Kristin Eckert

Professor of Pathology and Biochemistry and Molecular Biology

Kristin Eckert

Research Summary

Mechanisms of human cell mutagenesis and repetitive DNA replication in relation to genome evolution.

Huck Affiliations

Publication Tags

Genome Microsatellite Repeats Dna Directed Dna Polymerase Dna Human Genome Tandem Repeat Sequences Rad30 Protein Proliferating Cell Nuclear Antigen Dna Replication Polymorphism Mutation Incidence Neoplasms Enzymes Genetic Polymorphism Holoenzymes Mutagenesis Dna Polymerase Beta Cytarabine Magnetic Resonance Spectroscopy Mitosis Primates Dna Polymerase Iii Dna Binding Proteins Human Activities

Most Recent Papers

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Simran Kaushal, Charles E. Wollmuth, Kohal Das, Suzanne E. Hile, Samantha B. Regan, Ryan P. Barnes, Alice Haouzi, Soo Mi Lee, Nealia C.M. House, Michael Guyumdzhyan, Kristin Eckert, Catherine H. Freudenreich, 2019, Cell Reports on p. 1151-1164.e5

DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress

Ryan P. Barnes, Wei Chung Tsao, George Lucian Moldovan, Kristin A. Eckert, 2018, Cancer Research on p. 6549-6560

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition

Nishita Shastri, Yu Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Jessica Chen, Dillon Maloney, Marei Dose, Yancy Lo, Theonie Anastassiadis, Osvaldo Rivera, Taehyong Kim, Sharvin Shah, Piyush Borole, Kanika Asija, Xiang Wang, Kevin D. Smith, Darren Finn, Jonathan Schug, Rafael Casellas, Liliya A. Yatsunyk, Kristin A. Eckert, Eric J. Brown, 2018, Molecular cell on p. 222-238.e11

DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis

Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, Kristin A. Eckert, 2017, DNA Repair on p. 1-11

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

Beverly A. Baptiste, Kimberly D. Jacob, Kristin Eckert, 2015, DNA Repair on p. 91-100

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

Arkarachai Fungtammasan, Guruprasad Ananda, Suzanne E. Hile, Marcia Shu Wei Su, Chen Sun, Robert Harris, Paul Medvedev, Kristin Eckert, Kateryna D. Makova, 2015, Genome research on p. 736-749

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068

Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes

Guruprasad Ananda, Suzanne E. Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D. Makova, Kristin A. Eckert, 2014, PLoS genetics

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome biology and evolution on p. 606-620

DNA synthesis by pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Valérie Bergoglio, Anne Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Marietta Y.W.T. Lee, Laurie Rey, Filippo Rosselli, Christophe Cazaux, Kristin A. Eckert, Jean Sébastien Hoffmann, 2013, Journal of Cell Biology on p. 395-408

Most-Cited Papers

DNA synthesis by pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Valérie Bergoglio, Anne Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Marietta Y.W.T. Lee, Laurie Rey, Filippo Rosselli, Christophe Cazaux, Kristin A. Eckert, Jean Sébastien Hoffmann, 2013, Journal of Cell Biology on p. 395-408

A genome-wide analysis of common fragile sites

Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome research on p. 993-1005

What is a microsatellite

Yogeshwar D. Kelkar, Noelle Strubczewski, Suzanne E. Hile, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2010, Genome biology and evolution on p. 620-635

A matter of life or death

Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome research on p. 2038-2048

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty, 2015, Nucleic acids research on p. 1056-1068

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

Arkarachai Fungtammasan, Guruprasad Ananda, Suzanne E. Hile, Marcia Shu Wei Su, Chen Sun, Robert Harris, Paul Medvedev, Kristin Eckert, Kateryna D. Makova, 2015, Genome research on p. 736-749

Beyond translesion synthesis

Suzanne E. Hile, Xiaoxiao Wang, Marietta Y.W.T. Lee, Kristin A. Eckert, 2012, Nucleic acids research on p. 1636-1647

Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication

Erin Walsh, Xiaoxiao Wang, Marietta Y. Lee, Kristin A. Eckert, 2013, Journal of Molecular Biology on p. 232-243

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome biology and evolution on p. 606-620

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase β and ligase III/XRCC1

A. S. Prakasha Gowda, Joanna M. Polizzi, Kristin A. Eckert, Thomas E. Spratt, 2010, Biochemistry on p. 4833-4840