Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Affiliations

Publication Tags

Skin Vasodilation Nitric Oxide Temperature Blood Vessels Blood Pressure Nitric Oxide Synthase Health Exercise Reflex Nitric Oxide Synthase Type Iii Young Adult Hydrogen Sulfide Hot Temperature Microdialysis Heating Arginase Microvessels Therapeutics Diet Muscles Dilatation Microcirculation Dairy Products Population

Most Recent Papers

Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults

Gabrielle A. Dillon, Zachary S. Lichter, Lacy M. Alexander, Lauro C. Vianna, Jing Wang, Paul J. Fadel, Jody Leigh Greaney, 2020, Journal of Applied Physiology on p. 1203-1213

AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction

Gabrielle A. Dillon, Jody L. Greaney, Sean Shank, Urs A. Leuenberger, Lacy M. Alexander, 2020, American Journal of Physiology on p. H539-H546

Childhood socioeconomic status, comorbidity of chronic kidney disease risk factors, and kidney function among adults in the midlife in the United States (MIDUS) study

Agus Surachman, Jonathan Daw, Bethany C. Bray, Lacy M. Alexander, Christopher L. Coe, David M. Almeida, 2020, BMC Nephrology

Dairy Foods and Dairy Fats

Kristin M. Hirahatake, Richard S. Bruno, Bradley W. Bolling, Christopher Blesso, Lacy M. Alexander, Sean H. Adams, 2020, Advances in nutrition (Bethesda, Md.) on p. 266-279

Local angiotensin-(1–7) administration improves microvascular endothelial function in women who have had preeclampsia

Anna E. Stanhewicz, Lacy M. Alexander, 2020, American Journal of Physiology on p. R148-R155

Temperature regulation during exercise in the heat

W. Larry Kenney, S. Tony Wolf, Gabrielle A. Dillon, Craig W. Berry, Lacy M. Alexander, 2020, Australian Journal of Science and Medicine in Sport

Controlled feeding of an 8-d, high-dairy cheese diet prevents sodium-induced endothelial dysfunction in the cutaneous microcirculation of healthy, older adults through reductions in superoxide

Billie K. Alba, Anna E. Stanhewicz, Priyankar Dey, Richard S. Bruno, W. Larry Kenney, Lacy M. Alexander, 2020, Journal of Nutrition on p. 55-63

Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder

Jody L. Greaney, Gabrielle A. Dillon, Erika F.H. Saunders, Lacy M. Alexander, 2020, Journal of Applied Physiology on p. 100-107

Historical reviews of the assessment of human cardiovascular function

David A. Low, Helen Jones, N. Tim Cable, Lacy M. Alexander, W. Larry Kenney, 2020, European Journal of Applied Physiology

Publisher Correction

Young Hee Nam, Warren B. Bilker, Charles E. Leonard, Michelle L. Bell, Lacy M. Alexander, Sean Hennessy, 2019, Scientific Reports

Most-Cited Papers

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy A. Holowatz, 2011, Hypertension on p. 935-942

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 2019-2026

Changes in the control of skin blood flow with exercise training

Grant H. Simmons, Brett J. Wong, Lacy A. Holowatz, W. Larry Kenney, 2011, Experimental Physiology on p. 822-828

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Lacy Marie Alexander, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 2093-2103

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 791-797

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults

Jody L. Greaney, Jessica L. Kutz, Sean W. Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 902-909

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature

Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129

Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms

Anna E. Stanhewicz, Lacy Marie Alexander, William Lawrence Kenney, Jr., 2015, Clinical Science on p. 159-167