Keith Cheng

Distinguished Professor of Pathology and Laboratory Medicine, of Biochemistry and Molecular Biology, and of Pharmacology

Keith Cheng

Research Summary

Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Brain Zebrafish X Rays Tissue Histology Color Genes Population Pigmentation Skin Skin Pigmentation Mutation Labels Atlases Datasets Phenotype Genome Secondary Ion Mass Spectrometry Marking Iron Skin (Animal) Reinforcement Learning Mice Malaysia Labeling

Most Recent Papers

Zebrafish histotomography noise removal in projection and reconstruction domains

Amogh Subbakrishna Adishesha, Daniel J. Vanselow, Patrick La Riviere, Xiaolei Huang, Keith Cheng, 2021, on p. 140-144

Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae Using ToF-SIMS

Sebastiaan Van Nuffel, Khai C. Ang, Alex Y. Lin, Keith C. Cheng, 2021, Journal of the American Society for Mass Spectrometry on p. 255-261

Selective synthetic augmentation with HistoGAN for improved histopathology image classification

Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, 2021, Medical Image Analysis

A map of cis-regulatory elements and 3D genome structures in zebrafish

Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N.K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith Cheng, Feng Yue, 2020, Nature on p. 337-343

Synthetic sample selection via reinforcement learning

Jiarong Ye, Yuan Xue, L. Rodney Long, Sameer Antani, Zhiyun Xue, Keith C. Cheng, Xiaolei Huang, 2020, on p. 53-63

Identification of African-Specific Admixture between Modern and Archaic Humans

Jeffrey D. Wall, Aakrosh Ratan, Eric Stawiski, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schrӧder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Samir Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, American Journal of Human Genetics on p. 1254-1261

The GenomeAsia 100K Project enables genetic discoveries across Asia

Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, Nature on p. 106-111

Enhanced and unified anatomical labeling for a common mouse brain atlas

Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications

Abstracts of presentations at the Association of Clinical Scientists 139<sup>th</sup> Meeting Hershey, PA, May 15-18, 2019

Keri Donaldson, Jeanine M. Buchanich, Patricia Sue Grigson, Erin Deneke, Kent E. Vrana, David B. Sacks, Gregory J. Kuehn, David Cardamone, Amadeo Pesce, Sarah Smiley, Joyce Nickley, Kevin Krock, Richard Thomas, Myra L. Wilkerson, Hosam A. Farag, Sashi Rameswara Challa, Ann Marie Tice, Donna M. Wolk, Jeffrey Prichard, Michelle L. Grant, Sandeep Regmi, Brian Kerbacher, Lawrence E. Quinton, A. M. Tice, Jordan Olson, Amanda Haynes, Elsie Yu, Kilmer S. McCully, Jasmeet Assi, Myra Wong, Neda Zarrin-Khameh, Thomas P. Nifong, Charles D. Hawker, George T. Carlton, Julia M. Rivera, Philip R. Foulis, Aleksandra Zuraw, Diana Morlote, Deniz Peker, Vishnu Reddy, Shuko Harada, Chris Crutchfield, Dani Zander, Mustafa A. Barbhuiya, Edward C. Pederson, Monica L. Straub, Sofia C. Scott, Terri L. Neibauer, Wayne F. Salter, Michael H. Creer, Yusheng Zhu, Joshua A. Bornhorst, J. Paul Theobald, Alicia Algeciras-Schimnich, Liyun Cao, James Knox, Robert Hardy, Hicks J. Texas, Mary F. McGuire, Robert L. Hunter, Robert E. Brown, John Hicks, Zhenjian Cai, Robert E. Brown, Yasir Ali, Keith C. Cheng, Spencer R. Katz, Yifu Ding, Daniel J. Vanselow, Maxsim A. Yakovlev, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B. van Rossum, Patrick J. La Rivière, Jordan Newell, Carrie Hossler, Michael Roche, Joshua Warrick, Rebecca Phaeton, Josh Kesterson, Charlotte Myers, Roberto Barrios, Paul Mintz, Kimberly Robyak, Christopher Hamilton, Pamela McGhee, Christopher Pederson, Monica Straub, Sofia Scott, Terri Neibauer, Wayne Salter, Kimberly Robyak, Nirupama Singh, Diana Morlote, Cindy Vnencak-Jones, Anna Yemelyanova, Shuko Harada, Mauli Shah, Soheil Zorofchian Moghadamtousi, Chieh Lan, Dzifa Duose, Peter Hu, Yoshua Esquenazi, Rajyalakshmi Luthra, Leomar Y. Ballester, Annie N. Koenig, Chang Gong Liu, Jianhua Zhang, Awdhesh Kalia, Ali Al-Habib, Melissa Van Arsdall, Sadhna Dhingra, Kalyani Patel, Nina Tatevian, 2019, Annals of Clinical and Laboratory Science on p. 403-416

