Leslie Parent

Professor of Medicine and Microbiology & Immunology

Leslie Parent

Huck Affiliations

Publication Tags

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Hiv 1 Proteins Rna Retroviridae Coronavirus Gag Gene Products Rous Sarcoma Virus Sars Virus Viral Rna Nucleic Acids Therapeutics Pharmaceutical Preparations Cohort Studies Infections Mouse Mammary Tumor Virus Mortality Systematic Reviews Virus Assembly Odds Ratio Meta Analysis Vaccines Retrospective Studies Product Packaging Glucagon Like Peptide 1 Receptor Ribonucleoproteins

Most Recent Publications

HIV-1 Gag co-localizes with euchromatin histone marks at the nuclear periphery

Jordan Chang, Leslie J. Parent, 2023, Journal of Virology

Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates

Anne Monette, Meijuan Niu, Rebecca Kaddis Maldonado, Jordan Chang, Gregory S. Lambert, John M. Flanagan, Alan Cochrane, Leslie J. Parent, Andrew J. Mouland, 2023, Journal of Molecular Biology

The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions

Rebecca Kaddis Maldonado, Gregory S. Lambert, Breanna L. Rice, Malgorzata Sudol, John M. Flanagan, Leslie J. Parent, 2023, Journal of Molecular Biology

Virus Induced Membraneless Organelles and Biomolecular Condensates

Andrew J. Mouland, Leslie Parent, Stephanie C. Weber, Alex S. Holehouse, 2023, Journal of Molecular Biology

Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

Bao An Chau, Venessa Chen, Alan W. Cochrane, Leslie J. Parent, Andrew J. Mouland, 2023, Cell Reports

SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis

Paddy Ssentongo, Anna E. Ssentongo, Navya Voleti, Destin Groff, Ashley Sun, Djibril M. Ba, Jonathan Nunez, Leslie J. Parent, Vernon M. Chinchilli, Catharine I. Paules, 2022, BMC Infectious Diseases

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Benoit Chabot, Scott D. Gray-Owen, Leslie J. Parent, Alan Cochrane, 2022, Retrovirology

Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding

Sinisa Dovat, Chandrika Gowda, Richard B. Mailman, Leslie J. Parent, Xuemei Huang, 2022, Advances in Medical Education and Practice on p. 1039-1050

Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study

Jennifer Nyland, N Raja-Khan, K Bettermann, P Haouzi, J Kraschnewski, L Parent, P Grigson, 2021, Diabetes on p. 2903-2916

Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses

R Kumar, Neil D. Christensen, R Kaddis Maldonado, Maria C. Bewley, A Ostman, M Sudol, E Chen, N Buchkovich, A Gontu, Meera Surendran Nair, R Nissly, A Minns, Vivek Kapur, R Rossi, Suresh V. Kuchipudi, Scott E. Lindner, Leslie J. Parent, John M. Flanagan, Nicholas J. Buchkovich, 2021, Viruses

Most-Cited Papers

SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis

Paddy Ssentongo, Anna E. Ssentongo, Navya Voleti, Destin Groff, Ashley Sun, Djibril M. Ba, Jonathan Nunez, Leslie J. Parent, Vernon M. Chinchilli, Catharine I. Paules, 2022, BMC Infectious Diseases

Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study

Jennifer Nyland, N Raja-Khan, K Bettermann, P Haouzi, J Kraschnewski, L Parent, P Grigson, 2021, Diabetes on p. 2903-2916

Orchestrating the selection and packaging of genomic RNA by retroviruses: An ensemble of viral and host factors

Rebecca J. Kaddis Maldonado, Leslie J. Parent, 2016, Viruses

HIV-1 and two avian retroviral 5' untranslated regions bind orthologous human and chicken RNA binding proteins

Matthew Stake, Deepali Singh, Gatikrushna Singh, J. Marcela Hernandez, Rebecca Kaddis Maldonado, Leslie J. Parent, Kathleen Boris-Lawrie, 2015, Virology on p. 307-320

Visualizing association of the retroviral gag protein with unspliced viral RNA in the nucleus

Rebecca J.Kaddis Maldonado, Breanna Rice, Eunice C. Chen, Kevin M. Tuffy, Estelle F. Chiari, Kelly M. Fahrbach, Thomas J. Hope, Leslie J. Parent, 2020, mBio

Hiv-1 gag forms ribonucleoprotein complexes with unspliced viral rna at transcription sites

Kevin M. Tuffy, Rebecca J. Kaddis Maldonado, Jordan Chang, Paul Rosenfeld, Alan Cochrane, Leslie J. Parent, 2020, Viruses

Functional equivalence of retroviral MA domains in facilitating Psi RNA binding specificity by Gag

Tiffiny Rye-McCurdy, Erik D. Olson, Shuohui Liu, Christiana Binkley, Joshua Paolo Reyes, Brian R. Thompson, John M. Flanagan, Leslie J. Parent, Karin Musier-Forsyth, 2016, Viruses

A non-cleavable hexahistidine affinity tag at the carboxyl-terminus of the HIV-1 Pr55<sup>Gag</sup> polyprotein alters nucleic acid binding properties

Maria C. Bewley, Lisa Reinhart, Matthew S. Stake, Shorena Nadaraia-Hoke, Leslie J. Parent, John M. Flanagan, 2017, Protein Expression and Purification on p. 137-145

Mechanistic differences between nucleic acid chaperone activities of the gag proteins of rous sarcoma virus and human immunodeficiency virus type 1 are attributed to the MA domain

Tiffiny D. Rye-McCurdy, Shorena Nadaraia-Hoke, Nicole Gudleski-O'Regan, John M. Flanagan, Leslie J. Parent, Karin Musier-Forsyth, 2014, Journal of Virology on p. 7852-7861

A murine retrovirus Co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly

Darrin V. Bann, Andrea R. Beyer, Leslie J. Parent, 2014, Journal of Virology on p. 4434-4450