Mechelle Lewis
Associate Professor Neurology and Pharmacology
Huck Affiliations
Publication Tags
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Parkinson Disease Manganese Red Nucleus Iron Metal Red Synucleins Brain Substantia Nigra Metals Pars Compacta Dopamine Agonists Prions Inflammasomes Short Term Memory Welding Arrestin Putamen Neurons Magnetic Resonance Imaging Neurotoxicity Dopamine Mesencephalon Dopamine D1 Receptors Pharmaceutical PreparationsMost Recent Publications
Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance
Eun Young Lee, Juhee Kim, Janina Manzieri Prado-Rico, Guangwei Du, Mechelle Lewis, Lan Kong, Byoung Gwon Kim, Young Seoub Hong, Jeff D. Yanosky, Richard B. Mailman, Xuemei Huang, 2023, NeuroToxicology on p. 53-68
Dopamine D1 Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease
Mechelle Lewis, L Van Scoy, S De Jesus, J Hakun, P Eslinger, J Fernandez-Mendoza, L Kong, Yang Yang, Bethany Snyder, Natalia Loktionova, Sridhar Duvvuri, David Gray, X Huang, R Mailman, 2023, Biomolecules
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Ernest W. Wang, Wang, Ernest W. W., Gregory L. Brown, Brown, Gregory L. L., Mechelle M. Lewis, Lewis, Mechelle M. M., Jellen, Leslie C. C., Leslie C. Jellen, Cunfeng Pu, Johnson, Melinda L. L., Melinda L. Johnson, Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang, 2023, Movement Disorders
Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing
P de Freitas, Sandra M.S.F. Freitas, Freitas SMSF, J Prado-Rico, Mechelle Lewis, Guangwei Du, Jeff D. Yanosky, Xuemei Huang, Mark L. Latash, 2022, NeuroToxicology on p. 324-336
A Dopamine D<sub>1</sub> Agonist Versus Methylphenidate in Modulating Prefrontal Cortical Working Memory
Yang Yang, Mechelle Lewis, Lan Kong, Richard B. Mailman, 2022, Journal of Pharmacology and Experimental Therapeutics on p. 88-89
Dopamine D<sub>1</sub> receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology
Yang Yang, Mechelle Lewis, Xuemei Huang, Nikolay V. Dokholyan, Richard Mailman, 2022, International Journal of Biochemistry
Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D<sub>1</sub> Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms
Yang Yang, Susan D. Kocher, Mechelle Lewis, Richard B. Mailman, 2022, Frontiers in Neuroscience
Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort
Janina Prado-Rico, Eun-Young Lee, Ernest Wang, Jeff D. Yanosky, Lan Kong, Hairong Chen, Ana Navas-Acien, Guangwei Du, Mechelle Lewis, Richard B. Mailman, Xuemei Huang, 2022, Toxicological Sciences on p. 345-354
Dopamine D-1 receptor-mediated beta-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology
Yang Yang, Mechelle Lewis, Xuemei Huang, V. Dokholyan, Nikolay, N Dokholyan, R Mailman, 2022, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY on p. 106235
Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage
Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, De Jesus, Sol, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662
Most-Cited Papers
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
S Sarkar, D Rokad, E Malovic, J Luo, D Harischandra, H Jin, V Anantharam, Xuemei Huang, Mechelle Lewis, A Kanthasamy, A Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment
Higher iron in the red nucleus marks Parkinson's dyskinesia
Mechelle Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L. Shaffer, Richard Mailman, Xuemei Huang, 2013, Neurobiology of Aging on p. 1497-1503
Striatal shape in Parkinson's disease
N Sterling, Guangwei Du, Mechelle M. Lewis, C Dimaio, Lan Kong, Paul J. Eslinger, M Styner, Xuemei Huang, 2013, Neurobiology of Aging on p. 2510-2516
Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients
Guangwei Du, Mechelle Lewis, Christopher Sica, L He, James Connor, Lan Kong, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 1423-1431
Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors
Conrad S. Tucker, Ishan Behoora, Harriet Black Nembhard, Mechelle Lewis, Nicholas W. Sterling, Xuemei Huang, 2015, Computers in Biology and Medicine on p. 120-134
Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database
Guodong Liu, N Sterling, Lan Kong, Mechelle M. Lewis, Richard B. Mailman, H Chen, Douglas Leslie, Xuemei Huang, 2017, Movement Disorders on p. 913-917
Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination
Jaebum Park, Mechelle Lewis, Xuemei Huang, Mark Latash, 2013, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 991-998
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease
Prasanna R. Karunanayaka, Eun Young Lee, Mechelle M. Lewis, Suman Sen, Paul J. Eslinger, Qing X. Yang, Xuemei Huang, 2016, Cortex on p. 239-250
News Articles Featuring Mechelle Lewis
Aug 25, 2022
Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline
As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.
Full Article