Lacy Alexander
Professor of Kinesiology

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113 Noll Lab
University Park, - lma191@psu.edu
- 814-867-1781
Research Summary
Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.
Huck Affiliations
Publication Tags
Skin Vasodilation Nitric Oxide Dilatation Endothelium Blood Vessels Young Adult Therapeutics Hydrogen Sulfide Hot Temperature Pre Eclampsia Microdialysis Sweating Microvessels Hypertension Reflex Blood Pressure Major Depressive Disorder Health Inflammation Temperature Laser Doppler Flowmetry Perfusion Heat Shock Response HeatingMost Recent Publications
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Gabrielle A. Dillon, Anna E. Stanhewicz, Corinna Serviente, Valerie A. Flores, Nina Stachenfeld, Lacy M. Alexander, 2022, Microvascular Research
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function
S. Tony Wolf, Gabrielle A. Dillon, Lacy M. Alexander, Nina G. Jablonski, W. Larry Kenney, 2022, American Journal of Physiology on p. 490-498
Short-term salicylate treatment improves microvascular endotheliumdependent dilation in young adults with major depressive disorder
Jody L. Greaney, Erika F.H. Saunders, Lacy M. Alexander, 2022, American Journal of Physiology on p. H880-H889
Why gender equity should remain a focus for the American Physiological Society
Nina S. Stachenfeld, Lacy M. Alexander, 2022, American Journal of Physiology on p. H575-H578
Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy
Anna E. Stanhewicz, Gabrielle A. Dillon, Corinna Serviente, Lacy M. Alexander, 2022, Pregnancy Hypertension on p. 81-86
Women with a history of preeclampsia have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature
Michael Pyevich, Lacy M. Alexander, Anna E. Stanhewicz, 2022, Experimental Physiology on p. 175-182
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection
Gabrielle A. Dillon, S. Tony Wolf, Lacy M. Alexander, 2022, American Journal of Physiology on p. H319-H327
Menthol-induced activation of TRPM8 receptors increases cutaneous blood flow across the dermatome
Gabrielle A. Dillon, Zachary S. Lichter, Lacy M. Alexander, 2022, Microvascular Research
Vascular Health Triad in Humans With Hypertension—Not the Usual Suspects
Sushant M. Ranadive, Gabrielle A. Dillon, Sara E. Mascone, Lacy M. Alexander, 2021, Frontiers in Physiology
Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension
Gabrielle A. Dillon, Anna E. Stanhewicz, Corinna Serviente, Jody L. Greaney, Lacy M. Alexander, 2021, American Journal of Physiology on p. H728-H734
Most-Cited Papers
Heat waves aging and human cardiovascular health
W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899
Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults
Jody L. Greaney, Jessica L. Kutz, Sean W. Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 902-909
Nonuniform, age-related decrements in regional sweating and skin blood flow
C Smith, Lacy Alexander, W. Larry Kenney, 2013, American Journal of Physiology on p. R877-R885
Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans
Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326
Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia
Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women with Major Depressive Disorder
Jody L. Greaney, Erika F.H. Saunders, Lakshmi Santhanam, Lacy M. Alexander, 2019, Circulation Research on p. 564-574
Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature
Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129
Sympathetic regulation during thermal stress in human aging and disease
Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2015, Journal of the Autonomic Nervous System on p. 81-90
Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms
Anna E. Stanhewicz, Lacy M. Alexander, W. Larry Kenney, 2015, Clinical Science on p. 159-167
INOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat
Naoto Fujii, Robert D. Meade, Lacy M. Alexander, Pegah Akbari, Imane Foudil-Bey, Jeffrey C. Louie, Pierre Boulay, Glen P. Kenny, 2016, Journal of Applied Physiology on p. 318-327