Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Affiliations

Publication Tags

Skin Vasodilation Nitric Oxide Young Adult Blood Pressure Hot Temperature Hydrogen Sulfide Reflex Temperature Health Blood Vessels Endothelium Nitric Oxide Synthase Dilatation Nitric Oxide Synthase Type Iii Heat Shock Response Kidney Pre Eclampsia Microdialysis Hypertension Exercise Angiotensin Ii Sweating Microvessels Heating

Most Recent Papers

Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension

Gabrielle A. Dillon, Anna E. Stanhewicz, Corinna Serviente, Jody L. Greaney, Lacy M. Alexander, 2021, American Journal of Physiology on p. H728-H734

Life course pathways from parental education to age-related decrements in kidney function among Black and white American adults

Agus Surachman, Alexis R. Santos, Jonathan K. Daw, Lacy Alexander, David M. Almeida, Christopher L. Coe, 2021, Psychoneuroendocrinology

Temperature regulation during exercise in the heat

W. Larry Kenney, S. Tony Wolf, Gabrielle A. Dillon, Craig W. Berry, Lacy M. Alexander, 2021, Australian Journal of Science and Medicine in Sport on p. 739-746

Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults

Gabrielle A. Dillon, Zachary S. Lichter, Lacy M. Alexander, Lauro C. Vianna, Jing Wang, Paul J. Fadel, Jody L. Greaney, 2020, Journal of Applied Physiology on p. 1203-1213

AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction

Gabrielle A. Dillon, Jody L. Greaney, Sean Shank, Urs A. Leuenberger, Lacy M. Alexander, 2020, American Journal of Physiology on p. H539-H546

Childhood socioeconomic status, comorbidity of chronic kidney disease risk factors, and kidney function among adults in the midlife in the United States (MIDUS) study

Agus Surachman, Jonathan Daw, Bethany C. Bray, Lacy M. Alexander, Christopher L. Coe, David M. Almeida, 2020, BMC Nephrology

Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.

J Greaney, A Surachman, Saunders EFH, Erika F.H. Saunders, Lacy Alexander, David M. Almeida, 2020, Journal of the American Heart Association on p. e015697

Dairy Foods and Dairy Fats

Kristin M. Hirahatake, Richard S. Bruno, Bradley W. Bolling, Christopher Blesso, Lacy M. Alexander, Sean H. Adams, 2020, Advances in nutrition (Bethesda, Md.) on p. 266-279

Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder

Jody L. Greaney, Gabrielle A. Dillon, Erika F.H. Saunders, Lacy M. Alexander, 2020, Journal of Applied Physiology on p. 100-107

Local angiotensin-(1–7) administration improves microvascular endothelial function in women who have had preeclampsia

Anna E. Stanhewicz, Lacy M. Alexander, 2020, American Journal of Physiology on p. R148-R155

Most-Cited Papers

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 2019-2026

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 791-797

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults

Jody L. Greaney, Jessica L. Kutz, Sean W. Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 902-909

Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature

Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129

Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms

Anna E. Stanhewicz, Lacy M. Alexander, W. Larry Kenney, 2015, Clinical Science on p. 159-167

Sympathetic regulation during thermal stress in human aging and disease

Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2016, Journal of the Autonomic Nervous System on p. 81-90

INOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat

Naoto Fujii, Robert D. Meade, Lacy M. Alexander, Pegah Akbari, Imane Foudil-Bey, Jeffrey C. Louie, Pierre Boulay, Glen P. Kenny, 2016, Journal of Applied Physiology on p. 318-327