Paul Babitzke
Co-Director of the Center for RNA Molecular Biology; Stanley R. Person Professor of Molecular Biology
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0203 Althouse Lab
University Park, PA - pxb28@psu.edu
- 814-865-0002
Research Summary
Regulation of gene expression by RNA structure and RNA-binding proteins
Huck Affiliations
Links
Most Recent Publications
A new reagent for in vivo structure probing of RNA G and U residues that improves RNA structure prediction alone and combined with DMS
Catherine A. Douds, Paul Babitzke, Philip C. Bevilacqua, 2024, RNA on p. 901-919
Multitier regulation of the E. coli extreme acid stress response by CsrA
Mark G. Gorelik, Helen Yakhnin, Archana Pannuri, Alyssa C. Walker, Christine Pourciau, Daniel Czyz, Tony Romeo, Paul Babitzke, 2024, Journal of Bacteriology
In vivo-like nearest neighbor parameters improve prediction of fractional RNA base-pairing in cells
Jacob P. Sieg, Elizabeth A. Jolley, Melanie J. Huot, Paul Babitzke, Philip C. Bevilacqua, 2023, Nucleic Acids Research on p. 11298-11317
CsrA positively and directly regulates the expression of the pdu, pocr, and eut genes required for the luminal replication of salmonella typhimurium
Jessica Nava-Galeana, Helen Yakhnin, Paul Babitzke, Víctor H. Bustamante, 2023, Microbiology spectrum
CsrA-Mediated Translational Activation of the hmsE mRNA Enhances HmsD-Dependent C-di-GMP-Enabled Biofilm Production in Yersinia pestis
Amelia R. Silva-Rohwer, Kiara Held, Helen Yakhnin, Paul Babitzke, Viveka Vadyvaloo, 2023, Journal of Bacteriology
Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in Bacillus subtilis
Elizabeth Jolley, Helen Yakhnin, E Yakhnin, David Tack, Paul Babitzke, Philip C. Bevilacqua, 2023, RNA on p. 1365-1378
Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase
Rishi K. Vishwakarma, M. Zuhaib Qayyum, Paul Babitzke, Katsuhiko S. Murakami, 2023, Proceedings of the National Academy of Sciences of the United States of America
Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG
Alexander V. Yakhnin, Mikhail Bubunenko, Zachary F. Mandell, Lucyna Lubkowska, Sara Husher, Paul Babitzke, Mikhail Kashlev, 2023, Proceedings of the National Academy of Sciences of the United States of America
CsrA coordinates the expression of ribosome hibernation and anti-σ factor proteins
Christine Pourciau, Helen Yakhnin, Elena Borisovna Yakhnina, Archanna Pannuri, Mark G. Gorelik, Ying-Jung Lai, Tony Romeo, Paul Babitzke, 2023, mBio on p. e0258523
Comprehensive transcription terminator atlas for Bacillus subtilis
Zachary Mandell, Rishi Vishwakarma, R Vishwakarma, Helen Yakhnina, H Yakhnin, K Murakami KS, Katsuhiko Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931
Most-Cited Papers
Regulation of bacterial virulence by Csr (Rsm) systems
Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596
Global regulation by CsrA and its RNA antagonists
T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354
NusA-dependent transcription termination prevents misregulation of global gene expression
Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology
NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble
Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308
Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system
Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639
Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA
Christine Pourciau, Ying Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology
Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins
Christopher A. Vakulskas, Yuanyuan Leng, Hazuki Abe, Takumi Amaki, Akihiro Okayama, Paul Babitzke, Kazushi Suzuki, Tony Romeo, 2016, Nucleic Acids Research on p. 7896-7910
Global effects of the DEAD-box RNA helicase DeaD (CsdA) on gene expression over a broad range of temperatures
Christopher A. Vakulskas, Archana Pannuri, Diana Cortés-Selva, Tesfalem R. Zere, Brian M. Ahmer, Paul Babitzke, Tony Romeo, 2014, Molecular Microbiology on p. 945-958
NusG/Spt5: Are there common functions of this ubiquitous transcription elongation factor?
Alexander V. Yakhnin, Paul Babitzke, 2014, Current Opinion in Microbiology on p. 68-71
News Articles Featuring Paul Babitzke
Feb 23, 2023
Nobel Prize-winning Penn State alumnus Paul Berg dies
Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.
Full Article
Feb 09, 2023
DNA stuck in the gears of the RNA production machine
Precise control of gene expression — ensuring that cells make the correct components in the right amount and at the right time — is vital for all organisms to function properly. Cells must regulate how genes encoded in the sequence of DNA are made into RNA molecules that can carry out cellular functions on their own or be further processed into proteins.
Full Article