Lu Bai
Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics

-
206B Huck Life Sciences
University Park, PA - lub15@psu.edu
- 814-863-4824
Research Summary
Single cell / single molecule study of chromatin and gene regulation.
Huck Graduate Students
Huck Affiliations
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Nucleosomes Genes Genome Gene Expression Yeasts Yeast Thermodynamics Saccharomycetales Transcription Factors Cells Saccharomyces Cerevisiae Chromatin Fluorescence Proteins Chromosomes Promoter Regions Modeling Memory Activins Human Embryonic Stem Cells Noise Cell Positioning Origin Recognition Complex DnaMost Recent Publications
Predicting Nucleosome Positioning Using Statistical Equilibrium Models
H Kharerin, Lu Bai, 2023, Star Protocol on p. 101926
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Nature Communications
Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles
Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications
Origin recognition complex harbors an intrinsic nucleosome remodeling activity
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Anna Yoney, Lu Bai, Ali H. Brivanlou, Eric D. Siggia, 2022, Journal of Embryology and Experimental Morphology
Partitioned usage of chromatin remodelers by nucleosome-displacing factors
Hengye Chen, Hungyo Kharerin, Archana Dhasarathy, Michael Kladde, Lu Bai, 2022, Cell Reports
Chemically-induced chromosomal interactions (CICI) method to perturb chromosomal conformation and study its functions
Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communication on p. 757
Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast
Hungyo Kharerin, Lu Bai, 2021, PLoS Computational Biology
Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction
Emily J. Parnell, Timothy J. Parnell, Chao Yan, Lu Bai, David J. Stillman, 2020, PLoS Genetics on p. e1009133
Most-Cited Papers
Transcription under torsion
Jie Ma, Lu Bai, Michelle D. Wang, 2013, Science on p. 1580-1583
Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-On Fluorescence
Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384
Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing
Jian Li, Yingyun Liu, Ho Sung Rhee, Saikat Kumar B. Ghosh, Lu Bai, B. Franklin Pugh, David S. Gilmour, 2013, Molecular Cell on p. 711-722
Systematic Study of Nucleosome-Displacing Factors in Budding Yeast
Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4
Dissociation rate compensation mechanism for budding yeast pioneer transcription factors
Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife
Stochastic expression and epigenetic memory at the yeast HO promoter
Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman, Lu Bai, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14012-14017
Regulation of cell-to-cell variability in divergent gene expression
Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai, 2016, Nature Communications
Decoupling of divergent gene regulation by sequence-specific DNA binding factors
Chao Yan, Daoyong Zhang, Juan Antonio Raygoza Garay, Michael M. Mwangi, Lu Bai, 2015, Nucleic Acids Research on p. 7292-7305
Interallelic interaction and gene regulation In budding yeast
Daoyong Zhang, Lu Bai, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 4428-4433
Three distinct mechanisms of long-distance modulation of gene expression in yeast
Manyu Du, Qian Zhang, Lu Bai, 2017, PLoS Genetics on p. e1006736