Director of the Center for Medical Genomics; Professor of Biology
Molecular evolution, population genetics, evolutionary genomics, bioinformatics, and human genetics.
Huck Graduate Students
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Center for Medical Genomics
Publication TagsMitochondrial Dna Genome Mutation Human Genome Gene Frequency High Throughput Nucleotide Sequencing Horses Mutation Rate Mothers Tissue Blood Tissues Dna Sequence Analysis Genetic Variation Germ Cells Mitochondrial Dynamics Single Nucleotide Polymorphism Microsatellite Repeats Dna Maternal Inheritance Life History Hairs Life History Traits Equus Przewalskii Aphidicolin
Most Recent Papers
Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
W Guiblet, Marzia Cremona, Robert Harris, Dong Chen, Kristin Eckert, Francesca Chiaromonte, Yifei Huang, Kateryna Makova, 2021, Nucleic acids research
Associations between stool micro-transcriptome, gut microbiota, and infant growth.
M Carney, Xiang Zhan, A Rangnekar, M Chroneos, Craig SJC, Kateryna Makova, Ian Paul, Steven Hicks, 2021, Journal of developmental origins of health and disease on p. 1-7
Human L1 Transposition Dynamics Unraveled with Functional Data Analysis.
Dong Chen, Marzia Cremona, Z Qi, R Mitra, Francesca Chiaromonte, Kateryna Makova, 2020, Molecular biology and evolution on p. 3576-3600
Dynamic evolution of great ape Y chromosomes
Monika Cechova, Rahulsimham Vegesna, Marta Hoover, Robert S. Harris, Di Chen, Samarth Rangavittal, Paul Medvedev, Kateryna Dmytrivna Makova, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 26273-26280
Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues
Barbara Arbeithuber, James Hester, Marzia A. Cremona, Nicholas Stoler, Arslan Zaidi, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2020, PLoS biology
Ampliconic genes on the great spe Y chromosomes: rapid evolution of copy number but conservation of expression levels
Rahulsimham Vegesna, Marta Tomaszkiewicz, Oliver A. Ryder, Rebeca Campos-Sánchez, Paul Medvedev, Michael DeGiorgio, Kateryna D. Makova, 2020, Genome biology and evolution on p. 842-859
Family reunion via error correction: An efficient analysis of duplex sequencing data
Nicholas Stoler, Barbara Arbeithuber, Gundula Povysil, Monika Heinzl, Renato Salazar, Kateryna D. Makova, Irene Tiemann-Boege, Anton Nekrutenko, 2020, BMC bioinformatics
Pronounced somatic bottleneck in mitochondrial DNA of human hair
Alison Barrett, Barbara Arbeithuber, Arslan Zaidi, Peter Wilton, Ian M. Paul, Rasmus Nielsen, Kateryna D. Makova, 2020, Philosophical transactions of the Royal Society of London. Series B, Biological sciences on p. 20190175
Bottleneck and selection in the germline and maternal age influence transmission of mitochondrial DNA in human pedigrees.
A Zaidi, P Wilton, Meng Su, Ian Paul, B Arbeithuber, K Anthony, Anton Nekrutenko, R Nielsen, Kateryna Makova, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 25172-25178
Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes.
