Keith Cheng
Distinguished Professor of Pathology and Laboratory Medicine, of Biochemistry and Molecular Biology, and of Pharmacology
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H059 Pathology
Hershey, PA - kcc2@psu.edu
- 717-531-5635
Research Summary
Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.
Huck Graduate Students
Huck Affiliations
Links
Most Recent Publications
Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice
Seoyoung Son, Steffy B. Manjila, Kyra T. Newmaster, Yuan Ting Wu, Daniel J. Vanselow, Matt Ciarletta, Todd E. Anthony, Keith C. Cheng, Yongsoo Kim, 2022, Journal of Neuroscience on p. 5021-5033
Quantitative relationship between cerebrovascular network and neuronal cell types in mice
Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, 2022, Cell Reports
A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale
Maksim A. Yakovlev, Daniel J. Vanselow, Mee Siing Ngu, Carolyn R. Zaino, Spencer R. Katz, Yifu Ding, Dula Parkinson, Steve Yuxin Wang, Khai Chung Ang, Patrick La Riviere, Keith C. Cheng, 2022, Journal of Synchrotron Radiation on p. 505-514
Whole-organism 3d quantitative characterization of zebrafish melanin by silver deposition micro-ct
Spencer R. Katz, Maksim A. Yakovlev, Daniel J. Vanselow, Yifu Ding, Alex Y. Lin, Dilworth Y. Parkinson, Yuxin Wang, Victor A. Canfield, Khai C. Ang, Keith C. Cheng, 2021, eLife
Zebrafish histotomography noise removal in projection and reconstruction domains
Amogh Subbakrishna Adishesha, Daniel J. Vanselow, Patrick La Riviere, Xiaolei Huang, Keith C. Cheng, 2021, on p. 140-144
Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae Using ToF-SIMS
Sebastiaan Van Nuffel, Khai C. Ang, Alex Y. Lin, Keith C. Cheng, 2021, Journal of the American Society for Mass Spectrometry on p. 255-261
Selective synthetic augmentation with HistoGAN for improved histopathology image classification
Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, Medical Image Analysis
A Multi-attribute Controllable Generative Model for Histopathology Image Synthesis
Jiarong Ye, Yuan Xue, Peter Liu, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, on p. 613-623
A map of cis-regulatory elements and 3D genome structures in zebrafish
Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N.K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith C. Cheng, Feng Yue, 2020, Nature on p. 337-343
Supervised machine learning for region assignment of zebrafish brain nuclei based on computational assessment of cell neighborhoods
S. Gupta, Y. Xue, Y. Ding, D. Vanselow, M. Yakovlev, Sharon Xiaolei Huang, 2020, Proc. of the SPIE Medical Imaging: Biomedical Applications Molecular, Structural, and Functional Imaging
Most-Cited Papers
The GenomeAsia 100K Project enables genetic discoveries across Asia
Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Khai C. Ang, 2019, Nature on p. 106-111
Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography
Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife
Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish
Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng, 2012, PLoS One
Enhanced and unified anatomical labeling for a common mouse brain atlas
Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications
Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish
Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith C. Cheng, 2018, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 38-46
A map of cis-regulatory elements and 3D genome structures in zebrafish
Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N.K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith C. Cheng, Feng Yue, 2020, Nature on p. 337-343
Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice
Douglas G. Peters, Alexis N. Pollack, Keith C. Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing X. Yang, James R. Connor, Mark D. Meadowcroft, 2018, Metallomics on p. 426-443
Selective synthetic augmentation with HistoGAN for improved histopathology image classification
Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, Medical Image Analysis
Skin color variation in Orang Asli tribes of Peninsular Malaysia
Khai C. Ang, Mee S. Ngu, Katherine P. Reid, Mei S. Teh, Zamzuraida S. Aida, Danny X.R. Koh, Arthur Berg, Stephen Oppenheimer, Hood Salleh, Mahani M. Clyde, Badrul M. Md-Zain, Victor A. Canfield, Keith C. Cheng, 2012, PLoS One
Molecular phylogeography of a human autosomal skin color locus under natural selection
Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067