Qunhua Li

Associate Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics; Associate Professor of Statistics

Qunhua Li

Research Summary

Developing statistical and computational methods for analyzing complex omics data and improving quality and reproducibility of high-throughout data

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Genes Chromatin Genome Dna Vitamin A Colon Gene Expression Small Intestine Epigenomics Reproducibility Chromatin Immunoprecipitation Transcription Factors Citrobacter Rodentium Histone Chromatin Immunoprecipitation Sequencing Interleukin 6 Galaxies Gata Transcription Factors Modification Paint Vitamin A Deficiency Proteins Encyclopedias Datasets Experiment

Most Recent Papers

Assessing reproducibility of high-throughput experiments in the case of missing data

Roopali Singh, Feipeng Zhang, Qunhua Li, 2022, Statistics in Medicine on p. 1884-1899

Systematic Integration of Epigenomic Landscapes in Human and Mouse Blood Cells to Predict Activity and Targets of Regulatory Elements

Ross C. Hardison, Guanjue Xiang, Camden Jansen, Cheryl A. Keller, Belinda M. Giardine, April Cockburn, Xi He, Michael E. Sauria, Kathryn Weaver, Qunhua Li, Yu Zhang, 2022, FASEB Journal

Transcriptional Profiling of the Small Intestine and the Colon Reveals Modulation of Gut Infection with Citrobacter rodentium According to the Vitamin A Status

Zhi Chai, Yafei Lyu, Qiuyan Chen, Cheng Hsin Wei, Lindsay M. Snyder, Veronika Weaver, Aswathy Sebastian, István Albert, Qunhua Li, Margherita T. Cantorna, Catharine Ross, 2022, Nutrients

Methods to Assess the Reproducibility and Similarity of Hi-C Data

Tao Yang, Xi He, Lin An, Qunhua Li, 2022, on p. 17-37

RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes

Zhi Chai, Yafei Lyu, Qiuyan Chen, Cheng Hsin Wei, Lindsay M. Snyder, Veronika Weaver, Aswathy Sebastian, István Albert, Qunhua Li, Margherita T. Cantorna, A. Catharine Ross, 2021, Nutrition Reports International

Model-based assessment of replicability for genome-wide association meta-analysis

Daniel McGuire, Yu Jiang, Mengzhen Liu, J. Dylan Weissenkampen, Scott Eckert, Lina Yang, Fang Chen, Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M. Brazel, Fang Chen, Gargi Datta, Jose Davila-Velderrain, Daniel McGuire, Chao Tian, Xiaowei Zhan, H. éléne Choquet, Anna R. Docherty, Jessica D. Faul, Johanna R. Foerster, Lars G. Fritsche, Maiken Elvestad Gabrielsen, Scott D. Gordon, Jeffrey Haessler, Jouke Jan Hottenga, Hongyan Huang, Seon Kyeong Jang, Philip R. Jansen, Yueh Ling, Reedik Ma ̈gi, Nana Matoba, George McMahon, Antonella Mulas, Valeria Orru, Teemu Palviainen, Anita Pandit, Gunnar W. Reginsson, Anne Heidi Skogholt, Jennifer A. Smith, Amy E. Taylor, Constance Turman, Gonneke Willemsen, Hannah Young, Kendra A. Young, Dajiang J. Liu, Arthur Berg, Bibo Jiang, Qunhua Li, 2021, Nature Communications

Model-based Assessment of Replicability of Association Signals: Applications to Genome-wide Association Meta-analysis of Smoking and Drinking Phenotypes in 1.2 Million Individuals

D. McGuire1, Y. Jiang, M. Liu, J Weissenkampen, Scott Eckert1, Lina Yang, F Chen, GWAS Sequencing Consortium of Alcohol Nicotine Use (GSCAN), A Berg, Scott Vrieze, B Jiang, Qunhua Li, D Liu, 2021, Nature communications

S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data

Guanjue Xiang, Cheryl A. Keller, Belinda Giardine, Lin An, Qunhua Li, Yu Zhang, Ross C. Hardison, 2020, Nucleic Acids Research on p. e43

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

Guanjue Xiang, Cheryl A. Keller, Elisabeth Heuston, Belinda M. Giardine, Lin An, Alexander Q. Wixom, Amber Miller, April Cockburn, Michael E.G. Sauria, Kathryn Weaver, Jens Lichtenberg, Berthold Göttgens, Qunhua Li, David Bodine, Shaun Mahony, James Taylor, Gerd A. Blobel, Mitchell J. Weiss, Yong Cheng, Feng Yue, Jim Hughes, Douglas R. Higgs, Yu Zhang, Ross C. Hardison, 2020, Genome Research on p. 472-484

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells

Ross C. Hardison, Yu Zhang, Cheryl A. Keller, Guanjue Xiang, Elisabeth F. Heuston, Lin An, Jens Lichtenberg, Belinda M. Giardine, David Bodine, Shaun Mahony, Qunhua Li, Feng Yue, Mitchell J. Weiss, Gerd A. Blobel, James Taylor, Jim Hughes, Douglas R. Higgs, Berthold Göttgens, 2020, Biochemistry and Molecular Biology International on p. 27-38

