Molly Hall
Dr. Frances Keesler Graham Early Career Professor; Assistant Professor of Veterinary and Biomedical Sciences

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512A Wartik Lab
University Park, PA - mah546@psu.edu
- 814-865-0794
Research Summary
Building tools to elucidate the complex genetic and environmental underpinnings of human disease. Integrating genetic (genotype, sequence, structural variation) and exposure (derived from surveys and metabolomics methods) big data to predict disease status.
Huck Graduate Students
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Integrative and Biomedical Physiology
- Center for Molecular Toxicology and Carcinogenesis
Links
Publication Tags
Genes Genomics Single Nucleotide Polymorphism Health Phenotype Electronic Health Records Genome Wide Association Study Cataract Metabolomics Gene Electronics Genome Precision Medicine Smoking Datasets (1,2 Diamino 4 Nitrobenzene)Dichloroplatinum(Ii) Environmental Exposure Glaucoma Nuclear Magnetic Resonance Pleiotropy Vaccines Obesity Polymorphism Medicine SoftwareMost Recent Publications
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Sougat Misra, Tai Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu, 2023, Redox Biology
Hypothalamic-pituitary-adrenal axis dysregulation and risk for obesity in sexually abused females
J Li, Molly Hall, F Putnam, J Noll, 2022, Psychoneuroendocrinology
Obesity and accelerated epigenetic aging in a high-risk cohort of children
Laura Etzel, Waylon Hastings, Molly A. Hall, Christine M. Heim, Michael Meaney, Jennie G. Noll, Kieran J. O’Donnell, E Rose, H Schrier, Irina Pokhvisneva, C Shenk, Emma J. Rose, Hannah M.C. Schreier, I Shalev, Chad E. Shenk, Idan Shalev, 2022, Scientific Reports
Sex differences in the metabolome of Alzheimer's disease progression
Tomas Gonzlaez-Zarzar, Brian Lee, Rory Coughlin, Dokyoon Kim, Li Shen, Molly Hall, 2022, Frontiers in Radiology
Dynamic assessment of the COVID-19 vaccine acceptance leveraging social media data
Lingyao Li, Jiayan Zhou, Zihui Ma, Michelle T. Bensi, Molly A. Hall, Gregory B. Baecher, 2022, Journal of Biomedical Informatics
Hypothalamic-pituitary-adrenal axis attenuation and obesity risk in sexually abused females
Jacinda Li, Molly A. Hall, Idan Shalev, Hannah M.C. Schreier, Tom´as Gonz´alez Zarzar, Isabel Marcovici, Frank Putnam, Jennie G. Noll, 2021, Psychoneuroendocrinology
Novel EDGE encoding method enhances ability to identify genetic interactions
Molly A. Hall, John Wallace, Anastasia M. Lucas, Yuki Bradford, Shefali S. Verma, Bertram Müller-Myhsok, Kristin Passero, Jiayan Zhou, John McGuigan, Beibei Jiang, Sarah A. Pendergrass, Yanfei Zhang, Peggy Peissig, Murray Brilliant, Patrick Sleiman, Hakon Hakonarson, John B. Harley, Krzysztof Kiryluk, Kristel van Steen, Jason H. Moore, Marylyn D. Ritchie, 2021, PLoS Genetics
Can social media be utilized to enhance early warning: Retrospective analysis of the U.S. COVID-19 pandemic outbreak
L Lingyao, L Gao, J Zhou, Z Ma, Molly Hall, 2021, medRxiv
Semi-automated NMR Pipeline for Environmental Exposures: New Insights on the Metabolomics of Smokers versus Non-smokers
Morris A. Aguilar, John McGuigan, Molly A. Hall, 2021, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing on p. 316-327
What about the environment? Leveraging multi-omic datasets to characterize the environment's role in human health
K Passero, S Setia-Verma, K McAllister, A Manrai, C Patel, Molly Hall, 2021, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing on p. 309-315
Most-Cited Papers
Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health
Arjun K. Manrai, Yuxia Cui, Pierre R. Bushel, Molly Hall, Spyros Karakitsios, Carolyn J. Mattingly, Marylyn Ritchie, Charles Schmitt, Denis A. Sarigiannis, Duncan C. Thomas, David Wishart, David M. Balshaw, Chirag J. Patel, 2017, Annual Review of Public Health on p. 279-294
Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
Molly A. Hall, Anurag Verma, Kristin D. Brown-Gentry, Robert Goodloe, Jonathan Boston, Sarah Wilson, Bob McClellan, Cara Sutcliffe, Holly H. Dilks, Nila B. Gillani, Hailing Jin, Ping Mayo, Melissa Allen, Nathalie Schnetz-Boutaud, Dana C. Crawford, Marylyn D. Ritchie, Sarah A. Pendergrass, 2014, PLoS Genetics
Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank
Molly A. Hall, Scott M. Dudek, Robert Goodloe, Dana C. Crawford, Sarah A. Pendergrass, Peggy Peissig, Murray Brilliant, Catherine A. McCarty, Marylyn D. Ritchie, 2014, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing on p. 200-211
Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium
Shefali Setia Verma, Jessica N. Cooke Bailey, Anastasia Lucas, Yuki Bradford, James G. Linneman, Michael A. Hauser, Louis R. Pasquale, Peggy L. Peissig, Murray H. Brilliant, Catherine A. McCarty, Jonathan L. Haines, Janey L. Wiggs, Tamara R. Vrabec, Gerard Tromp, Marylyn D. Ritchie, Jonathan Bickel, Ariel Chandler, Ingrid Holm, Isaac Kohane, Shannon Manzi, Kyriacos Markianos, Nathan Palmer, Cassandra Perry, Guergana Savova, Wendy Wolf, Sek Wong Kong, Armand Antommaria, Beth Cobb, John Harley, John Hutton, Todd Lingren, John Lynch, Keith Marsolo, Melanie Myers, Bahram Namjou, Cindy Prows, Imre Solti, Sander Vinks, Michael Wagner, Debbie Abrams, Berta Almoguera, Rosetta Chiavacci, John Connolly, Marcella Devoto, Hakon Hakonarson, Brendan Keating, Cecilia Kim, Frank Mentch, Haijun Qui, Patrick Sleiman, 2016, PLoS Genetics
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci
Marylyn D. Ritchie, Shefali S. Verma, Molly A. Hall, Robert J. Goodloe, Richard L. Berg, Dave S. Carrell, Christopher S. Carlson, Lin Chen, David R. Crosslin, Joshua C. Denny, Gail Jarvik, Rongling Li, James G. Linneman, Jyoti Pathak, Peggy Peissig, Luke V. Rasmussen, Andrea H. Ramirez, Xiaoming Wang, Russell A. Wilke, Wendy A. Wolf, Eric S. Torstenson, Stephen D. Turner, Catherine A. McCarty, 2014, Molecular Vision on p. 1281-1295
The joint effect of air pollution exposure and copy number variation on risk for autism
Dokyoon Kim, Heather Volk, Santhosh Girirajan, Sarah Pendergrass, Molly A. Hall, Shefali S. Verma, Rebecca J. Schmidt, Robin L. Hansen, Debashis Ghosh, Yunin Ludena-Rodriguez, Kyoungmi Kim, Marylyn D. Ritchie, Irva Hertz-Picciotto, Scott B. Selleck, 2017, Autism Research on p. 1470-1480
PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies
Molly A. Hall, John Wallace, Anastasia Lucas, Dokyoon Kim, Anna O. Basile, Shefali S. Verma, Cathy A. McCarty, Murray H. Brilliant, Peggy L. Peissig, Terrie E. Kitchner, Anurag Verma, Sarah A. Pendergrass, Scott M. Dudek, Jason H. Moore, Marylyn D. Ritchie, 2017, Nature Communications
Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine
Molly A. Hall, Jason H. Moore, Marylyn D. Ritchie, 2016, Trends in Genetics on p. 470-484
Next-generation analysis of cataracts: Determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the PhenX Toolkit
Sarah A. Pendergrass, Shefali S. Verma, Molly A. Hall, Emily R. Holzinger, Carrie B. Moore, John R. Wallace, Scott M. Dudek, Wayne Huggins, Terrie Kitchner, Carol Waudby, Richard Berg, Catherine A. McCarty, Marylyn D. Ritchie, 2013, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing on p. 147-158
Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network
Molly A. Hall, Shefali S. Verma, John Wallace, Anastasia Lucas, Richard L. Berg, John Connolly, Dana C. Crawford, David R. Crosslin, Mariza de Andrade, Kimberly F. Doheny, Jonathan L. Haines, John B. Harley, Gail P. Jarvik, Terrie Kitchner, Helena Kuivaniemi, Eric B. Larson, David S. Carrell, Gerard Tromp, Tamara R. Vrabec, Sarah A. Pendergrass, Catherine A. Mccarty, Marylyn D. Ritchie, 2015, Genetic Epidemiology on p. 376-384
News Articles Featuring Molly Hall
Aug 25, 2022
Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline
As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.
Full Article
Mar 26, 2019
Hall, Brent to receive Roy C. Buck awards during annual celebration
Two faculty members in Penn State’s College of Agricultural Sciences have been named the recipients of the 2018 Roy C. Buck Faculty Award, which recognizes exceptional articles accepted or published by refereed scholarly journals in the social and human sciences within the past two years.
Full Article