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Most-Cited Papers

Whole-animal imaging, gene function, and the Zebrafish Phenome Project

Keith C. Cheng, Xuying Xin, Darin P. Clark, Patrick La Riviere, 2011, Current Opinion in Genetics and Development on p. 620-629

The GenomeAsia 100K Project enables genetic discoveries across Asia

Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph Guillory, Sameer Phalke, Analabha Basu, Jeremy Stinson, Sandhya Nair, Sivasankar Malaichamy, Nidhan K. Biswas, John C. Chambers, Keith C. Cheng, Joyner T. George, Seik Soon Khor, Jong Il Kim, Belong Cho, Ramesh Menon, Thiramsetti Sattibabu, Akshi Bassi, Manjari Deshmukh, Anjali Verma, Vivek Gopalan, Jong Yeon Shin, Mahesh Pratapneni, Sam Santhosh, Katsushi Tokunaga, Badrul M. Md-Zain, Kok Gan Chan, Madasamy Parani, Purushothaman Natarajan, Michael Hauser, R. Rand Allingham, Cecilia Santiago-Turla, Arkasubhra Ghosh, Santosh Gopi Krishna Gadde, 2019, Nature on p. 106-111

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng, 2012, PLoS One

Skin color variation in Orang Asli tribes of Peninsular Malaysia

Khai C. Ang, Mee S. Ngu, Katherine P. Reid, Mei S. Teh, Zamzuraida S. Aida, Danny X.R. Koh, Arthur Berg, Stephen Oppenheimer, Hood Salleh, Mahani M. Clyde, Badrul M. Md-Zain, Victor A. Canfield, Keith C. Cheng, 2012, PLoS One

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Yifu Ding, Daniel J. Vanselow, Maksim A. Yakovlev, Spencer R. Katz, Alex Y. Lin, Darin P. Clark, Phillip Vargas, Xuying Xin, Jean E. Copper, Victor A. Canfield, Khai C. Ang, Yuxin Wang, Xianghui Xiao, Francesco De Carlo, Damian B.Van Rossum, Patrick La Riviere, Keith C. Cheng, 2019, eLife

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Jean E. Copper, Lynn R. Budgeon, Christina A. Foutz, Damian B. van Rossum, Daniel J. Vanselow, Margaret J. Hubley, Darin P. Clark, David T. Mandrell, Keith C. Cheng, 2018, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 38-46

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Douglas G. Peters, Alexis N. Pollack, Keith C. Cheng, Dongxiao Sun, Takaomi Saido, Michael P. Haaf, Qing X. Yang, James R. Connor, Mark D. Meadowcroft, 2018, Metallomics on p. 426-443

Enhanced and unified anatomical labeling for a common mouse brain atlas

Uree Chon, Daniel J. Vanselow, Keith C. Cheng, Yongsoo Kim, 2019, Nature Communications

Molecular phylogeography of a human autosomal skin color locus under natural selection

Victor A. Canfield, Arthur Berg, Steven Peckins, Steven M. Wentzel, Khai Chung Ang, Stephen Oppenheimer, Keith C. Cheng, 2013, G3: Genes, Genomes, Genetics on p. 2059-2067

SHIRAZ

Brian A. Canada, Georgia K. Thomas, Keith C. Cheng, James Z. Wang, 2011, Multimedia Tools and Applications on p. 401-440