Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Affiliations

Publication Tags

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Skin Vasodilation Nitric Oxide Dilatation Endothelium Blood Vessels Therapeutics Young Adult Microdialysis Hot Temperature Major Depressive Disorder Pre Eclampsia Menthol Hydrogen Sulfide Reflex Heat Shock Response Temperature Inflammation Sweating Nitric Oxide Synthase Microvessels Perfusion Laser Doppler Flowmetry Oxidative Stress Nitric Oxide Synthase Type Iii

Most Recent Publications

Letter to the Editor in response to: Microvascular endothelial function following the cessation of long-term oral contraceptive pill use: A case report

Nathalie V. Kirby, Nina S. Stachenfeld, Lacy M. Alexander, 2023, Experimental Physiology on p. 1092-1094

Back to the future

Lacy M. Alexander, 2023, Journal of Applied Physiology on p. 1-2

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Auni C. Williams, Virginia G. Content, Nathalie V. Kirby, Lacy M. Alexander, 2023, Journal of Visualized Experiments

Nitric oxide-mediated cutaneous microvascular function is not altered in middle-aged-to-older adults following mild SARS-CoV-2 infection: A pilot study

G Dillon, S Wolf, A Williams, W. Larry Kenney, Lacy Alexander, 2023, Physiological Reports on p. e15704

Science and cycling: Creating meaningful connections

Lacy M. Alexander, 2023, Physiologist on p. 40

Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis

Gabrielle A. Dillon, Anna E. Stanhewicz, Corinna Serviente, Valerie A. Flores, Nina Stachenfeld, Lacy M. Alexander, 2022, Microvascular Research

Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function

S Wolf, G Dillon, Lacy Alexander, Nina G. Jablonski, W. Larry Kenney, 2022, American Journal of Physiology on p. 490-498

Short-term salicylate treatment improves microvascular endotheliumdependent dilation in young adults with major depressive disorder

Jody L. Greaney, Erika F.H. Saunders, Lacy M. Alexander, 2022, American Journal of Physiology on p. H880-H889

Why gender equity should remain a focus for the American Physiological Society

Nina S. Stachenfeld, Lacy M. Alexander, 2022, American Journal of Physiology on p. H575-H578

Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy

Anna E. Stanhewicz, Gabrielle A. Dillon, Corinna Serviente, Lacy M. Alexander, 2022, Pregnancy Hypertension on p. 81-86

Most-Cited Papers

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults

Jody L. Greaney, Jessica L. Kutz, Sean W. Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 902-909

Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women with Major Depressive Disorder

Jody L. Greaney, Erika F.H. Saunders, Lakshmi Santhanam, Lacy M. Alexander, 2019, Circulation Research on p. 564-574

Sympathetic regulation during thermal stress in human aging and disease

Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2015, Journal of the Autonomic Nervous System on p. 81-90

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature

Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129

Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms

Anna E. Stanhewicz, Lacy M. Alexander, W. Larry Kenney, 2015, Clinical Science on p. 159-167

INOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat

Naoto Fujii, Robert D. Meade, Lacy M. Alexander, Pegah Akbari, Imane Foudil-Bey, Jeffrey C. Louie, Pierre Boulay, Glen P. Kenny, 2016, Journal of Applied Physiology on p. 318-327

Mechanisms and time course of menthol-induced cutaneous vasodilation

Daniel H. Craighead, Nathaniel B. McCartney, James H. Tumlinson, Lacy M. Alexander, 2017, Microvascular Research on p. 43-47