Philip Smith

Director, Metabolomics Core Facility; Associate Research Professor, Proteomics and Mass Spectrometry Core Facility (University Park)

Philip Smith

Huck Affiliations

Publication Tags

Aryl Hydrocarbon Receptors Liver Metabolomics Fungi Metabolites Lipid Metabolism Parasites Genes Fatty Acids Insects Hydrocarbons Saliva Obesity Diet Nuclear Magnetic Resonance Muricholic Acid Brain Gastrointestinal Microbiome Muscles Purine Receptors 2,8 Dihydroxyquinoline Glycine Muscle Plant Growth Regulators

Most Recent Papers

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity.

F Dong, F Hao, Iain Murray, Philip Smith, I Koo, A Tindall, Penny Kris-Etherton, Krishnegowda Gowdahalli, Shantu Amin, Andrew Patterson, Gary Perdew, 2020, Gut microbes on p. 1-24

The microbiome modulating activity of bile acids.

Y Tian, W Gui, I Koo, Philip Smith, E Allman, R Nichols, B Rimal, J Cai, Q Liu, Andrew Patterson, 2020, Gut microbes on p. 979-996

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice.

L Zhang, B Rimal, R Nichols, Y Tian, Philip Smith, E Hatzakis, S Chang, J Butenhoff, Jeffrey Peters, Andrew Patterson, 2020, Toxicology on p. 152365

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.

Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites

Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host

Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences

Phytohormones in fall armyworm saliva modulate defense responses in plants

Flor Edith Acevedo, Philip B. Smith, Michelle Peiffer, Anjel Helms, John Frazier Tooker, Gary Felton, 2019, Journal of Chemical Ecology on p. 598-609

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

G Muku, N Blazanin, F Dong, Philip Smith, Diane Thiboutot, Krishnegowda Gowdahalli, Shantu Amin, Iain Murray, Gary Perdew, 2019, Toxicological sciences : an official journal of the Society of Toxicology on p. 146-158

A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin.

Q Liu, Jingjing Cai, Renea Nichols, Y Tian, Jian Zhang, Philip Smith, Yanling Wang, C Yan, Andrew Patterson, 2019, Metabolites

Isolation and identification of aryl hydrocarbon receptor modulators in white button mushrooms (Agaricus bisporus)

Yuan Tian, Wei Gui, Philip B. Smith, Imhoi Koo, Iain A. Murray, Margherita T. Cantorna, Gary H. Perdew, Andrew D. Patterson, 2019, Journal of agricultural and food chemistry on p. 9286-9294

Microbiota metabolism promotes synthesis of the human Ah receptor agonist 2,8-dihydroxyquinoline.

Troy D. Hubbard, Qing Liu, Iain A. Murray, Fangcong Dong, Charles Miller, Philip B. Smith, Krishne Gowda, Jyh Ming Lin, Shantu Amin, Andrew D. Patterson, Gary H. Perdew, 2019, Journal of Proteome Research on p. 1715-1724

Most-Cited Papers

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

The analytical investigation of synthetic street drugs containing cathinone analogs

Amanda M. Leffler, Philip B. Smith, Adriana de Armas, Franklin Lewis Dorman, Jr., 2014, Forensic Science International on p. 50-56

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet

Naoki Tanaka, Shogo Takahashi, Yuan Zhang, Kristopher W. Krausz, Philip B. Smith, Andrew D. Patterson, Frank J. Gonzalez, 2015, Biochimica et Biophysica Acta - Molecular Basis of Disease on p. 1242-1252

Species-specific ant brain manipulation by a specialized fungal parasite

Charissa De Bekker, Lauren E. Quevillon, Philip B. Smith, Kimberly R. Fleming, Debashis Ghosh, Andrew David Patterson, David Peter Hughes, 2014, BMC Evolutionary Biology

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Rachel Tanos, Rushang D. Patel, Iain Alexander Murray, Philip B. Smith, Andrew David Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science and Technology on p. 8067-8077

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Limin Zhang, Cen Xie, Robert G. Nichols, Siu H.J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson, 2016, mSystems on p. e00070-16

Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis

Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson, Stephen J. Benkovic, 2015, Journal of Biological Chemistry on p. 6705-6713

Metabolomics Reveals the Heterogeneous Secretome of Two Entomopathogenic Fungi to Ex Vivo Cultured Insect Tissues

Charissa de Bekker, Philip B. Smith, Andrew D. Patterson, David P. Hughes, 2013, PloS one on p. e70609