Pamela Giblin
Professor of Immunology
-
105 Henning
University Park, PA - phc7@psu.edu
- 814-863-0128
Research Summary
The role of receptor tyrosine kinases in normal physiology and disease progression; the downstream signals that mediate these responses in vivo and in vitro.
Huck Affiliations
Links
Publication Tags
Macrophages Inflammation Receptor Protein Tyrosine Kinases Liver Chemical Activation Tissue Obesity Diet Heme Purification Ribosomes Mitochondria Neoplasms Erythropoiesis Cells Stem Cells Nutrition Macrophage Activation Ron Protein Therapeutics Proteins Atherosclerosis Spleen Ligands LeukemiaMost Recent Papers
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science Signaling
Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8<sup>+</sup> T-cell activation
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting, 2019, Frontiers in Immunology
Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Joselyn Allen, Jingtao Zhang, Michael D. Quickel, Mary J. Kennett, Andrew David Patterson, Pamela Hankey Giblin, 2018, Journal of Proteome Research on p. 3268-3280
Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in Immunology
Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice
Michael W. Epperly, Xichen Zhang, Renee Fisher, Wen Hou, Darcy Franicola, Donna Shields, Michael Quickel, Pamela Hankey-Giblin, Hong Wang, Joel S. Greenberger, 2017, In Vivo on p. 313-320
Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Joselyn N. Allen, Adwitia Dey, Ruth Nissly, James Fraser, Shan Yu, Gayathri Balandaram, Jeffrey M. Peters, Pamela A. Hankey-Giblin, 2017, Journal of Visualized Experiments
The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics
Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Xin Wang, Neela Yennawar, Pamela A. Hankey, 2014, Cell Communication and Signaling
The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression.
Xiaoxing Wang, Pamela Hankey, 2013, Critical Reviews in Immunology on p. 549-574
Most-Cited Papers
Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase
Daniel R. Sharda, Shan Yu, Manujendra Ray, Mario Leonardo Squadrito, Michele De Palma, Thomas A. Wynn, Sidney M. Morris, Pamela A. Hankey, 2011, Journal of Immunology on p. 2181-2192
Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
C Gardner, Pamela Hankey, V Mishin, Matthew Francis, Shaoyong Yu, J Laskin, D Laskin, 2012, Toxicology and Applied Pharmacology on p. 139-148
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science Signaling
The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265
Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
Shailaja Hegde, Pamela Hankey, Robert F. Paulson, 2012, Stem Cells on p. 121-130
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics
The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression.
Xiaoxing Wang, Pamela Hankey, 2013, Critical Reviews in Immunology on p. 549-574
Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats
Narasimha V. Hegde, Erica L. Unger, Gordon L. Jensen, Pamela A. Hankey, Robert F. Paulson, 2011, American Journal of Physiology on p. 470-476
Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Joselyn N. Allen, Adwitia Dey, Ruth Nissly, James Fraser, Shan Yu, Gayathri Balandaram, Jeffrey M. Peters, Pamela A. Hankey-Giblin, 2017, Journal of Visualized Experiments