Margherita Cantorna
Emphasis Area Representative, Immunology and Infectious Disease; Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor in Molecular Immunology
- 125 Henning
University Park, PA - mxc69@psu.edu
- 814-863-2819
Research Summary
The research in the Cantorna lab seeks to understand the working of the immune system. Animal models of several human diseases including enteric infections and inflammatory bowel disease are utilized to determine the cellular targets and molecular signals by which dietary components regulate immunity.
Areas of expertise: Host resistance to infection; immune-mediated diseases; multiple sclerosis; inflammatory bowel disease; T cells; gastrointestinal microbiota; gnotobiotics; vitamins A & D regulation of immune function; edible mushrooms; and selenium.
Graduate Students
Huck Institutes Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Molecular Immunology and Infectious Disease
- Center for Infectious Disease Dynamics
Links
- Center for Molecular Immunology and Infectious Diseases
- Department of Veterinary and Biomedical Sciences
- Cantorna Lab
Publication Tags
Vitamin D Calcitriol Receptors Microbiota T Lymphocytes Knockout Mice Natural Killer T Cells Inflammation Gastrointestinal Microbiome Lymphocytes Interleukin 17 Inflammatory Bowel Diseases Vitamin D Deficiency T Cells Homeostasis Ultraviolet Radiation Succinic Acid Prebiotics 1,25 Dihydroxyvitamin D Gluconeogenesis Bacteria Liver Glucose Immune System Vitamin A Interleukin 10Most Recent Papers
Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics
Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Nutritional Biochemistry on p. 65-73
Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice
Yuan Tian, Robert G. Nichols, Pratiti Roy, Wei Gui, Philip B. Smith, Jingtao Zhang, Yangding Lin, Veronika Weaver, Jingwei Cai, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Functional Foods on p. 223-232
Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis
Yuan Tian, Robert G. Nichols, Jingwei Cai, Andrew D. Patterson, Margherita T. Cantorna, 2018, Journal of Nutritional Biochemistry on p. 28-34
Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in Immunology
The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23
Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna, 2018, Frontiers in Immunology
Control of circulating IgE by the Vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms
Jamaal James, Veronika Weaver, Margherita T. Cantorna, 2017, Journal of Immunology on p. 1164-1171
The role of UVR and Vitamin D on T cells and inflammatory bowel disease
Stephanie Bora, Margherita T. Cantorna, 2017, Photochemical and Photobiological Sciences on p. 347-353
Vitamin D and lung infection
Margherita T. Cantorna, 2016, Infection and Immunity on p. 3094-3096
NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D<sub>3</sub> in experimental autoimmune encephalomyelitis in mice
Amanda Waddell, Jun Zhao, Margherita T. Cantorna, 2015, International Immunology on p. 237-244
Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells
J. Chen, A. Waddell, Y. D. Lin, M. T. Cantorna, 2015, Mucosal Immunology on p. 618-626
High-Impact Papers
Failure of T cell homing, reduced CD4/CD8αα intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice
Sanhong Yu, Danny Bruce, Monica Froicu, Veronika Weaver, Margherita T. Cantorna, 2008, Proceedings of the National Academy of Sciences of the United States of America on p. 20834-20839
Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced coliti
Jot Hui Ooi, Yunfei Li, Connie J. Rogers, Margherita T. Cantorna, 2013, Journal of Nutrition on p. 1679-1686
The vitamin D receptor is required for iNKT cell development
Sanhong Yu, Margherita T. Cantorna, 2008, Proceedings of the National Academy of Sciences of the United States of America on p. 5207-5212
Therapeutic effect of vitamin d supplementation in a pilot study of crohn's patients
Linlin Yang, Veronika Weaver, Jill P. Smith, Sandra Bingaman, Terryl J. Hartman, Margherita T. Cantorna, 2013, Clinical and Translational Gastroenterology
Mechanisms underlying the effect of vitamin D on the immune system
Margherita T. Cantorna, 2010, Proceedings of the Nutrition Society on p. 286-289
Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling
Danny Bruce, Sanhong Yu, Jot Hui Ooi, Margherita T. Cantorna, 2011, International Immunology on p. 519-528
Vitamin D and multiple sclerosis
Margherita T. Cantorna, 2008, Nutrition Reviews
Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
Margherita T. Cantorna, Kaitlin McDaniel, Stephanie Bora, Jing Chen, Jamaal James, 2014, Experimental Biology and Medicine on p. 1524-1530
Vitamin D regulation of immune function in the gut
Jot Hui Ooi, Jing Chen, Margherita T. Cantorna, 2012, Molecular Aspects of Medicine on p. 77-82
Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice
Sanhong Yu, Margherita T. Cantorna, 2011, Journal of Immunology on p. 1384-1390