Kristin Eckert
Professor of Pathology and Laboratory Medicine and of Biochemistry and Molecular Biology

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500 University Drive
Hershey, PA 17033 - kae4@psu.edu
- 717-531-4065
Research Summary
Mechanisms of human cell mutagenesis and repetitive DNA replication in relation to genome evolution.
Huck Affiliations
Links
Publication Tags
Microsatellite Repeats Dna Genome Dna Directed Dna Polymerase Human Genome Holoenzymes Proliferating Cell Nuclear Antigen Rad30 Protein Dna Damage Dna Replication Tandem Repeat Sequences Enzymes Dna Polymerase Iii Rna Mutation Neoplasms Primates In Vitro Techniques Cells Reverse Transcription Human Activities Carrier Proteins Single Nucleotide Polymorphism Dna Primase Mitochondrial DnaMost Recent Papers
Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
W Guiblet, Marzia Cremona, Robert Harris, Dong Chen, Kristin Eckert, Francesca Chiaromonte, Yifei Huang, Kateryna Makova, 2021, Nucleic acids research
Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D
Simran Kaushal, Charles E. Wollmuth, Kohal Das, Suzanne E. Hile, Samantha B. Regan, Ryan P. Barnes, Alice Haouzi, Soo Mi Lee, Nealia C.M. House, Michael Guyumdzhyan, Kristin A. Eckert, Catherine H. Freudenreich, 2019, Cell Reports on p. 1151-1164.e5
DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress
Ryan P. Barnes, Wei Chung Tsao, George Lucian Moldovan, Kristin A. Eckert, 2018, Cancer Research on p. 6549-6560
Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition
Nishita Shastri, Yu Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Jessica Chen, Dillon Maloney, Marei Dose, Yancy Lo, Theonie Anastassiadis, Osvaldo Rivera, Taehyong Kim, Sharvin Shah, Piyush Borole, Kanika Asija, Xiang Wang, Kevin D. Smith, Darren Finn, Jonathan Schug, Rafael Casellas, Liliya A. Yatsunyk, Kristin A. Eckert, Eric J. Brown, 2018, Molecular cell on p. 222-238.e11
DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis
Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, Kristin A. Eckert, 2017, DNA Repair on p. 1-11
Non-B DNA affects polymerization speed and error rate in sequencers and living cells
Wilfried Guiblet, Marzia Cremona, Monika Cechova, Robert Harris, Iva Kejnovska, Eduard Kejnovsky, Kristin Eckert, Francesca Chiaromonte, Kateryna Makova, 2017, bioRxiv on p. 237461
Reverse transcription errors and RNA-DNA differences at short tandem repeats
Arkarachai Fungtammasan, Marta Hoover, Rebeca Campos-Sánchez, Kristin Eckert, Michael DeGiorgio, Kateryna Dmytrivna Makova, 2016, Molecular biology and evolution on p. 2744-2758
Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites
Beverly A. Baptiste, Kimberly D. Jacob, Kristin Eckert, 2015, DNA Repair on p. 91-100
Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins
Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068
Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes
Guruprasad Ananda, Suzanne E. Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D. Makova, Kristin A. Eckert, 2014, PLoS genetics
Most-Cited Papers
DNA synthesis by pol η promotes fragile site stability by preventing under-replicated DNA in mitosis
Valérie Bergoglio, Anne Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Marietta Y.W.T. Lee, Laurie Rey, Filippo Rosselli, Christophe Cazaux, Kristin A. Eckert, Jean Sébastien Hoffmann, 2013, Journal of Cell Biology on p. 395-408
A genome-wide analysis of common fragile sites
Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome research on p. 993-1005
Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins
Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068
A matter of life or death
Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome research on p. 2038-2048
Beyond translesion synthesis
Suzanne E. Hile, Xiaoxiao Wang, Marietta Y.W.T. Lee, Kristin A. Eckert, 2012, Nucleic acids research on p. 1636-1647
Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication
Erin Walsh, Xiaoxiao Wang, Marietta Y. Lee, Kristin A. Eckert, 2013, Journal of Molecular Biology on p. 232-243
Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome
Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome biology and evolution on p. 606-620
Down-regulation of HtrA1 activates the Epithelial-Mesenchymal transition and ATM DNA damage response pathways
Ning Wang, Kristin Eckert, Ali R. Zomorrodi, Ping Xin, Weihua Pan, Debra A. Shearer, Judith Weisz, Costas D. Maranas, Gary Clawson, 2012, PLoS One
DNA polymerase kappa microsatellite synthesis
Beverly A. Baptiste, Kristin Eckert, 2012, Environmental and Molecular Mutagenesis on p. 787-796
The in vitro fidelity of yeast DNA polymerase δ and polymerase e{open} holoenzymes during dinucleotide microsatellite DNA synthesis
Amy L. Abdulovic, Suzanne E. Hile, Thomas A. Kunkel, Kristin A. Eckert, 2011, DNA Repair on p. 497-505