Michael Axtell

Professor of Biology

Michael Axtell

Research Summary

Discovery and characterization of plant microRNAs and siRNAs. Functions of microRNAs and siRNAs in the evolution of plant development. Genomics and bioinformatics of microRNAs, siRNAs, and their targets

Graduate Students

Huck Affiliations

Links

Publication Tags

Rna Small Interfering Rna Micrornas Arabidopsis Genome Microrna Genes Nucleotides Loci Bioinformatics Arabidopsis Thaliana Proteins Tobacco Transcriptome Parasitic Plants Messenger Rna Dna Methylation Mutants Angiosperms Cuscuta Campestris Lycopersicon Esculentum Zea Mays Oryza Bryopsida Viruses

Most Recent Papers

Convergent horizontal gene transfer and cross-talk of mobile nucleic acids in parasitic plants

Zhenzhen Yang, Eric K. Wafula, Gunjune Kim, Saima Shahid, Joel R. McNeal, Paula E. Ralph, Prakash R. Timilsena, Wen bin Yu, Elizabeth A. Kelly, Huiting Zhang, Thomas Nate Person, Naomi S. Altman, Michael J. Axtell, James H. Westwood, Claude W. dePamphilis, 2019, Nature Plants on p. 991-1001

Arabidopsis bioinformatics resources

Colleen Doherty, Joanna Friesner, Brian Gregory, Ann Loraine, Molly Megraw, Nicholas Provart, R. Keith Slotkin, Chris Town, Sarah M. Assmann, Michael Axtell, Tanya Berardini, Sixue Chen, Malia Gehan, Eva Huala, Pankaj Jaiswal, Stephen Larson, Song Li, Sean May, Todd Michael, Chris Pires, Chris Topp, Justin Walley, Eve Wurtele, 2019, Plant Direct

Analysis of RDR1/RDR2/RDR6-independent small RNAs in Arabidopsis thaliana improves MIRNA annotations and reveals unexplained types of short interfering RNA loci

Seth Polydore, Michael Axtell, 2018, Plant Journal on p. 1051-1063

MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs

Saima Shahid, Gunjune Kim, Nathan R. Johnson, Eric Wafula, Feng Wang, Ceyda Coruh, Vivian Bernal-Galeano, Tamia Phifer, Claude W. Depamphilis, James H. Westwood, Michael J. Axtell, 2018, Nature on p. 82-85

AGO4 is specifically required for heterochromatic siRNA accumulation at Pol V-dependent loci in Arabidopsis thaliana

Feng Wang, Michael J. Axtell, 2017, Plant Journal on p. 37-47

Genome-wide analysis of single non-Templated nucleotides in plant endogenous siRNAs and miRNAs

Feng Wang, Nathan R. Johnson, Ceyda Coruh, Michael J. Axtell, 2016, Nucleic acids research on p. 7395-7405

Improved placement of multi-mapping small RNAs

Nathan R. Johnson, Jonathan M. Yeoh, Ceyda Coruh, Michael J. Axtell, 2016, G3: Genes, Genomes, Genetics on p. 2103-2111

Genome-wide characterization of maize small RNA loci and their regulation in the Required to maintain repression6-1 (Rmr6-1) mutant and long-term abiotic stresses

Alice Lunardon, Cristian Forestan, Silvia Farinati, Michael Axtell, Serena Varotto, 2016, Plant physiology on p. 1535-1548

Comparison of small RNA profiles in Nicotiana benthamiana and Solanum lycopersicum infected by polygonum ringspot tospovirus reveals host-specific responses to viral infection

Paolo Margaria, Laura Miozzi, Marina Ciuffo, Cristina Rosa, Michael Axtell, Hanu R. Pappu, Massimo Turina, 2016, Virus Research on p. 38-45

Identification of apple miRNAs and their potential role in fire blight resistance

Elżbieta Kaja, Michał W. Szcześniak, Philip J. Jensen, Michael Axtell, Timothy W. McNellis, Izabela Makałowska, 2015, Tree Genetics and Genomes

