Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Affiliations

Publication Tags

Skin Vasodilation Blood Vessels Hot Temperature Nitric Oxide Microdialysis Heating Sweating Arginase Temperature Therapeutics Reflex Vasoconstriction Nitric Oxide Synthase Oxidative Stress Atorvastatin Calcium Major Depressive Disorder Sapropterin Dilatation Acetylcholine Laser Doppler Flowmetry Forearm Microvessels Endothelium Perfusion

Most Recent Papers

Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population

Young Hee Nam, Warren B. Bilker, Charles E. Leonard, Michelle L. Bell, Lacy M. Alexander, Sean Hennessy, 2019, Scientific reports on p. 4685

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder

Jody L. Greaney, Erika F.H. Saunders, Lakshmi Santhanam, Lacy M. Alexander, 2019, Circulation research on p. 564-574

Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder

Jody L. Greaney, Rachel E. Koffer, Erika F.H. Saunders, David M. Almeida, Lacy M. Alexander, 2019, Journal of the American Heart Association

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise

Robert D. Meade, Naoto Fujii, Gregory W. McGarr, Lacy Marie Alexander, Pierre Boulay, Ronald J. Sigal, Glen P. Kenny, 2019, Journal of Applied Physiology on p. 1129-1137

Vascular aging

Douglas R. Seals, Lacy Marie Alexander, 2018, Journal of applied physiology (Bethesda, Md. : 1985) on p. 1841-1842

Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women

Daniel H. Craighead, Huilei Wang, Lakshmi Santhanam, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H424-H433

Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation

Billie K. Alba, Jody Leigh Greaney, Sara Ferguson, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H343-H349

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Clinical Science on p. 2777-2789

Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating

Caroline J. Smith, Daniel H. Craighead, Lacy M. Alexander, 2017, Journal of applied physiology on p. 1461-1467

Sympathetic function during whole body cooling is altered in hypertensive adults

Jody Leigh Greaney, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2017, Journal of Applied Physiology on p. 1617-1624

Most-Cited Papers

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and science in sports and exercise on p. 1891-1899

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy A. Holowatz, 2011, Hypertension on p. 935-942

Aging and the control of human skin blood flow

Lacy A. Holowatz, Caitlin Thompson-Torgerson, W. Larry Kenney, 2010, Frontiers in Bioscience on p. 718-739

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Lacy Marie Alexander, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 2093-2103

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of applied physiology on p. 791-797

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Nonuniform, age-related decrements in regional sweating and skin blood flow

Caroline J. Smith, Lacy M. Alexander, W. Larry Kenney, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R877-R885

Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans

Lacy Marie Alexander, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 4787-4797

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature

Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129

Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans

Caroline J. Smith, W. Larry Kenney, Lacy M. Alexander, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R566-R573