Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

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Publication Tags

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Rna Proteins Gene Expression Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Protein Dna Bacteria In Vitro Techniques Rna Stability Ribonuclease E Carbon Rna Binding Proteins Regulation Genes Protein Biosynthesis Virulence Transcription Factors Ribosomes Transcriptome Genome Operon Glucose

Most Recent Publications

Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in Bacillus subtilis

Elizabeth A. Jolley, Helen Yakhnin, David Tack, Paul Babitzke, Philip C. Bevilacqua, 2023, RNA on p. 1365-1378

CsrA Positively and Directly Regulates the Expression of the pdu, pocR, and eut Genes Required for the Luminal Replication of Salmonella Typhimurium

Jessica Nava-Galeana, Helen Yakhnin, Paul Babitzke, Víctor H. Bustamante, 2023, Microbiology spectrum on p. e0151623

CsrA-Mediated Translational Activation of the hmsE mRNA Enhances HmsD-Dependent C-di-GMP-Enabled Biofilm Production in Yersinia pestis

Amelia R. Silva-Rohwer, Kiara Held, Helen Yakhnin, Paul Babitzke, Viveka Vadyvaloo, 2023, Journal of Bacteriology

Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase

Rishi K. Vishwakarma, M. Zuhaib Qayyum, Paul Babitzke, Katsuhiko S. Murakami, 2023, Proceedings of the National Academy of Sciences of the United States of America

Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG

Alexander V. Yakhnin, Mikhail Bubunenko, Zachary F. Mandell, Lucyna Lubkowska, Sara Husher, Paul Babitzke, Mikhail Kashlev, 2023, Proceedings of the National Academy of Sciences of the United States of America

Comprehensive transcription terminator atlas for Bacillus subtilis

Zachary Mandell, Rishi Vishwakarma, R Vishwakarma, Helen Yakhnina, H Yakhnin, K Murakami KS, Katsuhiko Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931

Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp

Hiraku Takada, Zachary Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin Wu, Ben Tresco, Andrew Myers, Gemma Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains

Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Oshadhi Jayasinghe, Zachary Mandell, Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology on p. e0053421

CsrA regulation via binding to the base-pairing small RNA Spot 42

Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53

Most-Cited Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems

Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage

Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble

Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306