Mechelle Lewis

Associate Professor Neurology and Pharmacology

Huck Affiliations

Publication Tags

Parkinson Disease Manganese Substantia Nigra Iron Brain Synucleins Prions Inflammasomes Semantics Neurotoxicity Paraquat Levodopa Anisotropy Putamen Cerebrospinal Fluid Pars Compacta Corpus Striatum Pharmaceutical Preparations Machine Learning Pathology Red Nucleus Mental Status And Dementia Tests Exosomes Sensors Farmers

Most Recent Papers

Folded concave penalized learning of high-dimensional MRI data in Parkinson's disease

Changcheng Li, Xue Wang, Guangwei Du, Hairong Chen, Gregory Brown, Mechelle M. Lewis, Tao Yao, Runze Li, Xuemei Huang, 2021, Journal of Neuroscience Methods

HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers

Ernest W. Wang, Max L. Trojano, Mechelle M. Lewis, Guangwei Du, Hairong Chen, Gregory L. Brown, Leslie C. Jellen, Insung Song, Elizabeth Neely, Lan Kong, James R. Connor, Xuemei Huang, 2021, Toxicological Sciences on p. 47-57

Nigral MRI features of asymptomatic welders

Eun Young Lee, Michael R. Flynn, Guangwei Du, Mechelle M. Lewis, Michael Goldenberg, Lan Kong, Richard B. Mailman, Young Seoub Hong, Xuemei Huang, 2021, Parkinsonism and Related Disorders on p. 37-43

Choroidal Thickness Correlates with Clinical and Imaging Metrics of Parkinson's Disease

Gregory L. Brown, Mona L. Camacci, Sean D. Kim, Stephanie Grillo, James V. Nguyen, Douglas A. Brown, Sarah P. Ullah, Mechelle Lewis, Guangwei Du, Lan Kong, Jeffrey M. Sundstrom, Xuemei Huang, Esther M. Bowie, 2021, Journal of Parkinson's Disease on p. 1857-1868

Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline

Feng Han, Gregory L. Brown, Yalin Zhu, Aaron E. Belkin-Rosen, Mechelle M. Lewis, Guangwei Du, Yameng Gu, Paul J. Eslinger, Richard B. Mailman, Xuemei Huang, Xiao Liu, 2021, Movement Disorders

Synergic control of action in levodopa-naïve Parkinson’s disease patients: II. Multi-muscle synergies stabilizing vertical posture

Sandra M.S.F. Freitas, Freitas SMSF, P de Freitas, A Falaki, T Corson, Mechelle M. Lewis, Xuemei Huang, Mark L. Latash, 2020, Experimental Brain Research on p. 2931-2945

Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease

Patrick L. Heilman, Ernest W. Wang, Mechelle M. Lewis, Stanislaw Krzyzanowski, Colt D. Capan, Amanda R. Burmeister, Guangwei Du, Martha L. Escobar Galvis, Patrik Brundin, Xuemei Huang, Lena Brundin, 2020, Movement Disorders on p. 2028-2037

The D<sub>1</sub>/D<sub>5</sub>Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease

Xuemei Huang, Mechelle M. Lewis, Lauren Van Scoy, Sol De Jesus, Paul J. Eslinger, Amy C. Arnold, Amanda J. Miller, Julio Fernandez-Mendoza, Bethany Snyder, William Harrington, Lan Kong, Xi Wang, Dongxiao Sun, Marielle Delnomdedieu, Sridhar Duvvuri, Susan E. Mahoney, David L. Gray, Richard Mailman, 2020, Journal of Parkinson's Disease on p. 1515-1527

Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease

Daymond Wagner, Paul J. Eslinger, Nicholas W. Sterling, Guangwei Du, Eun Young Lee, Martin Styner, Mechelle M. Lewis, Xuemei Huang, 2020, Brain and Language

Factors Influencing Pediatric Recovery from Traumatic Brain Injury.

A. Feldman, S. Thomas, J. Hess, Mechelle Lewis, 2020, Penn State J. Med.

Most-Cited Papers

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Changes in multifinger interaction and coordination in Parkinson's disease

Jaebum Park, Yen Hsun Wu, Mechelle M. Lewis, Xuemei Huang, Mark L. Latash, 2012, Journal of Neurophysiology on p. 915-924

Imaging nigral pathology and clinical progression in Parkinson's disease

Guangwei Du, Mechelle M. Lewis, Suman Sen, Jianli Wang, Michele L. Shaffer, Martin Styner, Qing X. Yang, Xuemei Huang, 2012, Movement Disorders on p. 1636-1643

Both coordination and symmetry of arm swing are reduced in Parkinson's disease

Xuemei Huang, Joseph M. Mahoney, Mechelle M. Lewis, Guangwei Du, Stephen J. Piazza, Joseph P. Cusumano, 2012, Gait and Posture on p. 373-377

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Striatal shape in Parkinson's disease

Nicholas W. Sterling, Guangwei Du, Mechelle M. Lewis, Christopher Dimaio, Lan Kong, Paul J. Eslinger, Martin Styner, Xuemei Huang, 2013, Neurobiology of Aging on p. 2510-2516

Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination

Jaebum Park, Mechelle Lewis, Xuemei Huang, Mark Latash, 2013, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 991-998

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Souvarish Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Mechelle Lewis, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Higher iron in the red nucleus marks Parkinson's dyskinesia

Mechelle Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L. Shaffer, Richard Mailman, Xuemei Huang, 2013, Neurobiology of Aging on p. 1497-1503

Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors

Conrad S. Tucker, Ishan Behoora, Harriet Black Nembhard, Mechelle Lewis, Nicholas W. Sterling, Xuemei Huang, 2015, Computers in Biology and Medicine on p. 120-134