Michael Axtell

Professor of Biology

Michael Axtell

Research Summary

Discovery and characterization of plant microRNAs and siRNAs. Functions of microRNAs and siRNAs in the evolution of plant development. Genomics and bioinformatics of microRNAs, siRNAs, and their targets

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Micrornas Genes Genome Rna Microrna Small Interfering Rna Parasitic Plants Messenger Rna Arabidopsis Cuscuta Campestris Angiosperms Tobacco Nicotiana Benthamiana Horizontal Gene Transfer Bryopsida Blood Vessels Angiospermae Nucleic Acids Assays Copper Binding Protein Selaginellaceae Cacao Physcomitrella Patens Proteins Nucleotides

Most Recent Papers

Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming

Xiaodong Yang, Robersy Sanchez, Hardik Kundariya, Tom Maher, Isaac Dopp, Rosemary Schwegel, Kamaldeep Virdi, Michael J. Axtell, Sally A. Mackenzie, 2020, Nature communications

MSH1-induced heritable enhanced growth vigor through grafting is associated with the RdDM pathway in plants

Hardik Kundariya, Xiaodong Yang, Kyla Morton, Robersy Sanchez, Michael J. Axtell, Samuel F. Hutton, Michael Fromm, Sally A. Mackenzie, 2020, Nature communications

Mechanisms of Resistance and Virulence in Parasitic Plant–Host Interactions

Markus Albert, Michael Axtell, Michael Timko, 2020, Plant Physiology

Integrated annotations and analyses of small RNA-producing loci from 47 diverse plants

Alice Lunardon, Nathan R. Johnson, Emily Hagerott, Tamia Phifer, Seth Polydore, Ceyda Coruh, Michael J. Axtell, 2020, Genome research on p. 497-513

Exchange of small regulatory rnas between plants and their pests

Collin Hudzik, Yingnan Hou, Wenbo Ma, Michael J. Axtell, 2020, Plant physiology on p. 51-62

Compensatory sequence variation between trans-species small rnas and their target sites

Nathan R. Johnson, Claude W. de Pamphilis, Michael J. Axtell, 2019, eLife

Exchange of small regulatory RNAs between plants and their pests

Collin Hudzik, Yingnan Hou, Wenbo Ma, Michael Axtell, 2019, Plant Physiology on p. pp.00931.2019

Convergent horizontal gene transfer and cross-talk of mobile nucleic acids in parasitic plants

Zhenzhen Yang, Eric K. Wafula, Gunjune Kim, Saima Shahid, Joel R. McNeal, Paula E. Ralph, Prakash R. Timilsena, Wen bin Yu, Elizabeth A. Kelly, Huiting Zhang, Thomas Nate Person, Naomi S. Altman, Michael J. Axtell, James H. Westwood, Claude W. dePamphilis, 2019, Nature Plants on p. 991-1001

Small RNA warfare: exploring origins and function of trans-species microRNAs from the parasitic plant Cuscuta

Nathan Johnson, Michael Axtell, 2019, Current Opinion in Plant Biology on p. 76--81

MicroRNAs in Plants: Key Findings from the Early Years

Blake Meyers, Michael Axtell, 2019, The Plant Cell on p. 1206--1207

Most-Cited Papers

The selaginella genome identifies genetic changes associated with the evolution of vascular plants

