Kenneth Keiler
Professor of Biochemistry and Molecular Biology

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401 Althouse
University Park, PA - kck11@psu.edu
- 814-863-0787
Research Summary
Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.
Huck Affiliations
Links
Publication Tags
Bacteria Ribosomes Proteins Anti Bacterial Agents Peptides Protein Membranes Polysaccharide Peptide Nanogel Messenger Rna Cells Pathogens Hyaluronic Acid Peptide Antimicrobial Agent Pharmaceutical Preparations Membrane Proteins Polysaccharides Escherichia Coli Genes Staphylococcus Aureus Shigella Flexneri Cathelicidin Antimicrobial Peptide Mitochondria NanogelsMost Recent Papers
Ribosome collisions
Stephanie L. Leedom, Kenneth C. Keiler, 2022, Current Biology on p. R469-R472
Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses
Delphine Larivière, Laura Wickham, Kenneth Keiler, Anton Nekrutenko, 2021, BMC Microbiology
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler, 2021, Nature Communications
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480
Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation
Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry.
A Simonson, A Mongia, M Aronson, John Alumasa, D Chan, A Lawanprasert, M Howe, A Bolotsky, Tapas Mal, Christy George, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina, 2020, Nature Biomedical Engineering
Reproducible and accessible analysis of transposon insertion data at scale
Delphine Lariviere, Laura Wickham, Kenneth Keiler, A Nekrutenko, 2020, bioRxiv
A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus
Yueyang Huang, John N. Alumasa, Lauren T. Callaghan, R. Samuel Baugh, Christopher D. Rae, Kenneth C. Keiler, Shauna M. McGillivray, 2019, Antimicrobial Agents and Chemotherapy
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo.
A Simonson, A Lawanprasert, Goralski TDP, Kenneth Keiler, Scott Medina, 2018, Nanomedicine : nanotechnology, biology, and medicine
Most-Cited Papers
Mechanisms of ribosome rescue in bacteria
Kenneth C. Keiler, 2015, Nature Reviews Microbiology on p. 285-297
Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity
Nitya S. Ramadoss, John N. Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth C. Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287
Resolving nonstop translation complexes is a matter of life or death
Kenneth C. Keiler, Heather A. Feaga, 2014, Journal of Bacteriology on p. 2123-2130
Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics
Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John N. Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth C. Keiler, Victor Nizet, 2012, Antimicrobial Agents and Chemotherapy on p. 1854-1861
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn, 2017, Scientific Reports on p. 6135
Release of nonstop ribosomes is essential
Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio
tmRNA Is Essential in Shigella flexneri
Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PLoS One on p. e57537
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela A. Hankey-Giblin, Kenneth C. Keiler, 2016, PLoS Genetics
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
News Articles Featuring Kenneth Keiler
Mar 19, 2021
New antibiotic clears multi-drug resistant gonorrhea in mice in single dose
A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.
Full Article
Mar 19, 2020
Developing a novel oral antibiotic to treat multidrug-resistant gonorrhea
Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.
Full Article