Keefe Manning

Professor of Biomedical Engineering and Surgery

Keefe Manning

Research Summary

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.

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Publication Tags

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Blood Hydrodynamics Computational Fluid Dynamics Thrombosis Pumps Equipment And Supplies Scaffolds Shear Stress Biomedical Equipment Heart Valves Anisotropy Hemodynamics Benchmarking Turbulent Flow Microfibers Laminar Flow Elastomeric Valve Flow Rate Tissue Pressure Velocity Measurement Nozzles Model Rheology

Most Recent Publications

Effect of Hematocrit and Elevated Beat Rate on the 12cc Penn State Pediatric Ventricular Assist Device

Sailahari Ponnaluri, Brady Houtz, Emma Raich, Bryan Good, Steven Deutsch, William Weiss, Keefe Manning, ASAIO Journal

Clot embolization studies and computational framework for embolization in a canonical tube model

Nicolas Tobin, Menghan Li, Gretchen Hiller, Arash Azimi, Keefe Manning, 2023, Scientific Reports on p. 14682

The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics

Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning, 2023, Journal of Biomechanical Engineering on p. 031005

Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation

Saurabh Bhardwaj, Brent A. Craven, Jacob E. Sever, Francesco Costanzo, Scott D. Simon, Keefe B. Manning, 2023, Frontiers in Medical Technology

Results of the Interlaboratory Computational Fluid Dynamics Study of the FDA Benchmark Blood Pump

Sailahari V. Ponnaluri, Prasanna Hariharan, Luke H. Herbertson, Keefe B. Manning, Richard A. Malinauskas, Brent A. Craven, 2023, Annals of Biomedical Engineering on p. 253-269

Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling

Connor Watson, Hicham Saaid, Vijay Vedula, Jessica C. Cardenas, Peter K. Henke, Franck Nicoud, Xiao Yun Xu, Beverley J. Hunt, Keefe B. Manning, 2023, Annals of Biomedical Engineering

Computational Modeling of the Penn State Fontan Circulation Assist Device

Bryan C. Good, Sailahari V. Ponnaluri, William Weiss, Keefe B. Manning, 2022, ASAIO Journal on p. 1513-1522

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

Nicolas Tobin, Keefe B. Manning, 2022, Communications in Applied Numerical Methods

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

Nicolas Tobin, Keefe Manning, 2022, Inter J Num Meth Biomed Eng on p. e3638

Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries

Nicolas Tobin, Bryan C. Good, Jonathan D. Plasencia, Mark A. Fogel, William J. Weiss, Keefe B. Manning, 2022, Annals of Biomedical Engineering on p. 929-940

Most-Cited Papers

Tri-layered elastomeric scaffolds for engineering heart valve leaflets

Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785

Electrospun PGS: PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy

Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939

FDA Benchmark Medical Device Flow Models for CFD Validation

Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160

Development of a computational model for macroscopic predictions of device-induced thrombosis

Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731

Results of FDA's First Interlaboratory Computational Study of a Nozzle with a Sudden Contraction and Conical Diffuser

Sandy F.C. Stewart, Prasanna Hariharan, Eric G. Paterson, Greg W. Burgreen, Varun Reddy, Steven W. Day, Matthew Giarra, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2013, Cardiovascular Engineering and Technology on p. 374-391

Science for surgeons: Understanding pump thrombogenesis in continuous-flow left ventricular assist devices

Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673

Hemodynamics in a Pediatric Ascending Aorta Using a Viscoelastic Pediatric Blood Model

Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582

Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)

Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640

In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses

Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2014, Journal of Biomechanical Engineering