Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Links

Publication Tags

Rna Messenger Rna Gene Expression Escherichia Coli Proteins Binding Sites Gels In Vitro Techniques Rna Binding Proteins Bacillus Subtilis Initiator Codon Genes Rna Stability Virulence Regulator Genes Open Reading Frames Pathogens Streptococcus Base Pairing Operon Genome Homeostasis Ribosomes Carbon Bacteria

Most Recent Papers

In vivo RNA structural probing of uracil and guanine base-pairing by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)

David Mitchell, Andrew J. Renda, Catherine A. Douds, Paul Lee Babitzke, Sarah Mary Assmann, Philip C. Bevilacqua, 2019, RNA on p. 147-157

Examination of Csr regulatory circuitry using epistasis analysis with RNA-seq (Epi-seq) confirms that CsrD affects gene expression via CsrA, CsrB and CsrC

Anastasia H. Potts, Yuanyuan Leng, Paul Lee Babitzke, Tony Romeo, 2018, Scientific reports

Global regulation by CsrA and its RNA antagonists

Tony Romeo, Paul Lee Babitzke, 2018, Microbiology Spectrum

Glyoxals as in vivo RNA structural probes of guanine base-pairing

David Mitchell, Laura E. Ritchey, Hongmarn Park, Paul Lee Babitzke, Sarah Mary Assmann, Philip C. Bevilacqua, 2018, RNA on p. 114-124

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Elena Borisovna Yakhnina, Paul Lee Babitzke, Tony Romeo, 2017, Nature communications

Noncanonical translation initiation comes of age

Paul Lee Babitzke, Michael O'Connor, 2017, Journal of bacteriology

Modular organization of the NusA- and NusG-stimulated RNA polymerase pause signal that participates in the Bacillus subtilis trp operon attenuation mechanism

Smarajit Mondal, Alexander Victor Yakhnin, Paul Lee Babitzke, 2017, Journal of bacteriology

Translational repression of the RpoS antiadapter IraD by CsrA is mediated via translational coupling to a short upstream open reading frame

Hongmarn Park, Louise C. McGibbon, Anastasia H. Potts, Elena Borisovna Yakhnina, Tony Romeo, Paul Lee Babitzke, 2017, mBio

Circuitry linking the global Csr- and σ <sup>E</sup> -dependent cell envelope stress response systems

Elena Borisovna Yakhnina, Robert Aichele, Sarah Ellen Ades, Tony Romeo, Paul Lee Babitzke, 2017, Journal of bacteriology

Eliminating blurry bands in gels with a simple cost-effective repair to the gel cassette

Jamie L. Bingaman, Erica A. Frankel, Chelsea M. Hull, Kathleen A. Leamy, Kyle J. Messina, David Mitchell, Hongmarn Park, Laura E. Ritchey, Paul Lee Babitzke, Philip C. Bevilacqua, 2016, RNA on p. 1929-1930

High-Impact Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Paul Lee Babitzke, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Circuitry linking the Csr and stringent response global regulatory systems

Adrianne N. Edwards, Laura M. Patterson-Fortin, Christopher A. Vakulskas, Jeffrey W. Mercante, Katarzyna Potrykus, Daniel Vinella, Martha I. Camacho, Joshua A. Fields, Stuart A. Thompson, Dimitris Georgellis, Michael Cashel, Paul Lee Babitzke, Tony Romeo, 2011, Molecular Microbiology on p. 1561-1580

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander Victor Yakhnin, Carol Sue Baker, Christopher A. Vakulskas, Elena Borisovna Yakhnina, Igor Berezin, Tony Romeo, Paul Lee Babitzke, 2013, Molecular Microbiology on p. 851-866

Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD

Luary C. Martínez, Elena Borisovna Yakhnina, Martha I. Camacho, Dimitris Georgellis, Paul Lee Babitzke, José L. Puente, Víctor H. Bustamante, 2011, Molecular Microbiology on p. 1637-1656

Molecular Geometry of CsrA (RsmA) Binding to RNA and Its Implications for Regulated Expression

Jeffrey Mercante, Adrianne N. Edwards, Ashok K. Dubey, Paul Lee Babitzke, Tony Romeo, 2009, Journal of Molecular Biology on p. 511-528

A genome-wide analysis of small regulatory RNAs in the human pathogen group a Streptococcus

Nataly Perez, Jeanette Treviño, Zhuyun Liu, Siu Chun Michael Ho, Paul Lee Babitzke, Paul Sumby, 2009, PLoS One

CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis

Sampriti Mukherjee, Elena Borisovna Yakhnina, Dave Kysela, Josh Sokoloski, Paul Lee Babitzke, Daniel B. Kearns, 2011, Molecular Microbiology on p. 447-461

Complex regulation of the global regulatory gene csrA

Elena Borisovna Yakhnina, Alexander Victor Yakhnin, Carol Sue Baker, Elena V. Sineva, Igor Berezin, Tony Romeo, Paul Lee Babitzke, 2011, Molecular Microbiology on p. 689-704

CsrA Represses Translation of sdiA, Which Encodes the N-acylhomoserine-L-lactone receptor of Escherichia coli, by Binding exclusively within the coding region of sdiA mRNA

Elena Borisovna Yakhnina, Carol Sue Baker, Igor Berezin, Michael A. Evangelista, Alisa Rassin, Tony Romeo, Paul Lee Babitzke, 2011, Journal of Bacteriology on p. 6162-6170

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Elena Borisovna Yakhnina, Paul Lee Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677