Mechelle Lewis
Associate Professor Neurology and Pharmacology
Huck Affiliations
Publication Tags
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Parkinson Disease Manganese Synucleins Substantia Nigra Dopamine Agonists Machine Learning Parkinsonian Disorders Pars Compacta Brain Short Term Memory Metal Prions Neuroglia Inflammasomes Iron Cerebrospinal Fluid Arrestin Metals Biomarkers Neurons Magnetic Resonance Imaging Pathology Movement Disorders Therapeutics Red NucleusMost Recent Publications
Multi-muscle synergies in preparation for gait initiation in Parkinson's disease
Ali Falaki, Cristian Cuadra, Mechelle M. Lewis, Janina M. Prado-Rico, Janina Prado Rico, Xuemei Huang, Mark L. Latash, 2023, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 12-24
Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance
Eun Young Lee, Juhee Kim, Janina Manzieri Prado-Rico, Guangwei Du, Mechelle Lewis, Lan Kong, et al., Byoung Gwon Kim, Young Seoub Hong, Jeff D. Yanosky, Richard B. Mailman, Xuemei Huang, 2023, NeuroToxicology on p. 53-68
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
E Wang, Wang, Ernest W. W., G Brown, Brown, Gregory L. L., Mechelle M. Lewis, Lewis, Mechelle M. M., Jellen, Leslie C. C., L Jellen, Cunfeng Pu, M Johnson, Johnson, Melinda L. L., Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang, 2023, Movement Disorders on p. 464-473
Neuronally enriched microvesicle RNAs are differentially expressed in the serums of Parkinson’s patients
Morris A. Aguilar, Shauna Ebanks, Havell Markus, Mechelle M. Lewis, Vishal Midya, Kent Vrana, Xuemei Huang, Molly A. Hall, Yuka Imamura Kawasawa, 2023, Frontiers in Neuroscience
Dopamine D<sub>1</sub> Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease
Mechelle Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul Eslinger, Julio Fernandez-Mendoza, L Kong, Yang Yang, Bethany Snyder, Natalia Loktionova, Sridhar Duvvuri, David Gray, Xuemei Huang, Richard B. Mailman, 2023, Biomolecules on p. 829
Effects of Toxic Metals on Neurotransmitters
Richard B. Mailman, Mechelle Mayleben, Cindy P. Lawler, 2023, on p. 627-638
A Dopamine D<sub>1</sub> Agonist Versus Methylphenidate in Modulating Prefrontal Cortical Working Memory
Yang Yang, Mechelle Lewis, Lan Kong, Richard B. Mailman, 2022, Journal of Pharmacology and Experimental Therapeutics on p. 88-89
Dopamine D<sub>1</sub> receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology
Yang Yang, Mechelle Lewis, Xuemei Huang, Nikolay V. Dokholyan, Richard Mailman, 2022, International Journal of Biochemistry
Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D<sub>1</sub> Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms
Yang Yang, Susan D. Kocher, Mechelle Lewis, Richard B. Mailman, 2022, Frontiers in Neuroscience
Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage
Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, De Jesus, Sol, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662
Most-Cited Papers
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
S Sarkar, D Rokad, E Malovic, J Luo, D Harischandra, H Jin, V Anantharam, Xuemei Huang, Mechelle Lewis, A Kanthasamy, A Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment
Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study
D Archer, J Bricker, W Chu, R Burciu, J Mccracken, S Lai, S Coombes, R Fang, A Barmpoutis, D Corcos, A Kurani, T Mitchell, M Black, E Herschel, T Simuni, T Parrish, C Comella, T Xie, K Seppi, N Bohnen, Müller MLTM, M Müller, R Albin, F Krismer, Guangwei Du, Mechelle Lewis, Xuemei Huang, H Li, O Pasternak, N McFarland, M Okun, D Vaillancourt, 2019, The Lancet Digital Health on p. e222-e231
Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors
Conrad S. Tucker, Ishan Behoora, Harriet Black Nembhard, Mechelle Lewis, Nicholas W. Sterling, Xuemei Huang, 2015, Computers in Biology and Medicine on p. 120-134
Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients
Guangwei Du, Mechelle Lewis, Christopher Sica, L He, James Connor, Lan Kong, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 1423-1431
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders
S Manne, N Kondru, M Hepker, H Jin, V Anantharam, Mechelle Lewis, Xuemei Huang, A Kanthasamy, A Kanthasamy, 2019, Journal of NeuroImmune Pharmacology on p. 423-435
Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease
P Heilman, E Wang, Mechelle M. Lewis, S Krzyzanowski, C Capan, A Burmeister, Guangwei Du, M Escobar Galvis, P Brundin, Xuemei Huang, L Brundin, 2020, Movement Disorders on p. 2028-2037
Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database
Guodong Liu, N Sterling, Lan Kong, Mechelle M. Lewis, Richard B. Mailman, H Chen, Douglas Leslie, Xuemei Huang, 2017, Movement Disorders on p. 913-917
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease
Prasanna R. Karunanayaka, Eun Young Lee, Mechelle M. Lewis, Suman Sen, Paul J. Eslinger, Qing X. Yang, Xuemei Huang, 2016, Cortex on p. 239-250
News Articles Featuring Mechelle Lewis
Aug 25, 2022
Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline
As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.
Full Article