Lacy Alexander

Associate Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Institutes Affiliations

Publication Tags

Skin Vasodilation Hot Temperature Blood Vessels Heating Nitric Oxide Synthase Blood Pressure Microdialysis Reflex Nitric Oxide Hypertension Vasoconstriction Temperature Nitric Oxide Synthase Type Iii Pre Eclampsia Microcirculation Vasodilator Agents Therapeutics Arginase Muscles Endothelium Laser Doppler Flowmetry Skin Temperature Dilatation Fever

Most Recent Papers

Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women

Daniel H. Craighead, Huilei Wang, Lakshmi Santhanam, Lacy M. Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H424-H433

Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation

Billie K. Alba, Jody L. Greaney, Sara B. Ferguson, Lacy M. Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H343-H349

Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating

Caroline J. Smith, Daniel H. Craighead, Lacy M. Alexander, 2017, Journal of Applied Physiology on p. 1461-1467

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Clinical Science on p. 2777-2789

Sympathetic function during whole body cooling is altered in hypertensive adults

Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2017, Journal of Applied Physiology on p. 1617-1624

Menthol-induced cutaneous vasodilation is preserved in essential hypertensive men and women

Daniel H. Craighead, Lacy M. Alexander, 2017, American journal of hypertension on p. 1156-1162

Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO-dependent and NO-independent mechanisms

Daniel H. Craighead, Caroline J. Smith, Lacy M. Alexander, 2017, Microcirculation

Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps

Daniel H. Craighead, Sean W. Shank, Jinger S. Gottschall, Dennis H. Passe, Bob Murray, Lacy M. Alexander, W. Larry Kenney, 2017, Muscle and Nerve on p. 379-385

Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389

Folic acid supplementation increases cutaneous vasodilator sensitivity to sympathetic nerve activity in older adults

Anna E. Stanhewicz, Jody L. Greaney, Lacy M. Alexander, W. Larry Kenney, 2017, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R681-R688

High-Impact Papers

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 2019-2026

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy A. Holowatz, 2011, Hypertension on p. 935-942

Aging and the control of human skin blood flow

Lacy A. Holowatz, Caitlin Thompson-Torgerson, W. Larry Kenney, 2010, Frontiers in Bioscience on p. 718-739

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Lacy A. Holowatz, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, W. Larry Kenney, 2011, Journal of Physiology on p. 2093-2103

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 791-797

Nonuniform, age-related decrements in regional sweating and skin blood flow

Caroline J. Smith, Lacy M. Alexander, W. Larry Kenney, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress

Rebecca S. Bruning, Jessica D. Dahmus, W. Larry Kenney, Lacy M. Alexander, 2013, Medicine and Science in Sports and Exercise on p. 674-682

Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin

Lacy A. Holowatz, John D. Jennings, James A. Lang, W. Larry Kenney, 2009, Journal of Applied Physiology on p. 1121-1127