Keefe Manning

Professor of Biomedical Engineering and Surgery

Keefe Manning

Research Summary

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Blood Computational Fluid Dynamics Hydrodynamics Equipment And Supplies Thrombosis Pumps Hemodynamics Scaffolds Biomedical Equipment Heart Valves Anisotropy Heparin Benchmarking Nozzles Model Shear Stress Hemolysis Laminar Flow Turbulent Flow Simulation Hydrogels Peptides Oligonucleotides Microfibers Elastomeric

Most Recent Publications

Thrombosis and thromboembolism modeling in laminar and turbulent flow regimes

Nicolas Tobin, Keefe Manning, Inter J Num Meth Biomed Eng

Computational fluid dynamics investigation of surgical options for the anastomosis of a right-heart pump to patient-specific pulmonary arteries

Nicolas Tobin, Bryan Good, Jonathan Plasencia, Mark Fogel, W Weiss, Keefe Manning, Ann Biomed Eng

The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics

Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning, 2023, Journal of Biomechanical Engineering

Results of the Interlaboratory Computational Fluid Dynamics Study of the FDA Benchmark Blood Pump

Sailahari V. Ponnaluri, Prasanna Hariharan, Luke H. Herbertson, Keefe B. Manning, Richard A. Malinauskas, Brent A. Craven, 2023, Annals of Biomedical Engineering on p. 253-269

Computational Modeling of the Penn State Fontan Circulation Assist Device

Bryan C. Good, Sailahari V. Ponnaluri, William J. Weiss, Keefe B. Manning, 2022, ASAIO Journal on p. 1513-1522

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

Nicolas Tobin, Keefe B. Manning, 2022, Communications in Applied Numerical Methods

Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries

Nicolas Tobin, Bryan C. Good, Jonathan D. Plasencia, Mark A. Fogel, William J. Weiss, Keefe B. Manning, 2022, Annals of Biomedical Engineering on p. 929-940

Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation

Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small

Examining the universality of the hemolysis power law model from simulations of the FDA nozzle using calibrated model coefficients

Alberto Mantegazza, Nicolas Tobin, Keefe B. Manning, Brent A. Craven, 2022, Biomechanics and Modeling in Mechanobiology

Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices

Connor Watson, Lidya Abune, Hicham Saaid, Connie Wen, Yong Wang, Keefe B. Manning, 2022, Cardiovascular Engineering and Technology

Most-Cited Papers

Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785

Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939

FDA Benchmark Medical Device Flow Models for CFD Validation

Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160

Development of a computational model for macroscopic predictions of device-induced thrombosis

Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731

Results of FDA's First Interlaboratory Computational Study of a Nozzle with a Sudden Contraction and Conical Diffuser

Sandy F.C. Stewart, Prasanna Hariharan, Eric G. Paterson, Greg W. Burgreen, Varun Reddy, Steven W. Day, Matthew Giarra, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2013, Cardiovascular Engineering and Technology on p. 374-391

Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582

A Computational method for predicting inferior vena cava filter performance on a patient-specific basis

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven, 2014, Journal of Biomechanical Engineering

Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035

Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)

Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640