Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Links

Publication Tags

Rna Proteins Gene Expression Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Protein In Vitro Techniques Rna Stability Bacteria Ribonuclease E Carbon Rna Binding Proteins Dna Regulation Genes Protein Biosynthesis Virulence Ribosomes Transcriptome Transcription Factors Genome Operon Glucose

Most Recent Publications

Comprehensive transcription terminator atlas for Bacillus subtilis

Zachary F. Mandell, Rishi K. Vishwakarma, Helen Yakhnin, Katsuhiko S. Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931

Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp

Hiraku Takada, Zachary F. Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin J.Y. Wu, Ben I.C. Tresco, Andrew G. Myers, Gemma C. Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains

Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio

Complex mechanism of tylosin resistance in Bacillus subtilis.

Paul Babitzke, 2022,

Intrinsic termination is mediated by NusA, NusG and Rho in Bacillus subtilis.

Zachary Mandell, Rishi Vishwakarma, Paul Babitzke, 2022,

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Oshadhi Jayasinghe, Zachary Mandell, Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology on p. e0053421

In vivo RNA structural probing of guanine and uracil by a novel carbodiimide.

Catherine Douds, Paul Babitzke, Philip Bevilacqua, 2022,

Rho-dependent intrinsic termination in Bacillus subtilis.

Zachary Mandell, Rishi Vishwakarma, Katsuhiko Murakami, Paul Babitzke, 2022,

CsrA regulation via binding to the base-pairing small RNA Spot 42

Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53

Structural basis for NusG-dependent transcriptional pausing.

Rishi Vishwakarma, Zuhaib Qayyum, Paul Babitzke, Katsuhiko Murakami, 2022,

Most-Cited Papers

Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems

Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble

Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306