Margherita Cantorna
Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor of Molecular Immunology
-
125 Henning
University Park, PA - She/Her
- mxc69@psu.edu
- 814-863-2819
Research Summary
Understanding the working of the immune system. Utilizing animal models of several human diseases including enteric infections and inflammatory bowel disease to determine the cellular targets and molecular signals by which dietary components regulate immunity.
Huck Graduate Students
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Immunology and Infectious Disease
- Center for Infectious Disease Dynamics
Links
Publication Tags
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Vitamin D Vitamin A Calcitriol Receptors T Lymphocytes Citrobacter Rodentium Infection Colon Small Intestine Infections Inflammation Homeostasis Microbiota Genes Mice Vitamin A Deficiency Vitamin Vitamin D Deficiency Lymphocytes Gene Expression Knockout Mice Inflammatory Bowel Diseases Cells Interleukin 22 Gastrointestinal Microbiome Interleukin 4Most Recent Publications
Highlights from the 24th workshop on vitamin D in Austin, September 2022
Mark B. Meyer, Carlos Bernal-Mizrachi, Daniel D. Bikle, Madhu Biyani, Moray J. Campbell, Snehal N. Chaudhari, Sylvia Christakos, Sue A. Ingles, Megan M. Knuth, Seong Min Lee, Thomas S. Lisse, Eva S. Liu, Isabelle Piec, Lori A. Plum, Sudhaker D. Rao, Carmen J. Reynolds, Tom D. Thacher, John H. White, Margherita T. Cantorna, 2023, Journal of Steroid Biochemistry and Molecular Biology
Two lineages of immune cells that differentially express the vitamin D receptor
Margherita T. Cantorna, Juhi Arora, 2023, Journal of Steroid Biochemistry and Molecular Biology
Vitamin D, microbiota, and inflammatory bowel disease
Margherita T. Cantorna, Juhi Arora, 2023, on p. 1057-1073
Vitamin D for COVID-19: where are we now?
Adrian R. Martineau, Margherita T. Cantorna, 2022, Nature Reviews Immunology on p. 529-530
Novel insight into the role of the vitamin D receptor in the development and function of the immune system
Juhi Arora, Jinpeng Wang, Veronika Weaver, Yongwei Zhang, Margherita T. Cantorna, 2022, Journal of Steroid Biochemistry and Molecular Biology
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues
Micha Davila, Ming Xu, Chengyu Huang, Erin Gaddes, Levi Winter, Margherita Cantorna, Yong Wang, N Xiong, 2022, iScience
Vitamin D and the Ability to Produce 1,25(OH)<sub>2</sub>D Are Critical for Protection from Viral Infection of the Lungs
Juhi Arora, Devanshi Patel, McKayla Nicol, Cassandra Field, Katherine Restori, Jinpeng Wang, Nicole Froelich, Bhuvana Katkere, Josey Terwilliger, Veronika Weaver, others, Erin Luley, Kathleen Kelly, Girish S. Kirimanjeswara, Troy Sutton, Margherita T. Cantorna, 2022, Nutrients on p. 3061
Transcriptional Profiling of the Small Intestine and the Colon Reveals Modulation of Gut Infection with Citrobacter rodentium According to the Vitamin A Status
Zhi Chai, Yafei Lyu, Q Chen, Cheng-Hsin Wei, Lindsay Snyder, I.M. Snyder, Veronika Weaver, Aswathy Sebastian, Albert, Istv\'an, István Albert, Qunhua Li, Margherita Cantorna, A Ross, Catharine Ross, others, 2022, Nutrients on p. 1563
RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes
Zhi Chai, Yafei Lyu, Qiuyan Chen, Cheng Hsin Wei, Lindsay M. Snyder, Veronika Weaver, Aswathy Sebastian, István Albert, Qunhua Li, Margherita T. Cantorna, A. Catharine Ross, 2021, Nutrition Reports International
Redefining the targets of the vitamin D receptor (VDR) utilizing a novel VDR reporter mouse.
