Kenneth Keiler
Professor of Biochemistry and Molecular Biology
-
401 Althouse
University Park, PA - kck11@psu.edu
- 814-863-0787
Research Summary
Small RNAs and protein localization in bacterial development and antimicrobial drug discovery.
Huck Affiliations
Links
Publication Tags
Ribosomes Bacteria Proteins Anti Bacterial Agents Peptides Protein Hyaluronic Acid Messenger Rna Membranes Antimicrobial Agent Pharmaceutical Preparations Peptide Mycobacterium Tuberculosis Polysaccharides Escherichia Coli Genes Nanogels Staphylococcus Aureus Pathogens Shigella Flexneri Polysaccharide Peptide Cathelicidin Antimicrobial Peptide Transfer Rna Cells TmrnaMost Recent Publications
Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action
Pooja Srinivas, Kenneth C. Keiler, Christine M. Dunham, 2022, BioEssays
Ribosome collisions: New ways to initiate ribosome rescue
Stephanie L. Leedom, Kenneth C. Keiler, 2022, Current Biology on p. R469-R472
Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses
D Larivière, L Wickham, Kenneth Keiler, Anton Nekrutenko, 2021, BMC Microbiology on p. 168
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
Z Aron, A Mehrani, E Hoffer, K Connolly, P Srinivas, M Torhan, John Alumasa, Mynthia Cabrera Goss, D Hosangadi, J Barbor, S Cardinale, S Kwasny, L Morin, M Butler, T Opperman, T Bowlin, A Jerse, S Stagg, C Dunham, Kenneth Keiler, 2021, Nature Communications on p. 1799
Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation
Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel, Nadja Raatschen, Ümran Ay, Yvonne Märtens, Pascal Prochnow, Melissa Vázquez Hernández, Abdulkadir Yayci, Britta Schubert, Niklas B.M. Janzing, Helen L. Warmuth, Martin Kozik, Jens Bongard, John N. Alumasa, Bauke Albada, Maya Penkova, Tadeja Lukežič, Nohemy A. Sorto, Nicole Lorenz, Reece G. Miller, Bingyao Zhu, Martin Benda, Jörg Stülke, Sina Schäkermann, Lars I. Leichert, Kathi Scheinpflug, Heike Brötz-Oesterhelt, Christian Hertweck, Jared T. Shaw, Hrvoje Petković, Jean M. Brunel, Kenneth C. Keiler, Nils Metzler-Nolte, Julia E. Bandow, 2021, Antimicrobial Agents and Chemotherapy
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew W. Simonson, Andrew Simonson^, Agustey Mongia^, Matthew R. Aronson, A Mongia, Matthew Aronson^, M Aronson, Agustey S. Mongia, John N. Alumasa, Dennis Chan, A Lawanprasert, Adam Bolotsky, Atip Lawanprasert^, Aida Ebrahimi, Michael Howe, Elizabeth Proctor, Adam Bolotsky, Tapas K. Mal, Kenneth C. Keiler, Christy George, Scott H. Medina, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480
Reproducible and accessible analysis of transposon insertion data at scale
Delphine Lariviere, Laura Wickham, Kenneth Keiler, A Nekrutenko, 2020, bioRxiv
Active Learning Spaces: Matching Science Classrooms with Pedagogy
Jenay Robert, C Ramsay, S Ades, Kenneth Keiler, Christopher Palma, 2020, on p. 483--498
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Andrew Simonson^, Atip Lawanprasert, Atip Lawanprasert^, Tyler D.P. Goralski, Kenneth C. Keiler, Scott Medina*, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus
Yueyang Huang, John N. Alumasa, Lauren T. Callaghan, R. Samuel Baugh, Christopher D. Rae, Kenneth C. Keiler, Shauna M. McGillivray, 2019, Antimicrobial Agents and Chemotherapy
Most-Cited Papers
Mechanisms of ribosome rescue in bacteria
Kenneth C. Keiler, 2015, Nature Reviews Microbiology on p. 285-297
Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity
Nitya S. Ramadoss, John N. Alumasa, Lin Cheng, Yu Wang, Sharon Li, Benjamin S. Chambers, Hoon Chang, Arnab K. Chatterjee, Achim Brinker, Ingo H. Engels, Kenneth C. Keiler, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 10282-10287
Resolving nonstop translation complexes is a matter of life or death
Kenneth C. Keiler, Heather A. Feaga, 2014, Journal of Bacteriology on p. 2123-2130
Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics
Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John N. Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth C. Keiler, Victor Nizet, 2012, Antimicrobial Agents and Chemotherapy on p. 1854-1861
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn, 2017, Scientific Reports on p. 6135
Release of nonstop ribosomes is essential
Heather A. Feaga, Patrick H. Viollier, Kenneth C. Keiler, 2014, mBio
tmRNA Is Essential in Shigella flexneri
Nitya S. Ramadoss, Xin Zhou, Kenneth C. Keiler, 2013, PLoS One on p. e57537
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Andrew W. Simonson, Andrew Simonson^, Atip Lawanprasert, Atip Lawanprasert^, Tyler D.P. Goralski, Kenneth C. Keiler, Scott Medina*, 2019, Nanomedicine: Nanotechnology, Biology, and Medicine on p. 391-400
Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
John N. Alumasa, Paolo S. Manzanillo, Nicholas D. Peterson, Tricia Lundrigan, Anthony D. Baughn, Jeffery S. Cox, Kenneth C. Keiler, 2017, ACS Infectious Diseases on p. 634-644
Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler, 2014, Antimicrobial Agents and Chemotherapy on p. 5500-5509
News Articles Featuring Kenneth Keiler
Oct 09, 2022
Why COVID-19 Made This Sexually Transmitted Superbug Even Worse
COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.
Full Article
Oct 05, 2022
Gonorrhea became more drug resistant while attention was on COVID-19 – a molecular biologist explains the sexually transmitted superbug
COVID-19 has rightfully dominated infectious disease news since 2020. However, that doesn’t mean other infectious diseases took a break. In fact, U.S. rates of infection by gonorrhea have risen during the pandemic.
Full Article
Mar 19, 2021
New antibiotic clears multi-drug resistant gonorrhea in mice in single dose
A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.
Full Article
Mar 19, 2020
Developing a novel oral antibiotic to treat multidrug-resistant gonorrhea
Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.
Full Article