Jo Ann Banks, Tomoaki Nishiyama, Mitsuyasu Hasebe, John L. Bowman, Michael Gribskov, Claude DePamphilis, Victor A. Albert, Naoki Aono, Tsuyoshi Aoyama, Barbara A. Ambrose, Neil W. Ashton, Michael J. Axtell, Elizabeth Barker, Michael S. Barker, Jeffrey L. Bennetzen, Nicholas D. Bonawitz, Clint Chapple, Chaoyang Cheng, Luiz Gustavo Guedes Correa, Michael Dacre, Jeremy DeBarry, Ingo Dreyer, Marek Elias, Eric M. Engstrom, Mark Estelle, Liang Feng, Cédric Finet, Sandra K. Floyd, Wolf B. Frommer, Tomomichi Fujita, Lydia Gramzow, Michael Gutensohn, Jesper Harholt, Mitsuru Hattori, Alexander Heyl, Tadayoshi Hirai, Yuji Hiwatashi, Masaki Ishikawa, Mineko Iwata, Kenneth G. Karol, Barbara Koehler, Uener Kolukisaoglu, Minoru Kubo, Tetsuya Kurata, Sylvie Lalonde, Kejie Li, Ying Li, Amy Litt, Eric Lyons, Gerard Manning, Takeshi Maruyama, Todd P. Michael, Koji Mikami, Saori Miyazaki, Shin Ichi Morinaga, TakashiMurata, Bernd Mueller-Roeber, David R. Nelson, Mari Obara, Yasuko Oguri, Richard G. Olmstead, Naoko Onodera, Bent Larsen Petersen, Birgit Pils, Michael Prigge, Stefan A. Rensing, Diego Mauricio Riaño-Pachón, Alison W. Roberts, Yoshikatsu Sato, Henrik Vibe Scheller, Burkhard Schulz, Christian Schulz, Eugene V. Shakirov, Nakako Shibagaki, Naoki Shinohara, Dorothy E. Shippen, Iben Sørensen, Ryo Sotooka, Nagisa Sugimoto, Mamoru Sugita, Naomi Sumikawa, Milos Tanurdzic, Günter Theißen, Peter Ulvskov, Sachiko Wakazuki, Jing Ke Weng, William W.G.T. Willats, Daniel Wipf, Paul G. Wolf, Lixing Yang, Andreas D. Zimmer, Qihui Zhu, Therese Mitros, Uffe Hellsten, Dominique Loqué, Robert Otillar, Asaf Salamov, Jeremy Schmutz, Harris Shapiro, Erika Lindquist, Susan Lucas, Daniel Rokhsar, Igor V. Grigoriev, 2011, Science on p. 960-963

The genome of Theobroma cacao

Xavier Argout, Jerome Salse, Jean Marc Aury, Mark Guiltinan, Gaetan Droc, Jerome Gouzy, Mathilde Allegre, Cristian Chaparro, Thierry Legavre, Siela Maximova, Michael Abrouk, Florent Murat, Olivier Fouet, Julie Poulain, Manuel Ruiz, Yolande Roguet, Maguy Rodier-Goud, Jose Fernandes Barbosa-Neto, Francois Sabot, Dave Kudrna, Jetty Siva S. Ammiraju, Stephan C. Schuster, John Edward Carlson, Erika Sallet, Thomas Schiex, Anne Dievart, Melissa Kramer, Laura Gelley, Zi Shi, Aurélie Bérard, Christopher Viot, Michel Boccara, Ange Marie Risterucci, Valentin Guignon, Xavier Sabau, Michael Axtell, Zhaorong Ma, Yufan Zhang, Spencer Brown, Mickael Bourge, Wolfgang Golser, Xiang Song, Didier Clement, Ronan Rivallan, Mathias Tahi, Joseph Moroh Akaza, Bertrand Pitollat, Karina Gramacho, Anglique D'Hont, Dominique Brunel, Diogenes Infante, Ismael Kebe, Pierre Costet, Rod Wing, W. Richard McCombie, Emmanuel Guiderdoni, Francis Quetier, Olivier Panaud, Patrick Wincker, Stephanie Bocs, Claire Lanaud, 2011, Nature Genetics on p. 101-108

