Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

0203 Althouse Lab
University Park, PA
pxb28@psu.edu
814-865-0002

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Center for RNA Molecular Biology

Publication Tags

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Rna Proteins Gene Expression Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Protein Dna Bacteria In Vitro Techniques Rna Stability Ribonuclease E Carbon Rna Binding Proteins Regulation Genes Protein Biosynthesis Virulence Transcription Factors Ribosomes Transcriptome Genome Operon Glucose

Most Recent Publications

Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase

Rishi K. Vishwakarma, M. Zuhaib Qayyum, Paul Babitzke, Katsuhiko S. Murakami, 2023, Proceedings of the National Academy of Sciences of the United States of America

Comprehensive transcription terminator atlas for Bacillus subtilis

Zachary Mandell, Rishi Vishwakarma, R Vishwakarma, Helen Yakhnina, H Yakhnin, K Murakami KS, Katsuhiko Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931

Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp

Hiraku Takada, Zachary Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin Wu, Ben Tresco, Andrew Myers, Gemma Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains

Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio

In vivo RNA structural probing of guanine and uracil by a novel carbodiimide.

Catherine Douds, Paul Babitzke, Philip Bevilacqua, 2022,

Rho-dependent intrinsic termination in Bacillus subtilis.

Zachary Mandell, Rishi Vishwakarma, Katsuhiko Murakami, Paul Babitzke, 2022,

Complex mechanism of tylosin resistance in Bacillus subtilis.

Paul Babitzke, 2022,

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Oshadhi Jayasinghe, Zachary Mandell, Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology on p. e0053421

CsrA regulation via binding to the base-pairing small RNA Spot 42

Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53

Intrinsic termination is mediated by NusA, NusG and Rho in Bacillus subtilis.

Zachary Mandell, Rishi Vishwakarma, Paul Babitzke, 2022,

Most-Cited Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems

Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble

Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

News Articles Featuring Paul Babitzke

Feb 23, 2023

Nobel Prize-winning Penn State alumnus Paul Berg dies

Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.

Full Article

Feb 09, 2023

DNA stuck in the gears of the RNA production machine

Precise control of gene expression — ensuring that cells make the correct components in the right amount and at the right time — is vital for all organisms to function properly. Cells must regulate how genes encoded in the sequence of DNA are made into RNA molecules that can carry out cellular functions on their own or be further processed into proteins.