Philip Smith
Director, Metabolomics Core Facility; Associate Research Professor, Proteomics and Mass Spectrometry Core Facility (University Park)

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319 Huck Life Sciences
University Park, PA 16802 - pbs13@psu.edu
- 814-867-4641
Huck Affiliations
Publication Tags
Liver Lipid Metabolism Parasites Metabolites Aryl Hydrocarbon Receptors Fatty Acids Fungi Genes Saliva Gastrointestinal Microbiome Obesity Metabolomics Diet Nuclear Magnetic Resonance Brain Muricholic Acid Muscles Purine Muscle Plant Growth Regulators Glycine Purine Nucleotides Inosine Monophosphate Phenotype GenomeMost Recent Papers
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa M. Tindall, Penny M. Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2020, Gut microbes on p. 1-24
Mdm2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models
Andrew Patt, Bryce Demoret, Colin Stets, Kate Lynn Bill, Philip Smith, Anitha Vijay, Andrew Patterson, John Hays, Mindy Hoang, James L. Chen, Ewy A. Mathé, 2020, Cancers on p. 1-14
The microbiome modulating activity of bile acids
Yuan Tian, Wei Gui, Imhoi Koo, Philip B. Smith, Erik L. Allman, Robert G. Nichols, Bipin Rimal, Jingwei Cai, Qing Liu, Andrew D. Patterson, 2020, Gut microbes on p. 979-996
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice
Limin Zhang, Bipin Rimal, Robert G. Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu Ching Chang, John L. Butenhoff, Jeffrey M. Peters, Andrew D. Patterson, 2020, Toxicology
Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran
Robert G. Nichols, Jingtao Zhang, Jingwei Cai, Iain A. Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew D. Patterson, 2020, Metabolites
Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.
Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites
Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host
Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences
Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.
Gulsum E. Muku, Nicholas Blazanin, Fangcong Dong, Philip B. Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A. Murray, Gary H. Perdew, 2019, Toxicological Sciences on p. 146-158
Phytohormones in fall armyworm saliva modulate defense responses in plants
Flor Edith Acevedo, Philip B. Smith, Michelle Peiffer, Anjel Helms, John Frazier Tooker, Gary Felton, 2019, Journal of Chemical Ecology on p. 598-609
A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin.
Q Liu, Jingjing Cai, Renea Nichols, Y Tian, Jian Zhang, Philip Smith, Yanling Wang, C Yan, Andrew Patterson, 2019, Metabolites
Most-Cited Papers
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Naoki Tanaka, Shogo Takahashi, Yuan Zhang, Kristopher W. Krausz, Philip B. Smith, Andrew D. Patterson, Frank J. Gonzalez, 2015, Biochimica et Biophysica Acta - Molecular Basis of Disease on p. 1242-1252
Species-specific ant brain manipulation by a specialized fungal parasite
Charissa De Bekker, Lauren E. Quevillon, Philip B. Smith, Kimberly R. Fleming, Debashis Ghosh, Andrew David Patterson, David Peter Hughes, 2014, BMC Evolutionary Biology
The analytical investigation of synthetic street drugs containing cathinone analogs
Amanda M. Leffler, Philip B. Smith, Adriana de Armas, Franklin Lewis Dorman, Jr., 2014, Forensic Science International on p. 50-56
Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner
Rachel Tanos, Rushang D. Patel, Iain Alexander Murray, Philip B. Smith, Andrew David Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004
Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver
Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379
Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism
Limin Zhang, Cen Xie, Robert G. Nichols, Siu H.J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson, 2016, mSystems on p. e00070-16
Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice
Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science and Technology on p. 8067-8077
Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis
Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson, Stephen J. Benkovic, 2015, Journal of Biological Chemistry on p. 6705-6713
The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Frontiers in immunology
News Articles Featuring Philip Smith
Mar 11, 2020
Listening to your gut: A powerful new tool on the microbiome and cell metabolism
Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.
Full Article
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.
Full Article