Lacy Alexander
Associate Professor of Kinesiology
- 113 Noll Lab
University Park, - lma191@psu.edu
- 814-867-1781
Research Summary
Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.
Huck Institutes Affiliations
Most Recent Papers
Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women
Daniel H. Craighead, Huilei Wang, Lakshmi Santhanam, Lacy M. Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H424-H433
Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation
Billie K. Alba, Jody L. Greaney, Sara B. Ferguson, Lacy M. Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H343-H349
Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating
Caroline J. Smith, Daniel H. Craighead, Lacy M. Alexander, 2017, Journal of Applied Physiology on p. 1461-1467
Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia
Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Clinical Science on p. 2777-2789
Sympathetic function during whole body cooling is altered in hypertensive adults
Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2017, Journal of Applied Physiology on p. 1617-1624
Menthol-induced cutaneous vasodilation is preserved in essential hypertensive men and women
Daniel H. Craighead, Lacy M. Alexander, 2017, American journal of hypertension on p. 1156-1162
Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO-dependent and NO-independent mechanisms
Daniel H. Craighead, Caroline J. Smith, Lacy M. Alexander, 2017, Microcirculation
Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps
Daniel H. Craighead, Sean W. Shank, Jinger S. Gottschall, Dennis H. Passe, Bob Murray, Lacy M. Alexander, W. Larry Kenney, 2017, Muscle and Nerve on p. 379-385
Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia
Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389
Folic acid supplementation increases cutaneous vasodilator sensitivity to sympathetic nerve activity in older adults
Anna E. Stanhewicz, Jody L. Greaney, Lacy M. Alexander, W. Larry Kenney, 2017, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R681-R688
High-Impact Papers
Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin
Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 2019-2026
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.
Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy A. Holowatz, 2011, Hypertension on p. 935-942
Aging and the control of human skin blood flow
Lacy A. Holowatz, Caitlin Thompson-Torgerson, W. Larry Kenney, 2010, Frontiers in Bioscience on p. 718-739
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans
Lacy A. Holowatz, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, W. Larry Kenney, 2011, Journal of Physiology on p. 2093-2103
Heat waves aging and human cardiovascular health
W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899
Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin
Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 791-797
Nonuniform, age-related decrements in regional sweating and skin blood flow
Caroline J. Smith, Lacy M. Alexander, W. Larry Kenney, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans
Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326
Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress
Rebecca S. Bruning, Jessica D. Dahmus, W. Larry Kenney, Lacy M. Alexander, 2013, Medicine and Science in Sports and Exercise on p. 674-682
Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin
Lacy A. Holowatz, John D. Jennings, James A. Lang, W. Larry Kenney, 2009, Journal of Applied Physiology on p. 1121-1127