Keefe Manning

Professor of Biomedical Engineering and Surgery

Keefe Manning

Research Summary

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Equipment And Supplies Thrombosis Computational Fluid Dynamics Blood Hemodynamics Biomedical Equipment Scaffolds Hydrodynamics Vena Cava Filters Anisotropy Shear Stress Platelets Benchmarking Pumps In Vitro Techniques Inferior Vena Cava Geometry Heart Valves Microfibers Elastomeric Valve Tissue Nozzles Growth Blood Platelets

Most Recent Papers

Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device

Sailahari V. Ponnaluri, Emma J. Christensen, Bryan C. Good, Cody J. Kubicki, Steven Deutsch, Joshua P. Cysyk, William J. Weiss, Keefe B. Manning, 2022, Journal of Biomechanical Engineering

Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries

Nicolas Tobin, Bryan C. Good, Jonathan D. Plasencia, Mark A. Fogel, William Weiss, Keefe B. Manning, 2022, Annals of Biomedical Engineering

Mathematical and computational modeling of device-induced thrombosis

Keefe B. Manning, Franck Nicoud, Susan M. Shea, 2021, Current Opinion in Biomedical Engineering

Modeling acute ischemic stroke recanalization through cyclic aspiration

Oyekola Oyekole, Scott Simon, Keefe B. Manning, Francesco Costanzo, 2021, Journal of Biomechanics

Transcatheter Heart Valve Downstream Fluid Dynamics in an Accelerated Evaluation Environment

Sailahari V. Ponnaluri, Steven Deutsch, Michael S. Sacks, Keefe B. Manning, 2021, Annals of Biomedical Engineering on p. 2170-2182

Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis

Janna N. Sloand, Eric Rokni, Connor T. Watson, Michael A. Miller, Keefe B. Manning, Julianna C. Simon, Scott H. Medina, 2021, Advanced healthcare materials

In Vitro Clot Trapping Efficiency of the FDA Generic Inferior Vena Cava Filter in an Anatomical Model

J. M. Riley, N. S. Price, H. M. Saaid, B. C. Good, K. I. Aycock, B. A. Craven, K. B. Manning, 2021, Cardiovascular Engineering and Technology on p. 339-352

Refining a numerical model for device-induced thrombosis and investigating the effects of non-Newtonian blood models

Ling Yang, Nicolas Tobin, Keefe B. Manning, 2021, Journal of Biomechanics

In vitro real-time magnetic resonance imaging for quantification of thrombosis

Ling Yang, Thomas Neuberger, Keefe B. Manning, 2021, Magnetic Resonance Materials in Physics, Biology, and Medicine on p. 285-295

John M. Tarbell

Keefe B. Manning, Steven Deutsch, Gerson Rosenberg, 2021, Cardiovascular Engineering and Technology on p. 9-14

Most-Cited Papers

Tri-layered elastomeric scaffolds for engineering heart valve leaflets

Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785

Assessment of CFD Performance in Simulations of an Idealized Medical Device

Sandy F C Stewart, Eric G. Paterson, Greg W. Burgreen, Prasanna Hariharan, Matthew Giarra, Varun Reddy, Steven W. Day, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2012, Cardiovascular Engineering and Technology on p. 139-160

Electrospun PGS

Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939

FDA Benchmark Medical Device Flow Models for CFD Validation

Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160

Development of a computational model for macroscopic predictions of device-induced thrombosis

Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731

Results of FDA's First Interlaboratory Computational Study of a Nozzle with a Sudden Contraction and Conical Diffuser

Sandy F.C. Stewart, Prasanna Hariharan, Eric G. Paterson, Greg W. Burgreen, Varun Reddy, Steven W. Day, Matthew Giarra, Keefe B. Manning, Steven Deutsch, Michael R. Berman, Matthew R. Myers, Richard A. Malinauskas, 2013, Cardiovascular Engineering and Technology on p. 374-391

Science for surgeons

Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673

A Computational method for predicting inferior vena cava filter performance on a patient-specific basis

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven, 2014, Journal of Biomechanical Engineering

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582

A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters

Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Brent A. Craven, 2017, Biomechanics and Modeling in Mechanobiology on p. 851-869