Keith Cheng

Distinguished Professor of Pathology; Professor of Biochemistry & Molecular Biology; Professor of Pharmacology

Keith Cheng

Research Summary

Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.

Graduate Students

Huck Affiliations

Links

Publication Tags

Histology Skin Pigmentation Skin Color Zebrafish Genes Mutation Pigmentation Tissue X Rays Phenotype Brain Population Malaysia Skin (Animal) Risk Management Iron Genomics Tomography Alleles Animals Polymorphism Population Groups Alzheimer Disease Genetic Polymorphism

Most Recent Papers

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Abstracts of presentations at the Association of Clinical Scientists 139<sup>th</sup> Meeting Hershey, PA, May 15-18, 2019

Keri Donaldson, Jeanine M. Buchanich, Patricia Sue Grigson, Erin Deneke, Kent E. Vrana, David B. Sacks, Gregory J. Kuehn, David Cardamone, Amadeo Pesce, Sarah Smiley, Joyce Nickley, Kevin Krock, Richard Thomas, Myra L. Wilkerson, Hosam A. Farag, Sashi Rameswara Challa, Ann Marie Tice, Donna M. Wolk, Jeffrey Prichard, Michelle L. Grant, Sandeep Regmi, Brian Kerbacher, Lawrence E. Quinton, A. M. Tice, Jordan Olson, Amanda Haynes, Elsie Yu, Kilmer S. McCully, Jasmeet Assi, Myra Wong, Neda Zarrin-Khameh, Thomas P. Nifong, Charles D. Hawker, George T. Carlton, Julia M. Rivera, Philip R. Foulis, Aleksandra Zuraw, Diana Morlote, Deniz Peker, Vishnu Reddy, Shuko Harada, Chris Crutchfield, Dani Zander, Mustafa A. Barbhuiya, Edward C. Pederson, Monica L. Straub, Sofia C. Scott, Terri L. Neibauer, Wayne F. Salter, Michael H. Creer, Yusheng Zhu, Joshua A. Bornhorst, J. Paul Theobald, Alicia Algeciras-Schimnich, Liyun Cao, James Knox, Robert Hardy, Hicks J. Texas, Mary F. McGuire, Robert L. Hunter, Robert E. Brown, John Hicks, Zhenjian Cai, Robert E. Brown, Yasir Ali, Keith C. Cheng, Spencer R. Katz, Yifu Ding, Daniel J. Vanselow, Maxsim A. Yakovlev, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B. van Rossum, Patrick J. La Rivière, Jordan Newell, Carrie Hossler, Michael Roche, Joshua Warrick, Rebecca Phaeton, Josh Kesterson, Charlotte Myers, Roberto Barrios, Paul Mintz, Kimberly Robyak, Christopher Hamilton, Pamela McGhee, Christopher Pederson, Monica Straub, Sofia Scott, Terri Neibauer, Wayne Salter, Kimberly Robyak, Nirupama Singh, Diana Morlote, Cindy Vnencak-Jones, Anna Yemelyanova, Shuko Harada, Mauli Shah, Soheil Zorofchian Moghadamtousi, Chieh Lan, Dzifa Duose, Peter Hu, Yoshua Esquenazi, Rajyalakshmi Luthra, Leomar Y. Ballester, Annie N. Koenig, Chang Gong Liu, Jianhua Zhang, Awdhesh Kalia, Ali Al-Habib, Melissa Van Arsdall, Sadhna Dhingra, Kalyani Patel, Nina Tatevian, 2019, Annals of clinical and laboratory science on p. 403-416

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography

Alex Y. Lin, Yifu Ding, Daniel J. Vanselow, Spencer R. Katz, Maksim A. Yakovlev, Darin P. Clark, David Mandrell, Jean E. Copper, Damian B. van Rossum, Keith C. Cheng, 2018, Journal of visualized experiments : JoVE

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. Van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith Cheng, 2018, Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology on p. 38-46

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing Yang, James Connor, Mark Meadowcroft, 2018, Metallomics on p. 426-443

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng, 2012, PloS one

Skin color variation in Orang Asli tribes of Peninsular Malaysia

Khai C. Ang, Mee S. Ngu, Katherine P. Reid, Mei S. Teh, Zamzuraida S. Aida, Danny X.R. Koh, Arthur Berg, Stephen Oppenheimer, Hood Salleh, Mahani M. Clyde, Badrul M. Md-Zain, Victor A. Canfield, Keith C. Cheng, 2012, PloS one

Aquatic models, genomics and chemical risk management

Keith Cheng, David E. Hinton, Carolyn J. Mattingly, Antonio Planchart, 2012, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 169-173

SHIRAZ

Brian A. Canada, Georgia K. Thomas, Keith Cheng, James Wang, 2011, Multimedia Tools and Applications on p. 401-440

Most-Cited Papers

Predicting phenotype from genotype

Robert K. Valenzuela, Miquia S. Henderson, Monica H. Walsh, Nanibaa A. Garrison, Jessica T. Kelch, Orit Cohen-Barak, Drew T. Erickson, F. John Meaney, J. Bruce Walsh, Keith C. Cheng, Shosuke Ito, Kazumasa Wakamatsu, Tony Frudakis, Matthew Thomas, Murray H. Brilliant, 2010, Journal of Forensic Sciences on p. 315-322

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng, 2012, PloS one

Skin color variation in Orang Asli tribes of Peninsular Malaysia

Khai C. Ang, Mee S. Ngu, Katherine P. Reid, Mei S. Teh, Zamzuraida S. Aida, Danny X.R. Koh, Arthur Berg, Stephen Oppenheimer, Hood Salleh, Mahani M. Clyde, Badrul M. Md-Zain, Victor A. Canfield, Keith C. Cheng, 2012, PloS one

SHIRAZ

Brian A. Canada, Georgia K. Thomas, Keith Cheng, James Wang, 2011, Multimedia Tools and Applications on p. 401-440

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

Aquatic models, genomics and chemical risk management

Keith Cheng, David E. Hinton, Carolyn J. Mattingly, Antonio Planchart, 2012, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 169-173

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing Yang, James Connor, Mark Meadowcroft, 2018, Metallomics on p. 426-443

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. Van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith Cheng, 2018, Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology on p. 38-46

Genetic ancestry., skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance

Robin Taylor Wilson, Alanna N. Roff, P. Jenny Dai, Tracey Fortugno, Jonathan Douds, Gang Chen, Sheila Ongeri Nikiforova, Vernon M. Chinchilli, Terryl J. Hartman, Laurence M. Demers, Victor A. Canfield, Keith C. Cheng, Gary L. Grove, Jill Barnholtz-Sloan, Tony Frudakis, Mark D. Shriver, Keith C. Cheng, Robin Taylor Wilson, 2011, Hormone Molecular Biology and Clinical Investigation on p. 279-293

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife