Paul Babitzke
Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology

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0203 Althouse Lab
University Park, PA - pxb28@psu.edu
- 814-865-0002
Research Summary
Regulation of gene expression by RNA structure and RNA-binding proteins
Huck Affiliations
Links
Publication Tags
Rna Messenger Rna Gene Expression Proteins Escherichia Coli Bacillus Subtilis Rna Binding Proteins Ribosomes In Vitro Techniques Virulence Rna Stability Iron Bacteria Homeostasis Dna Directed Rna Polymerases Protein Regulation Regulator Genes Binding Sites Growth Biofilms Operon Gels Ribonuclease E GenesMost Recent Papers
NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome
Alexander V. Yakhnin, Peter C. FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F. Mandell, Mikhail Kashlev, Paul Babitzke, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 21628-21636
NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor
A Yakhnin, Mikhail Kashlev, Paul Babitzke, 2020, Critical Reviews in Biochemistry and Molecular Biology on p. 716-728
Diverse mechanisms and circuitry for global regulation by the RNA-binding protein CsrA
Christine Pourciao, Ying-Jung Lai, Mark Gorelik, Paul Babitzke, Tony Romeo, 2020, Frontiers in Microbiology on p. 601352
Nusg-dependent rna polymerase pausing and tylosin-dependent ribosome stalling are required for tylosin resistance by inducing 23s rrna methylation in bacillus subtilis
Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke, 2019, mBio
Regulation of iron storage by CsrA supports exponential growth of Escherichia coli
Christine Pourciau, Archana Pannuri, Anastasia Potts, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2019, mBio
Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins.
P Babitzke, Y-J Lai, A Renda, T Romeo, 2019, Annual Review of Microbiology on p. 43–67
NusG-dependent RNA polymerase pausing and tylosin-dependent ribosome stalling lead to antibiotic resistance by inducing 23S rRNA methylation
H Yakhnin, A Yakhnin, B Mouery, Z Mandell, C Karbasiafshar, M Kashlev, P Babitzke, 2019, mBio on p. e02665-19
In vivo RNA structural probing of uracil and guanine base-pairing by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)
David Mitchell, Andrew J. Renda, Catherine A. Douds, Paul Babitzke, Sarah M. Assmann, Philip C. Bevilacqua, 2019, RNA on p. 147-157
Examination of Csr regulatory circuitry using epistasis analysis with RNA-seq (Epi-seq) confirms that CsrD affects gene expression via CsrA, CsrB and CsrC
Anastasia H. Potts, Yuanyuan Leng, Paul Lee Babitzke, Tony Romeo, 2018, Scientific Reports
Global regulation by CsrA and its RNA antagonists
Tony Romeo, Paul Lee Babitzke, 2018, Microbiology spectrum
Most-Cited Papers
Regulation of bacterial virulence by Csr (Rsm) systems
Christopher A. Vakulskas, Anastasia H. Potts, Babitzke Paul, Brian M.M. Ahmer, Romeo Tony, 2015, Microbiology and Molecular Biology Reviews on p. 193-224
Circuitry linking the Csr and stringent response global regulatory systems
Adrianne N. Edwards, Laura M. Patterson-Fortin, Christopher A. Vakulskas, Jeffrey W. Mercante, Katarzyna Potrykus, Daniel Vinella, Martha I. Camacho, Joshua A. Fields, Stuart A. Thompson, Dimitris Georgellis, Michael Cashel, Paul Babitzke, Tony Romeo, 2011, Molecular Microbiology on p. 1561-1580
CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage
Alexander Victor Yakhnin, Carol Sue Baker, Christopher A. Vakulskas, Elena Borisovna Yakhnina, Igor Berezin, Tony Romeo, Paul Lee Babitzke, 2013, Molecular Microbiology on p. 851-866
Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD
Luary C. Martínez, Helen Yakhnin, Martha I. Camacho, Dimitris Georgellis, Paul Babitzke, José L. Puente, Víctor H. Bustamante, 2011, Molecular Microbiology on p. 1637-1656
CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis.
Subhanan Mukherjee, Elena Yakhnin, D Kysela, J Sokoloski, Paul Babitzke, D Kearns, 2011, Molecular Microbiology on p. 447-61
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
Anastasia H. Potts, Christopher A. Vakulskas, Archana Pannuri, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2017, Nature Communications on p. 1596
Complex regulation of the global regulatory gene csrA
Helen Yakhnin, Alexander V. Yakhnin, Carol S. Baker, Elena Sineva, Igor Berezin, Tony Romeo, Paul Babitzke, 2011, Molecular Microbiology on p. 689-704
Global regulation by CsrA and its RNA antagonists
Tony Romeo, Paul Lee Babitzke, 2018, Microbiology spectrum
Dual posttranscriptional regulation via a cofactor-responsive mRNA leader
Laura M. Patterson-Fortin, Christopher A. Vakulskas, Helen Yakhnin, Paul Babitzke, Tony Romeo, 2013, Journal of Molecular Biology on p. 3662-3677
Translational repression of NhaR, a novel pathway for multi-tier regulation of biofilm circuitry by CsrA
Archana Pannuri, Helen Yakhnin, Christopher A. Vakulskas, Adrianne N. Edwards, Paul Babitzke, Tony Romeo, 2012, Journal of Bacteriology on p. 79-89