Maciej Boni

Professor of Biology

Maciej Boni

Research Summary

Human influenza epidemiology and evolution, evaluating population-level malaria treatment strategies with individual-based microsimulation models, phylogenetic analysis of avian influenza evolution in southern Vietnam, economic epidemiology of avian influenza, evaluating population-level efficacy of a potential dengue vaccine with mathematical models

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Publication Tags

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Population Artemisinine Sars Virus Malaria Epidemics Mutation Pandemics Genome Dengue Norovirus Parasites Plasmodium Falciparum Drug Resistance Therapeutics Genetic Recombination Immunity Infections Panama Resistance Basic Reproduction Number Southern Africa Pakistan Poultry New England Pandemic

Most Recent Publications

National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso

Robert J. Zupko, Tran Dang Nguyen, Amy Wesolowski, Jaline Gerardin, Maciej F. Boni, 2023, Scientific Reports

Benefits of near-universal vaccination and treatment access to manage COVID-19 burden in the United States

Fuhan Yang, Thu Nguyen Anh Tran, Emily Howerton, Maciej F. Boni, Joseph L. Servadio, 2023, BMC Medicine

Preventing antimalarial drug resistance with triple artemisinin-based combination therapies

Tran Dang Nguyen, Bo Gao, Chanaki Amaratunga, Mehul Dhorda, Thu Nguyen Anh Tran, Nicholas J. White, Arjen M. Dondorp, Maciej F. Boni, Ricardo Aguas, 2023, Nature Communications

Repeatability and timing of tropical influenza epidemics

Joseph L. Servadio, Pham Quang Thai, Marc Choisy, Maciej F. Boni, 2023, PLoS Computational Biology

Using compartmental models and Particle Swarm Optimization to assess Dengue basic reproduction number R<sub>0</sub> for the Republic of Panama in the 1999-2022 period

Vicente Alonso Navarro Valencia, Yamilka Díaz, Jose Miguel Pascale, Maciej F. Boni, Javier E. Sanchez-Galan, 2023, Heliyon

Seroprotection against tetanus in southern Vietnam

C. Louise Thwaites, Tran Tan Thanh, Nguyen Thi Han Ny, Lam Anh Nguyet, Nguyen Thi Duy Nhat, Cao Thu Thuy, Nguyen Thi Le Thanh, Nguyen Thanh Dung, James Campbell, Pham Quang Thai, Le Van Tan, Marc Choisy, Maciej F. Boni, 2023, Vaccine on p. 2208-2213

Elasticity and substitutability of food demand and emerging disease risk on livestock farms

Alexis Delabouglise, Guillaume Fournié, Marisa Peyre, Nicolas Antoine-Moussiaux, MacIej F. Boni, 2023, Royal Society Open Science

Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Ben Andagalu, Tim Anderson, Voahangy Andrianaranjaka, Ifeyinwa Aniebo, Enoch Aninagyei, Felix Ansah, Patrick O. Ansah, Tobias Apinjoh, Paulo Arnaldo, Elizabeth Ashley, Sarah Auburn, Gordon A. Awandare, Hampate Ba, Vito Baraka, Alyssa Barry, Philip Bejon, Gwladys I. Bertin, Maciej F. Boni, Steffen Borrmann, Teun Bousema, Marielle Bouyou-Akotet, Oralee Branch, Peter C. Bull, Huch Cheah, Keobouphaphone Chindavongsa, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David J. Conway, Vladimir Corredor, Erin Courtier, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mehul Dhorda, Mahamadou Diakite, Abdoulaye Djimde, Christiane Dolecek, Arjen Dondorp, Seydou Doumbia, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F. Echeverry, Thomas G. Egwang, Sonia Maria Mauricio Enosse, Berhanu Erko, Rick M. Fairhurst, Abdul Faiz, Caterina A. Fanello, Mark Fleharty, Matthew Forbes, Mark Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, G. L.Abby Harrison, Sara Anne Healy, Jason A. Hendry, Anastasia Hernandez-Koutoucheva, Tran Tinh Hien, Catherine A. Hill, Francis Hombhanje, Amanda Hott, Ye Htut, Mazza Hussein, Mallika Imwong, Deus Ishengoma, Scott A. Jackson, Chris G. Jacob, Julia Jeans, Kimberly J. Johnson, Claire Kamaliddin, Edwin Kamau, Jon Keatley, Theerarat Kochakarn, Drissa S. Konate, Abibatou Konaté, Aminatou Kone, Dominic P. Kwiatkowski, Myat P. Kyaw, Dennis Kyle, Mara Lawniczak, Samuel K. Lee, Martha Lemnge, Pharath Lim, Chanthap Lon, Kovana M. Loua, Celine I. Mandara, Jutta Marfurt, Kevin Marsh, Richard James Maude, Mayfong Mayxay, Oumou Maïga-Ascofaré, Olivo Miotto, Toshihiro Mita, Victor Mobegi, Abdelrahim Osman Mohamed, Olugbenga A. Mokuolu, Jaqui Montgomery, Collins Misita Morang’a, Ivo Mueller, Kathryn Murie, Paul N. Newton, Thang Ngo Duc, Thuy Nguyen, Thuy Nhien Nguyen, Tuyen Nguyen Thi Kim, Hong Nguyen Van, Harald Noedl, Francois Nosten, Rintis Noviyanti, Vincent Ntui Njock Ntui, Alexis Nzila, Lynette Isabella Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A. Onyamboko, Jean Bosco Ouedraogo, Kolapo Oyebola, Wellington Aghoghovwia Oyibo, Richard Pearson, Norbert Peshu, Aung P. Phyo, Christopher V. Plowe, Ric N. Price, Sasithon Pukrittayakamee, Huynh Hong Quang, Milijaona Randrianarivelojosia, Julian C. Rayner, Pascal Ringwald, Anna Rosanas-Urgell, Eduard Rovira-Vallbona, Valentin Ruano-Rubio, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J. Simpson, Mahamadou S. Sissoko, Christen Smith, Xin Zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Arthur Talman, Livingstone Tavul, Ngo Viet Thanh, Vandana Thathy, Aung Myint Thu, Mahamoudou Toure, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E. Wellems, Jason Wendler, Nicholas J. White, Georgia Whitton, William Yavo, Rob W. van der Pluijm, 2023, Wellcome Open Research

Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus modelling study

Oliver J. Watson, Bo Gao, Tran Dang Nguyen, Thu Nguyen Anh Tran, Melissa A. Penny, David L. Smith, Lucy Okell, Ricardo Aguas, Maciej F. Boni, 2022, The Lancet Microbe on p. e701-e710

SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021

T Tran, N Wikle, F Yang, H Inam, S Leighow, B Gentilesco, P Chan, E Albert, E Strong, Justin R. Pritchard, W Hanage, Ephraim Hanks, F Crawford, Maciej F. Boni, 2022, JAMA network open on p. e2214171

Most-Cited Papers

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

Raquel Viana, Sikhulile Moyo, Daniel G. Amoako, Houriiyah Tegally, Cathrine Scheepers, Christian L. Althaus, Ugochukwu J. Anyaneji, Phillip A. Bester, Maciej F. Boni, Mohammed Chand, Wonderful T. Choga, Rachel Colquhoun, Michaela Davids, Koen Deforche, Deelan Doolabh, Louis du Plessis, Susan Engelbrecht, Josie Everatt, Jennifer Giandhari, Marta Giovanetti, Diana Hardie, Verity Hill, Nei Yuan Hsiao, Arash Iranzadeh, Arshad Ismail, Charity Joseph, Rageema Joseph, Legodile Koopile, Sergei L. Kosakovsky Pond, Moritz U.G. Kraemer, Lesego Kuate-Lere, Oluwakemi Laguda-Akingba, Onalethatha Lesetedi-Mafoko, Richard J. Lessells, Shahin Lockman, Alexander G. Lucaci, Arisha Maharaj, Boitshoko Mahlangu, Tongai Maponga, Kamela Mahlakwane, Zinhle Makatini, Gert Marais, Dorcas Maruapula, Kereng Masupu, Mogomotsi Matshaba, Simnikiwe Mayaphi, Nokuzola Mbhele, Mpaphi B. Mbulawa, Adriano Mendes, Koleka Mlisana, Anele Mnguni, Thabo Mohale, Monika Moir, Kgomotso Moruisi, Mosepele Mosepele, Gerald Motsatsi, Modisa S. Motswaledi, Thongbotho Mphoyakgosi, Nokukhanya Msomi, Peter N. Mwangi, Yeshnee Naidoo, Noxolo Ntuli, Martin Nyaga, Lucier Olubayo, Sureshnee Pillay, Botshelo Radibe, Yajna Ramphal, Upasana Ramphal, James E. San, Lesley Scott, Roger Shapiro, Lavanya Singh, Pamela Smith-Lawrence, Wendy Stevens, Amy Strydom, Kathleen Subramoney, Naume Tebeila, Derek Tshiabuila, Joseph Tsui, Stephanie van Wyk, Steven Weaver, Constantinos K. Wibmer, Eduan Wilkinson, Nicole Wolter, Alexander E. Zarebski, Boitumelo Zuze, Dominique Goedhals, Wolfgang Preiser, Florette Treurnicht, Marietje Venter, Carolyn Williamson, Oliver G. Pybus, Jinal Bhiman, Allison Glass, Darren P. Martin, Andrew Rambaut, Simani Gaseitsiwe, Anne von Gottberg, Tulio de Oliveira, 2022, Nature on p. 679-686

