Margherita Cantorna
Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor of Molecular Immunology
-
125 Henning
University Park, PA - She/Her
- mxc69@psu.edu
- 814-863-2819
Research Summary
Understanding the working of the immune system. Utilizing animal models of several human diseases including enteric infections and inflammatory bowel disease to determine the cellular targets and molecular signals by which dietary components regulate immunity.
Huck Graduate Students
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Infectious Disease Dynamics
Links
Most Recent Publications
Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis
Juhi Arora, Nicole E. Froelich, Mengzhu Tang, Veronika Weaver, Robert F. Paulson, Margherita T. Cantorna, 2024, Journal of Immunology on p. 1479-1487
Two lineages of immune cells that differentially express the vitamin D receptor
Margherita T. Cantorna, Juhi Arora, 2023, Journal of Steroid Biochemistry and Molecular Biology
Highlights from the 24th workshop on vitamin D in Austin, September 2022
Mark B. Meyer, Carlos Bernal-Mizrachi, Daniel D. Bikle, Madhu Biyani, Moray J. Campbell, Snehal N. Chaudhari, Sylvia Christakos, Sue A. Ingles, Megan M. Knuth, Seong Min Lee, Thomas S. Lisse, Eva S. Liu, Isabelle Piec, Lori A. Plum, Sudhaker D. Rao, Carmen J. Reynolds, Tom D. Thacher, John H. White, Margherita T. Cantorna, 2023, Journal of Steroid Biochemistry and Molecular Biology
Vitamin D, microbiota, and inflammatory bowel disease
Margherita T. Cantorna, Juhi Arora, 2023, on p. 1057-1073
Vitamin D for COVID-19: where are we now?
Adrian R. Martineau, Margherita T. Cantorna, 2022, Nature Reviews Immunology on p. 529-530
Novel insight into the role of the vitamin D receptor in the development and function of the immune system
Juhi Arora, Jinpeng Wang, Veronika Weaver, Yongwei Zhang, Margherita T. Cantorna, 2022, Journal of Steroid Biochemistry and Molecular Biology
Transcriptional Profiling of the Small Intestine and the Colon Reveals Modulation of Gut Infection with Citrobacter rodentium According to the Vitamin A Status
Zhi Chai, Yafei Lyu, Q Chen, Cheng-Hsin Wei, Lindsay Snyder, I.M. Snyder, Veronika Weaver, Aswathy Sebastian, Albert, Istv\'an, István Albert, Qunhua Li, Margherita Cantorna, A Ross, Catharine Ross, others, 2022, Nutrients on p. 1563
Vitamin D and the Ability to Produce 1,25(OH)<sub>2</sub>D Are Critical for Protection from Viral Infection of the Lungs
Juhi Arora, Devanshi Patel, McKayla Nicol, Cassandra Field, Katherine Restori, Jinpeng Wang, Nicole Froelich, Bhuvana Katkere, Josey Terwilliger, Veronika Weaver, others, Erin Luley, Kathleen Kelly, Girish S. Kirimanjeswara, Troy Sutton, Margherita T. Cantorna, 2022, Nutrients on p. 3061
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues
Micha Davila, Ming Xu, Chengyu Huang, Erin Gaddes, Levi Winter, Margherita Cantorna, Yong Wang, N Xiong, 2022, iScience
RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes
Zhi Chai, Yafei Lyu, Qiuyan Chen, Cheng Hsin Wei, Lindsay M. Snyder, Veronika Weaver, Aswathy Sebastian, István Albert, Qunhua Li, Margherita T. Cantorna, A. Catharine Ross, 2021, Nutrition Reports International
Most-Cited Papers
Vitamin D and 1,25(OH)<sub>2</sub>D regulation of T cells
Margherita T. Cantorna, Lindsay Snyder, Yang Ding Lin, Linlin Yang, 2015, Nutrients on p. 3011-3021
Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis
Margherita T. Cantorna, Lindsay Snyder, Juhi Arora, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 184-192
Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells
Jing Chen, Amanda Waddell, Yang-Ding Lin, Margherita Cantorna, 2015, Mucosal Immunology on p. 618--626
The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Stephanie Bora, M Kennett, Philip B. Smith, Andrew D. Patterson, Margherita Cantorna, 2018, Frontiers in Immunology on p. 315814
Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection
Yang-Ding Lin, Juhi Arora, Kevin Diehl, Stephanie Bora, Margherita T. Cantorna, 2019, Frontiers in Immunology on p. 435382
Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis
Y Tian, Robert Nichols, Jingwei Cai, A Patterson, M Cantorna, 2018, Nutrition Reports International on p. 28--34
Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon
Margherita T. Cantorna, Yang Ding Lin, Juhi Arora, Stephanie Bora, Yuan Tian, Robert G. Nichols, Andrew D. Patterson, 2019, Frontiers in Immunology
Control of circulating IgE by the Vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms
Jamaal James, Veronika Weaver, Margherita T. Cantorna, 2017, Journal of Immunology on p. 1164-1171
NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D<sub>3</sub> in experimental autoimmune encephalomyelitis in mice
Amanda Waddell, Jun Zhao, Margherita T. Cantorna, 2015, International Immunology on p. 237--244
Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections
K McDaniel, Katherine Restori, Jeffery W. Dodds, M Kennett, A. Catharine Ross, Margherita T. Cantornaa, M Cantorna, 2015, Infection and Immunity on p. 2984-2991
News Articles Featuring Margherita Cantorna
Oct 25, 2023
22 Best Vitamin D-Rich Foods for Immunity & Bone Health
Give your health a boost during the winter months with these foods rich in vitamin D
Full Article
Apr 06, 2023
How Vitamin D Can Affect Your Gut Microbiome
Getting daily sunlight is good for your mind — and your microbiome.
Full Article
Nov 21, 2020
7 Things to know before taking Vitamin D Supplements
Known as the "sunshine pill” for its supposed ability to mimic the effects of sunshine on health, vitamin D supplements are a billion-dollar industry. People take vitamin D supplements for a variety of reasons, mental and physical. Some take it if they feel sad, perhaps as the result of the winter blues, for example. Others take it because vitamin D supposedly plays a role in bone health.
Full Article
Jan 19, 2020
Why getting enough vitamin D in wintertime is so important
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D — which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes — is essential for good health.
Full Article
Jan 16, 2020
Why you need more Vitamin D in the winter
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D, which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes, is essential for good health.
Full Article
Jan 16, 2020
Why you need more Vitamin D in the winter
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D, which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes, is essential for good health.
Full Article