Pamela Giblin

Professor of Immunology

Pamela Giblin

Research Summary

The role of receptor tyrosine kinases in normal physiology and disease progression; the downstream signals that mediate these responses in vivo and in vitro.

Huck Affiliations

Links

Publication Tags

Macrophages Receptor Protein Tyrosine Kinases Inflammation Liver Obesity Acetaminophen Purification Chemical Activation Ron Protein Tissue Neoplasms Macrophage Activation Stem Cells Diet Leukemia Leukemia, Erythroblastic, Acute Friend Murine Leukemia Virus Rice Bran Saccharide Atherosclerosis Erythropoiesis Phosphotransferases Spleen Ligands Heme Prostaglandins

Most Recent Papers

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science signaling

Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8<sup>+</sup> T-cell activation

Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting, 2019, Frontiers in immunology

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology

Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice

Michael W. Epperly, Xichen Zhang, Renee Fisher, Wen Hou, Darcy Franicola, Donna Shields, Michael Quickel, Pamela Hankey-Giblin, Hong Wang, Joel S. Greenberger, 2017, In Vivo on p. 313-320

Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation

Joselyn N. Allen, Adwitia Dey, Ruth Nissly, James Fraser, Shan Yu, Gayathri Balandaram, Jeffrey M. Peters, Pamela A. Hankey-Giblin, 2017, Journal of Visualized Experiments

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain

Xin Wang, Neela Yennawar, Pamela A. Hankey, 2014, Cell Communication and Signaling

The RON receptor tyrosine kinase

Xin Wang, Pamela Hankey Giblin, 2013, Critical Reviews in Immunology on p. 549-574

Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase

Carol R. Gardner, Pamela Hankey Giblin, Vladimir Mishin, Mary Francis, Shan Yu, Jeffrey D. Laskin, Debra L. Laskin, 2012, Toxicology and Applied Pharmacology on p. 139-148

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53

Shailaja Hegde, Pamela Hankey Giblin, Robert Paulson, 2012, STEM CELLS on p. 121-130

Most-Cited Papers

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase

Daniel R. Sharda, Shan Yu, Manujendra Ray, Mario Leonardo Squadrito, Michele De Palma, Thomas A. Wynn, Sidney M. Morris, Pamela A. Hankey, 2011, Journal of Immunology on p. 2181-2192

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein

Manujendra Ray, Shan Yu, Daniel R. Sharda, Caleph B. Wilson, Qingping Liu, Naveen Kaushal, K. Sandeep Prabhu, Pamela A. Hankey, 2010, Journal of Immunology on p. 7309-7316

Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase

Carol R. Gardner, Pamela Hankey Giblin, Vladimir Mishin, Mary Francis, Shan Yu, Jeffrey D. Laskin, Debra L. Laskin, 2012, Toxicology and Applied Pharmacology on p. 139-148

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53

Shailaja Hegde, Pamela Hankey Giblin, Robert Paulson, 2012, STEM CELLS on p. 121-130

The RON receptor tyrosine kinase

Xin Wang, Pamela Hankey Giblin, 2013, Critical Reviews in Immunology on p. 549-574

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265

Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats

Narasimha V. Hegde, Erica L. Unger, Gordon L. Jensen, Pamela A. Hankey, Robert F. Paulson, 2011, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. 470-476

Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation

Joselyn N. Allen, Adwitia Dey, Ruth Nissly, James Fraser, Shan Yu, Gayathri Balandaram, Jeffrey M. Peters, Pamela A. Hankey-Giblin, 2017, Journal of Visualized Experiments

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology