Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Stanley R. Person Professor of Molecular Biology

0203 Althouse Lab
University Park, PA
pxb28@psu.edu
814-865-0002

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations

Center for RNA Molecular Biology

Most Recent Publications

NusG-dependent RNA polymerase pausing is a common feature of riboswitch regulatory mechanisms

Oshadhi T. Jayasinghe, Laura E. Ritchey, Thomas Breil, Paxton Newman, Helen Yakhnin, Paul Babitzke, 2024, Nucleic Acids Research on p. 12945-12960

A new reagent for in vivo structure probing of RNA G and U residues that improves RNA structure prediction alone and combined with DMS

Catherine A. Douds, Paul Babitzke, Philip C. Bevilacqua, 2024, RNA on p. 901-919

Multitier regulation of the E. coli extreme acid stress response by CsrA

Mark G. Gorelik, Helen Yakhnin, Archana Pannuri, Alyssa C. Walker, Christine Pourciau, Daniel Czyz, Tony Romeo, Paul Babitzke, 2024, Journal of Bacteriology

In vivo-like nearest neighbor parameters improve prediction of fractional RNA base-pairing in cells

Jacob P. Sieg, Elizabeth A. Jolley, Melanie J. Huot, Paul Babitzke, Philip C. Bevilacqua, 2023, Nucleic Acids Research on p. 11298-11317

CsrA positively and directly regulates the expression of the pdu, pocr, and eut genes required for the luminal replication of salmonella typhimurium

Jessica Nava-Galeana, Helen Yakhnin, Paul Babitzke, Víctor H. Bustamante, 2023, Microbiology spectrum

CsrA-Mediated Translational Activation of the hmsE mRNA Enhances HmsD-Dependent C-di-GMP-Enabled Biofilm Production in Yersinia pestis

Amelia R. Silva-Rohwer, Kiara Held, Helen Yakhnin, Paul Babitzke, Viveka Vadyvaloo, 2023, Journal of Bacteriology

Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in Bacillus subtilis

Elizabeth Jolley, Helen Yakhnin, E Yakhnin, David Tack, Paul Babitzke, Philip C. Bevilacqua, 2023, RNA on p. 1365-1378

Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase

Rishi K. Vishwakarma, M. Zuhaib Qayyum, Paul Babitzke, Katsuhiko S. Murakami, 2023, Proceedings of the National Academy of Sciences of the United States of America

CsrA coordinates the expression of ribosome hibernation and anti-σ factor proteins

Christine Pourciau, Helen Yakhnin, Elena Borisovna Yakhnina, Archanna Pannuri, Mark G. Gorelik, Ying-Jung Lai, Tony Romeo, Paul Babitzke, 2023, mBio on p. e0258523

Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG

Alexander V. Yakhnin, Mikhail Bubunenko, Zachary F. Mandell, Lucyna Lubkowska, Sara Husher, Paul Babitzke, Mikhail Kashlev, 2023, Proceedings of the National Academy of Sciences of the United States of America

Most-Cited Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA

Christine Pourciau, Ying Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology

NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble

Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins

Christopher A. Vakulskas, Yuanyuan Leng, Hazuki Abe, Takumi Amaki, Akihiro Okayama, Paul Babitzke, Kazushi Suzuki, Tony Romeo, 2016, Nucleic Acids Research on p. 7896-7910

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636

In vivo RNA structural probing of uracil and guanine base-pairing by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)

David Mitchell, Andrew J. Renda, Catherine A. Douds, Paul Babitzke, Sarah M. Assmann, Philip C. Bevilacqua, 2019, RNA on p. 147-157

News Articles Featuring Paul Babitzke

Feb 23, 2023

Nobel Prize-winning Penn State alumnus Paul Berg dies

Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.

Full Article

Feb 09, 2023

DNA stuck in the gears of the RNA production machine

Precise control of gene expression — ensuring that cells make the correct components in the right amount and at the right time — is vital for all organisms to function properly. Cells must regulate how genes encoded in the sequence of DNA are made into RNA molecules that can carry out cellular functions on their own or be further processed into proteins.