Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Links

Publication Tags

Rna Messenger Rna Gene Expression Proteins Escherichia Coli Bacillus Subtilis Rna Binding Proteins Ribosomes In Vitro Techniques Virulence Rna Stability Iron Bacteria Homeostasis Dna Directed Rna Polymerases Protein Regulation Regulator Genes Binding Sites Growth Biofilms Operon Gels Ribonuclease E Genes

Most Recent Papers

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor

A Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728

Diverse mechanisms and circuitry for global regulation by the RNA-binding protein CsrA

Christine Pourciao, Ying-Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology on p. 601352

Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis

Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio

Regulation of iron storage by CsrA supports exponential growth of Escherichia coli

Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2019, mBio

Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins.

P Babitzke, Y-J Lai, A Renda, T Romeo, 2019, Annual Review of Microbiology on p. 43–67

NusG-dependent RNA polymerase pausing and tylosin-dependent ribosome stalling lead to antibiotic resistance by inducing 23S rRNA methylation

H Yakhnin, A Yakhnin, B Mouery, Z Mandell, C Karbasiafshar, M Kashlev, P Babitzke, 2019, mBio on p. e02665-19

In vivo RNA structural probing of uracil and guanine base-pairing by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)

David Mitchell, Andrew J. Renda, Catherine A. Douds, Paul Babitzke, Sarah M. Assmann, Philip C. Bevilacqua, 2019, RNA on p. 147-157

Examination of Csr regulatory circuitry using epistasis analysis with RNA-seq (Epi-seq) confirms that CsrD affects gene expression via CsrA, CsrB and CsrC

Anastasia H. Potts, Yuanyuan Leng, Paul Lee Babitzke, Tony Romeo, 2018, Scientific Reports

Global regulation by CsrA and its RNA antagonists

Tony Romeo, Paul Lee Babitzke, 2018, Microbiology spectrum

Most-Cited Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Circuitry linking the Csr and stringent response global regulatory systems

Adrianne N. Edwards, Laura M. Patterson-Fortin, Christopher A. Vakulskas, Jeffrey W. Mercante, Katarzyna Potrykus, Daniel Vinella, Martha I. Camacho, Joshua A. Fields, Stuart A. Thompson, Dimitris Georgellis, Michael Cashel, Paul Babitzke, Tony Romeo, 2011, Molecular Microbiology on p. 1561-1580

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander Victor Yakhnin, Carol Sue Baker, Christopher A. Vakulskas, Elena Borisovna Yakhnina, Igor Berezin, Tony Romeo, Paul Lee Babitzke, 2013, Molecular Microbiology on p. 851-866

Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD

Luary C. Martínez, Helen Yakhnin, Martha I. Camacho, Dimitris Georgellis, Paul Babitzke, José L. Puente, Víctor H. Bustamante, 2011, Molecular Microbiology on p. 1637-1656

CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis.

Subhanan Mukherjee, Elena Yakhnin, D Kysela, J Sokoloski, Paul Babitzke, D Kearns, 2011, Molecular Microbiology on p. 447-61

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Complex regulation of the global regulatory gene csrA

Helen Yakhnin, Alexander V. Yakhnin, Carol S. Baker, Elena Sineva, Igor Berezin, Tony Romeo, Paul Babitzke, 2011, Molecular Microbiology on p. 689-704

Global regulation by CsrA and its RNA antagonists

Tony Romeo, Paul Lee Babitzke, 2018, Microbiology spectrum

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA

Archana Pannuri, Helen Yakhnin, Christopher A. Vakulskas, Adrianne N. Edwards, Paul Babitzke, Tony Romeo, 2012, Journal of Bacteriology on p. 79-89