Lorraine Santy

Associate Professor of Biochemistry and Molecular Biology

Lorraine Santy

Research Summary

The signals and processes that initiate migration in epithelial cells.

Huck Affiliations

Links

Publication Tags

Cytohesin 2 Recycling Integrins Proteins Guanine Nucleotide Exchange Factors Epithelial Cells Cell Movement Gtp Phosphohydrolases Adp Ribosylation Factors Stiffness Hepatocyte Growth Factor Cells Cell Membrane Gels Thresholds Histones Cytohesin 1 Guanosine Extracellular Traps Kidney Phase Diagrams Traction Heterochromatin Phosphatidylinositols Epithelium

Most Recent Papers

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210

ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment

Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular biology of the cell on p. 4265-4279

The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice

Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological reports

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in immunology

Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2012, Journal of Cell Science on p. 3195-3201

Differential effects of cytohesins 2 and 3 on β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2010, Journal of Biological Chemistry on p. 14610-14616

ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells

Miriam Shmuel, Lorraine C. Santy, Scott Frank, Dana Avrahami, James E. Casanova, Yoram Altschuler, 2006, Journal of Biological Chemistry on p. 13300-13308

The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1

Lorraine C. Santy, Kodi S. Ravichandran, James E. Casanova, 2005, Current Biology on p. 1749-1754

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6

Lenka Martinu, Jeffrey M. Masuda-Robens, Sarah E. Robertson, Lorraine C. Santy, James E. Casanova, Margaret M. Chou, 2004, Molecular and cellular biology on p. 9752-9762

Most-Cited Papers

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in immunology

Differential effects of cytohesins 2 and 3 on β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2010, Journal of Biological Chemistry on p. 14610-14616

Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2012, Journal of Cell Science on p. 3195-3201

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology

The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice

Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological reports

ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment

Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular biology of the cell on p. 4265-4279

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210