Juhi Arora, Margherita Cantorna, 2021, The Journal of Immunology on p. 24--10
Most-Cited Papers
Vitamin D and 1,25(OH)<sub>2</sub>D regulation of T cells
Margherita T. Cantorna, Lindsay Snyder, Yang Ding Lin, Linlin Yang, 2015, Nutrients on p. 3011-3021
Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis
Margherita T. Cantorna, Lindsay Snyder, Juhi Arora, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 184-192
Mushrooms and health summit proceedings
Mary Jo Feeney, Johanna Dwyer, Clare M. Hasler-Lewis, John A. Milner, Manny Noakes, Sylvia Rowe, Mark Wach, Robert B. Beelman, Joe Caldwell, Margherita T. Cantorna, Lisa A. Castlebury, Shu Ting Chang, Lawrence J. Cheskin, Roger Clemens, Greg Drescher, Victor L. Fulgoni, David B. Haytowitz, Van S. Hubbard, David Law, Amy Myrdal Miller, Bart Minor, Susan S. Percival, Gabriela Riscuta, Barbara Schneeman, Suzanne Thornsbury, Cheryl D. Toner, Catherine E. Woteki, Dayong Wu, 2014, Journal of Nutrition
Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
Margherita T. Cantorna, Kaitlin McDaniel, Stephanie Bora, Jing Chen, Jamaal James, 2014, Experimental Biology and Medicine on p. 1524-1530
Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells
Jing Chen, Amanda Waddell, Yang-Ding Lin, Margherita Cantorna, 2015, Mucosal Immunology on p. 618--626
Crucial role of macrophage selenoproteins in experimental colitis
Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692
The vitamin D receptor turns off chronically activated T cells
Margherita Cantorna, Amanda Waddell, 2014, Annals of the New York Academy of Sciences on p. 70--75
Vitamin D receptor expression controls proliferation of naïve CD8<sup>+</sup> T cells and development of CD8 mediated gastrointestinal inflammation
Jing Chen, Danny Bruce, Margherita Cantorna, 2014, BMC Immunology on p. 1--11
The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Stephanie Bora, M Kennett, Philip B. Smith, Andrew D. Patterson, Margherita Cantorna, 2018, Frontiers in Immunology on p. 315814
Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection
Yang-Ding Lin, Juhi Arora, Kevin Diehl, Stephanie Bora, Margherita T. Cantorna, 2019, Frontiers in Immunology on p. 435382
News Articles Featuring Margherita Cantorna
Oct 25, 2023
22 Best Vitamin D-Rich Foods for Immunity & Bone Health
Give your health a boost during the winter months with these foods rich in vitamin D
Full Article
Apr 06, 2023
How Vitamin D Can Affect Your Gut Microbiome
Getting daily sunlight is good for your mind — and your microbiome.
Full Article
Nov 21, 2020
7 Things to know before taking Vitamin D Supplements
Known as the "sunshine pill” for its supposed ability to mimic the effects of sunshine on health, vitamin D supplements are a billion-dollar industry. People take vitamin D supplements for a variety of reasons, mental and physical. Some take it if they feel sad, perhaps as the result of the winter blues, for example. Others take it because vitamin D supposedly plays a role in bone health.
Full Article
Jan 19, 2020
Why getting enough vitamin D in wintertime is so important
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D — which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes — is essential for good health.
Full Article
Jan 16, 2020
Why you need more Vitamin D in the winter
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D, which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes, is essential for good health.
Full Article
Jan 16, 2020
Why you need more Vitamin D in the winter
Winter is upon us and so is the risk of vitamin D deficiency and infections. Vitamin D, which is made in our skin following sunlight exposure and also found in oily fish (mackerel, tuna and sardines), mushrooms and fortified dairy and nondairy substitutes, is essential for good health.
Full Article
Aug 21, 2018
Eating white button mushrooms may improve blood sugar control
A new study has found that eating white button mushrooms can affect glucose, or blood sugar, regulation, thereby reducing diabetes and other metabolic conditions, such as obesity.
Full Article