Keith Cheng

Distinguished Professor of Pathology and Laboratory Medicine, of Biochemistry and Molecular Biology, and of Pharmacology

Keith Cheng

Research Summary

Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Brain Histology Tissue X Rays Zebrafish Population Iron Skin Pigmentation Color Mutation Atlases Tomography Genes Skin Labels Datasets Phenotype Pigmentation Image Classification Histological Techniques Risk Management Labeling Phylogeography Dietary Iron Genetic Selection

Most Recent Papers

Selective synthetic augmentation with HistoGAN for improved histopathology image classification

Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith Cheng, Xiaolei Huang, 2021, Medical Image Analysis

The GenomeAsia 100K Project enables genetic discoveries across Asia

Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, Nature on p. 106-111

Identification of African-Specific Admixture between Modern and Archaic Humans

Jeffrey D. Wall, Aakrosh Ratan, Eric Stawiski, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schrӧder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Samir Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, American Journal of Human Genetics on p. 1254-1261

Enhanced and unified anatomical labeling for a common mouse brain atlas

Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications

Abstracts of presentations at the Association of Clinical Scientists 139<sup>th</sup> Meeting Hershey, PA, May 15-18, 2019

Keri Donaldson, Jeanine M. Buchanich, Patricia Sue Grigson, Erin Deneke, Kent E. Vrana, David B. Sacks, Gregory J. Kuehn, David Cardamone, Amadeo Pesce, Sarah Smiley, Joyce Nickley, Kevin Krock, Richard Thomas, Myra L. Wilkerson, Hosam A. Farag, Sashi Rameswara Challa, Ann Marie Tice, Donna M. Wolk, Jeffrey Prichard, Michelle L. Grant, Sandeep Regmi, Brian Kerbacher, Lawrence E. Quinton, A. M. Tice, Jordan Olson, Amanda Haynes, Elsie Yu, Kilmer S. McCully, Jasmeet Assi, Myra Wong, Neda Zarrin-Khameh, Thomas P. Nifong, Charles D. Hawker, George T. Carlton, Julia M. Rivera, Philip R. Foulis, Aleksandra Zuraw, Diana Morlote, Deniz Peker, Vishnu Reddy, Shuko Harada, Chris Crutchfield, Dani Zander, Mustafa A. Barbhuiya, Edward C. Pederson, Monica L. Straub, Sofia C. Scott, Terri L. Neibauer, Wayne F. Salter, Michael H. Creer, Yusheng Zhu, Joshua A. Bornhorst, J. Paul Theobald, Alicia Algeciras-Schimnich, Liyun Cao, James Knox, Robert Hardy, Hicks J. Texas, Mary F. McGuire, Robert L. Hunter, Robert E. Brown, John Hicks, Zhenjian Cai, Robert E. Brown, Yasir Ali, Keith C. Cheng, Spencer R. Katz, Yifu Ding, Daniel J. Vanselow, Maxsim A. Yakovlev, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B. van Rossum, Patrick J. La Rivière, Jordan Newell, Carrie Hossler, Michael Roche, Joshua Warrick, Rebecca Phaeton, Josh Kesterson, Charlotte Myers, Roberto Barrios, Paul Mintz, Kimberly Robyak, Christopher Hamilton, Pamela McGhee, Christopher Pederson, Monica Straub, Sofia Scott, Terri Neibauer, Wayne Salter, Kimberly Robyak, Nirupama Singh, Diana Morlote, Cindy Vnencak-Jones, Anna Yemelyanova, Shuko Harada, Mauli Shah, Soheil Zorofchian Moghadamtousi, Chieh Lan, Dzifa Duose, Peter Hu, Yoshua Esquenazi, Rajyalakshmi Luthra, Leomar Y. Ballester, Annie N. Koenig, Chang Gong Liu, Jianhua Zhang, Awdhesh Kalia, Ali Al-Habib, Melissa Van Arsdall, Sadhna Dhingra, Kalyani Patel, Nina Tatevian, 2019, Annals of Clinical and Laboratory Science on p. 403-416

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography

Alex Y. Lin, Yifu Ding, Daniel J. Vanselow, Spencer R. Katz, Maksim A. Yakovlev, Darin P. Clark, David Mandrell, Jean E. Copper, Damian B. van Rossum, Keith C. Cheng, 2018, Journal of Visualized Experiments

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith C. Cheng, 2018, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 38-46

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith C. Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing X. Yang, James R. Connor, Mark D. Meadowcroft, 2018, Metallomics on p. 426-443

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

Most-Cited Papers

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng, 2012, PLoS One

The GenomeAsia 100K Project enables genetic discoveries across Asia

Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, Nature on p. 106-111

Skin color variation in Orang Asli tribes of Peninsular Malaysia

Khai C. Ang, Mee S. Ngu, Katherine P. Reid, Mei S. Teh, Zamzuraida S. Aida, Danny X.R. Koh, Arthur Berg, Stephen Oppenheimer, Hood Salleh, Mahani M. Clyde, Badrul M. Md-Zain, Victor A. Canfield, Keith C. Cheng, 2012, PLoS One

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith C. Cheng, 2018, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 38-46

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith C. Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing X. Yang, James R. Connor, Mark D. Meadowcroft, 2018, Metallomics on p. 426-443

Aquatic models, genomics and chemical risk management

Keith C. Cheng, David E. Hinton, Carolyn J. Mattingly, Antonio Planchart, 2012, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 169-173

SHIRAZ

Brian A. Canada, Georgia K. Thomas, Keith C. Cheng, James Z. Wang, 2011, Multimedia Tools and Applications on p. 401-440

Enhanced and unified anatomical labeling for a common mouse brain atlas

Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications