Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations


Publication Tags

Gene Expression Proteins Rna Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Rna Binding Proteins Transcription Factors Virulence Genes Carbon Protein Ribosomes Growth Peptide Elongation Factors Ribonuclease E Protein Biosynthesis Bacteria Iron Transcription In Vitro Techniques Rna Stability Operon Regulation

Most Recent Papers

CsrA regulation via binding to the base-pairing small RNA Spot 42

Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53

An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium

Deyanira Pérez-Morales, Jessica Nava-Galeana, Roberto Rosales-Reyes, Paige Teehan, Helen Yakhnin, Erika I. Melchy-Pérez, Yvonne Rosenstein, Miguel A. De La Cruz, Paul Babitzke, Víctor H. Bustamante, 2021, PLoS Pathogens

Nusg is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with nusa

Zachary F. Mandell, Reid T. Oshiro, Alexander V. Yakhnin, Rishi Vishwakarma, Mikhail Kashlev, Daniel B. Kearns, Paul Babitzke, 2021, eLife

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor

Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728

Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA

Christine Pourciau, Ying Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636

Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis

Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio

Regulation of iron storage by CsrA supports exponential growth of Escherichia coli

Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2019, mBio

NusG-dependent RNA polymerase pausing and tylosin-dependent ribosome stalling lead to antibiotic resistance by inducing 23S rRNA methylation

H Yakhnin, A Yakhnin, B Mouery, Z Mandell, C Karbasiafshar, M Kashlev, P Babitzke, 2019, mBio on p. e02665-19

Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins

Paul Babitzke, Ying Jung Lai, Andrew J. Renda, Tony Romeo, 2019, Annual Review of Microbiology on p. 43-67

Most-Cited Papers

Post-transcriptional regulation on a global scale

Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Global regulation by CsrA and its RNA antagonists

Tony Romeo, Paul Babitzke, 2018, Microbiology spectrum

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA

Archana Pannuri, Helen Yakhnin, Christopher A. Vakulskas, Adrianne N. Edwards, Paul Babitzke, Tony Romeo, 2012, Journal of Bacteriology on p. 79-89

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306