Mechelle Lewis

Associate Professor Neurology and Pharmacology

Mechelle Lewis

Huck Affiliations

Publication Tags

Parkinson Disease Manganese Iron Red Nucleus Substantia Nigra Brain Metal Dopamine Agonists Prions Inflammasomes Red Short Term Memory Synucleins Hydroxymethylglutaryl Coa Reductase Inhibitors Putamen Arrestin Metals Corpus Striatum Neurotoxicity Pars Compacta Dopamine Pharmaceutical Preparations Databases Cognitive Dysfunction Dopamine D1 Receptors

Most Recent Publications

Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing

Paulo B. de Freitas, Sandra M.S.F. Freitas, Janina M. Prado-Rico, Mechelle M. Lewis, Guangwei Du, Jeff D. Yanosky, Xuemei Huang, Mark L. Latash, 2022, NeuroToxicology on p. 324-336

A Dopamine D<sub>1</sub> Agonist Versus Methylphenidate in Modulating Prefrontal Cortical Working Memory

Yang Yang, Mechelle M. Lewis, Lan Kong, Richard B. Mailman, 2022, Journal of Pharmacology and Experimental Therapeutics on p. 88-99

Dopamine D<sub>1</sub> receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology

Yang Yang, Mechelle Lewis, Xuemei Huang, Nikolay V. Dokholyan, Richard Mailman, 2022, International Journal of Biochemistry

Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D<sub>1</sub> Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms

Yang Yang, Susan D. Kocher, Mechelle Lewis, Richard B. Mailman, 2022, Frontiers in Neuroscience

Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort

Janina Manzieri Prado-Rico, Eun Young Lee, Ernest W. Wang, Jeff D. Yanosky, Lan Kong, Hairong Chen, Ana Navas-Acien, Guangwei Du, Mechelle Lewis, Richard B. Mailman, Xuemei Huang, 2022, Toxicological Sciences on p. 345-354

Parkinson's Disease Progression and Statins: Hydrophobicity Matters

Mechelle M. Lewis, Richard M. Albertson, Guangwei Du, Lan Kong, Andrew Foy, Xuemei Huang, 2022, Journal of Parkinson's Disease on p. 821-830

Frontostriatal and limbic contributions to cognitive decline in Parkinson's disease

Gregory Brown, Jonathan Hakun, Mechelle Lewis, Sol De Jesus, Guangwei Du, Paul Eslinger, Lan Kong, Xuemei Huang, 2022, Journal of Neuroimaging

Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage

Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662

Subcortical Iron Accumulation Pattern May Predict Neuropsychological Outcomes after Subthalamic Nucleus Deep Brain Stimulation: A Pilot Study

Gregory Brown, Guangwei Du, Elana Farace, Mechelle M. Lewis, Paul J. Eslinger, James McInerney, Lan Kong, Runze Li, Xuemei Huang, Sol De Jesus, De Jesus, Sol, 2021, Journal of Parkinson's Disease on p. 851-863

Parkinson's Disease Progression and Statins: Hydrophobicity Matters.

Mechelle Lewis, R Albertson, G Du, L Kong, A Foy, X Huang, 2021, Journal of Parkinson's disease

Most-Cited Papers

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

S Sarkar, D Rokad, E Malovic, J Luo, D Harischandra, H Jin, V Anantharam, Xuemei Huang, Mechelle Lewis, A Kanthasamy, A Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Higher iron in the red nucleus marks Parkinson's dyskinesia

Mechelle Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L. Shaffer, Richard Mailman, Xuemei Huang, 2013, Neurobiology of Aging on p. 1497-1503

Striatal shape in Parkinson's disease

Nicholas W. Sterling, Guangwei Du, Mechelle M. Lewis, Christopher Dimaio, Lan Kong, Paul J. Eslinger, Martin Styner, Xuemei Huang, 2013, Neurobiology of Aging on p. 2510-2516

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Guodong Liu, Nicholas W. Sterling, Lan Kong, Mechelle M. Lewis, Richard B. Mailman, Honglei Chen, Douglas Leslie, Xuemei Huang, 2017, Movement Disorders on p. 913-917

Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination

Jaebum Park, Mechelle Lewis, Xuemei Huang, Mark Latash, 2013, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 991-998

Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors

Conrad S. Tucker, Ishan Behoora, Harriet Black Nembhard, Mechelle Lewis, Nicholas W. Sterling, Xuemei Huang, 2015, Computers in Biology and Medicine on p. 120-134

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Guangwei Du, Mechelle Lewis, Christopher Sica, L He, James Connor, Lan Kong, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 1423-1431

Default mode network differences between rigidity- and tremor-predominant Parkinson's disease

Prasanna R. Karunanayaka, Eun Young Lee, Mechelle M. Lewis, Suman Sen, Paul J. Eslinger, Qing X. Yang, Xuemei Huang, 2016, Cortex on p. 239-250