The Amborella genome and the evolution of flowering plants

Claude W. DePamphilis, Jeffrey D. Palmer, Steve Rounsley, David Sankoff, Stephan C. Schuster, Jetty S.S. Ammiraju, W. Bradley Barbazuk, Srikar Chamala, Andre S. Chanderbali, Ronald Determann, Ma Hong, Paula Ralph, Jason Talag, Lynn Tomsho, Brandon Walts, Stefan Wanke, Rod A. Wing, Tien Hao Chang, Tianying Lan, Douglas E. Soltis, Siwaret Arikit, Michael J. Axtell, Saravanaraj Ayyampalayam, James M. Burnette, Emanuele De Paoli, Nina P. Farrell, Alex Harkess, Yuannian Jiao, James Leebens-Mack, Kun Liu, Wenbin Mei, Blake C. Meyers, Saima Shahid, Eric Wafula, Susan R. Wessler, Jixian Zhai, Xiaoyu Zhang, Victor A. Albert, Lorenzo Carretero-Paulet, Eric Lyons, Haibao Tang, Chunfang Zheng, Naomi S. Altman, Feng Chen, Jian Qun Chen, Vincent Chiang, Joshua P. Der, Bruno Fogliani, Chunce Guo, Jesper Harholt, Claudette Job, Dominique Job, Sangtae Kim, Hongzhi Kong, Guanglin Li, N. Li, Jie Liu, Jongsun Park, Xinshuai Qi, Loïc Rajjou, Valérie Burtet-Sarramegna, Ron Sederoff, Ying Hsuan Sun, Peter Ulvskov, Matthieu Villegente, Jia Yu Xue, Ting Feng Yeh, Xianxian Yu, Juan J. Acosta, Riva A. Bruenn, Alexandre De Kochko, Luis R. Herrera-Estrella, Enrique Ibarra-Laclette, Matias Kirst, Solon P. Pissis, Valérie Poncet, Pamela S. Soltis, 2013, Science

ShortStack

Michael J. Axtell, 2013, RNA on p. 740-751

Analysis of complementarity requirements for plant MicroRNA targeting using a Nicotiana benthamiana quantitative transient assay

Qikun Liu, Feng Wang, Michael J. Axtell, 2014, Plant Cell on p. 741-753

MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs

Saima Shahid, Gunjune Kim, Nathan R. Johnson, Eric Wafula, Feng Wang, Ceyda Coruh, Vivian Bernal-Galeano, Tamia Phifer, Claude W. Depamphilis, James H. Westwood, Michael J. Axtell, 2018, Nature on p. 82-85

miR156 and miR390 regulate tasiRNA accumulation and developmental timing in physcomitrella patens

Sung Hyun Cho, Ceyda Coruh, Michael J. Axtell, 2013, Plant Cell on p. 4837-4849

Improved placement of multi-mapping small RNAs

Nathan R. Johnson, Jonathan M. Yeoh, Ceyda Coruh, Michael J. Axtell, 2016, G3: Genes, Genomes, Genetics on p. 2103-2111

Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1

Hongliang Zhu, Yuyi Zhou, Claudia Castillo-González, Amber Lu, Chunxiao Ge, Ying Tao Zhao, Liusheng Duan, Zhaohu Li, Michael Axtell, Xiu Jie Wang, Xiuren Zhang, 2013, Nature Structural and Molecular Biology on p. 1106-1115

A non-canonical plant microRNA target site

Cécile Brousse, Qikun Liu, Linda Beauclair, Aurélie Deremetz, Michael J. Axtell, Nicolas Bouché, 2014, Nucleic acids research on p. 5270-5279

News Articles Featuring Michael Axtell

Agricultural parasite avoids evolutionary arms race, shuts down genes of host

A parasitic plant has found a way to circumvent an evolutionary arms race with the host plants from which it steals nutrients, allowing the parasite to thrive on a variety of agriculturally important plants. The parasite dodder, an agricultural pest found on every continent, sends genetic material into its host to shut down host defense genes.

Natural GMOs: Parasitic plants steal host DNA to siphon off needed resources

Some parasitic plants steal genetic material from their host plants and use the stolen genes to more effectively siphon off the host’s nutrients. A new study led by researchers at Penn State and Virginia Tech reveals that the parasitic plant dodder has stolen a large amount of genetic material from its hosts, including over 100 functional genes.

Parasitic plants use stolen genes to make them better parasites

Some parasitic plants steal genetic material from their host plants and use the stolen genes to more effectively siphon off the host’s nutrients. A new study led by researchers at Penn State and Virginia Tech reveals that the parasitic plant dodder has stolen a large amount of genetic material from its hosts, including over 100 functional genes.

Michael Axtell Among Five Receiving Faculty Scholar Medals

Five Penn State faculty members have received 2019 Faculty Scholar Medals for Outstanding Achievement for excellence in scholarship, research and the arts.