
Carrie D. House, Charles J. Vaske, Arnold M. Schwartz, Vincent Obias, Bryan Frank, Truong Luu, Narine Sarvazyan, Rosalyn Irby, Robert L. Strausberg, Tim G. Hales, Joshua M. Stuart, Norman H. Lee, 2010, Cancer Research on p. 6957-6967
Most-Cited Papers
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
Jeffrey Q. Nguyen, Rosalyn B. Irby, 2017, Cancer Biology and Therapy on p. 16-25
The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
Joshua E. Allen, Jean Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry, 2013, PLoS One
Par-4 as a potential target for cancer therapy
Rosalyn B. Irby, Christina Lb Kline, 2013, Expert Opinion on Therapeutic Targets on p. 77-87
Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria
Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn B. Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jason Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran, 2012, Leukemia Research on p. 581-587
Intra-cellular tyrosine kinase
Rosalyn Irby, Timothy J. Yeatman, 2015, on p. 231-242