Keefe Manning

Professor of Biomedical Engineering and Surgery

Keefe Manning

Research Summary

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.

Graduate Students

Huck Affiliations

Links

Publication Tags

Computational Fluid Dynamics Equipment And Supplies Hydrodynamics Velocity Measurement Blood Pediatrics Heart Assist Devices Thrombosis Pumps Flow Fields Rheology Shear Deformation Benchmarking Shear Stress Vena Cava Filters Embolism Inferior Vena Cava Hemodynamics Trapping Filter Fluid Dynamics Left Ventricular Assist Devices Transplants Flow Patterns Geometry

Most Recent Papers

Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration

Bryan C. Good, Scott Simon, Keefe Manning, Francesco Costanzo, 2019, Biomechanics and Modeling in Mechanobiology

Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)

Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640

Steady Flow in a Patient-Averaged Inferior Vena Cava—Part I

Maureen B. Gallagher, Kenneth I. Aycock, Brent A. Craven, Keefe B. Manning, 2018, Cardiovascular Engineering and Technology on p. 641-653

An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC

Elisabetta Tedaldi, Chiara Montanari, Kenneth I. Aycock, Francesco Sturla, Alberto Redaelli, Keefe B. Manning, 2018, Medical Engineering and Physics on p. 44-55

Determination of Reynolds Shear Stress Level for Hemolysis

Choon Sik Jhun, Megan A. Stauffer, John D. Reibson, Eric E. Yeager, Raymond K. Newswanger, Joshua O. Taylor, Keefe B. Manning, William J. Weiss, Gerson Rosenberg, 2018, ASAIO journal (American Society for Artificial Internal Organs : 1992) on p. 63-69

Computational predictions of the embolus-trapping performance of an IVC filter in patient-specific and idealized IVC geometries

Kenneth I. Aycock, Robert L. Campbell, Frank C. Lynch, Keefe B. Manning, Brent A. Craven, 2017, Biomechanics and Modeling in Mechanobiology on p. 1957-1969

Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices

Alessandro Caimi, Francesco Sturla, Bryan Good, Marco Vidotto, Rachele De Ponti, Filippo Piatti, Keefe B. Manning, Alberto Redaelli, 2017, Journal of Biomechanical Engineering

Asynchronous Pumping of a Pulsatile Ventricular Assist Device in a Pediatric Anastomosis Model

Bryan C. Good, William Weiss, Steven Deutsch, Keefe B. Manning, 2017, World journal for pediatric & congenital heart surgery on p. 511-519

A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Brent A. Craven, 2017, Biomechanics and Modeling in Mechanobiology on p. 851-869

Development of a platelet adhesion transport equation for a computational thrombosis model

Joshua O. Taylor, Ling Yang, Steven Deutsch, Keefe B. Manning, 2017, Journal of Biomechanics on p. 114-120

Most-Cited Papers

Tri-layered elastomeric scaffolds for engineering heart valve leaflets

Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785

FDA Benchmark Medical Device Flow Models for CFD Validation

Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160

Development of a computational model for macroscopic predictions of device-induced thrombosis

Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731

Results of FDA's First Interlaboratory Computational Study of a Nozzle with a Sudden Contraction and Conical Diffuser

Sandy F.C. Stewart, Prasanna Hariharan, Eric G. Paterson, Greg W. Burgreen, Varun Reddy, Steven W. Day, Matthew Giarra, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2013, Cardiovascular Engineering and Technology on p. 374-391

The Use of Fluid Mechanics to Predict Regions of Microscopic Thrombus Formation in Pulsatile VADs

Stephen R. Topper, Michael A. Navitsky, Richard B. Medvitz, Eric G. Paterson, Christopher Siedlecki, Margaret June Slattery, Steven Deutsch, Gerson Rosenberg, Keefe B. Manning, 2014, Cardiovascular Engineering and Technology on p. 54-69

A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Brent A. Craven, 2017, Biomechanics and Modeling in Mechanobiology on p. 851-869

Flow visualization of three-dimensionality inside the 12 cc penn state pulsatile pediatric ventricular assist device

Breigh N. Roszelle, Steven Deutsch, Keefe B. Manning, 2010, Annals of Biomedical Engineering on p. 439-455

A fluid dynamics study in a 50 cc pulsatile ventricular assist device

Jason C. Nanna, Michael A. Navitsky, Stephen R. Topper, Steven Deutsch, Keefe B. Manning, 2011, Journal of Biomechanical Engineering

Flow field study comparing design iterations of a 50 cc left ventricular assist device

Jason C. Nanna, Jennifer A. Wivholm, Steven Deutsch, Keefe B. Manning, 2011, ASAIO Journal on p. 349-357

A parametric study of valve orientation on the flow patterns of the penn state pulsatile pediatric ventricular assist device

Breigh N. Roszelle, Steven Deutsch, Keefe B. Manning, 2010, ASAIO Journal on p. 356-363