Lu Bai
Professor of Biochemistry and Molecular Biology; Professor of Physics

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206B Huck Life Sciences
University Park, PA - lub15@psu.edu
- 814-863-4824
Research Summary
Single cell / single molecule study of chromatin and gene regulation.
Huck Graduate Students
Huck Affiliations
Publication Tags
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Genes Gene Expression Nucleosomes Saccharomycetales Yeasts Transcription Factors Genome Cells Yeast Fluorescence Proteins Chromosomes Human Embryonic Stem Cells Memory Activins Dna Sequence Chromatin Noise Origin Recognition Complex Time Deoxyribonucleic Acid Replication Origin Thermodynamics Dna LicensureMost Recent Publications
Using Synthetic DNA Libraries to Investigate Chromatin and Gene Regulation
Holly Kleinschmidt, Cheng Xu, Lu Bai, 2023, Chromosoma on p. 167-189
Investigating pioneer factor activity and its coordination with chromatin remodelers using integrated synthetic oligo assay
Hengye Chen, Chao Yan, Archana Dhasarathy, Michael Kladde, Lu Bai, 2023, STAR Protocols
Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions
Benjamin T. Donovan, Hengye Chen, Priit Eek, Zhiyuan Meng, Caroline Jipa, Song Tan, Lu Bai, Michael G. Poirier, 2023, Molecular Cell on p. 1251-1263.e6
Predicting nucleosome positioning using statistical equilibrium models in budding yeast
Hungyo Kharerin, Lu Bai, 2023, STAR Protocols
Long range chromosomal interactions and first passage process in budding yeast
Lu Bai, 2023, Biophysical Journal on p. 18a-19a
Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles
Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Nature Communications
Origin recognition complex harbors an intrinsic nucleosome remodeling activity
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology
Most-Cited Papers
Transcription under torsion
Jie Ma, Lu Bai, Michelle D. Wang, 2013, Science on p. 1580-1583
Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence
Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384
Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing
Jian Li, Yingyun Liu, Ho Sung Rhee, Saikat Kumar B. Ghosh, Lu Bai, B. Franklin Pugh, David S. Gilmour, 2013, Molecular Cell on p. 711-722
Systematic Study of Nucleosome-Displacing Factors in Budding Yeast
Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4
Dissociation rate compensation mechanism for budding yeast pioneer transcription factors
Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife
Stochastic expression and epigenetic memory at the yeast HO promoter
Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman, Lu Bai, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14012-14017
Decoupling of divergent gene regulation by sequence-specific DNA binding factors
Chao Yan, Daoyong Zhang, Juan Antonio Raygoza Garay, Michael M. Mwangi, Lu Bai, 2015, Nucleic Acids Research on p. 7292-7305
Regulation of cell-to-cell variability in divergent gene expression
Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai, 2016, Nature Communications
Interallelic interaction and gene regulation In budding yeast
Daoyong Zhang, Lu Bai, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 4428-4433
Three distinct mechanisms of long-distance modulation of gene expression in yeast
Manyu Du, Qian Zhang, Lu Bai, 2017, PLoS Genetics on p. e1006736
News Articles Featuring Lu Bai
Jun 12, 2023
Penn State announces tenure-line faculty promotions, effective July 1, 2023
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.
Full Article
Apr 20, 2023
How 'master regulators' of cells make DNA accessible for gene expression
New insight into proteins called “pioneer factors” helps to explain their unusual ability to open up the typically dense genetic material within our cells. This behavior makes the genetic material accessible for proteins involved in important cellular processes, such as DNA replication and repair, gene expression, and the creation of proteins.
Full Article