Margherita Cantorna

Emphasis Area Representative, Immunology and Infectious Disease; Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor in Molecular Immunology

Margherita Cantorna

Research Summary

The research in the Cantorna lab seeks to understand the working of the immune system. Animal models of several human diseases including enteric infections and inflammatory bowel disease are utilized to determine the cellular targets and molecular signals by which dietary components regulate immunity.

Areas of expertise: Host resistance to infection; immune-mediated diseases; multiple sclerosis; inflammatory bowel disease; T cells; gastrointestinal microbiota; gnotobiotics; vitamins A & D regulation of immune function; edible mushrooms; and selenium.

Graduate Students

Huck Institutes Affiliations

Links

Publication Tags

Vitamin D Calcitriol Receptors Microbiota T Lymphocytes Knockout Mice Natural Killer T Cells Inflammation Gastrointestinal Microbiome Lymphocytes Interleukin 17 Inflammatory Bowel Diseases Vitamin D Deficiency T Cells Homeostasis Ultraviolet Radiation Succinic Acid Prebiotics 1,25 Dihydroxyvitamin D Gluconeogenesis Bacteria Liver Glucose Immune System Vitamin A Interleukin 10

Most Recent Papers

Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics

Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Nutritional Biochemistry on p. 65-73

Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

Yuan Tian, Robert G. Nichols, Pratiti Roy, Wei Gui, Philip B. Smith, Jingtao Zhang, Yangding Lin, Veronika Weaver, Jingwei Cai, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Functional Foods on p. 223-232

Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis

Yuan Tian, Robert G. Nichols, Jingwei Cai, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Nutritional Biochemistry on p. 28-34

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in Immunology

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23

Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Frontiers in Immunology

Control of circulating IgE by the Vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms

Jamaal James, Veronika Weaver, Margherita T. Cantorna, 2017, Journal of Immunology on p. 1164-1171

The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Stephanie Bora, Margherita T. Cantorna, 2017, Photochemical and Photobiological Sciences on p. 347-353

Vitamin D and lung infection

Margherita T. Cantorna, 2016, Infection and Immunity on p. 3094-3096

NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D<sub>3</sub> in experimental autoimmune encephalomyelitis in mice

Amanda Waddell, Jun Zhao, Margherita T. Cantorna, 2015, International Immunology on p. 237-244

Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells

J. Chen, A. Waddell, Y. D. Lin, M. T. Cantorna, 2015, Mucosal Immunology on p. 618-626

High-Impact Papers

Failure of T cell homing, reduced CD4/CD8αα intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice

Sanhong Yu, Danny Bruce, Monica Froicu, Veronika Weaver, Margherita T. Cantorna, 2008, Proceedings of the National Academy of Sciences of the United States of America on p. 20834-20839

Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced coliti

Jot Hui Ooi, Yunfei Li, Connie J. Rogers, Margherita T. Cantorna, 2013, Journal of Nutrition on p. 1679-1686

The vitamin D receptor is required for iNKT cell development

Sanhong Yu, Margherita T. Cantorna, 2008, Proceedings of the National Academy of Sciences of the United States of America on p. 5207-5212

Therapeutic effect of vitamin d supplementation in a pilot study of crohn's patients

Linlin Yang, Veronika Weaver, Jill P. Smith, Sandra Bingaman, Terryl J. Hartman, Margherita T. Cantorna, 2013, Clinical and Translational Gastroenterology

Mechanisms underlying the effect of vitamin D on the immune system

Margherita T. Cantorna, 2010, Proceedings of the Nutrition Society on p. 286-289

Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling

Danny Bruce, Sanhong Yu, Jot Hui Ooi, Margherita T. Cantorna, 2011, International Immunology on p. 519-528

Vitamin D and multiple sclerosis

Margherita T. Cantorna, 2008, Nutrition Reviews

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

Margherita T. Cantorna, Kaitlin McDaniel, Stephanie Bora, Jing Chen, Jamaal James, 2014, Experimental Biology and Medicine on p. 1524-1530

Vitamin D regulation of immune function in the gut

Jot Hui Ooi, Jing Chen, Margherita T. Cantorna, 2012, Molecular Aspects of Medicine on p. 77-82

Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice

Sanhong Yu, Margherita T. Cantorna, 2011, Journal of Immunology on p. 1384-1390