R Vegesna, Marta Tomaszkiewicz, Paul Medvedev, Kateryna Makova, 2019, PLoS genetics on p. e1008369
The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes
Stephen B. Montgomery, David L. Goode, Erika Kvikstad, Cornelis A. Albers, Zhengdong D. Zhang, Xinmeng Jasmine Mu, Guruprasad Ananda, Bryan Howie, Konrad J. Karczewski, Kevin S. Smith, Vanessa Anaya, Rhea Richardson, Joe Davis, Daniel G. MacArthur, Arend Sidow, Laurent Duret, Mark Gerstein, Kateryna D. Makova, Jonathan Marchini, Gil McVean, Gerton Lunter, 2013, Genome research on p. 749-761
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
Boris Rebolledo-Jaramillo, Marcia Shu Wei Su, Nicholas Stoler, Jennifer A. McElhoe, Benjamin Dickins, Daniel Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, Mitchell M. Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479
A genome-wide analysis of common fragile sites
Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome research on p. 993-1005
Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study
Hiroki Goto, Benjamin Dickins, Enis Afgan, Ian Paul, James Taylor, Kateryna Dmytrivna Makova, Anton Nekrutenko, 2011, Genome biology
Development and assessment of an optimized next-generation DNA sequencing approach for the mtgenome using the Illumina MiSeq
Jennifer A. McElhoe, Mitchell M. Holland, Kateryna D. Makova, Marcia Shu Wei Su, Ian M. Paul, Christine H. Baker, Seth A. Faith, Brian Young, 2014, Forensic Science International: Genetics on p. 20-29
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study
Ian M. Paul, Jennifer S. Williams, Stephanie Anzman-Frasca, Jessica S. Beiler, Kateryna D. Makova, Michele E. Marini, Lindsey B. Hess, Susan E. Rzucidlo, Nicole Verdiglione, Jodi A. Mindell, Leann L. Birch, 2014, BMC pediatrics
Do variations in substitution rates and male mutation bias correlate with life-history traits? a study of 32 mammalian genomes
Melissa A.Wilson Sayres, Chris Venditti, Mark Pagel, Kateryna D. Makova, 2011, Evolution on p. 2800-2815
A matter of life or death
Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome research on p. 2038-2048
Genome analyses substantiate male mutation bias in many species
Melissa A. Wilson Sayres, Kateryna D. Makova, 2011, BioEssays on p. 938-945
A massively parallel sequencing approach uncovers ancient origins and high genetic variability of endangered Przewalski's horses
Hiroki Goto, Oliver A. Ryder, Allison R. Fisher, Bryant Schultz, Sergei L.Kosakovsky Pond, Anton Nekrutenko, Kateryna D. Makova, 2011, Genome biology and evolution on p. 1096-1106
News Articles Featuring Kateryna Makova
Oct 09, 2020
Makova selected as holder of the Verne M. Willaman Chair in the Life Sciences
Kateryna Makova, Pentz Professor of Biology at Penn State, has been appointed as holder of the Verne M. Willaman Chair in the Life Sciences. The appointment, effective on Sept. 1, was made by the Office of the President of the University, based on the recommendation of the dean, in recognition of Makova’s national and international reputation for excellence in research and teaching.
Oct 06, 2020
Evolution of the Y chromosome in great apes deciphered
New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved.
Sep 29, 2020
Scientists take a step toward understanding 'jumping genes' effect on the genome
Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.
Nov 18, 2019
Tracking inheritance of human mitochondrial DNA
New insight into how genetic information stored in human mitochondria is passed from one generation to the next could have important implications for genetic counseling of people planning pregnancies, according to a study by researchers at Penn State and the University of California, Berkeley.
Jan 14, 2019
Mixed Ancestry Might Affect Our Mitochondria
Oct 09, 2018
Could the bacteria in a child’s mouth predict obesity?
There may soon be a simple way to identify children at risk for developing obesity later in life. Researchers from Penn State University analyzed the bacteria in the mouths of 226 2-year-olds and found that a child's oral microbiota can be used as a tool to predict weight gain during the first two years of their life.
Sep 21, 2018
Mouth bacteria in toddlers may predict obesity, study says
Bacteria in a toddler's mouth might help predict later obesity, new research suggests. Scientists at Penn State University found the composition of microorganisms in the mouths of 2-year-olds offers clues to the child's future weight.
Sep 20, 2018
Swabbing a child’s mouth for bacteria could predict how likely they are to become obese
A swab of a toddler’s mouth may predict their odds of growing into obese children, a new study suggests. Scientists at Pennsylvania State University discovered that the harmless microorganisms living in a two-year-old’s mouth were less diverse if they had gained more weight more quickly than most since birth.
Sep 19, 2018
Your Child's Mouth Could Reveal Their Obesity Risk
Scientists believe the bacteria that live in a toddler’s mouth could provide clues as to whether they will become obese. Existing research suggests the microbes inhabiting the guts and mouths of obese adults differ to those without the condition, but less is known about this pattern in children. So biologists at Pennsylvania State University set out to investigate what a child’s microbiota could say about their weight.
Sep 19, 2018
Child Weight Gain Trajectories Linked To Oral Microbiota Composition
Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children.