Lu Bai

Professor of Biochemistry and Molecular Biology; Professor of Physics

Lu Bai

Research Summary

Single cell / single molecule study of chromatin and gene regulation.

Huck Graduate Students

Huck Affiliations

Publication Tags

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Genes Gene Expression Nucleosomes Saccharomycetales Yeasts Transcription Factors Genome Cells Yeast Fluorescence Proteins Chromosomes Human Embryonic Stem Cells Memory Activins Dna Sequence Chromatin Noise Origin Recognition Complex Time Deoxyribonucleic Acid Replication Origin Thermodynamics Dna Licensure

Most Recent Publications

Using Synthetic DNA Libraries to Investigate Chromatin and Gene Regulation

Holly Kleinschmidt, Cheng Xu, Lu Bai, 2023, Chromosoma on p. 167-189

Investigating pioneer factor activity and its coordination with chromatin remodelers using integrated synthetic oligo assay

Hengye Chen, Chao Yan, Archana Dhasarathy, Michael Kladde, Lu Bai, 2023, STAR Protocols

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions

Benjamin T. Donovan, Hengye Chen, Priit Eek, Zhiyuan Meng, Caroline Jipa, Song Tan, Lu Bai, Michael G. Poirier, 2023, Molecular Cell on p. 1251-1263.e6

Predicting nucleosome positioning using statistical equilibrium models in budding yeast

Hungyo Kharerin, Lu Bai, 2023, STAR Protocols

Long range chromosomal interactions and first passage process in budding yeast

Lu Bai, 2023, Biophysical Journal on p. 18a-19a

Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles

Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Nature Communications

Origin recognition complex harbors an intrinsic nucleosome remodeling activity

Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America

Mechanisms underlying WNT-mediated priming of human embryonic stem cells

Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology

Mechanisms underlying WNT-mediated priming of human embryonic stem cells

Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology

Most-Cited Papers

Transcription under torsion

Jie Ma, Lu Bai, Michelle D. Wang, 2013, Science on p. 1580-1583

Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence

Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384

Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing

Jian Li, Yingyun Liu, Ho Sung Rhee, Saikat Kumar B. Ghosh, Lu Bai, B. Franklin Pugh, David S. Gilmour, 2013, Molecular Cell on p. 711-722

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Stochastic expression and epigenetic memory at the yeast HO promoter

Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman, Lu Bai, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14012-14017

Decoupling of divergent gene regulation by sequence-specific DNA binding factors

Chao Yan, Daoyong Zhang, Juan Antonio Raygoza Garay, Michael M. Mwangi, Lu Bai, 2015, Nucleic Acids Research on p. 7292-7305

Regulation of cell-to-cell variability in divergent gene expression

Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai, 2016, Nature Communications

Interallelic interaction and gene regulation In budding yeast

Daoyong Zhang, Lu Bai, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 4428-4433

Three distinct mechanisms of long-distance modulation of gene expression in yeast

Manyu Du, Qian Zhang, Lu Bai, 2017, PLoS Genetics on p. e1006736