Paul Babitzke
Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

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0203 Althouse Lab
University Park, PA - pxb28@psu.edu
- 814-865-0002
Research Summary
Regulation of gene expression by RNA structure and RNA-binding proteins
Huck Affiliations
Links
Publication Tags
Gene Expression Proteins Rna Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Rna Binding Proteins Transcription Factors Virulence Genes Carbon Protein Ribosomes Growth Peptide Elongation Factors Ribonuclease E Protein Biosynthesis Bacteria Iron Transcription In Vitro Techniques Rna Stability Operon RegulationMost Recent Papers
CsrA regulation via binding to the base-pairing small RNA Spot 42
Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53
An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium
Deyanira Pérez-Morales, Jessica Nava-Galeana, Roberto Rosales-Reyes, Paige Teehan, Helen Yakhnin, Erika I. Melchy-Pérez, Yvonne Rosenstein, Miguel A. De La Cruz, Paul Babitzke, Víctor H. Bustamante, 2021, PLoS Pathogens
Nusg is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with nusa
Zachary F. Mandell, Reid T. Oshiro, Alexander V. Yakhnin, Rishi Vishwakarma, Mikhail Kashlev, Daniel B. Kearns, Paul Babitzke, 2021, eLife
NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor
Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728
Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA
Christine Pourciau, Ying Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology
NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome
Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636
Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis
Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio
Regulation of iron storage by CsrA supports exponential growth of Escherichia coli
Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2019, mBio
NusG-dependent RNA polymerase pausing and tylosin-dependent ribosome stalling lead to antibiotic resistance by inducing 23S rRNA methylation
H Yakhnin, A Yakhnin, B Mouery, Z Mandell, C Karbasiafshar, M Kashlev, P Babitzke, 2019, mBio on p. e02665-19
Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins
Paul Babitzke, Ying Jung Lai, Andrew J. Renda, Tony Romeo, 2019, Annual Review of Microbiology on p. 43-67
Most-Cited Papers
Post-transcriptional regulation on a global scale
Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324
Regulation of bacterial virulence by Csr (Rsm) systems
Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224
CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage
Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596
Global regulation by CsrA and its RNA antagonists
Tony Romeo, Paul Babitzke, 2018, Microbiology spectrum
Dual posttranscriptional regulation via a cofactor-responsive mRNA leader
Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677
Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate
Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639
NusA-dependent transcription termination prevents misregulation of global gene expression
Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology
Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA
Archana Pannuri, Helen Yakhnin, Christopher A. Vakulskas, Adrianne N. Edwards, Paul Babitzke, Tony Romeo, 2012, Journal of Bacteriology on p. 79-89
FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis
Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306