Leslie Parent

Professor of Medicine and Microbiology & Immunology

Leslie Parent

Huck Affiliations

Most Recent Publications

Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates

Gregory S. Lambert, Rebecca J.Kaddis Maldonado, Leslie J. Parent, 2025, Viruses

Death From Infection Among Patients Living With Cancer

Mckenzee Chiam, Kyle Mani, Xi Wang, Ming Wang, Daniel M. Trifiletti, Leslie J. Parent, Daniel E. Spratt, Leila Tchelebi, Nicholas Zaorsky, 2025, American Journal of Clinical Oncology

Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome

Gregory S. Lambert, Breanna L. Rice, Rebecca J.Kaddis Maldonado, Jordan Chang, Leslie J. Parent, 2024, Retrovirology

ESCRT Protein VPS4A Is Required for the Formation of Replication Centers and Replication of Human Coronavirus 229E (HCoV-229E)

Rinki Kumar, Rebecca Kaddis Maldonado, Neil Christensen, Maria C. Bewley, John Flanagan, Nicholas Buchkovich, Leslie Parent, 2024, COVID on p. 1338-1354

Effects of ACE inhibitor/ARB therapy and long COVID on kidney disease: a retrospective cohort study using real-world data

Yue Zhang, Djibril M. Ba, Kathryn Risher, Duanping Liao, Leslie J. Parent, Nasrollah Ghahramani, Vernon M. Chinchilli, 2024, CKJ: Clinical Kidney Journal

HIV-1 Gag co-localizes with euchromatin histone marks at the nuclear periphery

Jordan Chang, Leslie J. Parent, 2023, Journal of Virology

Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates

Anne Monette, Meijuan Niu, Rebecca Kaddis Maldonado, Jordan Chang, Gregory S. Lambert, John M. Flanagan, Alan Cochrane, Leslie J. Parent, Andrew J. Mouland, 2023, Journal of Molecular Biology

Virus Induced Membraneless Organelles and Biomolecular Condensates

Andrew J. Mouland, Leslie Parent, Stephanie C. Weber, Alex S. Holehouse, 2023, Journal of Molecular Biology

The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions

Rebecca Kaddis Maldonado, Gregory S. Lambert, Breanna L. Rice, Malgorzata Sudol, John M. Flanagan, Leslie J. Parent, 2023, Journal of Molecular Biology

Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

Bao An Chau, Venessa Chen, Alan W. Cochrane, Leslie J. Parent, Andrew J. Mouland, 2023, Cell Reports

Most-Cited Papers

SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis

Paddy Ssentongo, Anna E. Ssentongo, Navya Voleti, Destin Groff, Ashley Sun, Djibril M. Ba, Jonathan Nunez, Leslie J. Parent, Vernon M. Chinchilli, Catharine I. Paules, 2022, BMC Infectious Diseases

Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study

Jennifer Nyland, N Raja-Khan, K Bettermann, P Haouzi, J Kraschnewski, L Parent, P Grigson, 2021, Diabetes on p. 2903-2916

Orchestrating the selection and packaging of genomic RNA by retroviruses: An ensemble of viral and host factors

Rebecca J. Kaddis Maldonado, Leslie J. Parent, 2016, Viruses

Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

Bao An Chau, Venessa Chen, Alan W. Cochrane, Leslie J. Parent, Andrew J. Mouland, 2023, Cell Reports

HIV-1 and two avian retroviral 5' untranslated regions bind orthologous human and chicken RNA binding proteins

Matthew Stake, Deepali Singh, Gatikrushna Singh, J. Marcela Hernandez, Rebecca Kaddis Maldonado, Leslie J. Parent, Kathleen Boris-Lawrie, 2015, Virology on p. 307-320

Hiv-1 gag forms ribonucleoprotein complexes with unspliced viral rna at transcription sites

Kevin M. Tuffy, Rebecca J. Kaddis Maldonado, Jordan Chang, Paul Rosenfeld, Alan Cochrane, Leslie J. Parent, 2020, Viruses

Visualizing association of the retroviral gag protein with unspliced viral RNA in the nucleus

Rebecca J.Kaddis Maldonado, Breanna Rice, Eunice C. Chen, Kevin M. Tuffy, Estelle F. Chiari, Kelly M. Fahrbach, Thomas J. Hope, Leslie J. Parent, 2020, mBio

Functional equivalence of retroviral MA domains in facilitating Psi RNA binding specificity by Gag

Tiffiny Rye-McCurdy, Erik D. Olson, Shuohui Liu, Christiana Binkley, Joshua Paolo Reyes, Brian R. Thompson, John M. Flanagan, Leslie J. Parent, Karin Musier-Forsyth, 2016, Viruses

A non-cleavable hexahistidine affinity tag at the carboxyl-terminus of the HIV-1 Pr55<sup>Gag</sup> polyprotein alters nucleic acid binding properties

Maria C. Bewley, Lisa Reinhart, Matthew S. Stake, Shorena Nadaraia-Hoke, Leslie J. Parent, John M. Flanagan, 2017, Protein Expression and Purification on p. 137-145

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Benoit Chabot, Scott D. Gray-Owen, Leslie J. Parent, Alan Cochrane, 2022, Retrovirology