Philip Smith

Director, Metabolomics Core Facility; Associate Research Professor, Proteomics and Mass Spectrometry Core Facility (University Park)

Philip Smith

Huck Affiliations

Publication Tags

Liver Lipid Metabolism Parasites Metabolites Aryl Hydrocarbon Receptors Fatty Acids Fungi Genes Saliva Gastrointestinal Microbiome Obesity Metabolomics Diet Nuclear Magnetic Resonance Brain Muricholic Acid Muscles Purine Muscle Plant Growth Regulators Glycine Purine Nucleotides Inosine Monophosphate Phenotype Genome

Most Recent Papers

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa M. Tindall, Penny M. Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2020, Gut microbes on p. 1-24

Mdm2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models

Andrew Patt, Bryce Demoret, Colin Stets, Kate Lynn Bill, Philip Smith, Anitha Vijay, Andrew Patterson, John Hays, Mindy Hoang, James L. Chen, Ewy A. Mathé, 2020, Cancers on p. 1-14

The microbiome modulating activity of bile acids

Yuan Tian, Wei Gui, Imhoi Koo, Philip B. Smith, Erik L. Allman, Robert G. Nichols, Bipin Rimal, Jingwei Cai, Qing Liu, Andrew D. Patterson, 2020, Gut microbes on p. 979-996

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Limin Zhang, Bipin Rimal, Robert G. Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu Ching Chang, John L. Butenhoff, Jeffrey M. Peters, Andrew D. Patterson, 2020, Toxicology

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Robert G. Nichols, Jingtao Zhang, Jingwei Cai, Iain A. Murray, Imhoi Koo, Philip B. Smith, Gary H. Perdew, Andrew D. Patterson, 2020, Metabolites

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.

Renea Nichols, Jian Zhang, Jingjing Cai, Iain Murray, I Koo, Philip Smith, Gary Perdew, Andrew Patterson, 2019, Metabolites

Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host

Shanshan Zheng, Raquel Loreto, Philip Smith, Andrew Patterson, David Hughes, Liande Wang, 2019, International journal of molecular sciences

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Gulsum E. Muku, Nicholas Blazanin, Fangcong Dong, Philip B. Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A. Murray, Gary H. Perdew, 2019, Toxicological Sciences on p. 146-158

Phytohormones in fall armyworm saliva modulate defense responses in plants

Flor Edith Acevedo, Philip B. Smith, Michelle Peiffer, Anjel Helms, John Frazier Tooker, Gary Felton, 2019, Journal of Chemical Ecology on p. 598-609

A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin.

Q Liu, Jingjing Cai, Renea Nichols, Y Tian, Jian Zhang, Philip Smith, Yanling Wang, C Yan, Andrew Patterson, 2019, Metabolites

Most-Cited Papers

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental health perspectives on p. 679-688

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet

Naoki Tanaka, Shogo Takahashi, Yuan Zhang, Kristopher W. Krausz, Philip B. Smith, Andrew D. Patterson, Frank J. Gonzalez, 2015, Biochimica et Biophysica Acta - Molecular Basis of Disease on p. 1242-1252

Species-specific ant brain manipulation by a specialized fungal parasite

Charissa De Bekker, Lauren E. Quevillon, Philip B. Smith, Kimberly R. Fleming, Debashis Ghosh, Andrew David Patterson, David Peter Hughes, 2014, BMC Evolutionary Biology

The analytical investigation of synthetic street drugs containing cathinone analogs

Amanda M. Leffler, Philip B. Smith, Adriana de Armas, Franklin Lewis Dorman, Jr., 2014, Forensic Science International on p. 50-56

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Rachel Tanos, Rushang D. Patel, Iain Alexander Murray, Philip B. Smith, Andrew David Patterson, Gary H. Perdew, 2012, Hepatology on p. 1994-2004

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Rachel Tanos, Iain A. Murray, Philip B. Smith, Andrew Patterson, Gary H. Perdew, 2012, Toxicological Sciences on p. 372-379

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Limin Zhang, Cen Xie, Robert G. Nichols, Siu H.J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson, 2016, mSystems on p. e00070-16

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Science and Technology on p. 8067-8077

Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis

Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson, Stephen J. Benkovic, 2015, Journal of Biological Chemistry on p. 6705-6713

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23

Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Frontiers in immunology