Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

Paul Babitzke

Research Summary

Regulation of gene expression by RNA structure and RNA-binding proteins

Huck Affiliations


Publication Tags

Messenger Rna Gene Expression Proteins Escherichia Coli Rna Rna Binding Proteins Ribosomes Iron Bacillus Subtilis Carbon Regulator Genes Virulence Growth Protein Biosynthesis Biofilms Homeostasis Bacteria Base Pairing Gels Operon In Vitro Techniques Rna Stability Binding Sites Nutritional Status Methylation

Most Recent Papers

Diverse mechanisms and circuitry for global regulation by the RNA-binding protein CsrA

Christine Pourciao, Ying-Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology on p. 601352

NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Alexander Yakhnin, Peter FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Science USA on p. 21628-21636

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor

Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728

CsrA-mediated translational activation of ymdA expression in Escherichia coli

Andrew Renda, Stephanie Poly, Ying-Jung Lai, Helen Yakhnin, Anastasia Potts, Philip Bevilacqua, Tony Romeo, Paul Babitzke, 2020, mBio on p. e00849-20

Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in Bacillus subtilis

Laura Ritchey, David Tack, Helen Yakhnin, Elizabeth Jolley, Sarah Assmann, Philip Bevilacqua, Paul Babitzke, 2020, RNA on p. 1431-1447

Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis

Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio

Regulation of iron storage by CsrA supports exponential growth of Escherichia coli

Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2019, mBio

NusG-dependent RNA polymerase pausing and tylosin-dependent ribosome stalling lead to antibiotic resistance by inducing 23S rRNA methylation

H Yakhnin, A Yakhnin, B Mouery, Z Mandell, C Karbasiafshar, M Kashlev, P Babitzke, 2019, mBio on p. e02665-19

In vivo RNA structural probing of uracil and guanine base-pairing by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)

David Mitchell, Andrew J. Renda, Catherine A. Douds, Paul Babitzke, Sarah M. Assmann, Philip C. Bevilacqua, 2019, RNA on p. 147-157

Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins.

P Babitzke, Y-J Lai, A Renda, T Romeo, 2019, Annual Review of Microbiology on p. 43–67

Most-Cited Papers

Regulation of bacterial virulence by Csr (Rsm) systems

Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224

Circuitry linking the Csr and stringent response global regulatory systems

Adrianne N. Edwards, Laura M. Patterson-Fortin, Christopher A. Vakulskas, Jeffrey W. Mercante, Katarzyna Potrykus, Daniel Vinella, Martha I. Camacho, Joshua A. Fields, Stuart A. Thompson, Dimitris Georgellis, Michael Cashel, Paul Lee Babitzke, Tony Romeo, 2011, Molecular Microbiology on p. 1561-1580

Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD

Luary C. Martínez, Helen Yakhnin, Martha I. Camacho, Dimitris Georgellis, Paul Babitzke, José L. Puente, Víctor H. Bustamante, 2011, Molecular Microbiology on p. 1637-1656

Complex regulation of the global regulatory gene csrA

Helen Yakhnin, Alexander V. Yakhnin, Carol S. Baker, Elena Sineva, Igor Berezin, Tony Romeo, Paul Babitzke, 2011, Molecular Microbiology on p. 689-704

Dual posttranscriptional regulation via a cofactor-responsive mRNA leader

Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677

Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA

Archana Pannuri, Helen Yakhnin, Christopher A. Vakulskas, Adrianne N. Edwards, Paul Babitzke, Tony Romeo, 2012, Journal of bacteriology on p. 79-89

Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate

Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature communications on p. 1596

FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis

Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of bacteriology on p. 297-306

Global effects of the DEAD-box RNA helicase DeaD (CsdA) on gene expression over a broad range of temperatures

Christopher A. Vakulskas, Archana Pannuri, Diana Cortés-Selva, Tesfalem R. Zere, Brian M. Ahmer, Paul Lee Babitzke, Tony Romeo, 2014, Molecular Microbiology on p. 945-958