Most-Cited Papers

The selaginella genome identifies genetic changes associated with the evolution of vascular plants

Jo Ann Banks, Tomoaki Nishiyama, Mitsuyasu Hasebe, John L. Bowman, Michael Gribskov, Claude DePamphilis, Victor A. Albert, Naoki Aono, Tsuyoshi Aoyama, Barbara A. Ambrose, Neil W. Ashton, Michael J. Axtell, Elizabeth Barker, Michael S. Barker, Jeffrey L. Bennetzen, Nicholas D. Bonawitz, Clint Chapple, Chaoyang Cheng, Luiz Gustavo Guedes Correa, Michael Dacre, Jeremy DeBarry, Ingo Dreyer, Marek Elias, Eric M. Engstrom, Mark Estelle, Liang Feng, Cédric Finet, Sandra K. Floyd, Wolf B. Frommer, Tomomichi Fujita, Lydia Gramzow, Michael Gutensohn, Jesper Harholt, Mitsuru Hattori, Alexander Heyl, Tadayoshi Hirai, Yuji Hiwatashi, Masaki Ishikawa, Mineko Iwata, Kenneth G. Karol, Barbara Koehler, Uener Kolukisaoglu, Minoru Kubo, Tetsuya Kurata, Sylvie Lalonde, Kejie Li, Ying Li, Amy Litt, Eric Lyons, Gerard Manning, Takeshi Maruyama, Todd P. Michael, Koji Mikami, Saori Miyazaki, Shin Ichi Morinaga, TakashiMurata, Bernd Mueller-Roeber, David R. Nelson, Mari Obara, Yasuko Oguri, Richard G. Olmstead, Naoko Onodera, Bent Larsen Petersen, Birgit Pils, Michael Prigge, Stefan A. Rensing, Diego Mauricio Riaño-Pachón, Alison W. Roberts, Yoshikatsu Sato, Henrik Vibe Scheller, Burkhard Schulz, Christian Schulz, Eugene V. Shakirov, Nakako Shibagaki, Naoki Shinohara, Dorothy E. Shippen, Iben Sørensen, Ryo Sotooka, Nagisa Sugimoto, Mamoru Sugita, Naomi Sumikawa, Milos Tanurdzic, Günter Theißen, Peter Ulvskov, Sachiko Wakazuki, Jing Ke Weng, William W.G.T. Willats, Daniel Wipf, Paul G. Wolf, Lixing Yang, Andreas D. Zimmer, Qihui Zhu, Therese Mitros, Uffe Hellsten, Dominique Loqué, Robert Otillar, Asaf Salamov, Jeremy Schmutz, Harris Shapiro, Erika Lindquist, Susan Lucas, Daniel Rokhsar, Igor V. Grigoriev, 2011, Science on p. 960-963

The Amborella genome and the evolution of flowering plants

Claude W. DePamphilis, Jeffrey D. Palmer, Steve Rounsley, David Sankoff, Stephan C. Schuster, Jetty S.S. Ammiraju, W. Bradley Barbazuk, Srikar Chamala, Andre S. Chanderbali, Ronald Determann, Ma Hong, Paula Ralph, Jason Talag, Lynn Tomsho, Brandon Walts, Stefan Wanke, Rod A. Wing, Tien Hao Chang, Tianying Lan, Douglas E. Soltis, Siwaret Arikit, Michael J. Axtell, Saravanaraj Ayyampalayam, James M. Burnette, Emanuele De Paoli, Nina P. Farrell, Alex Harkess, Yuannian Jiao, James Leebens-Mack, Kun Liu, Wenbin Mei, Blake C. Meyers, Saima Shahid, Eric Wafula, Susan R. Wessler, Jixian Zhai, Xiaoyu Zhang, Victor A. Albert, Lorenzo Carretero-Paulet, Eric Lyons, Haibao Tang, Chunfang Zheng, Naomi S. Altman, Feng Chen, Jian Qun Chen, Vincent Chiang, Joshua P. Der, Bruno Fogliani, Chunce Guo, Jesper Harholt, Claudette Job, Dominique Job, Sangtae Kim, Hongzhi Kong, Guanglin Li, N. Li, Jie Liu, Jongsun Park, Xinshuai Qi, Loïc Rajjou, Valérie Burtet-Sarramegna, Ron Sederoff, Ying Hsuan Sun, Peter Ulvskov, Matthieu Villegente, Jia Yu Xue, Ting Feng Yeh, Xianxian Yu, Juan J. Acosta, Riva A. Bruenn, Alexandre De Kochko, Luis R. Herrera-Estrella, Enrique Ibarra-Laclette, Matias Kirst, Solon P. Pissis, Valérie Poncet, Pamela S. Soltis, 2013, Science

