Kristin Eckert

Professor of Pathology and Laboratory Medicine and of Biochemistry and Molecular Biology

Kristin Eckert

Research Summary

Mechanisms of human cell mutagenesis and repetitive DNA replication in relation to genome evolution.

Huck Affiliations

Links

Publication Tags

Microsatellite Repeats Dna Genome Dna Directed Dna Polymerase Human Genome Holoenzymes Proliferating Cell Nuclear Antigen Rad30 Protein Dna Damage Dna Replication Tandem Repeat Sequences Enzymes Dna Polymerase Iii Rna Mutation Neoplasms Primates In Vitro Techniques Cells Reverse Transcription Human Activities Carrier Proteins Single Nucleotide Polymorphism Dna Primase Mitochondrial Dna

Most Recent Papers

Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.

W Guiblet, Marzia Cremona, Robert Harris, Dong Chen, Kristin Eckert, Francesca Chiaromonte, Yifei Huang, Kateryna Makova, 2021, Nucleic acids research

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Simran Kaushal, Charles E. Wollmuth, Kohal Das, Suzanne E. Hile, Samantha B. Regan, Ryan P. Barnes, Alice Haouzi, Soo Mi Lee, Nealia C.M. House, Michael Guyumdzhyan, Kristin A. Eckert, Catherine H. Freudenreich, 2019, Cell Reports on p. 1151-1164.e5

DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress

Ryan P. Barnes, Wei Chung Tsao, George Lucian Moldovan, Kristin A. Eckert, 2018, Cancer Research on p. 6549-6560

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition

Nishita Shastri, Yu Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Jessica Chen, Dillon Maloney, Marei Dose, Yancy Lo, Theonie Anastassiadis, Osvaldo Rivera, Taehyong Kim, Sharvin Shah, Piyush Borole, Kanika Asija, Xiang Wang, Kevin D. Smith, Darren Finn, Jonathan Schug, Rafael Casellas, Liliya A. Yatsunyk, Kristin A. Eckert, Eric J. Brown, 2018, Molecular cell on p. 222-238.e11

DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis

Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, Kristin A. Eckert, 2017, DNA Repair on p. 1-11

Non-B DNA affects polymerization speed and error rate in sequencers and living cells

Wilfried Guiblet, Marzia Cremona, Monika Cechova, Robert Harris, Iva Kejnovska, Eduard Kejnovsky, Kristin Eckert, Francesca Chiaromonte, Kateryna Makova, 2017, bioRxiv on p. 237461

Reverse transcription errors and RNA-DNA differences at short tandem repeats

Arkarachai Fungtammasan, Marta Hoover, Rebeca Campos-Sánchez, Kristin Eckert, Michael DeGiorgio, Kateryna Dmytrivna Makova, 2016, Molecular biology and evolution on p. 2744-2758

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

Beverly A. Baptiste, Kimberly D. Jacob, Kristin Eckert, 2015, DNA Repair on p. 91-100

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068

Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes

Guruprasad Ananda, Suzanne E. Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D. Makova, Kristin A. Eckert, 2014, PLoS genetics

Most-Cited Papers

DNA synthesis by pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Valérie Bergoglio, Anne Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Marietta Y.W.T. Lee, Laurie Rey, Filippo Rosselli, Christophe Cazaux, Kristin A. Eckert, Jean Sébastien Hoffmann, 2013, Journal of Cell Biology on p. 395-408

A genome-wide analysis of common fragile sites

Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome research on p. 993-1005

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068

A matter of life or death

Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome research on p. 2038-2048

Beyond translesion synthesis

Suzanne E. Hile, Xiaoxiao Wang, Marietta Y.W.T. Lee, Kristin A. Eckert, 2012, Nucleic acids research on p. 1636-1647

Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication

Erin Walsh, Xiaoxiao Wang, Marietta Y. Lee, Kristin A. Eckert, 2013, Journal of Molecular Biology on p. 232-243

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome biology and evolution on p. 606-620

Down-regulation of HtrA1 activates the Epithelial-Mesenchymal transition and ATM DNA damage response pathways

Ning Wang, Kristin Eckert, Ali R. Zomorrodi, Ping Xin, Weihua Pan, Debra A. Shearer, Judith Weisz, Costas D. Maranas, Gary Clawson, 2012, PLoS One

DNA polymerase kappa microsatellite synthesis

Beverly A. Baptiste, Kristin Eckert, 2012, Environmental and Molecular Mutagenesis on p. 787-796

The in vitro fidelity of yeast DNA polymerase δ and polymerase e{open} holoenzymes during dinucleotide microsatellite DNA synthesis

Amy L. Abdulovic, Suzanne E. Hile, Thomas A. Kunkel, Kristin A. Eckert, 2011, DNA Repair on p. 497-505