Most-Cited Papers

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham, Anshul Kundaje, Shelley F. Aldred, Patrick J. Collins, Carrie A. Davis, Francis Doyle, Charles B. Epstein, Seth Frietze, Jennifer Harrow, Rajinder Kaul, Jainab Khatun, Bryan R. Lajoie, Stephen G. Landt, Bum Kyu Lee, Florencia Pauli, Kate R. Rosenbloom, Peter Sabo, Alexias Safi, Amartya Sanyal, Noam Shoresh, Jeremy M. Simon, Lingyun Song, Nathan D. Trinklein, Robert C. Altshuler, Ewan Birney, James B. Brown, Chao Cheng, Sarah Djebali, Xianjun Dong, Jason Ernst, Terrence S. Furey, Mark Gerstein, Belinda Giardine, Melissa Greven, Ross C. Hardison, Robert S. Harris, Javier Herrero, Michael M. Hoffman, Sowmya Iyer, Manolis Kellis, Pouya Kheradpour, Timo Lassmann, Qunhua Li, Xinying Lin, Georgi K. Marinov, Angelika Merkel, Ali Mortazavi, Stephen C.J. Parker, Timothy E. Reddy, Joel Rozowsky, 2012, Nature on p. 57-74

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

Stephen G. Landt, Georgi K. Marinov, Anshul Kundaje, Pouya Kheradpour, Florencia Pauli, Serafim Batzoglou, Bradley E. Bernstein, Peter Bickel, James B. Brown, Philip Cayting, Yiwen Chen, Gilberto DeSalvo, Charles Epstein, Katherine I. Fisher-Aylor, Ghia Euskirchen, Mark Gerstein, Jason Gertz, Alexander J. Hartemink, Michael M. Hoffman, Vishwanath R. Iyer, Youngsook L. Jung, Subhradip Karmakar, Manolis Kellis, Peter V. Kharchenko, Qunhua Li, Tao Liu, X. Shirley Liu, Lijia Ma, Aleksandar Milosavljevic, Richard M. Myers, Peter J. Park, Michael J. Pazin, Marc D. Perry, Debasish Raha, Timothy E. Reddy, Joel Rozowsky, Noam Shoresh, Arend Sidow, Matthew Slattery, John A. Stamatoyannopoulos, Michael Y. Tolstorukov, Kevin P. White, Simon Xi, Peggy J. Farnham, Jason D. Lieb, Barbara J. Wold, Michael Snyder, 2012, Genome Research on p. 1813-1831

Practical Guidelines for the Comprehensive Analysis of ChIP-seq Data

Timothy Bailey, Pawel Krajewski, Istvan Ladunga, Celine Lefebvre, Qunhua Li, Tao Liu, Pedro Madrigal, Cenny Taslim, Jie Zhang, 2013, PLoS Computational Biology

HiCRep: assessing the reproducibility of Hi-C data using a stratum-adjusted correlation coefficient

Tao Yang, Feipeng Zhang, Galip Gürkan Yardımci, Fan Song, Ross C. Hardison, William Stafford Noble, Feng Yue, Qunhua Li, 2017, Genome Research on p. 1939-1949

Systematic evaluation of factors influencing ChIP-seq fidelity

Yiwen Chen, Nicolas Negre, Qunhua Li, Joanna O. Mieczkowska, Matthew Slattery, Tao Liu, Yong Zhang, Tae Kyung Kim, Housheng Hansen He, Jennifer Zieba, Yijun Ruan, Peter J. Bickel, Richard M. Myers, Barbara J. Wold, Kevin P. White, Jason D. Lieb, X. Shirley Liu, 2012, Nature Methods on p. 609-614

Measuring the reproducibility and quality of Hi-C data

Galip Gürkan Yardımcı, Hakan Ozadam, Michael E.G. Sauria, Oana Ursu, Koon Kiu Yan, Tao Yang, Abhijit Chakraborty, Arya Kaul, Bryan R. Lajoie, Fan Song, Ye Zhan, Ferhat Ay, Mark Gerstein, Anshul Kundaje, Qunhua Li, James Taylor, Feng Yue, Job Dekker, William S. Noble, 2019, Genome Biology

A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis

Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K.P. Vanamala, 2017, Nutrition Reports International on p. 11-17

Galaxy tools to study genome diversity.

Oscar C. Bedoya-Reina, Aakrosh Ratan, Richard Burhans, Hie Lim Kim, Belinda Giardine, Cathy Riemer, Qunhua Li, Thomas L. Olson, Thomas P. Loughran, Bridgett M. vonHoldt, George H. Perry, Stephan C. Schuster, Webb Miller, 2013, GigaScience on p. 17

OnTAD

Lin An, Tao Yang, Jiahao Yang, Johannes Nuebler, Guanjue Xiang, Ross C. Hardison, Qunhua Li, Yu Zhang, 2019, Genome Biology on p. 1-16

A continuous threshold expectile model

Feipeng Zhang, Qunhua Li, 2017, Computational Statistics and Data Analysis on p. 49-66