Reyad Elbarbary

Co-Director of the Center for RNA Molecular Biology; Assistant Professor of Orthopaedics

Reyad  Elbarbary

Research Summary

Roles of non-coding RNAs and retrotransposons in musculoskeletal diseases.

Huck Institutes Affiliations

Publication Tags

Rna Messenger Rna Micrornas Guide Rna Gene Expression Alu Elements Gene Silencing 3' Untranslated Regions Therapeutics Apoptosis Technology Hl 60 Cells Leukemia Genes Direction Compound Hematologic Neoplasms Transfer Rna Cytoplasm Down Regulation Cell Nucleus Active Transport In Vitro Techniques Rna Precursors Protein Kinases Vascular Endothelial Growth Factor A Phase Transition

Most Recent Papers

Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro

Reyad A. Elbarbary, Lynne E. Maquat, 2018, Methods

Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism

Reyad A. Elbarbary, Lynne E. Maquat, 2017, Nature Structural and Molecular Biology on p. 496-498

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat, 2017, Science on p. 859-862

Extraction of high-quality RNA from human articular cartilage

Heather K. Le Bleu, Fadia A. Kamal, Meghan Kelly, John P. Ketz, Michael J. Zuscik, Reyad A. Elbarbary, 2017, Analytical Biochemistry on p. 134-138

UPF1 helicase promotes TSN-mediated miRNA decay

Reyad A. Elbarbary, Keita Miyoshi, Omar Hedaya, Jason R. Myers, Lynne E. Maquat, 2017, Genes and Development on p. 1483-1493

Coupling pre-mRNA splicing and 3′ end formation to mRNA export

Reyad A. Elbarbary, Lynne E. Maquat, 2016, Genes and Development on p. 487-488

CARMing down the SINEs of anarchy

Reyad A. Elbarbary, Lynne E. Maquat, 2015, Genes and Development on p. 687-689

Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

Masayuki Takahashi, Reyad A. Elbarbary, Norihiro Watanabe, Atsushi Goto, Daichi Kamiya, Yoshihiro Watabe, Takayoshi Uchiyama, Miwako Narita, Masuhiro Takahashi, Yoshiaki Takahashi, Noriko Ishihara, Tatsuya Miyazawa, Tetsuo Yoshida, Mitsuoki Kawano, Masato Tamura, Masayuki Nashimoto, 2014, Leukemia Research on p. 808-815

STAU1 binding 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown

Reyad A. Elbarbary, Wencheng Li, Bin Tian, Lynne E. Maquat, 2013, Genes and Development on p. 1495-1510

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

Masayuki Takahashi, Reyad A. Elbarbary, Aiko Nakashima, Mayumi Abe, Norihiro Watanabe, Miwako Narita, Masuhiro Takahashi, Masato Tamura, Tetsuo Yoshida, Masayuki Nashimoto, 2013, Cancer Letters on p. 362-368

High-Impact Papers

Modulation of gene expression by human cytosolic tRNase Z<sup>L</sup> through 5′-half-tRNA

Reyad A. Elbarbary, Hiroaki Takaku, Naoto Uchiumi, Hiroko Tamiya, Mayumi Abe, Masayuki Takahashi, Hiroshi Nishida, Masayuki Nashimoto, 2009, PLoS One

STAU1 binding 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown

Reyad A. Elbarbary, Wencheng Li, Bin Tian, Lynne E. Maquat, 2013, Genes and Development on p. 1495-1510

Human cytosolic tRNase Z<sup>L</sup> can downregulate gene expression through miRNA

Reyad A. Elbarbary, Hiroaki Takaku, Naoto Uchiumi, Hiroko Tamiya, Mayumi Abe, Hiroshi Nishida, Masayuki Nashimoto, 2009, FEBS Letters on p. 3241-3246

A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy

Fadia Ali Kamal, Kenichi Watanabe, Meilei Ma, Yuichi Abe, Reyad Elbarbary, Makoto Kodama, Yoshifusa Aizawa, 2011, Heart and Vessels on p. 81-90

Inhibition of vascular endothelial growth factor expression by TRUE gene silencing

Reyad A. Elbarbary, Hiroaki Takaku, Masato Tamura, Masayuki Nashimoto, 2009, Biochemical and Biophysical Research Communications on p. 924-927

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

Masayuki Takahashi, Reyad A. Elbarbary, Aiko Nakashima, Mayumi Abe, Norihiro Watanabe, Miwako Narita, Masuhiro Takahashi, Masato Tamura, Tetsuo Yoshida, Masayuki Nashimoto, 2013, Cancer Letters on p. 362-368

Elimination of specific miRNAs by naked 14-nt sgRNAs

Masayuki Takahashi, Reyad A. Elbarbary, Mayumi Abe, Mari Sato, Tetsuo Yoshida, Yoji Yamada, Masato Tamura, Masayuki Nashimoto, 2012, PLoS One

Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

Masayuki Takahashi, Reyad A. Elbarbary, Norihiro Watanabe, Atsushi Goto, Daichi Kamiya, Yoshihiro Watabe, Takayoshi Uchiyama, Miwako Narita, Masuhiro Takahashi, Yoshiaki Takahashi, Noriko Ishihara, Tatsuya Miyazawa, Tetsuo Yoshida, Mitsuoki Kawano, Masato Tamura, Masayuki Nashimoto, 2014, Leukemia Research on p. 808-815

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat, 2017, Science on p. 859-862

CARMing down the SINEs of anarchy

Reyad A. Elbarbary, Lynne E. Maquat, 2015, Genes and Development on p. 687-689