Margherita Cantorna

Emphasis Area Representative, Immunology and Infectious Disease; Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor of Molecular Immunology

Margherita Cantorna

Research Summary

The research in the Cantorna lab seeks to understand the working of the immune system. Animal models of several human diseases including enteric infections and inflammatory bowel disease are utilized to determine the cellular targets and molecular signals by which dietary components regulate immunity.

Areas of expertise: Host resistance to infection; immune-mediated diseases; multiple sclerosis; inflammatory bowel disease; T cells; gastrointestinal microbiota; gnotobiotics; vitamins A & D regulation of immune function; edible mushrooms; and selenium.

Graduate Students

Huck Affiliations

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Publication Tags

Vitamin D Calcitriol Receptors T Lymphocytes Microbiota Inflammation T Cells Knockout Mice Interleukin 17 Gastrointestinal Microbiome Inflammatory Bowel Diseases Homeostasis Prebiotics Ultraviolet Radiation Gluconeogenesis Succinic Acid Bacteria Liver Vitamin D Deficiency Glucose Infection Vitamin A Health Natural Killer T Cells Immune System Fibroblast Growth Factor 23

Most Recent Papers

Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection

Yang Ding Lin, Juhi Arora, Kevin Diehl, Stephanie A. Bora, Margherita Teresa-Anna Cantorna, 2019, Frontiers in immunology

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells

Lindsay M. Snyder, Kaitlin L. McDaniel, Yuan Tian, Cheng Hsin Wei, Mary J. Kennett, Andrew David Patterson, A. Catharine Ross, Margherita Teresa-Anna Cantorna, 2019, Frontiers in immunology

Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

Yuan Tian, Robert G. Nichols, Pratiti Roy, Wei Gui, Philip B. Smith, Jingtao Zhang, Yangding Lin, Veronika Weaver, Jingwei Cai, Andrew David Patterson, Margherita Teresa-Anna Cantorna, 2018, Journal of Functional Foods on p. 223-232

Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics

Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew David Patterson, Margherita Teresa-Anna Cantorna, 2018, Journal of Nutritional Biochemistry on p. 65-73

Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis

Yuan Tian, Robert G. Nichols, Jingwei Cai, Andrew David Patterson, Margherita Teresa-Anna Cantorna, 2018, Journal of Nutritional Biochemistry on p. 28-34

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert Paulson, Andrew David Patterson, Margherita Teresa-Anna Cantorna, Pamela Hankey Giblin, 2018, Frontiers in immunology

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23

Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew David Patterson, Margherita Teresa-Anna Cantorna, 2018, Frontiers in immunology

Control of circulating IgE by the Vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms

Jamaal James, Veronika Weaver, Margherita Teresa-Anna Cantorna, 2017, Journal of Immunology on p. 1164-1171

The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Stephanie Bora, Margherita Teresa-Anna Cantorna, 2017, Photochemical and Photobiological Sciences on p. 347-353

Vitamin D and lung infection

Margherita Teresa-Anna Cantorna, 2016, Infection and Immunity on p. 3094-3096

High-Impact Papers

Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced coliti

Jot Hui Ooi, Yunfei Li, Connie Jo Rogers, Margherita Teresa-Anna Cantorna, 2013, Journal of Nutrition on p. 1679-1686

Therapeutic effect of vitamin d supplementation in a pilot study of crohn's patients

Linlin Yang, Veronika Weaver, Jill P. Smith, Sandra Bingaman, Terryl Johnson Hartman, Margherita Teresa-Anna Cantorna, 2013, Clinical and Translational Gastroenterology

Mechanisms underlying the effect of vitamin D on the immune system

Margherita Teresa-Anna Cantorna, 2010, Proceedings of the Nutrition Society on p. 286-289

Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling

Danny Bruce, Sanhong Yu, Jot Hui Ooi, Margherita Teresa-Anna Cantorna, 2011, International Immunology on p. 519-528

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

Margherita Teresa-Anna Cantorna, Kaitlin McDaniel, Stephanie Bora, Jing Chen, Jamaal James, 2014, Experimental Biology and Medicine on p. 1524-1530

Vitamin D regulation of immune function in the gut

Jot Hui Ooi, Jing Chen, Margherita Teresa-Anna Cantorna, 2012, Molecular Aspects of Medicine on p. 77-82

Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice

Sanhong Yu, Margherita Teresa-Anna Cantorna, 2011, Journal of Immunology on p. 1384-1390

The vitamin D receptor turns off chronically activated T cells

Margherita Teresa-Anna Cantorna, Amanda Waddell, 2014, Annals of the New York Academy of Sciences on p. 70-75

Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults

Mark Pinkerton, Vernon Chinchilli, Erin Banta, Timothy Craig, Avery August, Rebecca Bascom, Margherita Teresa-Anna Cantorna, Eric Thomas Harvill, Faoud Ishmael, 2013, Journal of Allergy and Clinical Immunology

Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and development of CD8 mediated gastrointestinal inflammation

Jing Chen, Danny Bruce, Margherita Teresa-Anna Cantorna, 2014, BMC Immunology