Kenneth Keiler

Professor of Biochemistry and Molecular Biology

Kenneth Keiler

Research Summary

Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.

Huck Affiliations

Links

Publication Tags

Ribosomes Bacteria Anti Bacterial Agents Proteins Peptides Messenger Rna Protein Pharmaceutical Preparations Membranes Pathogens Antimicrobial Agent Mycobacterium Tuberculosis Membrane Proteins Cells Escherichia Coli Genes Peptide Mitochondria Nanogel Staphylococcus Aureus Tmrna Polysaccharide Peptide Cathelicidin Antimicrobial Peptide Shigella Flexneri Kkl 35

Most Recent Papers

Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses

Delphine Larivière, Laura Wickham, Kenneth Keiler, Anton Nekrutenko, 2021, BMC Microbiology

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler, 2021, Nature Communications

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry.

A Simonson, A Mongia, M Aronson, John Alumasa, D Chan, A Lawanprasert, M Howe, A Bolotsky, Tapas Mal, Christy George, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina, 2020, Nature Biomedical Engineering

Reproducible and accessible analysis of transposon insertion data at scale

Delphine Lariviere, Laura Wickham, Kenneth Keiler, A Nekrutenko, 2020, bioRxiv

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400

A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus

Yueyang Huang, John N. Alumasa, Lauren T. Callaghan, R. Samuel Baugh, Christopher D. Rae, Kenneth C. Keiler, Shauna M. McGillivray, 2019, Antimicrobial Agents and Chemotherapy

Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo.

A Simonson, A Lawanprasert, Goralski TDP, Kenneth Keiler, Scott Medina, 2018, Nanomedicine : nanotechnology, biology, and medicine

A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes

Tyler D.P. Goralski, Girish S. Kirimanjeswara, Kenneth C. Keiler, 2018, mBio

Most-Cited Papers

Mechanisms of ribosome rescue in bacteria

Kenneth C. Keiler, 2015, Nature Reviews Microbiology on p. 285-297

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Nitya S. Ramadoss, John N. Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth C. Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287

Resolving nonstop translation complexes is a matter of life or death

Kenneth C. Keiler, Heather A. Feaga, 2014, Journal of Bacteriology on p. 2123-2130

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics

Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John N. Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth C. Keiler, Victor Nizet, 2012, Antimicrobial Agents and Chemotherapy on p. 1854-1861

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn, 2017, Scientific Reports on p. 6135

tmRNA Is Essential in Shigella flexneri

Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PLoS One on p. e57537

Release of nonstop ribosomes is essential

Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela A. Hankey-Giblin, Kenneth C. Keiler, 2016, PLoS Genetics

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644