Mary Jane De Souza

Distinguished Professor of Kinesiology

Research Summary

Women's health and Physical Activity, Endocrinology of the Female Athlete, Effects of Exercise on the Menstrual Cycle, Female Athlete Triad (Eating disorders, amenorrhea and osteoporosis), Eating Behaviors, Food Intake, and Exercise, Luteal Phase Defects and Amenorrhea, Bone Health and Osteoporosis in Female Athletes, and Energy Deficiency and Bone Health.

Huck Affiliations

Center for Reproductive Biology and Health

Integrative and Biomedical Physiology

Publication Tags

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Bone Density Female Athlete Triad Syndrome Exercise Therapeutics Randomized Controlled Trials Bone And Bones Consensus Return To Sport Energy Intake Athletes Metabolic Bone Diseases Sports San Francisco Health Congresses Glucuronides Weight Loss Fats Amenorrhea Physicians Menstrual Cycle Energy Metabolism Hormones Oligomenorrhea Guidelines

Most Recent Publications

The Influence of Energy Balance and Availability on Resting Metabolic Rate: Implications for Assessment and Future Research Directions

Madelin R. Siedler, Mary Jane De Souza, Kembra Albracht-Schulte, Yasuki Sekiguchi, Grant M. Tinsley, 2023, Sports Medicine on p. 1507-1526

12-months of increased dietary intake does not exacerbate disordered eating-related attitudes, stress, or depressive symptoms in women with exercise-associated menstrual disturbances: The REFUEL randomized controlled trial

Nicole C.A. Strock, Mary Jane De Souza, Rebecca J. Mallinson, Marion Olmsted, Heather C.M. Allaway, Emma O'Donnell, Franziska Plessow, Nancy I. Williams, 2023, Psychoneuroendocrinology

Sex differences and indications of metabolic compensation in within-day energy balance in elite Division 1 swimmers

E Lundstrom, M De Souza, Mary Jane De Souza, H Canil, Nancy I. Williams, 2023, Applied Physiology, Nutrition and Metabolism on p. 74-87

Exercise training modifies the bone and endocrine response to graded reductions in energy availability in skeletally mature female rodents

Susan A. Bloomfield, Sibyl N. Swift, Corinne E. Metzger, Kyunghwa Baek, Mary Jane De Souza, Scott Lenfest, Yasaman Shirazi-Fard, Harry A. Hogan, 2023, Frontiers in Endocrinology

Associations Between Inflammatory Mediators and Bone Outcomes in Postmenopausal Women: A Cross-Sectional Analysis of Baseline Data from the Prune Study

Janhavi J. Damani, Mary Jane De Souza, Nicole C.A. Strock, Kristen J. Koltun, Nancy I. Williams, Connie Weaver, Connie J. Rogers, 2023, Journal of Inflammation Research on p. 639-663

Prune supplementation for 12 months alters the gut microbiome in postmenopausal women

Abigayle M.R. Simpson, Simpson AMR, Mary Jane De Souza, J Damani, Connie Rogers, Nancy Williams, C Weaver, M Ferruzzi, S Chadwick-Corbin, C Nakatsu, 2022, Food and Function on p. 12316-12329

Moderate Weight Loss is associated with Reductions in LH Pulse Frequency and Increases in 24-hour Cortisol with no change in Perceived Stress in Young Ovulatory Women

K Ruffing, K Koltun, Mary Jane De Souza, Nancy Williams, 2022, Physiology and Behavior on p. 113885

Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study

Mary Jane De Souza, Nicole C.A. Strock, Strock NCA, Nancy Williams, H Lee, K Koltun, Connie Rogers, M Ferruzzi, C Nakatsu, C Weaver, 2022, American Journal of Clinical Nutrition on p. 897-910

Bone mineral density in response to increased energy intake in exercising women with oligomenorrhea/amenorrhea: The REFUEL randomized controlled trial

Mary Jane De Souza, E Ricker, Rebecca J. Mallinson, Allaway HCM, Heather C.M. Allaway, K Koltun, Nicole C.A. Strock, Strock NCA, J Gibbs, P Kuruppumullage Don, Nancy Williams, 2022, American Journal of Clinical Nutrition on p. 1457-1472

Rationale and study design of Randomized Controlled Trial of Dietary Supplementation with prune (dried plums) on bone density, geometry, and estimated bone strength in postmenopausal women: The Prune study

