Mechelle Lewis

Associate Professor Neurology and Pharmacology

Huck Affiliations

Publication Tags

Parkinson Disease Manganese Brain Synucleins Parkinsonian Disorders Magnetic Resonance Imaging Anisotropy Hand Substantia Nigra Machine Learning Inflammasomes Prions Corpus Striatum Diffusion Tensor Imaging Biomarkers Pathology Hippocampus Progressive Supranuclear Palsy Mesencephalon Magnetic Resonance Spectroscopy Tremor Proteins Multiple System Atrophy Sensitivity And Specificity Exosomes

Most Recent Papers

Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay

Sireesha Manne, Naveen Kondru, Monica Hepker, Huajun Jin, Vellareddy Anantharam, Mechelle Lewis, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Journal of Neuroimmune Pharmacology on p. 423-435

Development and validation of the automated imaging differentiation in parkinsonism (AID-P)

Derek B. Archer, Justin T. Bricker, Winston T. Chu, Roxana G. Burciu, Johanna L. McCracken, Song Lai, Stephen A. Coombes, Ruogu Fang, Angelos Barmpoutis, Daniel M. Corcos, Ajay S. Kurani, Trina Mitchell, Mieniecia L. Black, Ellen Herschel, Tanya Simuni, Todd B. Parrish, Cynthia Comella, Tao Xie, Klaus Seppi, Nicolaas I. Bohnen, Martijn LTM Müller, Roger L. Albin, Florian Krismer, Guangwei Du, Mechelle M. Lewis, Xuemei Huang, Hong Li, Ofer Pasternak, Nikolaus R. McFarland, Michael S. Okun, David E. Vaillancourt, 2019, The Lancet Digital Health on p. e222-e231

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Eun Young Lee, Michael R. Flynn, Guangwei Du, Mechelle Lewis, Lan Kong, Jeffrey Yanosky, Richard Mailman, Xuemei Huang, 2019, Toxicological Sciences on p. 486-496

Multimodal MRI evaluation of parkinsonian limbic pathologies

Ernest W. Wang, Guangwei Du, Mechelle M. Lewis, Eun Young Lee, Sol De Jesus, Sangam Kanekar, Lan Kong, Xuemei Huang, 2019, Neurobiology of Aging on p. 194-200

Brain cholesterol metabolism and Parkinson's disease

Xuemei Huang, Nicholas W. Sterling, Guangwei Du, Dongxiao Sun, Christina Stetter, Lan Kong, Yusheng Zhu, Jeffrey Neighbors, Mechelle Lewis, Honglei Chen, Raymond Hohl, Richard Mailman, 2019, Movement Disorders on p. 386-395

Quantitative analysis of multi-element synergy stabilizing performance

Sandra M.S.F. Freitas, Paulo B. de Freitas, Mechelle Lewis, Xuemei Huang, Mark Latash, 2019, Experimental Brain Research on p. 453-465

Individual preferences in motor coordination seen across the two hands

Paulo B. de Freitas, Sandra M.S.F. Freitas, Mechelle Lewis, Xuemei Huang, Mark Latash, 2019, Experimental Brain Research

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Souvarish Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Mechelle Lewis, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science Signaling

Magnetic resonance T1w/T2w ratio

Guangwei Du, Mechelle M. Lewis, Christopher Sica, Lan Kong, Xuemei Huang, 2019, Annals of Neurology on p. 96-104

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science signaling

Most-Cited Papers

Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

Guangwei Du, Mechelle M. Lewis, Martin Styner, Michele L. Shaffer, Suman Sen, Qing X. Yang, Xuemei Huang, 2011, Movement Disorders on p. 1627-1632

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Mechelle Lewis, Guangwei Du, S. Sen, A. Kawaguchi, Y. Truong, S. Lee, Richard Mailman, Xuemei Huang, 2011, Neuroscience on p. 230-239

Changes in multifinger interaction and coordination in Parkinson's disease

Jaebum Park, Yen Hsun Wu, Mechelle M. Lewis, Xuemei Huang, Mark L. Latash, 2012, Journal of neurophysiology on p. 915-924

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Imaging nigral pathology and clinical progression in Parkinson's disease

Guangwei Du, Mechelle M. Lewis, Suman Sen, Jianli Wang, Michele L. Shaffer, Martin Styner, Qing X. Yang, Xuemei Huang, 2012, Movement Disorders on p. 1636-1643

Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease

S. Sen, A. Kawaguchi, Y. Truong, M. M. Lewis, X. Huang, 2010, Neuroscience on p. 712-719

Both coordination and symmetry of arm swing are reduced in Parkinson's disease

Xuemei Huang, Joseph M. Mahoney, Mechelle M. Lewis, Du Guangwei Du, Stephen J. Piazza, Joseph P. Cusumano, 2012, Gait and Posture on p. 373-377

Striatal shape in Parkinson's disease

Nicholas W. Sterling, Guangwei Du, Mechelle Lewis, Christopher Dimaio, Lan Kong, Paul Eslinger, Martin Styner, Xuemei Huang, 2013, Neurobiology of Aging on p. 2510-2516

Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients

Eun Young Lee, Suman Sen, Paul J. Eslinger, Daymond Wagner, Michele L. Shaffer, Lan Kong, Mechelle M. Lewis, Guangwei Du, Xuemei Huang, 2013, Parkinsonism and Related Disorders on p. 1088-1093

Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination

Jaebum Park, Mechelle Lewis, Xuemei Huang, Mark Latash, 2013, Clinical Neurophysiology on p. 991-998