Kateryna Makova

Director of the Center for Medical Genomics; Professor of Biology

Kateryna Makova

Research Summary

Molecular evolution, population genetics, evolutionary genomics, bioinformatics, and human genetics.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Genome Dna Mitochondrial Dna Mutation Genes Vertebrates Y Chromosome Human Genome G Quadruplexes Chromosomes Obesity Growth Nurses Mutation Rate Child Single Nucleotide Polymorphism Parenting Nucleotides Gene Expression Rna High Throughput Nucleotide Sequencing Siblings Costs And Cost Analysis Population Sex Chromosomes

Most Recent Publications

Mary Elizabeth Stein, Suzanne E. Hile, Matthias H. Weissensteiner, Marietta Lee, Sufang Zhang, Eduard Kejnovský, Iva Kejnovská, Kateryna D. Makova, Kristin A. Eckert, 2022, DNA Repair

Edmundo Torres-Gonzalez, Kateryna D. Makova, 2022, Frontiers in Genetics

D Nandy, Craig SJC, J Cai, Y Tian, I Paul, J Savage, M Marini, E Hohman, M Reimherr, Andrew Patterson, K Makova, F Chiaromonte, 2022, Pediatric obesity on p. e12833

Barbara Arbeithuber, Mazia Cremona, James Hester, Alison Barrett, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2118740119

Jennifer Savage Williams, Anna K. Hochgraf, Eric Loken, Michele E. Marini, Sarah J.C. Craig, Kateryna D. Makova, Leann L. Birch, Ian Paul, 2022, Obesity on p. 183-190

Arang Rhie, Shane A. McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L. Gedman, Lindsey J. Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jason Howard, Sonja C. Vernes, Tanya M. Lama, Frank Grutzner, Wesley C. Warren, Christopher N. Balakrishnan, Dave Burt, Julia M. George, Matthew T. Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F. Kautt, Paolo Franchini, H. William Detrich, Hannes Svardal, Maximilian Wagner, Gavin J.P. Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B. Kingan, Richard Hall, Zev Kronenberg, Ivan Sović, Christopher Dunn, Zemin Ning, Alex Hastie, Joyce Lee, Siddarth Selvaraj, Richard E. Green, Nicholas H. Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E. Dagnew, Dengfeng Guan, Sarah E. London, David F. Clayton, Claudio V. Mello, Samantha R. Friedrich, Peter V. Lovell, Ekaterina Osipova, Farooq O. Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S. Harris, Kateryna D. Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kevin Howe, Paul Flicek, Brian P. Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert H.S. Kraus, Andrew J. Crawford, M. Thomas P. Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert W. Murphy, Klaus Peter Koepfli, Beth Shapiro, Warren E. Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma C. Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A. Ryder, David Haussler, Stephen J. O’Brien, Jonas Korlach, Harris A. Lewin, Kerstin Howe, Eugene W. Myers, Richard Durbin, Adam M. Phillippy, Erich D. Jarvis, 2021, Nature on p. 737-746

Molly C. Carney, A Rangnekar, Xiang Zhan, Akanksha Rangnekar, M Chroneos, Maria Z. Chroneos, Kateryna Makova, Sarah J.C. Craig, Ian Paul, Kateryna D. Makova, Steven Hicks, Steven Hicks, Ian M. Paul, 2021, Journal of Developmental Origins of Health and Disease on p. 1-7

Wilfried M. Guiblet, Michael DeGiorgio, Michael , Xiaoheng Cheng, Francesca Chiaromonte, Kristin A. Eckert, Yi Fei Huang, Kateryna D. Makova, 2021, Genome Research on p. 1136-1149

Wilfried Guiblet, Marzia Cremona, Robert Harris, Di Chen, Kristin A. Eckert, Francesca Chiaromonte, Yi Fei Huang, Kateryna D. Makova, 2021, Nucleic Acids Research on p. 1497--1516

Sarah J.C. Craig, Ana M. Kenney, Junli Lin, Ian M. Paul, Leann L. Birch, Jennifer S. Savage, Michelle Marini, Francesca Chiaromonte, Matthew Remherr, Matthew L. Reimherr, Kateryna D. Makova, 2021, Econometrics and Statistics

Most-Cited Papers

Arang Rhie, Shane A. McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L. Gedman, Lindsey J. Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jason Howard, Sonja C. Vernes, Tanya M. Lama, Frank Grutzner, Wesley C. Warren, Christopher N. Balakrishnan, Dave Burt, Julia M. George, Matthew T. Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F. Kautt, Paolo Franchini, H. William Detrich, Hannes Svardal, Maximilian Wagner, Gavin J.P. Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B. Kingan, Richard Hall, Zev Kronenberg, Ivan Sović, Christopher Dunn, Zemin Ning, Alex Hastie, Joyce Lee, Siddarth Selvaraj, Richard E. Green, Nicholas H. Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E. Dagnew, Dengfeng Guan, Sarah E. London, David F. Clayton, Claudio V. Mello, Samantha R. Friedrich, Peter V. Lovell, Ekaterina Osipova, Farooq O. Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S. Harris, Kateryna D. Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kevin Howe, Paul Flicek, Brian P. Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert H.S. Kraus, Andrew J. Crawford, M. Thomas P. Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert W. Murphy, Klaus Peter Koepfli, Beth Shapiro, Warren E. Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma C. Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A. Ryder, David Haussler, Stephen J. O’Brien, Jonas Korlach, Harris A. Lewin, Kerstin Howe, Eugene W. Myers, Richard Durbin, Adam M. Phillippy, Erich D. Jarvis, 2021, Nature on p. 737-746

Stephen B. Montgomery, David L. Goode, Erika Kvikstad, Cornelis A. Albers, Zhengdong D. Zhang, Xinmeng Jasmine Mu, Guruprasad Ananda, Bryan Howie, Konrad J. Karczewski, Kevin S. Smith, Vanessa Anaya, Rhea Richardson, Joe Davis, Daniel G. MacArthur, Arend Sidow, Laurent Duret, Mark Gerstein, Kateryna D. Makova, Jonathan Marchini, Gil McVean, Gerton Lunter, 2013, Genome Research on p. 749-761

Boris Rebolledo-Jaramillo, Marcia Su, Nicholas Stoler, Jennifer A. McElhoe, N Stoler, Ben Dickins, D Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, M Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479

Kateryna D. Makova, Ross C. Hardison, 2015, Nature Reviews Genetics on p. 213-223

Ian M. Paul, Jennifer S. Williams, Stephanie Anzman-Frasca, Jessica S. Beiler, Kateryna D. Makova, Michele E. Marini, Lindsey B. Hess, Susan E. Rzucidlo, Nicole Verdiglione, Jodi A. Mindell, Leann L. Birch, 2014, BMC Pediatrics

Jennifer McElhoe, M Holland, Kateryna D. Makova, Marcia Shu Wei Su, A Nekrutenko, Boris Rebolledo-Jaramillo, Ian M. Paul, Christine Baker, Seth Faith, Brian Young, 2014, Forensic Science International: Genetics on p. 20-29

Marta Tomaszkiewicz, Samarth Rangavittal, Monika Cechova, Rebeca Campos Sanchez, Howard W. Fescemyer, Robert Harris, Danling Ye, Patricia C.M. O'Brien, Rayan Chikhi, Oliver A. Ryder, Malcolm A. Ferguson-Smith, Paul Medvedev, Kateryna D. Makova, 2016, Genome Research on p. 530-540

Arkarachai Fungtammasan, Guruprasad Ananda, Suzanne E. Hile, Marcia Shu Wei Su, Chen Sun, Robert Harris, Paul Medvedev, Kristin Eckert, Kateryna D. Makova, 2015, Genome Research on p. 736-749

Marta Tomaszkiewicz, Paul Medvedev, Kateryna D. Makova, 2017, Trends in Genetics on p. 266-282

Melissa A. Wilson Sayres, Kateryna D. Makova, 2013, Molecular Biology and Evolution on p. 781-787

News Articles Featuring Kateryna Makova

Makova awarded Masatoshi Nei Innovation Prize in Biology

Kateryna Makova, Verne M. Willaman Chair in the Life Sciences and professor of biology at Penn State, has been awarded the Masatoshi Nei Innovation Prize in Biology. The award was established through a generous gift from Masatoshi Nei, emeritus professor of biology at Penn State and Laura Carnell Professor of Biology at Temple University, and his wife Nobuko Nei.

Help for Ukraine scholars: Higher education rallies to provide jobs, support

Institutions post opportunities for scientific researchers and students who have been displaced by the war with Russia.

Are egg cells in aging primates protected from mutations?

A new study shows that mutation frequencies in mitochondrial DNA are lower, and increase less with age, in the precursors of egg cells than in the cells of other tissues in a primate.

Are egg cells in aging primates protected from mutations?

New mutations occur at increasing rates in the mitochondrial genomes of developing egg cells in aging rhesus monkeys, but the increases appear to plateau at a certain age and are not as large as those seen in non-reproductive cells, like muscle and liver.

Unusual DNA folding increases the rates of mutations

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research by a team of Penn State scientists shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome.

Makova selected as holder of the Verne M. Willaman Chair in the Life Sciences

Kateryna Makova, Pentz Professor of Biology at Penn State, has been appointed as holder of the Verne M. Willaman Chair in the Life Sciences. The appointment, effective on Sept. 1, was made by the Office of the President of the University, based on the recommendation of the dean, in recognition of Makova’s national and international reputation for excellence in research and teaching.

Evolution of the Y chromosome in great apes deciphered

New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved.

Scientists take a step toward understanding 'jumping genes' effect on the genome

Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.

Tracking inheritance of human mitochondrial DNA

New insight into how genetic information stored in human mitochondria is passed from one generation to the next could have important implications for genetic counseling of people planning pregnancies, according to a study by researchers at Penn State and the University of California, Berkeley.

Mixed Ancestry Might Affect Our Mitochondria