Lu Bai

Professor of Biochemistry and Molecular Biology; Professor of Physics

Lu Bai

Research Summary

Single cell / single molecule study of chromatin and gene regulation.

Huck Graduate Students

Huck Affiliations

Publication Tags

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Nucleosomes Genes Saccharomycetales Transcription Factors Promoter Region Gene Expression Dna Sequence Gene Control Deoxyribonucleic Acid Fluorescence Genome Proteins Replication Origin Chromosomes Origin Recognition Complex Licensure Yeasts Licensing Cells Consensus Sequence Cofactor Yeast Budding Yeast Time Chromatin

Most Recent Publications

DNA methylation-based high-resolution mapping of long-distance chromosomal interactions in nucleosome-depleted regions

Yi Li, James Lee, Lu Bai, 2024, Nature Communications

Pioneer factors: nature or nurture?

Shane Stoeber, Holly Godin, Cheng Xu, Lu Bai, 2024, Critical Reviews in Biochemistry and Molecular Biology

Using Synthetic DNA Libraries to Investigate Chromatin and Gene Regulation

Holly Kleinschmidt, Cheng Xu, Lu Bai, 2023, Chromosoma on p. 167-189

Investigating pioneer factor activity and its coordination with chromatin remodelers using integrated synthetic oligo assay

Hengye Chen, Chao Yan, Archana Dhasarathy, Michael Kladde, Lu Bai, 2023, STAR Protocols

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions

Benjamin T. Donovan, Hengye Chen, Priit Eek, Zhiyuan Meng, Caroline Jipa, Song Tan, Lu Bai, Michael G. Poirier, 2023, Molecular Cell on p. 1251-1263.e6

Predicting nucleosome positioning using statistical equilibrium models in budding yeast

Hungyo Kharerin, Lu Bai, 2023, STAR Protocols

Long range chromosomal interactions and first passage process in budding yeast

Lu Bai, 2023, Biophysical Journal on p. 18a-19a

Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles

Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Nature Communications

Origin recognition complex harbors an intrinsic nucleosome remodeling activity

Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America

Most-Cited Papers

Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence

Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Decoupling of divergent gene regulation by sequence-specific DNA binding factors

Chao Yan, Daoyong Zhang, Juan Antonio Raygoza Garay, Michael M. Mwangi, Lu Bai, 2015, Nucleic Acids Research on p. 7292-7305

Regulation of cell-to-cell variability in divergent gene expression

Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai, 2016, Nature Communications

Enhancement of LacI binding in vivo

Manyu Du, Seth Kodner, Lu Bai, 2019, Nucleic Acids Research on p. 9609-9618

Interallelic interaction and gene regulation In budding yeast

Daoyong Zhang, Lu Bai, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 4428-4433

Partitioned usage of chromatin remodelers by nucleosome-displacing factors

Hengye Chen, Hungyo Kharerin, Archana Dhasarathy, Michael Kladde, Lu Bai, 2022, Cell Reports

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions

Benjamin T. Donovan, Hengye Chen, Priit Eek, Zhiyuan Meng, Caroline Jipa, Song Tan, Lu Bai, Michael G. Poirier, 2023, Molecular Cell on p. 1251-1263.e6

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Nature Communications