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

Maciej F. Boni, Philippe Lemey, Xiaowei Jiang, Tommy Tsan Yuk Lam, Blair W. Perry, Todd A. Castoe, Andrew Rambaut, David L. Robertson, 2020, Nature Microbiology on p. 1408-1417

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Olivo Miotto, Jacob Almagro-Garcia, Magnus Manske, Bronwyn MacInnis, Susana Campino, Kirk A. Rockett, Chanaki Amaratunga, Pharath Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Socheat Duong, Chea Nguon, Char Meng Chuor, David Saunders, Youry Se, Chantap Lon, Mark M. Fukuda, Lucas Amenga-Etego, Abraham V.O. Hodgson, Victor Asoala, Mallika Imwong, Shannon Takala-Harrison, François Nosten, Xin Zhuan Su, Pascal Ringwald, Frédéric Ariey, Christiane Dolecek, Tran Tinh Hien, Maciej F. Boni, Cao Quang Thai, Alfred Amambua-Ngwa, David J. Conway, Abdoulaye A. Djimdé, Ogobara K. Doumbo, Issaka Zongo, Jean Bosco Ouedraogo, Daniel Alcock, Eleanor Drury, Sarah Auburn, Oliver Koch, Mandy Sanders, Christina Hubbart, Gareth Maslen, Valentin Ruano-Rubio, Dushyanth Jyothi, Alistair Miles, John O'Brien, Chris Gamble, Samuel O. Oyola, Julian C. Rayner, Chris I. Newbold, Matthew Berriman, Chris C.A. Spencer, Gilean McVean, Nicholas P. Day, Nicholas J. White, Delia Bethell, Arjen M. Dondorp, Christopher V. Plowe, Rick M. Fairhurst, Dominic P. Kwiatkowski, 2013, Nature Genetics on p. 648-655

Role for migratory wild birds in the global spread of avian influenza H5N8

Samantha Lycett, Rogier Bodewes, Anne Pohlmann, Jill Banks, Krisztián Bányai, Maciej Boni, Ruth Bouwstra, Andrew Breed, Ian Brown, Hualan Chen, Ádám Dán, Thomas DeLiberto, Nguyen Diep, Marius Gilbert, Sarah Hill, Hon Ip, Chang Ke, Hiroshi Kida, Mary Killian, Marion Koopmans, Jung Kwon, Dong Lee, Youn Lee, Lu Lu, Isabella Monne, John Pasick, Oliver Pybus, Andrew Rambaut, Timothy Robinson, Yoshihiro Sakoda, Siamak Zohari, Chang Song, David Swayne, Mia Torchetti, Hsiang Tsai, Ron Fouchier, Martin Beer, Mark Woolhouse, Thijs Kuiken, 2016, Science on p. 213-217

Impact of human mobility on the emergence of dengue epidemics in Pakistan

Amy Wesolowski, Taimur Qureshi, Maciej F. Boni, Pål Roe Sundsøy, Michael A. Johansson, Syed Basit Rasheed, Kenth Engø-Monsen, Caroline O. Buckee, Burton H. Singer, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 11887-11892

The origins of SARS-CoV-2: A critical review

E Holmes, S Goldstein, A Rasmussen, D Robertson, A Crits-Christoph, J Wertheim, S Anthony, W Barclay, Maciej Boni, P Doherty, J Farrar, J Geoghegan, X Jiang, J Leibowitz, Neil SJD, T Skern, S Weiss, M Worobey, K Andersen, R Garry, A Rambaut, 2021, Cell on p. 4848-4856

Recombination within the pandemic norovirus GII.4 lineage

John Sebastian Eden, Mark M. Tanaka, Maciej F. Boni, William D. Rawlinson, Peter A. White, 2013, Journal of Virology on p. 6270-6282

