Keefe Manning

Professor of Biomedical Engineering and Surgery

Keefe Manning

Research Summary

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Blood Hydrodynamics Computational Fluid Dynamics Hemodynamics Pumps Scaffolds Equipment And Supplies Thrombosis Shear Stress Heart Valves Anisotropy Biomedical Equipment Benchmarking Elastomeric Microfibers Valve Inferior Vena Cava Tissue Pressure Hemolysis Pump Poly(Glycerol Sebacate) Velocity Measurement Polycaprolactone Geometry

Most Recent Publications

Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling

Connor Watson, Hicham Saaid, Vijay Vedula, Jessica C. Cardenas, Peter K. Henke, Franck Nicoud, Xiao Yun Xu, Beverley J. Hunt, Keefe B. Manning, 2024, Annals of Biomedical Engineering on p. 467-486

Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling

Connor Watson, Hicham Saaid, Vijay Vedula, Jessica Cardenas, Peter Henke, Franck Nicoud, Xiao Yu, Beverley Hunt, Keefe Manning, 2024, Ann Biomed Eng on p. 467-486

Influence of Hematocrit Level and Integrin α<sub>IIb</sub>β<sub>III</sub> Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion

Connor T. Watson, Shane C. Ward, Stefano A. Rizzo, Alberto Redaelli, Keefe B. Manning, 2024, Cellular and Molecular Bioengineering on p. 49-65

Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction

Boyang Su, Hannah Palahnuk, Thaddeus Harbaugh, Elias Rizk, Sprague Hazard, W Hazard, Angel Chan, Jonathan Weinsaft, J Bernstein, K Manning, J Weinsaft, Keefe B. Manning, 2024, Annals of Biomedical Engineering on p. 1378-1392

Effect of Hematocrit and Elevated Beat Rate on the 12cc Penn State Pediatric Ventricular Assist Device

Sailahari V. Ponnaluri, Brady L. Houtz, Emma C. Raich, Bryan C. Good, Steven Deutsch, William J. Weiss, Keefe B. Manning, 2023, ASAIO Journal on p. 1065-1073

Nicolas Tobin, Menghan Li, Gretchen Hiller, Arash Azimi, Keefe B. Manning, 2023, Scientific Reports

Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning, 2023, Journal of Biomechanical Engineering on p. 031005

Results of the Interlaboratory Computational Fluid Dynamics Study of the FDA Benchmark Blood Pump

Sailahari V. Ponnaluri, Prasanna Hariharan, Luke H. Herbertson, Keefe B. Manning, Richard A. Malinauskas, Brent A. Craven, 2023, Annals of Biomedical Engineering on p. 253-269

S Bhardwaj, B Craven, J Sever, Francesco Costanzo, Scott D. Simon, Keefe B. Manning, 2023, Frontiers in Medical Technology

Computational Modeling of the Penn State Fontan Circulation Assist Device

Bryan C. Good, Sailahari V. Ponnaluri, William Weiss, Keefe B. Manning, 2022, ASAIO Journal on p. 1513-1522

Most-Cited Papers

Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785

FDA Benchmark Medical Device Flow Models for CFD Validation

Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160

Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939

Development of a computational model for macroscopic predictions of device-induced thrombosis

Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731

Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035

Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673

In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses

Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2014, Journal of Biomechanical Engineering

A Computational method for predicting inferior vena cava filter performance on a patient-specific basis

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven, 2014, Journal of Biomechanical Engineering

Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)

Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582