Mechelle Lewis

Associate Professor Neurology and Pharmacology

Mechelle Lewis

Huck Affiliations

Most Recent Publications

Multi-muscle synergies in preparation for gait initiation in Parkinson's disease

Ali Falaki, Cristian Cuadra, Mechelle M. Lewis, Janina M. Prado-Rico, Janina Prado Rico, Xuemei Huang, Mark L. Latash, 2023, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 12-24

Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance

Eun Young Lee, Juhee Kim, Janina Manzieri Prado-Rico, Guangwei Du, Mechelle Lewis, Lan Kong, et al., Byoung Gwon Kim, Young Seoub Hong, Jeff D. Yanosky, Richard B. Mailman, Xuemei Huang, 2023, NeuroToxicology on p. 53-68

Effects of Toxic Metals on Neurotransmitters

Richard B. Mailman, Mechelle Mayleben, Cindy P. Lawler, 2023, on p. 627-638

Neuronally enriched microvesicle RNAs are differentially expressed in the serums of Parkinson’s patients

Morris A. Aguilar, Shauna Ebanks, Havell Markus, Mechelle M. Lewis, Vishal Midya, Kent Vrana, Xuemei Huang, Molly A. Hall, Yuka Imamura Kawasawa, 2023, Frontiers in Neuroscience

Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta

E Wang, Wang, Ernest W. W., G Brown, Brown, Gregory L. L., Mechelle M. Lewis, Lewis, Mechelle M. M., Jellen, Leslie C. C., L Jellen, Cunfeng Pu, M Johnson, Johnson, Melinda L. L., Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang, 2023, Movement Disorders on p. 464-473

Dopamine D<sub>1</sub> Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease

Mechelle Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul Eslinger, Julio Fernandez-Mendoza, L Kong, Yang Yang, Bethany Snyder, Natalia Loktionova, Sridhar Duvvuri, David Gray, Xuemei Huang, Richard B. Mailman, 2023, Biomolecules on p. 829

A Dopamine D<sub>1</sub> Agonist Versus Methylphenidate in Modulating Prefrontal Cortical Working Memory

Yang Yang, Mechelle Lewis, Lan Kong, Richard B. Mailman, 2022, Journal of Pharmacology and Experimental Therapeutics on p. 88-89

Dopamine D<sub>1</sub> receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology

Yang Yang, Mechelle Lewis, Xuemei Huang, Nikolay V. Dokholyan, Richard Mailman, 2022, International Journal of Biochemistry

Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D<sub>1</sub> Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms

Yang Yang, Susan D. Kocher, Mechelle Lewis, Richard B. Mailman, 2022, Frontiers in Neuroscience

Dopamine D-1 receptor-mediated beta-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology

Yang Yang, Mechelle Lewis, Xuemei Huang, V. Dokholyan, Nikolay, N Dokholyan, R Mailman, 2022, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY on p. 106235

Most-Cited Papers

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

S Sarkar, D Rokad, E Malovic, J Luo, D Harischandra, H Jin, V Anantharam, Xuemei Huang, Mechelle Lewis, A Kanthasamy, A Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

D Archer, J Bricker, W Chu, R Burciu, J Mccracken, S Lai, S Coombes, R Fang, A Barmpoutis, D Corcos, A Kurani, T Mitchell, M Black, E Herschel, T Simuni, T Parrish, C Comella, T Xie, K Seppi, N Bohnen, Müller MLTM, M Müller, R Albin, F Krismer, Guangwei Du, Mechelle Lewis, Xuemei Huang, H Li, O Pasternak, N McFarland, M Okun, D Vaillancourt, 2019, The Lancet Digital Health on p. e222-e231

Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease

P Heilman, E Wang, Mechelle M. Lewis, S Krzyzanowski, C Capan, A Burmeister, Guangwei Du, M Escobar Galvis, P Brundin, Xuemei Huang, L Brundin, 2020, Movement Disorders on p. 2028-2037

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Guangwei Du, Mechelle Lewis, Christopher Sica, L He, James Connor, Lan Kong, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 1423-1431

Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders

S Manne, N Kondru, M Hepker, H Jin, V Anantharam, Mechelle Lewis, Xuemei Huang, A Kanthasamy, A Kanthasamy, 2019, Journal of NeuroImmune Pharmacology on p. 423-435

Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors

Conrad S. Tucker, Ishan Behoora, Harriet Black Nembhard, Mechelle Lewis, Nicholas W. Sterling, Xuemei Huang, 2015, Computers in Biology and Medicine on p. 120-134

Sleep Disturbance Following Concussion Is a Risk Factor for a Prolonged Recovery

H Bramley, A Henson, Mechelle M. Lewis, Lan Kong, C Stetter, Matthew Silvis, 2017, Clinical Pediatrics on p. 1280-1285

Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

Edward Ofori, Florian Krismer, Roxana G. Burciu, Ofer Pasternak, Johanna L. McCracken, Mechelle M. Lewis, Guangwei Du, Nikolaus R. McFarland, Michael S. Okun, Werner Poewe, Christoph Mueller, Elke R. Gizewski, Michael Schocke, Christian Kremser, Hong Li, Xuemei Huang, Klaus Seppi, David E. Vaillancourt, 2017, Movement Disorders on p. 1457-1464