Mary Jane De Souza, Strock NCA, Nicole C.A. Strock, Connie Jo Rogers, Nancy Williams, M Ferruzzi, C Nakatsu, Abigayle M.R. Simpson, Simpson AMR, C Weaver, 2022, Contemporary Clinical Trials Communications on p. 100941

Most-Cited Papers

2014 Female Athlete Triad Coalition Consensus Statement on Treatment and Return to Play of the Female Athlete Triad: 1st International conference held in San Francisco, California, May 2012 and 2nd International conference held in Indianapolis, Indiana, May 2013

Mary Jane De Souza, Aurelia Nattiv, Elizabeth Joy, Madhusmita Misra, Nancy I. Williams, Rebecca J. Mallinson, Jenna C. Gibbs, Marion Olmsted, Marci Goolsby, Gordon Matheson, 2014, British Journal of Sports Medicine on p. 289

Higher incidence of bone stress injuries with increasing female athlete triad-related risk factors: A prospective multisite study of exercising girls and women

Michelle T. Barrack, Jenna C. Gibbs, Mary Jane De Souza, Nancy I. Williams, Jeanne F. Nichols, Mitchell J. Rauh, Aurelia Nattiv, 2014, The Journal of sports medicine on p. 949-958

Prevalence of individual and combined components of the female athlete triad

Jenna C. Gibbs, Nancy I. Williams, Mary Jane De Souza, 2013, Medicine and Science in Sports and Exercise on p. 985-996

2014 female athlete triad coalition consensus statement on treatment and return to play of the female athlete triad: 1st international conference held in San Francisco, CA, May 2012, and 2nd international conference held in Indianapolis, IN, May 2013

Ovarian suppression impairs sport performance in junior elite female swimmers

Jaci L. Vanheest, Carol D. Rodgers, Carrie E. Mahoney, Mary Jane De Souza, 2014, Medicine and Science in Sports and Exercise on p. 156-166

2014 female athlete triad coalition consensus statement on treatment and return to play of the female athlete triad

Elizabeth Joy, Mary Jane De Souza, Aurelia Nattiv, Madhusmita Misra, Nancy I. Williams, Rebecca J. Mallinson, Jenna C. Gibbs, Marion Olmsted, Marci Goolsby, Gordon Matheson, Michelle Barrack, Louise Burke, Barbara Drinkwater, Connie Lebrun, Anne B. Loucks, Margo Mountjoy, Jeanne Nichols, Jorunn Sundgot Borgen, 2014, Current Sports Medicine Reports on p. 219-231

Low energy availability in exercising men is associated with reduced leptin and insulin but not with changes in other metabolic hormones

Karsten Koehler, Neele R. Hoerner, Jenna C. Gibbs, Christoph Zinner, Hans Braun, Mary Jane De Souza, Wilhelm Schaenzer, 2016, Journal of Sports Sciences on p. 1921-1929

Magnitude of daily energy deficit predicts frequency but not severity of menstrual disturbances associated with exercise and caloric restriction

Nancy I. Williams, Heather J. Leidy, Brenna R. Hill, Jay L. Lieberman, Richard S. Legro, Mary Jane De Souza, 2015, American Journal of Physiology on p. E29-E39

Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold

Jay L. Lieberman, Mary Jane De Souza, David A. Wagstaff, Nancy I. Williams, 2018, Medicine and Science in Sports and Exercise on p. 551-561

Low bone density risk is higher in exercising women with multiple triad risk factors

Jenna C. Gibbs, Aurelia Nattiv, Michelle T. Barrack, Nancy I. Williams, Mitchell J. Rauh, Jeanne F. Nichols, Mary Jane De Souza, 2014, Medicine and Science in Sports and Exercise on p. 167-176

News Articles Featuring Mary Jane De Souza

Jul 31, 2023

Penn State CTSI announces seven Bridges to Translation pilot funding recipients

Penn State Clinical and Translational Science Institute is helping to generate innovative health research ideas and promote collaboration through the awarding of pilot grants in its "Bridges to Translation" program.

Full Article

Dec 06, 2022

Prunes may help prevent bone loss and preserve bone strength

In the United States, about 10 million adults over the age of 50 have osteoporosis, with women four times more likely than men to experience the condition, according to prior research.