Lu Bai

Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics

Lu Bai

Research Summary

Single cell / single molecule study of chromatin and gene regulation.

Huck Graduate Students

Huck Affiliations

Publication Tags

Genes Nucleosomes Gene Expression Genome Transcription Factors Yeasts Yeast Saccharomycetales Thermodynamics Saccharomyces Cerevisiae Time Fluorescence Microscopy Cells Chromosomes Proteins Fluorescence Noise Compensation And Redress Promoter Regions Modeling Dissociation Dna Cell Positioning Genomics

Most Recent Papers

Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles

Manyu Du, Fan Zou, Yi Li, Yujie Yan, Lu Bai, 2022, Nature Communications

Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast

Hungyo Kharerin, Lu Bai, 2021, PLoS Computational Biology

Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.

Emily J. Parnell, Timothy J. Parnell, Chao Yan, Lu Bai, David J. Stillman, 2020, PLoS Genetics on p. e1009133

A role for mediator core in limiting coactivator recruitment in saccharomyces cerevisiae

Robert M. Yarrington, Yaxin Yu, Chao Yan, Lu Bai, David J. Stillman, 2020, Genetics on p. 407-420

Existence, transition, and propagation of intermediate silencing states in ribosomal DNA

Fan Zou, Manyu Du, Hengye Chen, Lu Baia, 2019, Molecular and Cellular Biology

Enhancement of LacI binding in vivo

Manyu Du, Seth Kodner, Lu Bai, 2019, Nucleic Acids Research on p. 9609-9618

Using time-lapse fluorescence microscopy to study gene regulation

Fan Zou, Lu Bai, 2019, ImmunoMethods on p. 138-145

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Using time-lapse fluorescence microscopy to study gene regulation.

F Zou, Lu Bai, 2018, Methods (San Diego, Calif.)

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4

Most-Cited Papers

Transcription under torsion

Jie Ma, Lu Bai, Michelle D. Wang, 2013, Science on p. 1580-1583

Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing

Jian Li, Yingyun Liu, Ho Sung Rhee, Saikat Kumar B. Ghosh, Lu Bai, B. Franklin Pugh, David S. Gilmour, 2013, Molecular Cell on p. 711-722

Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence

Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

Chao Yan, Hengye Chen, Lu Bai, 2018, Molecular Cell on p. 294-305.e4

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Benjamin T. Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G. Poirier, 2019, eLife

Stochastic expression and epigenetic memory at the yeast HO promoter

Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman, Lu Bai, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14012-14017

Decoupling of divergent gene regulation by sequence-specific DNA binding factors

Chao Yan, Daoyong Zhang, Juan Antonio Raygoza Garay, Michael M. Mwangi, Lu Bai, 2015, Nucleic Acids Research on p. 7292-7305

Regulation of cell-to-cell variability in divergent gene expression

Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai, 2016, Nature Communications

Interallelic interaction and gene regulation In budding yeast

Daoyong Zhang, Lu Bai, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 4428-4433

Three distinct mechanisms of long-distance modulation of gene expression in yeast

Manyu Du, Qian Zhang, Lu Bai, 2017, PLoS Genetics on p. e1006736