Paul Babitzke
Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

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0203 Althouse Lab
University Park, PA - pxb28@psu.edu
- 814-865-0002
Research Summary
Regulation of gene expression by RNA structure and RNA-binding proteins
Huck Affiliations
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Publication Tags
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Rna Proteins Gene Expression Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Protein Dna Bacteria In Vitro Techniques Rna Stability Ribonuclease E Carbon Rna Binding Proteins Regulation Genes Protein Biosynthesis Virulence Transcription Factors Ribosomes Transcriptome Genome Operon GlucoseMost Recent Publications
Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in Bacillus subtilis
Elizabeth A. Jolley, Helen Yakhnin, David Tack, Paul Babitzke, Philip C. Bevilacqua, 2023, RNA on p. 1365-1378
CsrA Positively and Directly Regulates the Expression of the pdu, pocR, and eut Genes Required for the Luminal Replication of Salmonella Typhimurium
Jessica Nava-Galeana, Helen Yakhnin, Paul Babitzke, Víctor H. Bustamante, 2023, Microbiology spectrum on p. e0151623
CsrA-Mediated Translational Activation of the hmsE mRNA Enhances HmsD-Dependent C-di-GMP-Enabled Biofilm Production in Yersinia pestis
Amelia R. Silva-Rohwer, Kiara Held, Helen Yakhnin, Paul Babitzke, Viveka Vadyvaloo, 2023, Journal of Bacteriology
Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase
Rishi K. Vishwakarma, M. Zuhaib Qayyum, Paul Babitzke, Katsuhiko S. Murakami, 2023, Proceedings of the National Academy of Sciences of the United States of America
Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG
Alexander V. Yakhnin, Mikhail Bubunenko, Zachary F. Mandell, Lucyna Lubkowska, Sara Husher, Paul Babitzke, Mikhail Kashlev, 2023, Proceedings of the National Academy of Sciences of the United States of America
Comprehensive transcription terminator atlas for Bacillus subtilis
Zachary Mandell, Rishi Vishwakarma, R Vishwakarma, Helen Yakhnina, H Yakhnin, K Murakami KS, Katsuhiko Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp
Hiraku Takada, Zachary Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin Wu, Ben Tresco, Andrew Myers, Gemma Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189
Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains
Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio
Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis
Oshadhi Jayasinghe, Zachary Mandell, Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology on p. e0053421
CsrA regulation via binding to the base-pairing small RNA Spot 42
Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53
Most-Cited Papers
Regulation of bacterial virulence by Csr (Rsm) systems
Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224
Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems
Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324
CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage
Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596
Global regulation by CsrA and its RNA antagonists
T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354
NusA-dependent transcription termination prevents misregulation of global gene expression
Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology
NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble
Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308
Dual posttranscriptional regulation via a cofactor-responsive mRNA leader
Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677
Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system
Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639
FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis
Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306
News Articles Featuring Paul Babitzke
Feb 23, 2023
Nobel Prize-winning Penn State alumnus Paul Berg dies
Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.
Full Article
Feb 09, 2023
DNA stuck in the gears of the RNA production machine
Precise control of gene expression — ensuring that cells make the correct components in the right amount and at the right time — is vital for all organisms to function properly. Cells must regulate how genes encoded in the sequence of DNA are made into RNA molecules that can carry out cellular functions on their own or be further processed into proteins.
Full Article