Peter Butler
Professor of Bioengineering

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230 Hallowell
University Park, PA 16802 - pjb28@psu.edu
- 814-865-8086
Research Summary
Fundamental molecular mechanisms by which vascular endothelial cells sense the forces from flowing blood and transduce this mechanical information into adjustments of cell and tissue biology.
Huck Affiliations
Links
Publication Tags
Enzymes Membranes Substrates Nanoparticles Molecules Aquaporins Cells Lipids Stiffness Calcium Macrophages Pancreatic Neoplasms Pumps Water Neoplasms Permeability Tumors Engines Encapsulation Selectivity Cracks Glucose Oxidase Exosomes Catalase BioactivityMost Recent Papers
Motility of enzyme-powered vesicles
Subhadip Ghosh, Farzad Mohajerani, Seoyoung Son, Darrell Velegol, Peter J. Butler, Ayusman Sen, 2019, Nano Letters on p. 6019-6026
Nonuniform crowding enhances transport
Matthew Collins, Farzad Mohajerani, Subhadip Ghosh, Rajarshi Guha, Tae Hee Lee, Peter J. Butler, Ayusman Sen, Darrell Velegol, 2019, ACS Nano on p. 8946-8956
Mechanobiology of the abluminal glycocalyx
Peter J. Butler, Amit Bhatnagar, 2019, Biorheology on p. 101-112
Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes
Yue Xiao Shen, Woochul C. Song, D. Ryan Barden, Tingwei Ren, Chao Lang, Hasin Feroz, Codey B. Henderson, Patrick O. Saboe, Daniel Tsai, Hengjing Yan, Peter J. Butler, Guillermo C. Bazan, William A. Phillip, Robert John Hickey, III, Paul S. Cremer, Harish Vashisth, Manish Kumar, 2018, Nature Communications
Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages
Samuel S. Linton, Thomas Abraham, Jason Liao, Gary A. Clawson, Peter J. Butler, Todd Fox, Mark Kester, Gail L. Matters, 2018, PLoS One
Light-Driven Chloride Transport Kinetics of Halorhodopsin
Hasin Feroz, Bryan Ferlez, Cecile Lefoulon, Tingwei Ren, Carol Sue Baker, John P. Gajewski, Daniel J. Lugar, Sandeep B. Gaudana, Peter J. Butler, Jonas Hühn, Matthias Lamping, Wolfgang J. Parak, Julian M. Hibberd, Cheryl A. Kerfeld, Nicholas Smirnoff, Michael R. Blatt, John H. Golbeck, Manish Kumar, 2018, Biophysical Journal on p. 353-360
Mechanotargeting: Mechanics-dependent cellular uptake of nanoparticles
Qiong Wei, Changjin Huang, Yao Zhang, Tiankai Zhao, Peng Zhao, Peter J. Butler, Sulin Zhang, 2018, Advanced Materials
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317
Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer
Welley S. Loc, Samuel S. Linton, Zachary R. Wilczynski, Gail Matters, Christopher O. McGovern, Thomas Abraham, Todd Fox, Christopher M. Gigliotti, Xiaomeng Tang, Amra Tabakovic, Jo Ann Martin, Gary Clawson, Jill P. Smith, Peter J. Butler, Mark Kester, James Hansell Adair, 2017, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 2313-2324
β<sub>1</sub>-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent
Seoyoung Son, George J. Moroney, Peter J. Butler, 2017, Biophysical Journal on p. 1080-1092
Most-Cited Papers
Enzyme molecules as nanomotors
Samudra Sengupta, Krishna K. Dey, Hari S. Muddana, Tristan Tabouillot, Michael E. Ibele, Peter J. Butler, Ayusman Sen, 2013, Journal of the American Chemical Society on p. 1406-1414
Highly permeable artificial water channels that can self-assemble into two-dimensional arrays
Yue Xiao Shen, Wen Si, Mustafa Erbakan, Karl Decker, Rita De Zorzi, Patrick O. Saboe, You Jung Kang, Sheereen Majd, Peter J. Butler, Thomas Walz, Aleksei Aksimentiev, Jun Li Hou, Manish Kumar, David A. Weitz, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 9810-9815
Chemotactic separation of enzymes
Krishna Kanti Dey, Sambeeta Das, Matthew F. Poyton, Samudra Sengupta, Peter J. Butler, Paul S. Cremer, Ayusman Sen, 2014, ACS Nano on p. 11941-11949
Tuning membrane phase separation using nonlipid amphiphiles
Hari S. Muddana, Homer H. Chiang, Peter J. Butler, 2012, Biophysical Journal on p. 489-497
DNA polymerase as a molecular motor and pump
Samudra Sengupta, Michelle Marie Spiering, Krishna K. Dey, Wentao Duan, Debabrata Patra, Peter J. Butler, R. Dean Astumian, Stephen Benkovic, Ayusman Sen, 2014, ACS Nano on p. 2410-2418
Substrate-driven chemotactic assembly in an enzyme cascade
Xi Zhao, Henri Palacci, Vinita Yadav, Michelle Marie Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen Benkovic, Ayusman Sen, 2018, Nature Chemistry on p. 311-317
Substrate stiffness regulates cellular uptake of nanoparticles
Changjin Huang, Peter J. Butler, Sheng Tong, Hari S. Muddana, Gang Bao, Sulin Zhang, 2013, Nano Letters on p. 1611-1615
Atomistic simulation of lipid and DiI dynamics in membrane bilayers under tension
Hari S. Muddana, Ramachandra R. Gullapalli, Evangelos Manias, Peter J. Butler, 2011, Physical Chemistry Chemical Physics on p. 1368-1378
Exothermicity Is Not a Necessary Condition for Enhanced Diffusion of Enzymes
Pierre Illien, Xi Zhao, Krishna K. Dey, Peter J. Butler, Ayusman Sen, Ramin Golestanian, 2017, Nano Letters on p. 4415-4420
Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes
Yue Xiao Shen, Woochul C. Song, D. Ryan Barden, Tingwei Ren, Chao Lang, Hasin Feroz, Codey B. Henderson, Patrick O. Saboe, Daniel Tsai, Hengjing Yan, Peter J. Butler, Guillermo C. Bazan, William A. Phillip, Robert John Hickey, III, Paul S. Cremer, Harish Vashisth, Manish Kumar, 2018, Nature Communications