Kenneth Keiler

Professor of Biochemistry and Molecular Biology

Kenneth Keiler

Research Summary

Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.

Huck Affiliations

Links

Publication Tags

Ribosomes Proteins Anti Bacterial Agents Bacteria Mitochondria Mycobacterium Tuberculosis Pharmaceutical Preparations Cells Growth Escherichia Coli Messenger Rna Shigella Flexneri Staphylococcus Aureus Mitochondrion Nanogel Francisella Tularensis Cathelicidin Antimicrobial Peptide Tmrna Protein Pyrazinamide Polysaccharide Peptide Caulobacter Crescentus Peptides In Vitro Techniques Pyrazinoic Acid

Most Recent Papers

A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus

Yueyang Huang, John N. Alumasa, Lauren T. Callaghan, R. Samuel Baugh, Christopher D. Rae, Kenneth C. Keiler, Shauna M. McGillivray, 2019, Antimicrobial agents and chemotherapy

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400

Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo.

A Simonson, A Lawanprasert, Goralski TDP, Kenneth Keiler, Scott Medina, 2018, Nanomedicine : nanotechnology, biology, and medicine

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth Charles Keiler, Anthony D. Baughn, 2017, Scientific reports on p. 6135

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644

Teaching broader impacts of science with undergraduate research.

Kenneth Keiler, Kathy Jackson, L Jaworski, D Lopatto, Sarah Ades, 2017, PLoS biology on p. e2001318

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication

Tyler D.P. Goralski, Kalyan K. Dewan, John Alumasa, Victoria Avanzato, David E. Place, Rachel L. Markley, Bhuvana Katkere, Seham M. Rabadi, Chandra Shekhar Bakshi, Kenneth Charles Keiler, Girish Soorapp Kirimanjeswara, 2016, Antimicrobial Agents and Chemotherapy on p. 3276-3282

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics

Mechanisms of ribosome rescue in bacteria.

Kenneth Keiler, 2015, Nature Reviews Microbiology on p. 285-97

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

S. A. El-Mowafi, E. Sineva, J. N. Alumasa, H. Nicoloff, J. W. Tomsho, S. E. Ades, K. C. Keiler, 2015, Antimicrobial agents and chemotherapy on p. 193-205

Most-Cited Papers

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Nitya S. Ramadoss, John Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth Charles Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics

Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth Charles Keiler, Victor Nizet, 2012, Antimicrobial Agents and Chemotherapy on p. 1854-1861

tmRNA Is Essential in Shigella flexneri

Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PloS one on p. e57537

Protein localization and dynamics within a bacterial organelle

H. Velocity Hughes, Edgar Huitema, Sean Pritchard, Kenneth C. Keiler, Yves V. Brun, Patrick H. Viollier, 2010, Proceedings of the National Academy of Sciences of the United States of America on p. 5599-5604

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth Charles Keiler, Anthony D. Baughn, 2017, Scientific reports on p. 6135

Release of nonstop ribosomes is essential

Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial agents and chemotherapy on p. 5500-5509

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication

Tyler D.P. Goralski, Kalyan K. Dewan, John Alumasa, Victoria Avanzato, David E. Place, Rachel L. Markley, Bhuvana Katkere, Seham M. Rabadi, Chandra Shekhar Bakshi, Kenneth Charles Keiler, Girish Soorapp Kirimanjeswara, 2016, Antimicrobial Agents and Chemotherapy on p. 3276-3282

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics