Pamela Giblin

Professor of Immunology

Pamela Giblin

Research Summary

The role of receptor tyrosine kinases in normal physiology and disease progression; the downstream signals that mediate these responses in vivo and in vitro.

Huck Affiliations

Links

Publication Tags

Macrophages Receptor Protein Tyrosine Kinases Inflammation Liver Mitochondria Ribosomes Diet Obesity Proteins Friend Murine Leukemia Virus Stem Cells Ligands Chemical Activation Cells Leukemia, Erythroblastic, Acute Tissue Health Leukemia Erythropoiesis Atherosclerosis Tyrosine Heme Purification Protein Omega 3 Fatty Acids

Most Recent Papers

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling.

J Allen, A Dey, Jingjing Cai, J Zhang, Y Tian, Mary Kennett, Yanyuan Ma, T Liang, Andrew Patterson, Pamela Hankey, 2020, Metabolites

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science signaling

Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8<sup>+</sup> T-cell activation

Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting, 2019, Frontiers in immunology

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model

Joselyn Allen, Jingtao Zhang, Michael D. Quickel, Mary J. Kennett, Andrew David Patterson, Pamela Hankey Giblin, 2018, Journal of Proteome Research on p. 3268-3280

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology

Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice

Michael W. Epperly, Xichen Zhang, Renee Fisher, Wen Hou, Darcy Franicola, Donna Shields, Michael Quickel, Pamela Hankey-Giblin, Hong Wang, Joel S. Greenberger, 2017, In Vivo on p. 313-320

Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation

Joselyn N. Allen, Adwitia Dey, Ruth Nissly, James Fraser, Shan Yu, Gayathri Balandaram, Jeffrey M. Peters, Pamela A. Hankey-Giblin, 2017, Journal of Visualized Experiments

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain

Xin Wang, Neela Yennawar, Pamela A. Hankey, 2014, Cell Communication and Signaling

Most-Cited Papers

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase

Daniel R. Sharda, Shan Yu, Manujendra Ray, Mario Leonardo Squadrito, Michele De Palma, Thomas A. Wynn, Sidney M. Morris, Pamela A. Hankey, 2011, Journal of Immunology on p. 2181-2192

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein

Manujendra Ray, Shan Yu, Daniel R. Sharda, Caleph B. Wilson, Qingping Liu, Naveen Kaushal, K. Sandeep Prabhu, Pamela A. Hankey, 2010, Journal of Immunology on p. 7309-7316

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53

Shailaja Hegde, Pamela Hankey Giblin, Robert Paulson, 2012, STEM CELLS on p. 121-130

Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia

Debra L. Laskin, Li Chen, Pamela A. Hankey, Jeffrey D. Laskin, 2010, Journal of Leukocyte Biology on p. 373-382

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey Maurice Peters, Andrew David Patterson, Pamela Hankey Giblin, 2016, Journal of Immunology on p. 256-265

Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk

Shihan He, Shuang Ni, Shailaja Hegde, Xin Wang, Daniel R. Sharda, Avery August, Robert F. Paulson, Pamela A. Hankey, 2010, Journal of virology on p. 2223-2235

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics

Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats

Narasimha V. Hegde, Erica L. Unger, Gordon L. Jensen, Pamela A. Hankey, Robert F. Paulson, 2011, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. 470-476

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology