Reyad Elbarbary
Assistant Professor of Orthopaedics
-
H089 Orthopedics & Rehabilitation
Hershey, PA - rae19@psu.edu
- 717-531-4836
Research Summary
Roles of non-coding RNAs and retrotransposons in musculoskeletal diseases.
Huck Affiliations
Publication Tags
Rna Cartilage Osteoarthritis Micrornas Therapeutics Proteins G Protein Coupled Receptor Kinase 2 Alu Elements Messenger Rna Chondrocytes Paroxetine Fibrillar Collagens Obesity Advanced Glycation End Products Poisons Diet Fracture Healing Gene Expression Apoptosis Guide Rna Collagen In Vitro Techniques Bone And Bones Hl 60 Cells LeukemiaMost Recent Publications
Assessment of bone fracture healing using Micro-computed Tomography
Reyad Elbarbary, Fadia Kamal, H Wee, D Khajuria, F Kamal, G Lewis, G Lewis, R Elbarbary, Journal of Visualized Experiments (JoVE)
Transcript shortening through alternative polyadenylation promotes gene expression during fracture healing
Reyad Elbarbary, Fadia Kamal, D Khajuria, I Nowak, M Leung, V Karuppagounder, Y Imamura, C Norbury, F Kamal, R Elbarbary, Bone Research
Early Gβγ-GRK2 Inhibition Ameliorates Osteoarthritis Development by Simultaneous Anti-Inflammatory and Chondroprotective Effects
V Karuppagounder, W Pinamont, N Yoshioka, Reyad Elbarbary, Fadia Kamal, 2022, International Journal of Molecular Sciences
Structural changes in the collagen network of joint tissues in late stages of murine OA
N Yoshioka, G Young, D Khajuria, V Karuppagounder, W Pinamont, Julie C. Fanburg-Smith, T Abraham, Reyad A. Elbarbary, Fadia Kamal, 2022, Scientific Reports on p. 9159
GRK2, a novel regulator of skeletal development
Natalie K. Yoshioka, Vengadeshprabhu Karuppagounder, William J. Pinamont, Gina M. Deiter, Reyad A. Elbarbary, Maurizio Pacifici, Fadia Kamal, 2022, FASEB Journal
Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis
Elijah L. Carlson, Vengadeshprabhu Karuppagounder, William J. Pinamont, Natalie K. Yoshioka, Adeel Ahmad, Eric M. Schott, Heather K. Le Bleu, Michael J. Zuscik, Reyad A. Elbarbary, Fadia Kamal, 2021, Science Translational Medicine
Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model
Deepak Khajuria, Marwa Soliman, John Elfar, Gregory Lewis, Thomas Abraham, Fadia Kamal, Reyad A. Elbarbary, 2020, Bone on p. 115436
Standardized histomorphometric evaluation of osteoarthritis in a surgical mouse model
William J. Pinamont, Natalie K. Yoshioka, Gregory M. Young, Vengadeshprabhu Karuppagounder, Elijah L. Carlson, Adeel Ahmad, Reyad Elbarbary, Fadia Kamal, 2020, Journal of Visualized Experiments
Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro
Reyad A. Elbarbary, Lynne E. Maquat, 2019, ImmunoMethods on p. 18-22
Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism
Reyad A. Elbarbary, Lynne E. Maquat, 2017, Nature Structural Biology on p. 496-498
Most-Cited Papers
Retrotransposons as regulators of gene expression
Reyad A. Elbarbary, Bronwyn A. Lucas, Lynne E. Maquat, 2016, Science
STAU1 binding 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown
Reyad A. Elbarbary, Wencheng Li, Bin Tian, Lynne E. Maquat, 2013, Genes and Development on p. 1495-1510
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition
Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat, 2017, Science on p. 859-862
Extraction of high-quality RNA from human articular cartilage
Heather K. Le Bleu, Fadia A. Kamal, Meghan Kelly, John P. Ketz, Michael J. Zuscik, Reyad A. Elbarbary, 2017, Analytical Biochemistry on p. 134-138
UPF1 helicase promotes TSN-mediated miRNA decay
Reyad A. Elbarbary, Keita Miyoshi, Omar Hedaya, Jason R. Myers, Lynne E. Maquat, 2017, Genes and Development on p. 1483-1493
A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells
Masayuki Takahashi, Reyad A. Elbarbary, Aiko Nakashima, Mayumi Abe, Norihiro Watanabe, Miwako Narita, Masuhiro Takahashi, Masato Tamura, Tetsuo Yoshida, Masayuki Nashimoto, 2013, Cancer Letters on p. 362-368
Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis
Elijah L. Carlson, Vengadeshprabhu Karuppagounder, William J. Pinamont, Natalie K. Yoshioka, Adeel Ahmad, Eric M. Schott, Heather K. Le Bleu, Michael J. Zuscik, Reyad A. Elbarbary, Fadia Kamal, 2021, Science Translational Medicine
Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model
Deepak Khajuria, Marwa Soliman, John Elfar, Gregory Lewis, Thomas Abraham, Fadia Kamal, Reyad A. Elbarbary, 2020, Bone on p. 115436
Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies
Masayuki Takahashi, Reyad A. Elbarbary, Norihiro Watanabe, Atsushi Goto, Daichi Kamiya, Yoshihiro Watabe, Takayoshi Uchiyama, Miwako Narita, Masuhiro Takahashi, Yoshiaki Takahashi, Noriko Ishihara, Tatsuya Miyazawa, Tetsuo Yoshida, Mitsuoki Kawano, Masato Tamura, Masayuki Nashimoto, 2014, Leukemia Research on p. 808-815
Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism
Reyad A. Elbarbary, Lynne E. Maquat, 2017, Nature Structural Biology on p. 496-498