Lacy Alexander

Professor of Kinesiology

Lacy Alexander

Research Summary

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.

Huck Affiliations

Publication Tags

Skin Vasodilation Hot Temperature Blood Vessels Sweating Arginase Nitric Oxide Synthase Temperature Therapeutics Reflex Nitric Oxide Synthase Type Iii Nitric Oxide Heating Atorvastatin Calcium Sapropterin Vasoconstriction Exercise Microdialysis Population Hydroxymethylglutaryl Coa Reductase Inhibitors Ng Nitroarginine Methyl Ester Nitric Oxide Synthase Type Ii Up Regulation Young Adult Oxidative Stress

Most Recent Papers

Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.

Jody Greaney, A Surachman, Erika F.H. Saunders, Lacy Alexander, David Almeida, 2020, Journal of the American Heart Association on p. e015697

Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.

A Stanhewicz, Lacy Alexander, 2020, American journal of physiology. Regulatory, integrative and comparative physiology on p. R148-R155

Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder.

Jody Greaney, Greg Dillon, Saunders EFH, Lacy Alexander, 2020, Journal of applied physiology (Bethesda, Md. : 1985) on p. 100-107

Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide.

B Alba, A Stanhewicz, P Dey, R Bruno, William Kenney, Lacy Alexander, 2020, The Journal of nutrition on p. 55-63

Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow.

D Low, H Jones, N Cable, Lacy Alexander, William Kenney, 2020, European journal of applied physiology on p. 1-16

Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population

Young Hee Nam, Warren B. Bilker, Charles E. Leonard, Michelle L. Bell, Lacy M. Alexander, Sean Hennessy, 2019, Scientific reports on p. 4685

Dairy Foods and Dairy Fats: New Perspectives on Pathways Implicated in Cardiometabolic Health.

K Hirahatake, R Bruno, B Bolling, C Blesso, Lacy Alexander, S Adams, 2019, Advances in nutrition (Bethesda, Md.)

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder

Jody L. Greaney, Erika F.H. Saunders, Lakshmi Santhanam, Lacy M. Alexander, 2019, Circulation research on p. 564-574

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise

Robert D. Meade, Naoto Fujii, Gregory W. McGarr, Lacy Marie Alexander, Pierre Boulay, Ronald J. Sigal, Glen P. Kenny, 2019, Journal of Applied Physiology on p. 1129-1137

Historical reviews of the assessment of human cardiovascular function – Assessment of cutaneous blood flow

David Low, Helen Jones, Tim Cable, Lacy Alexander, William Kenney, 2019, European Journal of Applied Physiology on p. doi: 10.1007/s00421-019-04246-y. [Epub ahead of print]

Most-Cited Papers

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning, Lakshmi Santhanam, Anna E. Stanhewicz, Caroline J. Smith, Dan E. Berkowitz, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of Applied Physiology on p. 2019-2026

Heat waves aging and human cardiovascular health

W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and science in sports and exercise on p. 1891-1899

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Caroline J. Smith, Lakshmi Santhanam, Rebecca S. Bruning, Anna Stanhewicz, Dan E. Berkowitz, Lacy A. Holowatz, 2011, Hypertension on p. 935-942

Aging and the control of human skin blood flow

Lacy A. Holowatz, Caitlin Thompson-Torgerson, W. Larry Kenney, 2010, Frontiers in Bioscience on p. 718-739

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Lacy Marie Alexander, Lakshmi Santhanam, Alanah Webb, Dan E. Berkowitz, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 2093-2103

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Anna E. Stanhewicz, Rebecca S. Bruning, Caroline J. Smith, W. Larry Kenney, Lacy A. Holowatz, 2012, Journal of applied physiology on p. 791-797

Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326

Nonuniform, age-related decrements in regional sweating and skin blood flow

Caroline J. Smith, Lacy M. Alexander, W. Larry Kenney, 2013, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R877-R885

Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans

Lacy Marie Alexander, William Lawrence Kenney, Jr., 2011, Journal of Physiology on p. 4787-4797

INOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat

Naoto Fujii, Robert D. Meade, Lacy Marie Alexander, Pegah Akbari, Imane Foudil-Bey, Jeffrey C. Louie, Pierre Boulay, Glen P. Kenny, 2016, Journal of Applied Physiology on p. 318-327