Paul Babitzke
Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

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0203 Althouse Lab
University Park, PA - pxb28@psu.edu
- 814-865-0002
Research Summary
Regulation of gene expression by RNA structure and RNA-binding proteins
Huck Affiliations
Links
Publication Tags
Rna Proteins Gene Expression Messenger Rna Bacillus Subtilis Escherichia Coli Dna Directed Rna Polymerases Protein In Vitro Techniques Rna Stability Bacteria Ribonuclease E Carbon Rna Binding Proteins Dna Regulation Genes Protein Biosynthesis Virulence Ribosomes Transcriptome Transcription Factors Genome Operon GlucoseMost Recent Publications
Comprehensive transcription terminator atlas for Bacillus subtilis
Zachary F. Mandell, Rishi K. Vishwakarma, Helen Yakhnin, Katsuhiko S. Murakami, Mikhail Kashlev, Paul Babitzke, 2022, Nature Microbiology on p. 1918-1931
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp
Hiraku Takada, Zachary F. Mandell, Helen Yakhnin, Anastasiya Glazyrina, Shinobu Chiba, Tatsuaki Kurata, Kelvin J.Y. Wu, Ben I.C. Tresco, Andrew G. Myers, Gemma C. Aktinson, Paul Babitzke, Vasili Hauryliuk, 2022, Nucleic Acids Research on p. 6174-6189
Analysis of mRNA Decay Intermediates in Bacillus subtilis 3' Exoribonuclease and RNA Helicase Mutant Strains
Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer, 2022, mBio
Complex mechanism of tylosin resistance in Bacillus subtilis.
Paul Babitzke, 2022,
Intrinsic termination is mediated by NusA, NusG and Rho in Bacillus subtilis.
Zachary Mandell, Rishi Vishwakarma, Paul Babitzke, 2022,
Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis
Oshadhi Jayasinghe, Zachary Mandell, Alexander Yakhnin, Mikhail Kashlev, Paul Babitzke, 2022, Journal of Bacteriology on p. e0053421
In vivo RNA structural probing of guanine and uracil by a novel carbodiimide.
Catherine Douds, Paul Babitzke, Philip Bevilacqua, 2022,
Rho-dependent intrinsic termination in Bacillus subtilis.
Zachary Mandell, Rishi Vishwakarma, Katsuhiko Murakami, Paul Babitzke, 2022,
CsrA regulation via binding to the base-pairing small RNA Spot 42
Ying Jung Lai, Helen Yakhnin, Archana Pannuri, Christine Pourciau, Paul Babitzke, Tony Romeo, 2022, Molecular Microbiology on p. 32-53
Structural basis for NusG-dependent transcriptional pausing.
Rishi Vishwakarma, Zuhaib Qayyum, Paul Babitzke, Katsuhiko Murakami, 2022,
Most-Cited Papers
Post-transcriptional regulation on a global scale: Form and function of Csr/Rsm systems
Tony Romeo, Christopher A. Vakulskas, Paul Babitzke, 2013, Environmental Microbiology on p. 313-324
Regulation of bacterial virulence by Csr (Rsm) systems
Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224
CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage
Alexander V. Yakhnin, Carol S. Baker, Christopher A. Vakulskas, Helen Yakhnin, Igor Berezin, Tony Romeo, Paul Babitzke, 2013, Molecular Microbiology on p. 851-866
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596
Global regulation by CsrA and its RNA antagonists
T Romeo, P Babitzke, 2018, Microbiology spectrum on p. 341-354
NusA-dependent transcription termination prevents misregulation of global gene expression
Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology
Dual posttranscriptional regulation via a cofactor-responsive mRNA leader
Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677
Regulation of CsrB/C sRNA decay by EIIA<sup>Glc</sup> of the phosphoenolpyruvate: Carbohydrate phosphotransferase system
Yuanyuan Leng, Christopher A. Vakulskas, Tesfalem R. Zere, Bradley S. Pickering, Paula I. Watnick, Paul Babitzke, Tony Romeo, 2016, Molecular Microbiology on p. 627-639
NusG is a sequence-specific RNA polymerase pause factor that binds to the non-template DNA within the paused transcription bubble
Alexander V. Yakhnin, Katsuhiko S. Murakami, Paul Babitzke, 2016, Journal of Biological Chemistry on p. 5299-5308
FliW and flis function independently to control cytoplasmic flagellin levels in Bacillus subtilis
Sampriti Mukherjee, Paul Babitzke, Daniel B. Kearns, 2013, Journal of Bacteriology on p. 297-306