Keith Cheng

Distinguished Professor of Pathology and Laboratory Medicine, of Biochemistry and Molecular Biology, and of Pharmacology

H059 Pathology
Hershey, PA
kcc2@psu.edu
717-531-5635

Research Summary

Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.

Huck Graduate Students

Huck Affiliations

Bioinformatics and Genomics

Publication Tags

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Brain Zebrafish Tissue Datasets X Rays Labels Image Classification Genome Histology Tomography Neurons Detectors Secondary Ion Mass Spectrometry Iron Oxytocin Imaging Techniques Phenotype Population Larva Atlases X Ray Phenomics Neoplasms Skin Pigmentation Pixels

Most Recent Publications

Promoting validation and cross-phylogenetic integration in model organism research

Keith C. Cheng, Rebecca D. Burdine, Mary E. Dickinson, Stephen C. Ekker, Alex Y. Lin, K. C.Kent Lloyd, Cathleen M. Lutz, Calum A. MacRae, John H. Morrison, David H. O'Connor, John H. Postlethwait, Crystal D. Rogers, Susan Sanchez, Julie H. Simpson, William S. Talbot, Douglas C. Wallace, Jill M. Weimer, Hugo J. Bellen, 2022, DMM Disease Models and Mechanisms

Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice

Seoyoung Son, Steffy B. Manjila, Kyra T. Newmaster, Yuan Ting Wu, Daniel J. Vanselow, Matt Ciarletta, Todd E. Anthony, Keith C. Cheng, Yongsoo Kim, 2022, Journal of Neuroscience on p. 5021-5033

Quantitative relationship between cerebrovascular network and neuronal cell types in mice

Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Mun˜ oz-Castan˜ eda, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, 2022, Cell Reports

A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale

Maksim A. Yakovlev, Daniel J. Vanselow, Mee Siing Ngu, Carolyn R. Zaino, Spencer R. Katz, Yifu Ding, Dula Parkinson, Steve Yuxin Wang, Khai Chung Ang, Patrick La Riviere, Keith C. Cheng, 2022, Journal of Synchrotron Radiation on p. 505-514

Whole-organism 3d quantitative characterization of zebrafish melanin by silver deposition micro-ct

Spencer R. Katz, Maksim A. Yakovlev, Daniel J. Vanselow, Yifu Ding, Alex Y. Lin, Dilworth Y. Parkinson, Yuxin Wang, Victor A. Canfield, Khai C. Ang, Keith C. Cheng, 2021, eLife

Zebrafish histotomography noise removal in projection and reconstruction domains

Amogh Subbakrishna Adishesha, Daniel J. Vanselow, Patrick La Riviere, Xiaolei Huang, Keith C. Cheng, 2021, on p. 140-144

Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae Using ToF-SIMS

Sebastiaan Van Nuffel, Khai C. Ang, Alex Y. Lin, Keith C. Cheng, 2021, Journal of the American Society for Mass Spectrometry on p. 255-261

Selective synthetic augmentation with HistoGAN for improved histopathology image classification

Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, Medical Image Analysis

A Multi-attribute Controllable Generative Model for Histopathology Image Synthesis

Jiarong Ye, Yuan Xue, Peter Liu, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, on p. 613-623

A map of cis-regulatory elements and 3D genome structures in zebrafish

Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N.K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith C. Cheng, Feng Yue, 2020, Nature on p. 337-343

Most-Cited Papers

The GenomeAsia 100K Project enables genetic discoveries across Asia

Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Khai C. Ang, 2019, Nature on p. 106-111

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Enhanced and unified anatomical labeling for a common mouse brain atlas

Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications

A map of cis-regulatory elements and 3D genome structures in zebrafish

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith C. Cheng, 2018, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 38-46

Selective synthetic augmentation with HistoGAN for improved histopathology image classification

Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, Medical Image Analysis

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith C. Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing X. Yang, James R. Connor, Mark D. Meadowcroft, 2018, Metallomics on p. 426-443

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

Whole-Organism Cellular Pathology: A Systems Approach to Phenomics

K. C. Cheng, S. R. Katz, A. Y. Lin, X. Xin, Y. Ding, 2016, on p. 89-115