Kenneth Keiler
Professor of Biochemistry and Molecular Biology
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401 Althouse
University Park, PA - kck11@psu.edu
- 814-863-0787
Research Summary
Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.
Huck Affiliations
Links
Publication Tags
Ribosomes Proteins Bacteria Anti Bacterial Agents Mitochondria Mycobacterium Tuberculosis Pharmaceutical Preparations Cells Growth Messenger Rna Francisella Tularensis Escherichia Coli Nanogel Protein Staphylococcus Aureus Tmrna Pyrazinamide Polysaccharide Peptide Cathelicidin Antimicrobial Peptide Mitochondrion Shigella Flexneri Caulobacter Crescentus Peptides Genes Pyrazinoic AcidMost Recent Papers
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Atip Lawanprasert, Tyler D.P. Goralski, Kenneth C. Keiler, Scott H. Medina, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus
Yueyang Huang, John N. Alumasa, Lauren T. Callaghan, R. Samuel Baugh, Christopher D. Rae, Kenneth C. Keiler, Shauna M. McGillivray, 2019, Antimicrobial agents and chemotherapy
Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo.
A Simonson, A Lawanprasert, Goralski TDP, Kenneth Keiler, Scott Medina, 2018, Nanomedicine : nanotechnology, biology, and medicine
A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
Tyler D.P. Goralski, Girish Soorapp Kirimanjeswara, Kenneth Charles Keiler, 2018, mBio
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth Charles Keiler, Anthony D. Baughn, 2017, Scientific reports on p. 6135
Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644
Teaching broader impacts of science with undergraduate research.
Kenneth Keiler, Kathy Jackson, L Jaworski, D Lopatto, Sarah Ades, 2017, PLoS biology on p. e2001318
Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Tyler D.P. Goralski, Kalyan K. Dewan, John Alumasa, Victoria Avanzato, David E. Place, Rachel L. Markley, Bhuvana Katkere, Seham M. Rabadi, Chandra Shekhar Bakshi, Kenneth Charles Keiler, Girish Soorapp Kirimanjeswara, 2016, Antimicrobial Agents and Chemotherapy on p. 3276-3282
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics
Mechanisms of ribosome rescue in bacteria.
Kenneth Keiler, 2015, Nature Reviews Microbiology on p. 285-97
Most-Cited Papers
Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity
Nitya S. Ramadoss, John Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth Charles Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287
Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics
Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth Charles Keiler, Victor Nizet, 2012, Antimicrobial Agents and Chemotherapy on p. 1854-1861
tmRNA Is Essential in Shigella flexneri
Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PloS one on p. e57537
Protein localization and dynamics within a bacterial organelle
H. Velocity Hughes, Edgar Huitema, Sean Pritchard, Kenneth C. Keiler, Yves V. Brun, Patrick H. Viollier, 2010, Proceedings of the National Academy of Sciences of the United States of America on p. 5599-5604
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth Charles Keiler, Anthony D. Baughn, 2017, Scientific reports on p. 6135
Release of nonstop ribosomes is essential
Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial agents and chemotherapy on p. 5500-5509
Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Tyler D.P. Goralski, Kalyan K. Dewan, John Alumasa, Victoria Avanzato, David E. Place, Rachel L. Markley, Bhuvana Katkere, Seham M. Rabadi, Chandra Shekhar Bakshi, Kenneth Charles Keiler, Girish Soorapp Kirimanjeswara, 2016, Antimicrobial Agents and Chemotherapy on p. 3276-3282
Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Heather A. Feaga, Michael D. Quickel, Pamela Hankey Giblin, Kenneth Charles Keiler, 2016, PLoS Genetics