Pia Abel zur Wiesch

Huck Early Career Chair in Systems Pharmacology; Associate Professor of Biology

Huck Affiliations

Links

Publication Tags

Antibiotics Anti Bacterial Agents Pharmaceutical Preparations Population Therapeutics Experiments Infection Population Dynamics Drugs Pathogens Reaction Kinetics Dose Plasmids Theoretical Models Antibiotic Resistance Cell Cycle Kinetics Drug Resistance Quinolones Asymmetry Caulobacter Dosage Growth Morbidity Mortality

Most Recent Papers

Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level

Viacheslav N. Kachalov, Huyen Nguyen, Suraj Balakrishna, Luisa Salazar-Vizcaya, Rami Sommerstein, Stefan P. Kuster, Anthony Hauser, Pia Abel Zur Wiesch, Eili Klein, Roger D. Kouyos, 2021, PLoS Computational Biology

RESTAMP – Rate estimates by sequence-tag analysis of microbial populations

Anel Mahmutovic, Aaron Nicholas Gillman, Silje Lauksund, Natasha Anne Robson Moe, Aime Manzi, Merete Storflor, Pia Abel zur Wiesch, Sören Abel, 2021, Computational and Structural Biotechnology Journal on p. 1035-1051

Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones

Fabrizio Clarelli, Adam Palmer, Bhupender Singh, Merete Storflor, Silje Lauksund, Ted Cohen, Sören Abel, Pia Abel zur Wiesch, 2020, PLoS Computational Biology

Multi-scale modeling of drug binding kinetics to predict drug efficacy

Fabrizio Clarelli, Jingyi Liang, Antal Martinecz, Ines Heiland, Pia Abel zur Wiesch, 2020, Cellular and Molecular Life Sciences on p. 381-394

Selection or drift: The population biology underlying transposon insertion sequencing experiments

Anel Mahmutovic, Pia Abel zur Wiesch, Sören Abel, 2020, Computational and Structural Biotechnology Journal on p. 791-804

Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota

Burcu Tepekule, Pia Abel Zur Wiesch, Roger D. Kouyos, Sebastian Bonhoeffer, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 23106-23116

Reaction kinetic models of antibiotic heteroresistance

Antal Martinecz, Fabrizio Clarelli, Sören Abel, Pia Abel Zur Wiesch, 2019, International Journal of Molecular Sciences

Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization

Alyson R. Warr, Troy P. Hubbard, Diana Munera, Carlos J. Blondel, Pia Abel Zur Wiesch, Sören Abel, Xiaoxue Wang, Brigid M. Davis, Matthew K. Waldor, 2019, PLoS Pathogens

Estimating treatment prolongation for persistent infections

Antal Martinecz, Pia Abel Zur Wiesch, 2018, Pathogens and Disease

Deciphering the landscape of host barriers to Listeria monocytogenes infection

Ting Zhang, Sören Abel, Pia Abelzur Wiesch, Jumpei Sasabe, Brigid M. Davis, Darren E. Higgins, Matthew K. Waldor, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 6334-6339

Most-Cited Papers

Population biological principles of drug-resistance evolution in infectious diseases

Pia Abel Zur Wiesch, Roger Kouyos, Jan Engelstädter, Roland R. Regoes, Sebastian Bonhoeffer, 2011, The Lancet Infectious Diseases on p. 236-247

Antagonism between bacteriostatic and bactericidal antibiotics is prevalent

Paolo S. Ocampo, Viktória Lázár, Balázs Papp, Markus Arnoldini, Pia Abel Zur Wiesch, Róbert Busa-Fekete, Gergely Fekete, Csaba Pál, Martin Ackermann, Sebastian Bonhoeffer, 2014, Antimicrobial Agents and Chemotherapy on p. 4573-4582

Bi-modal Distribution of the Second Messenger c-di-GMP Controls Cell Fate and Asymmetry during the Caulobacter Cell Cycle

Sören Abel, Tabitha Bucher, Micaël Nicollier, Isabelle Hug, Volkhard Kaever, Pia Abel zur Wiesch, Urs Jenal, 2013, PLoS Genetics

Analysis of Bottlenecks in Experimental Models of Infection

Sören Abel, Pia Abel zur Wiesch, Brigid M. Davis, Matthew K. Waldor, 2015, PLoS Pathogens

The path of least resistance

Roger D. Kouyos, C. Jessica E. Metcalf, Ruthie Birger, Eili Y. Klein, Pia Abel zur Wiesch, Peter Ankomah, Nimalan Arinaminpathy, Tiffany L. Bogich, Sebastian Bonhoeffer, Charles Brower, Geoffrey Chi-Johnston, Ted Cohen, Troy Day, Bryan Greenhouse, Silvie Huijben, Joshua Metlay, Nicole Mideo, Laura C. Pollitt, Andrew F. Read, David L. Smith, Claire Standley, Nina Wale, Bryan Grenfell, 2014, Proceedings of the Royal Society B: Biological Sciences

Cycling Empirical Antibiotic Therapy in Hospitals

Pia Abel zur Wiesch, Roger Kouyos, Sören Abel, Wolfgang Viechtbauer, Sebastian Bonhoeffer, 2014, PLoS Pathogens

Sequence tag-based analysis of microbial population dynamics

Sören Abel, Pia Abel Zur Wiesch, Hsiao Han Chang, Brigid M. Davis, Marc Lipsitch, Matthew K. Waldor, 2015, Nature Methods on p. 223-226

Genetic analysis of vibrio parahaemolyticus intestinal colonization

Troy P. Hubbard, Michael C. Chao, Sören Abel, Carlos J. Blondel, Pia Abel Zur Wiesch, Xiaohui Zhou, Brigid M. Davis, Matthew K. Waldor, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6283-6288

Classic reaction kinetics can explain complex patterns of antibiotic action

Pia Abel Zur Wiesch, Sören Abel, Spyridon Gkotzis, Paolo Ocampo, Jan Engelstädter, Trevor Hinkley, Carsten Magnus, Matthew K. Waldor, Klas Udekwu, Ted Cohen, 2015, Science Translational Medicine

Informed switching strongly decreases the prevalence of antibiotic resistance in hospital wards

Roger D. Kouyos, Pia Abel zur Wiesch, Sebastian Bonhoeffer, 2011, PLoS Computational Biology