Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Institutes Affiliations

Publication Tags

Skin Vasodilation Hot Temperature Blood Vessels Heating Nitric Oxide Synthase Microdialysis Blood Pressure Nitric Oxide Reflex Arginase Hypertension Vasoconstriction Temperature Therapeutics Nitric Oxide Synthase Type Iii Major Depressive Disorder Sweating Oxidative Stress Microcirculation Exercise Dilatation Laser Doppler Flowmetry Endothelium Skin Temperature

Most Recent Papers

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise

Robert D. Meade, Naoto Fujii, Gregory W. McGarr, Lacy Marie Alexander, Pierre Boulay, Ronald J. Sigal, Glen P. Kenny, 2019, Journal of applied physiology (Bethesda, Md. : 1985) on p. 1129-1137

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder

Jody Leigh Greaney, Erika F. H. Saunders, Lakshmi Santhanam, Lacy Marie Alexander, 2019, Circulation research on p. 564-574

Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder

Jody Leigh Greaney, Rachel E. Koffer, Erika F. H. Saunders, David Almeida, Lacy Marie Alexander, 2019, Journal of the American Heart Association

Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women

Daniel H. Craighead, Huilei Wang, Lakshmi Santhanam, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H424-H433

Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation

Billie K. Alba, Jody Leigh Greaney, Sara Ferguson, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H343-H349

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy Marie Alexander, 2017, Clinical Science on p. 2777-2789

Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating

Caroline J. Smith, Daniel H. Craighead, Lacy Marie Alexander, 2017, Journal of Applied Physiology on p. 1461-1467

Sympathetic function during whole body cooling is altered in hypertensive adults

Jody Leigh Greaney, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2017, Journal of Applied Physiology on p. 1617-1624

Menthol-induced cutaneous vasodilation is preserved in essential hypertensive men and women

Daniel H. Craighead, Lacy Marie Alexander, 2017, American journal of hypertension on p. 1156-1162

Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO-dependent and NO-independent mechanisms

Daniel H. Craighead, Caroline J. Smith, Lacy Marie Alexander, 2017, Microcirculation

High-Impact Papers

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2012, Journal of Applied Physiology on p. 2019-2026

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy Marie Alexander, 2011, Hypertension on p. 935-942

Aging and the control of human skin blood flow

Lacy Marie Alexander, Caitlin Thompson-Torgerson, William Lawrence Kenney, Jr., 2010, Frontiers in Bioscience on p. 718-739

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Lacy Marie Alexander, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 2093-2103

Heat waves aging and human cardiovascular health

William Lawrence Kenney, Jr., Daniel H. Craighead, Lacy Marie Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2012, Journal of Applied Physiology on p. 791-797

Nonuniform, age-related decrements in regional sweating and skin blood flow

Caroline J. Smith, Lacy Marie Alexander, William Lawrence Kenney, Jr., 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy Marie Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress

Rebecca S. Bruning, Jessica D. Dahmus, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2013, Medicine and Science in Sports and Exercise on p. 674-682

Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin

Lacy Marie Alexander, John D. Jennings, James A. Lang, William Lawrence Kenney, Jr., 2009, Journal of Applied Physiology on p. 1121-1127