Ramesh Ramachandran
Professor of Molecular Endocrinology
-
Wm Henning Bldg
University Park, - rur11@psu.edu
- 814-865-5202
Research Summary
The influence of hypothalamic neurotransmitters, hormones, and their receptors on avian reproduction.
Huck Affiliations
Most Recent Publications
Metformin alters liver metabolism to sustain egg production in the reproductively aging broiler breeder hen.
E Weaver, N Connolly, T Kim, Ramesh Ramachandran, 2025, Biology of reproduction
Metformin improves ovarian function and increases egg production in broiler breeder hens
Evelyn A. Weaver, Ramesh Ramachandran, 2023, Reproduction on p. 289-300
Feeding laying hens docosa hexaenoic acid-rich microalgae oil at 40 g/kg diet causes hypotriglyceridemia, depresses egg production, and attenuates expression of key genes affecting hepatic triglyceride synthesis and secretion, but is rescued by dietary co-supplementation of high-oleic sunflower oil
R Elkin, Ahmed S.A. El-Zenary, El-Zenary ASA, R Bomberger, A Haile, E Weaver, Ramesh Ramachandran, Kevin J. Harvatine, 2023, Poultry Science on p. 102318
Metformin modulates the gut microbiome in broiler breeder hens
E Van Syoc, E Weaver, Connie Jo Rogers, J , Justin Silverman, Ramesh Ramachandran, Erika Ganda, 2022, Frontiers in Physiology on p. 1000144
Ad libitum feeding alters mRNA abundance in the ovarian cortex of broiler breeder hens
Kate Anthony, Tyler Garner, Ramesh Ramachandran, Francisco Javier Diaz, F Diaz, 2022, Reproduction and Fertility on p. 110-121
Evaluation of the central effects of systemic lentiviral-mediated leptin delivery in streptozotocin-induced diabetic rats
Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. Mohankumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. Mohankumar, Sheba M.J. Mohankumar, 2021, International Journal of Molecular Sciences
Metformin affects the transcriptomic profile of chicken ovarian cancer cells
Lalitha Gopalan, Aswathy Sebastian, C Praul, Istvan Albert, Ramesh Ramachandran, 2021, Genes on p. 30
Metformin attenuates steroidogenesis in ovarian follicles of the broiler breeder hen
Evelyn A. Weaver, Ramesh Ramachandran, 2020, Reproduction on p. 659-672
Adiponectin and its receptor genes' expression in response to Marek's disease virus infection of White Leghorns
Ying Bai, Ping Yuan, Huanmin Zhang, Ramesh Ramachandran, Ning Yang, Jiuzhou Song, 2020, Poultry Science on p. 4249-4258
Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens
Charlene Hanlon, Ramesh Ramachandran, Martin J. Zuidhof, Grégoy Y. Bédécarrats, 2020, Frontiers in Physiology
Most-Cited Papers
Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens
Charlene Hanlon, Ramesh Ramachandran, Martin J. Zuidhof, Grégoy Y. Bédécarrats, 2020, Frontiers in Physiology
Expression of adiponectin and its receptors is altered in epithelial ovarian tumors and ascites-derived ovarian cancer cell lines
Anupama Tiwari, Olga M. Ocon-Grove, Jill A. Hadley, James R. Giles, Patricia A. Johnson, Ramesh Ramachandran, 2015, International Journal of Gynecological Cancer on p. 399-406
Adiponectin is secreted by theca layer cells isolated from chicken ovarian follicles
Jill A. Hadley, Olga Ocón-Grove, Ramesh Ramachandran, 2020, Reproduction on p. 275-288
Metformin attenuates steroidogenesis in ovarian follicles of the broiler breeder hen
Evelyn A. Weaver, Ramesh Ramachandran, 2020, Reproduction on p. 659-672
Feeding laying hens docosa hexaenoic acid-rich microalgae oil at 40 g/kg diet causes hypotriglyceridemia, depresses egg production, and attenuates expression of key genes affecting hepatic triglyceride synthesis and secretion, but is rescued by dietary co-supplementation of high-oleic sunflower oil
R Elkin, Ahmed S.A. El-Zenary, El-Zenary ASA, R Bomberger, A Haile, E Weaver, Ramesh Ramachandran, Kevin J. Harvatine, 2023, Poultry Science on p. 102318
Metformin affects the transcriptomic profile of chicken ovarian cancer cells
Lalitha Gopalan, Aswathy Sebastian, C Praul, Istvan Albert, Ramesh Ramachandran, 2021, Genes on p. 30
Metformin modulates the gut microbiome in broiler breeder hens
E Van Syoc, E Weaver, Connie Jo Rogers, J , Justin Silverman, Ramesh Ramachandran, Erika Ganda, 2022, Frontiers in Physiology on p. 1000144
Chicken: Female Reproduction
Ramesh Ramachandran, 2018, on p. 586-594
Metformin improves ovarian function and increases egg production in broiler breeder hens
Evelyn A. Weaver, Ramesh Ramachandran, 2023, Reproduction on p. 289-300
Evaluation of the central effects of systemic lentiviral-mediated leptin delivery in streptozotocin-induced diabetic rats
Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. Mohankumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. Mohankumar, Sheba M.J. Mohankumar, 2021, International Journal of Molecular Sciences
News Articles Featuring Ramesh Ramachandran
May 21, 2025
Common drug humans take is found to boost fertility in both women and chickens
Researchers at Penn State have made an unexpected discovery. Metformin, often prescribed for type 2 diabetes and PCOS in humans, can boost egg-laying in aging chickens.
Full Article
May 07, 2025
Common diabetes drug helps chickens lay more eggs
Metformin, a drug commonly prescribed to humans, could be a game-changer for farms and food production, researchers said.
Full Article
Dec 07, 2023
USDA grant supports reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, US$238,500 grant to establish a graduate training pipeline in reproductive microbiome research
Full Article
Dec 06, 2023
New USDA grant to support graduate reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, $238,500 grant to establish a graduate training pipeline in reproductive microbiome research.
Full Article
Nov 29, 2022
Too much of a good thing: Over-supplementation of chickens' diet backfires
When it comes to supplementing the diet of laying hens with omega-3 fatty acids to enrich their eggs — making them more heart healthy for consumers.
Full Article