Reyad Elbarbary

Assistant Professor of Orthopaedics

Reyad Elbarbary

Research Summary

Roles of non-coding RNAs and retrotransposons in musculoskeletal diseases.

Huck Affiliations

Publication Tags

Rna Micrornas Cartilage Osteoarthritis Therapeutics Guide Rna Proteins G Protein Coupled Receptor Kinase 2 Chondrocytes Paroxetine Messenger Rna Gene Expression Articular Cartilage Fibrillar Collagens Alu Elements Obesity Phase Transition Advanced Glycation End Products S Phase Diet G1 Phase Fracture Healing Rna Sequencing In Vitro Techniques Bone And Bones

Most Recent Publications

Early Gβγ-GRK2 Inhibition ameliorates osteoarthritis development by simultaneous anti-inflammatory and chondroprotective effects

V Karuppagounder, W Pinamont, N Yoshioka, Reyad Elbarbary, Fadia Kamal, 2022, International Journal of Molecular Sciences

Structural changes in the collagen network of joint tissues in late stages of murine OA

N Yoshioka, G Young, D Khajuria, V Karuppagounder, W Pinamont, Julie C. Fanburg-Smith, T Abraham, Reyad A. Elbarbary, Fadia Kamal, 2022, Scientific Reports on p. 9159

GRK2, a novel regulator of skeletal development

Natalie K. Yoshioka, Vengadeshprabhu Karuppagounder, William J. Pinamont, Gina M. Deiter, Reyad A. Elbarbary, Maurizio Pacifici, Fadia Kamal, 2022, FASEB Journal

Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis

Elijah L. Carlson, Vengadeshprabhu Karuppagounder, William J. Pinamont, Natalie K. Yoshioka, Adeel Ahmad, Eric M. Schott, Heather K. Le Bleu, Michael J. Zuscik, Reyad A. Elbarbary, Fadia Kamal, 2021, Science Translational Medicine

Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model.

Deepak Khajuria, Marwa Soliman, John Elfar, Gregory Lewis, Thomas Abraham, Fadia Kamal, Reyad A. Elbarbary, 2020, Bone on p. 115436

Standardized histomorphometric evaluation of osteoarthritis in a surgical mouse model

William J. Pinamont, Natalie K. Yoshioka, Gregory M. Young, Vengadeshprabhu Karuppagounder, Elijah L. Carlson, Adeel Ahmad, Reyad Elbarbary, Fadia Kamal, 2020, Journal of Visualized Experiments

Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro

Reyad A. Elbarbary, Lynne E. Maquat, 2019, ImmunoMethods on p. 18-22

Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism

Reyad A. Elbarbary, Lynne E. Maquat, 2017, Nature Structural Biology on p. 496-498

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat, 2017, Science on p. 859-862

Extraction of high-quality RNA from human articular cartilage

Heather K. Le Bleu, Fadia A. Kamal, Meghan Kelly, John P. Ketz, Michael J. Zuscik, Reyad A. Elbarbary, 2017, Analytical Biochemistry on p. 134-138

Most-Cited Papers

Retrotransposons as regulators of gene expression

Reyad A. Elbarbary, Bronwyn A. Lucas, Lynne E. Maquat, 2016, Science

STAU1 binding 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown

Reyad A. Elbarbary, Wencheng Li, Bin Tian, Lynne E. Maquat, 2013, Genes and Development on p. 1495-1510

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

Reyad A. Elbarbary, Keita Miyoshi, Jason R. Myers, Peicheng Du, John M. Ashton, Bin Tian, Lynne E. Maquat, 2017, Science on p. 859-862

Extraction of high-quality RNA from human articular cartilage

Heather K. Le Bleu, Fadia A. Kamal, Meghan Kelly, John P. Ketz, Michael J. Zuscik, Reyad A. Elbarbary, 2017, Analytical Biochemistry on p. 134-138

UPF1 helicase promotes TSN-mediated miRNA decay

Reyad A. Elbarbary, Keita Miyoshi, Omar Hedaya, Jason R. Myers, Lynne E. Maquat, 2017, Genes and Development on p. 1483-1493

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

Masayuki Takahashi, Reyad A. Elbarbary, Aiko Nakashima, Mayumi Abe, Norihiro Watanabe, Miwako Narita, Masuhiro Takahashi, Masato Tamura, Tetsuo Yoshida, Masayuki Nashimoto, 2013, Cancer Letters on p. 362-368

Elimination of specific miRNAs by naked 14-nt sgRNAs

Masayuki Takahashi, Reyad A. Elbarbary, Mayumi Abe, Mari Sato, Tetsuo Yoshida, Yoji Yamada, Masato Tamura, Masayuki Nashimoto, 2012, PLoS One

Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

Masayuki Takahashi, Reyad A. Elbarbary, Norihiro Watanabe, Atsushi Goto, Daichi Kamiya, Yoshihiro Watabe, Takayoshi Uchiyama, Miwako Narita, Masuhiro Takahashi, Yoshiaki Takahashi, Noriko Ishihara, Tatsuya Miyazawa, Tetsuo Yoshida, Mitsuoki Kawano, Masato Tamura, Masayuki Nashimoto, 2014, Leukemia Research on p. 808-815

Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model.

Deepak Khajuria, Marwa Soliman, John Elfar, Gregory Lewis, Thomas Abraham, Fadia Kamal, Reyad A. Elbarbary, 2020, Bone on p. 115436

Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis

Elijah L. Carlson, Vengadeshprabhu Karuppagounder, William J. Pinamont, Natalie K. Yoshioka, Adeel Ahmad, Eric M. Schott, Heather K. Le Bleu, Michael J. Zuscik, Reyad A. Elbarbary, Fadia Kamal, 2021, Science Translational Medicine