Kenneth Keiler

Professor of Biochemistry and Molecular Biology

Kenneth Keiler

Research Summary

Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.

Huck Affiliations

Links

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Ribosomes Bacteria Proteins Anti Bacterial Agents Protein Messenger Rna Peptides Antimicrobial Agent Mycobacterium Tuberculosis Membranes Hyaluronic Acid Escherichia Coli Genes Tmrna Shigella Flexneri Mitochondria Transfer Rna Cells Peptide Kkl 35 Pharmaceutical Preparations Pathogens Genome Molecule Translation (Genetics)

Most Recent Publications

Physiology of trans-translation deficiency in Bacillus subtilis – a comparative proteomics study

Melissa Vázquez-Hernández, Stephanie L. Leedom, Kenneth C. Keiler, Julia Elisabeth Bandow, 2023, Proteomics

Ribosome Rescue

Kenneth Keiler, 2023,

Gonorrhea became more drug resistant while attention was on COVID-19 – a molecular biologist explains the sexually transmitted superbug

Kenneth Keiler, 2022, The Conversation

Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action

Pooja Srinivas, Kenneth C. Keiler, Christine M. Dunham, 2022, BioEssays

Ribosome collisions: New ways to initiate ribosome rescue

Stephanie L. Leedom, Kenneth C. Keiler, 2022, Current Biology on p. R469-R472

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Z Aron, A Mehrani, E Hoffer, K Connolly, P Srinivas, M Torhan, John Alumasa, Mynthia Cabrera Goss, D Hosangadi, J Barbor, S Cardinale, S Kwasny, L Morin, M Butler, T Opperman, T Bowlin, A Jerse, S Stagg, C Dunham, Kenneth Keiler, 2021, Nature Communications on p. 1799

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy

Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses

D Larivière, L Wickham, Kenneth Keiler, Anton Nekrutenko, 2021, BMC Microbiology on p. 1--15

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew Simonson^, Andrew W. Simonson, A Mongia, Agustey Mongia^, Matthew R. Aronson, Agustey S. Mongia, M Aronson, Matthew Aronson^, John N. Alumasa, Dennis Chan, Adam Bolotsky, Atip Lawanprasert^, A Lawanprasert, Michael Howe, Aida Ebrahimi, Elizabeth Proctor, Adam Bolotsky, T. Mal, Kenneth C. Keiler, Scott H. Medina, Christy George, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480

Active Learning Spaces: Matching Science Classrooms with Pedagogy

Jenay Robert, C Ramsay, Sarah E. Ades, Kenneth Keiler, Christopher Palma, 2020, on p. 483--498

Most-Cited Papers

Mechanisms of ribosome rescue in bacteria

Kenneth C. Keiler, 2015, Nature Reviews Microbiology on p. 285-297

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Nitya S. Ramadoss, John N. Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth C. Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287

Resolving nonstop translation complexes is a matter of life or death

Kenneth C. Keiler, Heather A. Feaga, 2014, Journal of Bacteriology on p. 2123-2130

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn, 2017, Scientific Reports on p. 6135

Release of nonstop ribosomes is essential

Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Andrew W. Simonson, Andrew Simonson^, Atip Lawanprasert, Atip Lawanprasert^, Tyler D.P. Goralski, Kenneth C. Keiler, Scott Medina*, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400

tmRNA Is Essential in Shigella flexneri

Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PLoS One on p. e57537

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela A. Hankey-Giblin, Kenneth C. Keiler, 2016, PLoS Genetics

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509

News Articles Featuring Kenneth Keiler

Apr 11, 2023

Penn State announces 2023 University-wide faculty and staff awards

Each spring, Penn State recognizes outstanding faculty and staff with annual awards in teaching and excellence. These awards highlight many of the University's faculty and staff who go above and beyond in their work at Penn State.

Full Article

Apr 11, 2023

Keiler honored with 2023 Graduate Program Chair Leadership Award

Kenneth Keiler, professor of biochemistry and molecular biology and associate department head for graduate education in Penn State's Eberly College of Science, is the 2023 recipient of the Graduate School Alumni Society Graduate Program Chair Leadership Award.

Full Article

Oct 09, 2022

Why COVID-19 Made This Sexually Transmitted Superbug Even Worse

COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.

Full Article

Oct 05, 2022

Gonorrhea became more drug resistant while attention was on COVID-19 – a molecular biologist explains the sexually transmitted superbug

COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.

Full Article

Mar 19, 2021

New antibiotic clears multi-drug resistant gonorrhea in mice in single dose

A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.

Full Article

Mar 19, 2020

Developing a novel oral antibiotic to treat multidrug-resistant gonorrhea

Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.

Full Article