Keefe Manning
Professor of Biomedical Engineering and Surgery
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530 Chemical and Biomedical Engineering
University Park, PA - kbm10@psu.edu
- 814-863-6318
Research Summary
Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.
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Publication Tags
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Blood Computational Fluid Dynamics Hydrodynamics Thrombosis Equipment And Supplies Pumps Hemodynamics Scaffolds Biomedical Equipment Heart Valves Heparin Anisotropy Benchmarking Nozzles Model Hemolysis Shear Stress Laminar Flow Simulation Elastomeric Valve Turbulent Flow Inferior Vena Cava Peptides MicrofibersMost Recent Publications
Modeling Flow in an In Vitro Anatomical Cerebrovascular Model with Experimental Validation
Saurabh Bhardwaj, Brent Craven, Jacob Sever, F Costanzo, Scott Simon, Keefe Manning, Frontiers of Medical Technology
The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics
Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning, 2023, Journal of Biomechanical Engineering on p. 031005
Results of the Interlaboratory Computational Fluid Dynamics Study of the FDA Benchmark Blood Pump
Sailahari V. Ponnaluri, Prasanna Hariharan, Luke H. Herbertson, Keefe B. Manning, Richard A. Malinauskas, Brent A. Craven, 2023, Annals of Biomedical Engineering on p. 253-269
Computational Modeling of the Penn State Fontan Circulation Assist Device
Bryan C. Good, Sailahari V. Ponnaluri, William Weiss, Keefe B. Manning, 2022, ASAIO Journal on p. 1513-1522
Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes
Nicolas Tobin, Keefe B. Manning, 2022, Communications in Applied Numerical Methods
Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes
Nicolas Tobin, Keefe Manning, 2022, Inter J Num Meth Biomed Eng on p. e3638
Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries
Nicolas Tobin, Bryan Good, Jonathan Plasencia, Mark Fogel, W Weiss, Keefe Manning, 2022, Ann Biomed Eng on p. 929-940
Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries
Nicolas Tobin, Bryan C. Good, Jonathan D. Plasencia, Mark A. Fogel, William J. Weiss, Keefe B. Manning, 2022, Annals of Biomedical Engineering on p. 929-940
Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation
Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small
Examining the universality of the hemolysis power law model from simulations of the FDA nozzle using calibrated model coefficients
Alberto Mantegazza, Nicolas Tobin, Keefe B. Manning, Brent A. Craven, 2022, Biomechanics and Modeling in Mechanobiology
Most-Cited Papers
Tri-layered elastomeric scaffolds for engineering heart valve leaflets
Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785
Electrospun PGS: PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy
Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939
FDA Benchmark Medical Device Flow Models for CFD Validation
Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160
Development of a computational model for macroscopic predictions of device-induced thrombosis
Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731
Results of FDA's First Interlaboratory Computational Study of a Nozzle with a Sudden Contraction and Conical Diffuser
Sandy F.C. Stewart, Prasanna Hariharan, Eric G. Paterson, Greg W. Burgreen, Varun Reddy, Steven W. Day, Matthew Giarra, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2013, Cardiovascular Engineering and Technology on p. 374-391
Science for surgeons: Understanding pump thrombogenesis in continuous-flow left ventricular assist devices
Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673
Hemodynamics in a Pediatric Ascending Aorta Using a Viscoelastic Pediatric Blood Model
Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035
The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava
Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582
A Computational method for predicting inferior vena cava filter performance on a patient-specific basis
Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven, 2014, Journal of Biomechanical Engineering
Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)
Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640
News Articles Featuring Keefe Manning
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article