Lacy Alexander
Professor of Kinesiology
-
113 Noll Lab
University Park, - lma191@psu.edu
- 814-867-1781
Research Summary
Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.
Huck Affiliations
Publication Tags
Skin Vasodilation Major Depressive Disorder Hot Temperature Dilatation Young Adult Oxidative Stress Blood Vessels Nitric Oxide Nitric Oxide Synthase Reflex Arginase Endothelium Heating Therapeutics Microdialysis Temperature Vasoconstriction Nitric Oxide Synthase Type Iii Sweating Exercise Laser Doppler Flowmetry Perfusion Ng Nitroarginine Methyl Ester DepressionMost Recent Papers
Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise
Robert D. Meade, Naoto Fujii, Gregory W. McGarr, Lacy Marie Alexander, Pierre Boulay, Ronald J. Sigal, Glen P. Kenny, 2019, Journal of applied physiology (Bethesda, Md. : 1985) on p. 1129-1137
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder
Jody Leigh Greaney, Erika F. H. Saunders, Lakshmi Santhanam, Lacy Marie Alexander, 2019, Circulation research on p. 564-574
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder
Jody Leigh Greaney, Erika F. H. Saunders, Lakshmi Santhanam, Lacy Marie Alexander, 2019, Circulation research on p. 564-574
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder
Jody Leigh Greaney, Erika F. H. Saunders, Lakshmi Santhanam, Lacy Marie Alexander, 2019, Circulation research on p. 564-574
Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder
Jody Leigh Greaney, Rachel E. Koffer, Erika F. H. Saunders, David Almeida, Lacy Marie Alexander, 2019, Journal of the American Heart Association
Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder
Jody Leigh Greaney, Rachel E. Koffer, Erika F. H. Saunders, David Almeida, Lacy Marie Alexander, 2019, Journal of the American Heart Association
Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder
Jody Leigh Greaney, Rachel E. Koffer, Erika F. H. Saunders, David Almeida, Lacy Marie Alexander, 2019, Journal of the American Heart Association
Self‐reported everyday psychosocial stressors are associated with greater impairments in endothelial function in young adults with major depressive disorder
Jody Leigh Greaney, Rachel E. Koffer, Erika F. H. Saunders, David Almeida, Lacy Marie Alexander, 2019, Journal of the American Heart Association
Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women
Daniel H. Craighead, Huilei Wang, Lakshmi Santhanam, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H424-H433
Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation
Billie K. Alba, Jody Leigh Greaney, Sara Ferguson, Lacy Marie Alexander, 2018, American Journal of Physiology - Heart and Circulatory Physiology on p. H343-H349
High-Impact Papers
Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin
Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2012, Journal of Applied Physiology on p. 2019-2026
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.
Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy Marie Alexander, 2011, Hypertension on p. 935-942
Aging and the control of human skin blood flow
Lacy Marie Alexander, Caitlin Thompson-Torgerson, William Lawrence Kenney, Jr., 2010, Frontiers in Bioscience on p. 718-739
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans
Lacy Marie Alexander, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 2093-2103
Heat waves aging and human cardiovascular health
William Lawrence Kenney, Jr., Daniel H. Craighead, Lacy Marie Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899
Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin
Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2012, Journal of Applied Physiology on p. 791-797
Nonuniform, age-related decrements in regional sweating and skin blood flow
Caroline J. Smith, Lacy Marie Alexander, William Lawrence Kenney, Jr., 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans
Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy Marie Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326
Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress
Rebecca S. Bruning, Jessica D. Dahmus, William Lawrence Kenney, Jr., Lacy Marie Alexander, 2013, Medicine and Science in Sports and Exercise on p. 674-682
Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin
Lacy Marie Alexander, John D. Jennings, James A. Lang, William Lawrence Kenney, Jr., 2009, Journal of Applied Physiology on p. 1121-1127