Genomic epidemiology of artemisinin resistant malaria

Roberto Amato, Olivo Miotto, Charles Woodrow, Jacob Almagro-Garcia, Ipsita Sinha, Susana Campino, Daniel Mead, Eleanor Drury, Mihir Kekre, Mandy Sanders, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Voahangy Andrianaranjaka, Tobias Apinjoh, Elizabeth Ashley, Sarah Auburn, Gordon Awandare, Vito Baraka, Alyssa Barry, Maciej Boni, Steffen Borrmann, Teun Bousema, Oralee Branch, Peter Bull, Kesinee Chotivanich, David Conway, Alister Craig, Nicholas Day, Abdoulaye Djimdé, Christiane Dolecek, Arjen Dondorp, Chris Drakeley, Patrick Duffy, Diego Echeverry, Thomas Egwang, Rick Fairhurst, Abul Faiz, Caterina Fanello, Tran Hien, Abraham Hodgson, Mallika Imwong, Deus Ishengoma, Pharath Lim, Chanthap Lon, Jutta Marfurt, Kevin Marsh, Mayfong Mayxay, Pascal Michon, Victor Mobegi, Olugbenga Mokuolu, Jacqui Montgomery, Ivo Mueller, Myat Kyaw, Paul Newton, Francois Nosten, Rintis Noviyanti, Alexis Nzila, Harold Ocholla, Abraham Oduro, Marie Onyamboko, Jean Ouedraogo, Aung Phyo, Christopher Plowe, Ric Price, Sasithon Pukrittayakamee, Milijaona Randrianarivelojosia, Pascal Ringwald, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Shannon Takala-Harrison, Thuy Thanh, Vandana Thathy, Federica Verra, Jason Wendler, Nicholas White, Htut Ye, Victoria Cornelius, Rachel Giacomantonio, Dawn Muddyman, Christa Henrichs, Cinzia Malangone, Dushyanth Jyothi, Richard Pearson, Julian Rayner, Gilean McVean, Kirk Rockett, Alistair Miles, Paul Vauterin, Ben Jeffery, Magnus Manske, Jim Stalker, Bronwyn Macinnis, Dominic Kwiatkowski, 2016, eLife

Malaria eradication within a generation: ambitious, achievable, and necessary

Richard G.A. Feachem, Ingrid Chen, Omar Akbari, Amelia Bertozzi-Villa, Samir Bhatt, Fred Binka, Maciej F. Boni, Caroline Buckee, Joseph Dieleman, Arjen Dondorp, Alex Eapen, Neelam Sekhri Feachem, Scott Filler, Peter Gething, Roly Gosling, Annie Haakenstad, Kelly Harvard, Arian Hatefi, Dean Jamison, Kate E. Jones, Corine Karema, Richard Nchabi Kamwi, Altaf Lal, Erika Larson, Margaret Lees, Neil F. Lobo, Angela E. Micah, Bruno Moonen, Gretchen Newby, Xiao Ning, Muhammad Pate, Martha Quiñones, Michelle Roh, Ben Rolfe, Dennis Shanks, Balbir Singh, Kenneth Staley, James Tulloch, Jennifer Wegbreit, Hyun Ju Woo, Winnie Mpanju-Shumbusho, 2019, The Lancet on p. 1056-1112

Genomic analysis of local variation and recent evolution in Plasmodium vivax

R Pearson, R Amato, S Auburn, O Miotto, J Almagro-Garcia, C Amaratunga, S Suon, S Mao, R Noviyanti, H Trimarsanto, J Marfurt, N Anstey, T William, Maciej Boni, C Dolecek, Hien Tinh Tran, T Hien, N White, P Michon, P Siba, L Tavul, G Harrison, A Barry, I Mueller, M Ferreira, N Karunaweera, M Randrianarivelojosia, Q Gao, C Hubbart, L Hart, B Jeffery, E Drury, D Mead, M Kekre, S Campino, M Manske, V Cornelius, B MacInnis, K Rockett, A Miles, J Rayner, R Fairhurst, F Nosten, R Price, D Kwiatkowski, 2016, Nature Genetics on p. 959-964

News Articles Featuring Maciej Boni

Sep 21, 2023

New strategies may reduce treatment failure in malaria by up to 81%

To slow resistance and reduce treatment failures to therapies for malaria, an international research team led by Penn State investigated various drug policy interventions in Rwanda.

Full Article

Aug 07, 2023

No, there isn’t a new disease called ‘Disease X’

Headlines have been spreading news about a false new Disease X currently spreading

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Aug 04, 2023

Influenza shows no seasonality in tropics, posing challenges for health care

In temperate climates, like North America and Europe, flu season starts in the fall, peaks in the winter and ends in the spring.

Full Article

Jun 12, 2023

Penn State announces tenure-line faculty promotions, effective July 1, 2023

The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.

Full Article

Apr 19, 2023

Covid Origins TV Segment

This syndicated Sinclair Broadcast Group story featured an interview with Maciej Boni, associate professor of biology at Penn State, and was broadcast by more than 70 tv stations.

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Apr 11, 2023

Penn State announces 2023 University-wide faculty and staff awards

Each spring, Penn State recognizes outstanding faculty and staff with annual awards in teaching and excellence. These awards highlight many of the University's faculty and staff who go above and beyond in their work at Penn State.

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Mar 20, 2023

Radio Clip

Radio clip from an appearance by Maciek Boni

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Mar 14, 2023

COVID’s ‘new normal’: 120,000 U.S. deaths per year?

Based on my research, 80% of Americans must get vaccinated every year to prevent a staggering toll from COVID. Let's draw on our experience meeting past public health challenges to make this happen.

Full Article