Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

0203 Althouse Lab
University Park, PA
pxb28@psu.edu
814-865-0002

Bio & Links
Publications

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Center for RNA Molecular Biology

Publication Tags

Gene Expression Rna Proteins Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Rna Binding Proteins Virulence Genes Carbon Ribosomes Rna Stability Protein Peptide Elongation Factors Transcription Factors In Vitro Techniques Genome Ribonuclease E Protein Biosynthesis Bacteria Operon Virulence Factors Salmonella Typhimurium Regulation

Most Recent Publications

Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp

Hiraku Takada, Zachary F. Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin J.Y. Wu, Ben I.C. Tresco, Andrew G. Myers, Gemma C. Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Oshadhi T. Jayasinghe, Zachary F. Mandell, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains

Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio

CsrA regulation via binding to the base-pairing small RNA Spot 42

Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53

Toeprint Assays for Detecting RNA Structure and Protein–RNA Interactions

Helen Yakhnin, Paul Babitzke, 2022, on p. 305-316

An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium

Deyanira Pérez-Morales, Jessica Nava-Galeana, Roberto Rosales-Reyes, Paige Teehan, Helen Yakhnin, Erika I. Melchy-Pérez, Yvonne Rosenstein, Miguel A. De La Cruz, Paul Babitzke, Víctor H. Bustamante, 2021, PLoS Pathogens

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor

Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728

Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA

Christine Pourciau, Ying Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636

Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis

Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio

Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Research Summary

Huck Affiliations

Links

Publication Tags

Most Recent Publications

Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains

CsrA regulation via binding to the base-pairing small RNA Spot 42

Toeprint Assays for Detecting RNA Structure and Protein–RNA Interactions

An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor

Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis

Most-Cited Papers

Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems

Regulation of bacterial virulence by Csr (Rsm) systems

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Global regulation by CsrA and its RNA antagonists

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

NusA-dependent transcription termination prevents misregulation of global gene expression

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system

Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA