Kenneth Keiler
Professor of Biochemistry and Molecular Biology
-
401 Althouse
University Park, PA - kck11@psu.edu
- 814-863-0787
Research Summary
Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for RNA Molecular Biology
- One Health Microbiome Center
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Ribosomes Bacteria Anti Bacterial Agents Proteins Protein Peptides Messenger Rna Antimicrobial Agent Mycobacterium Tuberculosis Membranes Hyaluronic Acid Cells Mitochondria Transfer Rna Peptide Proteomics Pathogens Genes Data Analysis Molecule Pharmaceutical Preparations Membrane Proteins Polysaccharides Antibiotics GrowthMost Recent Publications
Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA
Neeraja Marathe, Ha An Nguyen, John N. Alumasa, Alexandra B. Kuzmishin Nagy, Michael Vazquez, Christine M. Dunham, Kenneth C. Keiler, 2023, mBio
Physiology of trans-translation deficiency in Bacillus subtilis – a comparative proteomics study
Melissa Vázquez-Hernández, Stephanie L. Leedom, Kenneth C. Keiler, Julia Elisabeth Bandow, 2023, Proteomics
Ribosome Rescue
Kenneth Keiler, 2023,
Gonorrhea became more drug resistant while attention was on COVID-19 – a molecular biologist explains the sexually transmitted superbug
Kenneth Keiler, 2022, The Conversation
Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action
Pooja Srinivas, Kenneth C. Keiler, Christine M. Dunham, 2022, BioEssays
Ribosome collisions: New ways to initiate ribosome rescue
Stephanie L. Leedom, Kenneth C. Keiler, 2022, Current Biology on p. R469-R472
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
Z Aron, A Mehrani, E Hoffer, K Connolly, P Srinivas, M Torhan, John Alumasa, Mynthia Cabrera Goss, D Hosangadi, J Barbor, S Cardinale, S Kwasny, L Morin, M Butler, T Opperman, T Bowlin, A Jerse, S Stagg, C Dunham, Kenneth Keiler, 2021, Nature Communications on p. 1799
Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation
Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy
Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses
D Larivière, L Wickham, Kenneth Keiler, Anton Nekrutenko, 2021, BMC Microbiology on p. 1--15
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew Simonson^, Andrew W. Simonson, A Mongia, Agustey Mongia^, Matthew R. Aronson, Agustey S. Mongia, M Aronson, Matthew Aronson^, John N. Alumasa, Dennis Chan, Adam Bolotsky, Atip Lawanprasert^, A Lawanprasert, Michael Howe, Aida Ebrahimi, Elizabeth Proctor, Adam Bolotsky, T. Mal, Kenneth C. Keiler, Scott H. Medina, Christy George, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480
Most-Cited Papers
Mechanisms of ribosome rescue in bacteria
Kenneth C. Keiler, 2015, Nature Reviews Microbiology on p. 285-297
Resolving nonstop translation complexes is a matter of life or death
Kenneth C. Keiler, Heather A. Feaga, 2014, Journal of Bacteriology on p. 2123-2130
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn, 2017, Scientific Reports on p. 6135
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Andrew Simonson^, Atip Lawanprasert, Atip Lawanprasert^, Tyler D.P. Goralski, Kenneth C. Keiler, Scott Medina*, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
Release of nonstop ribosomes is essential
Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela A. Hankey-Giblin, Kenneth C. Keiler, 2016, PLoS Genetics
Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644
Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation
Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509
A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
Tyler D.P. Goralski, Girish S. Kirimanjeswara, Kenneth C. Keiler, 2018, mBio
News Articles Featuring Kenneth Keiler
Feb 14, 2024
Lab Bench to Commercialization 2024 grant recipients announced
Four projects led by researchers in the Penn State Eberly College of Science have been selected to receive Lab Bench to Commercialization (LB2C) grants in 2024
Full Article
Apr 11, 2023
Penn State announces 2023 University-wide faculty and staff awards
Each spring, Penn State recognizes outstanding faculty and staff with annual awards in teaching and excellence. These awards highlight many of the University's faculty and staff who go above and beyond in their work at Penn State.
Full Article
Apr 11, 2023
Keiler honored with 2023 Graduate Program Chair Leadership Award
Kenneth Keiler, professor of biochemistry and molecular biology and associate department head for graduate education in Penn State's Eberly College of Science, is the 2023 recipient of the Graduate School Alumni Society Graduate Program Chair Leadership Award.
Full Article
Oct 09, 2022
Why COVID-19 Made This Sexually Transmitted Superbug Even Worse
COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.
Full Article
Oct 05, 2022
Gonorrhea became more drug resistant while attention was on COVID-19 – a molecular biologist explains the sexually transmitted superbug
COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.
Full Article
Mar 19, 2021
New antibiotic clears multi-drug resistant gonorrhea in mice in single dose
A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.
Full Article
Mar 19, 2020
Developing a novel oral antibiotic to treat multidrug-resistant gonorrhea
Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.
Full Article