Lu Bai

Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics

206B Huck Life Sciences
University Park, PA
lub15@psu.edu
814-863-4824

Bio & Links
Publications

Research Summary

Single cell / single molecule study of chromatin and gene regulation.

Huck Graduate Students

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Center for Cellular Dynamics

Publication Tags

Genes Nucleosomes Gene Expression Genome Yeasts Transcription Factors Yeast Thermodynamics Saccharomycetales Saccharomyces Cerevisiae Time Fluorescence Microscopy Cells Chromosomes Proteins Fluorescence Noise Dissociation Modeling Compensation And Redress Promoter Regions Dna Memory Cell Positioning

Most Recent Publications

Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles

Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications

Mechanisms underlying WNT-mediated priming of human embryonic stem cells

Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology

Chemically-induced chromosomal interactions (CICI) method to perturb chromosomal conformation and study its functions

Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communication on p. 757

Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast

Hungyo Kharerin, Lu Bai, 2021, PLoS Computational Biology

Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction

Emily J. Parnell, Timothy J. Parnell, Chao Yan, Lu Bai, David J. Stillman, 2020, PLoS Genetics on p. e1009133

A role for mediator core in limiting coactivator recruitment in saccharomyces cerevisiae

Robert M. Yarrington, Yaxin Yu, Chao Yan, Lu Bai, David J. Stillman, 2020, Genetics on p. 407-420

Existence, transition, and propagation of intermediate silencing states in ribosomal DNA

Fan Zou, Manyu Du, Hengye Chen, Lu Baia, 2019, Molecular and Cellular Biology

Enhancement of LacI binding in vivo

Manyu Du, Seth Kodner, Lu Bai, 2019, Nucleic Acids Research on p. 9609-9618

Using time-lapse fluorescence microscopy to study gene regulation

Fan Zou, Lu Bai, 2019, ImmunoMethods on p. 138-145

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Most-Cited Papers

Transcription under torsion

Jie Ma, Lu Bai, Michelle D. Wang, 2013, Science on p. 1580-1583

Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence

Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384

Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing

Jian Li, Yingyun Liu, Ho Sung Rhee, Saikat Kumar B. Ghosh, Lu Bai, B. Franklin Pugh, David S. Gilmour, 2013, Molecular Cell on p. 711-722

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Stochastic expression and epigenetic memory at the yeast HO promoter

Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman, Lu Bai, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14012-14017

Lu Bai

Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics

Research Summary

Huck Graduate Students

Huck Affiliations

Publication Tags

Most Recent Publications

Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles

Mechanisms underlying WNT-mediated priming of human embryonic stem cells

Chemically-induced chromosomal interactions (CICI) method to perturb chromosomal conformation and study its functions

Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast

Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction

A role for mediator core in limiting coactivator recruitment in saccharomyces cerevisiae

Existence, transition, and propagation of intermediate silencing states in ribosomal DNA

Enhancement of LacI binding in vivo

Using time-lapse fluorescence microscopy to study gene regulation

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Most-Cited Papers

Transcription under torsion

Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence

Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Stochastic expression and epigenetic memory at the yeast HO promoter

Regulation of cell-to-cell variability in divergent gene expression

Decoupling of divergent gene regulation by sequence-specific DNA binding factors

Interallelic interaction and gene regulation In budding yeast

Three distinct mechanisms of long-distance modulation of gene expression in yeast