Karolina Skibicka

Huck Chair of Metabolic Physiology; Associate Professor of Nutritional Sciences

Karolina Skibicka

Research Summary

Utilizing rodent models to discover novel neural substrates that control fundamental homeostatic and reward controls of food intake, and their failures in the case of obesity and infection-induced anorexia; How food and feeding behavior affect neural circuits controlling sociability and emotionality.

Huck Affiliations

Publication Tags

Food Ghrelin Reward Eating Glucagon Like Peptide 1 Glucagon Like Peptide 1 Receptor Brain Interleukin 6 Body Weight Motivation Glutamic Acid Ghrelin Receptor Pharmaceutical Preparations Parabrachial Nucleus Rats Ventral Tegmental Area Anxiety Molecules Exenatide Obesity Posterior Hypothalamus Energy Metabolism Amygdala Sucrose Neurons

Most Recent Papers

The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R

L. López-Ferreras, K. Eerola, O. T. Shevchouk, J. E. Richard, F. H. Nilsson, L. E. Jansson, M. R. Hayes, K. P. Skibicka, 2020, Psychoneuroendocrinology

Ghrelin Receptor Stimulation of the Lateral Parabrachial Nucleus in Rats Increases Food Intake but not Food Motivation

Tina Bake, Marie V. Le May, Christian E. Edvardsson, Heike Vogel, Ulrika Bergström, Marjorie Nicholson Albers, Karolina P. Skibicka, Imre Farkas, Zsolt Liposits, Suzanne L. Dickson, 2020, Obesity on p. 1503-1511

Glucagon-like Peptide-1-, but not growth and differentiation Factor 15-, receptor activation increases the number of interleukin-6-expressing cells in the external lateral parabrachial nucleus

Fredrik Anesten, Devesh Mishra, Adrià Dalmau Gasull, Linda Engström-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P. Skibicka, Matti Poutanen, John Olov Jansson, 2019, Neuroendocrinology on p. 310-321

Counting the number of glutamate molecules in single synaptic vesicles

Yuanmo Wang, Hoda Fathali, Devesh Mishra, Thomas Olsson, Jacqueline D. Keighron, Karolina P. Skibicka, Ann Sofie Cans, 2019, Journal of the American Chemical Society on p. 17507-17511

Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor

Fredrik Anesten, Adrià Dalmau Gasull, Jennifer E. Richard, Imre Farkas, Devesh Mishra, Lilly Taing, Fuping Zhang, Matti Poutanen, Vilborg Palsdottir, Zsolt Liposits, Karolina P. Skibicka, John Olov Jansson, 2019, Journal of Neuroendocrinology

Ultrafast Glutamate Biosensor Recordings in Brain Slices Reveal Complex Single Exocytosis Transients

Yuanmo Wang, Devesh Mishra, Jenny Bergman, Jacqueline D. Keighron, Karolina P. Skibicka, Ann Sofie Cans, 2019, ACS Chemical Neuroscience on p. 1744-1752

Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism

Devesh Mishra, Jennifer E. Richard, Ivana Maric, Begona Porteiro, Martin Häring, Sander Kooijman, Saliha Musovic, Kim Eerola, Lorena López-Ferreras, Eduard Peris, Katarzyna Grycel, Olesya T. Shevchouk, Peter Micallef, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm, Harvey J. Grill, Ruben Nogueiras, Karolina P. Skibicka, 2019, Cell Reports on p. 3011-3026.e5

GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner

Lorena López-Ferreras, Kim Eerola, Devesh Mishra, Olesya T. Shevchouk, Jennifer E. Richard, Fredrik H. Nilsson, Matthew R. Hayes, Karolina P. Skibicka, 2019, Molecular Metabolism on p. 178-193

New horizons for future research – Critical issues to consider for maximizing research excellence and impact

Wolfgang Langhans, Roger Adan, Myrtha Arnold, William A. Banks, J. Patrick Card, Megan J. Dailey, Derek Daniels, Annette D. de Kloet, Guillaume de Lartigue, Suzanne Dickson, Shahana Fedele, Harvey J. Grill, John Olov Jansson, Sharon Kaufman, Grant Kolar, Eric Krause, Shin J. Lee, Christelle Le Foll, Barry E. Levin, Thomas A. Lutz, Abdelhak Mansouri, Timothy H. Moran, Gustavo Pacheco-López, Deepti Ramachandran, Helen Raybould, Linda Rinaman, Willis K. Samson, Graciela Sanchez-Watts, Randy J. Seeley, Karolina P. Skibicka, Dana Small, Alan C. Spector, Kellie L. Tamashiro, Brian Templeton, Stefan Trapp, Patrick Tso, Alan G. Watts, Nadja Weissfeld, Diana Williams, Christian Wolfrum, Gina Yosten, Stephen C. Woods, 2018, Molecular Metabolism on p. 53-59

Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight

L. López-Ferreras, J. E. Richard, E. E. Noble, K. Eerola, R. H. Anderberg, K. Olandersson, L. Taing, S. E. Kanoski, M. R. Hayes, K. P. Skibicka, 2018, Molecular Psychiatry on p. 1157-1168

Most-Cited Papers

Ghrelin directly targets the ventral tegmental area to increase food motivation

K. P. Skibicka, C. Hansson, M. Alvarez-Crespo, P. A. Friberg, S. L. Dickson, 2011, Neuroscience on p. 129-137

The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: A new role for mesolimbic GLP-1 receptors

Suzanne L. Dickson, Rozita H. Shirazi, Caroline Hansson, Filip Bergquist, Hans Nissbrandt, Karolina P. Skibicka, 2012, Journal of Neuroscience on p. 4812-4820

The role of the central ghrelin system in reward from food and chemical drugs

Suzanne L. Dickson, Emil Egecioglu, Sara Landgren, Karolina P. Skibicka, Jörgen A. Engel, Elisabet Jerlhag, 2011, Molecular and Cellular Endocrinology on p. 80-87

Role of ghrelin in food reward: Impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

Karolina P. Skibicka, Caroline Hansson, Emil Egecioglu, Suzanne L. Dickson, 2012, Addiction Biology on p. 95-107

Hedonic and incentive signals for body weight control

Emil Egecioglu, Karolina P. Skibicka, Caroline Hansson, Mayte Alvarez-Crespo, P. Anders Friberg, Elisabet Jerlhag, Jörgen A. Engel, Suzanne L. Dickson, 2011, Reviews in Endocrine and Metabolic Disorders on p. 141-151

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

Mayte Alvarez-Crespo, Karolina P. Skibicka, Imre Farkas, Csilla S. Molnár, Emil Egecioglu, Erik Hrabovszky, Zsolt Liposits, Suzanne L. Dickson, 2012, PLoS One

GLP-1 and weight loss

Scott E. Kanoski, Matthew R. Hayes, Karolina P. Skibicka, 2016, American Journal of Physiology on p. R885-R895

Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6

Rozita Shirazi, Vilborg Palsdottir, Jim Collander, Fredrik Anesten, Heike Vogel, Fanny Langlet, Alexander Jaschke, Annette Schürmann, Vincent Prévot, Ruijin Shao, John Olov Jansson, Karolina Patrycja Skibicka, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 16199-16204

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake

Karolina P. Skibicka, Rozita H. Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L. Dickson, 2013, Neuropharmacology on p. 274-283

The central GLP-1

Karolina P. Skibicka, 2013, Frontiers in Neuroscience