Lorraine Santy

Associate Professor of Biochemistry and Molecular Biology

Lorraine Santy

Research Summary

The signals and processes that initiate migration in epithelial cells.

Huck Affiliations

Links

Publication Tags

Proteins Cytohesin 2 Hepatocyte Growth Factor Recycling Threonine Cell Movement Epithelial Cells Gtp Phosphohydrolases Membranes Integrins Guanine Nucleotide Exchange Factors Stiffness Monomeric Gtp Binding Proteins Phosphorylation Cells Chemical Activation Protein Association Reactions Guanosine Triphosphate Pleckstrin Homology Domains Acute Kidney Injury Chromatin Phosphatidylinositols Gels Protein Arginine Deiminases

Most Recent Papers

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210

Arf GTPases and their GEFs and GAPS

Elizabeth Sztul, Pei Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schürmann, Ilka Wilhelmi, Marielle E. Yohe, Richard A. Kahn, 2019, Molecular Biology of the Cell on p. 1249-1271

ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation

Emily J. Koubek, Lorraine C. Santy, 2018, Small GTPases on p. 242-259

ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment

Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular Biology of the Cell on p. 4265-4279

The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice

Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological Reports

The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association

Kevin G. Hiester, Lorraine C. Santy, 2013, PLoS One

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in Immunology

Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2012, The Quarterly journal of microscopical science on p. 3195-3201

CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration

Myriam A. Attar, Joseph C. Salem, Heather S. Pursel, Lorraine C. Santy, 2012, Experimental Cell Research on p. 228-237

Most-Cited Papers

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in Immunology

Arf GTPases and their GEFs and GAPS

Elizabeth Sztul, Pei Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schürmann, Ilka Wilhelmi, Marielle E. Yohe, Richard A. Kahn, 2019, Molecular Biology of the Cell on p. 1249-1271

CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration

Myriam A. Attar, Joseph C. Salem, Heather S. Pursel, Lorraine C. Santy, 2012, Experimental Cell Research on p. 228-237

The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association

Kevin G. Hiester, Lorraine C. Santy, 2013, PLoS One

Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2012, The Quarterly journal of microscopical science on p. 3195-3201

The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice

Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological Reports

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology

ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation

Emily J. Koubek, Lorraine C. Santy, 2018, Small GTPases on p. 242-259

ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment

Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular Biology of the Cell on p. 4265-4279

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210