Transcriptome-wide identification of microRNA targets in rice

Yong Fang Li, Yun Zheng, Charles Addo-Quaye, Li Zhang, Ajay Saini, Guru Jagadeeswaran, Michael J. Axtell, Weixiong Zhang, Ramanjulu Sunkar, 2010, Plant Journal on p. 742-759

Arabidopsis lyrata small RNAs

Zhaorong Ma, Ceyda Coruh, Michael J. Axtell, 2010, Plant Cell on p. 1090-1103

RNA Secondary Structural Determinants of miRNA Precursor Processing in Arabidopsis

Liang Song, Michael J. Axtell, Nina V. Fedoroff, 2010, Current Biology on p. 37-41

ShortStack

Michael J. Axtell, 2013, RNA on p. 740-751

Analysis of complementarity requirements for plant MicroRNA targeting using a Nicotiana benthamiana quantitative transient assay

Qikun Liu, Feng Wang, Michael J. Axtell, 2014, Plant Cell on p. 741-753

miR156 and miR390 regulate tasiRNA accumulation and developmental timing in physcomitrella patens

Sung Hyun Cho, Ceyda Coruh, Michael J. Axtell, 2013, Plant Cell on p. 4837-4849

Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1

Hongliang Zhu, Yuyi Zhou, Claudia Castillo-González, Amber Lu, Chunxiao Ge, Ying Tao Zhao, Liusheng Duan, Zhaohu Li, Michael Axtell, Xiu Jie Wang, Xiuren Zhang, 2013, Nature Structural and Molecular Biology on p. 1106-1115

A non-canonical plant microRNA target site

Cécile Brousse, Qikun Liu, Linda Beauclair, Aurélie Deremetz, Michael J. Axtell, Nicolas Bouché, 2014, Nucleic acids research on p. 5270-5279

News Articles Featuring Michael Axtell

Agricultural parasite avoids evolutionary arms race, shuts down genes of host

A parasitic plant has found a way to circumvent an evolutionary arms race with the host plants from which it steals nutrients, allowing the parasite to thrive on a variety of agriculturally important plants. The parasite dodder, an agricultural pest found on every continent, sends genetic material into its host to shut down host defense genes.

Natural GMOs: Parasitic plants steal host DNA to siphon off needed resources

Some parasitic plants steal genetic material from their host plants and use the stolen genes to more effectively siphon off the host’s nutrients. A new study led by researchers at Penn State and Virginia Tech reveals that the parasitic plant dodder has stolen a large amount of genetic material from its hosts, including over 100 functional genes.

Parasitic plants use stolen genes to make them better parasites

Some parasitic plants steal genetic material from their host plants and use the stolen genes to more effectively siphon off the host’s nutrients. A new study led by researchers at Penn State and Virginia Tech reveals that the parasitic plant dodder has stolen a large amount of genetic material from its hosts, including over 100 functional genes.

Michael Axtell Among Five Receiving Faculty Scholar Medals

Five Penn State faculty members have received 2019 Faculty Scholar Medals for Outstanding Achievement for excellence in scholarship, research and the arts.