Karolina Skibicka

Associate Professor of Nutritional Sciences; Lloyd & Dorothy Foehr Huck Chair in Metabolic Physiology

Karolina Skibicka

Research Summary

Utilizing rodent models to discover novel neural substrates that control fundamental homeostatic and reward controls of food intake, and their failures in the case of obesity and infection-induced anorexia; How food and feeding behavior affect neural circuits controlling sociability and emotionality.

Huck Affiliations

Publication Tags

Food Ghrelin Reward Body Weight Eating Brain Interleukin 6 Glucagon Like Peptide 1 Receptor Glutamic Acid Motivation Glucagon Like Peptide 1 Ventral Tegmental Area Ghrelin Receptor Sucrose Energy Metabolism Neurons Lateral Hypothalamic Area Rats Molecules Exenatide Amygdala Parabrachial Nucleus Rodentia Leptin Enzymes

Most Recent Papers

Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

Fredrik Anesten, Devesh Mishra, Adrià Dalmau Gasull, Linda Engström-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P. Skibicka, Matti Poutanen, John Olov Jansson, 2019, Neuroendocrinology on p. 310-321

Counting the Number of Glutamate Molecules in Single Synaptic Vesicles

Yuanmo Wang, Hoda Fathali, Devesh Mishra, Thomas Olsson, Jacqueline D. Keighron, Karolina P. Skibicka, Ann Sofie Cans, 2019, Journal of the American Chemical Society on p. 17507-17511

Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor

Fredrik Anesten, Adrià Dalmau Gasull, Jennifer E. Richard, Imre Farkas, Devesh Mishra, Lilly Taing, Fuping Zhang, Matti Poutanen, Vilborg Palsdottir, Zsolt Liposits, Karolina P. Skibicka, John Olov Jansson, 2019, Journal of Neuroendocrinology

Ultrafast Glutamate Biosensor Recordings in Brain Slices Reveal Complex Single Exocytosis Transients

Yuanmo Wang, Devesh Mishra, Jenny Bergman, Jacqueline D. Keighron, Karolina Skibicka, Ann Sofie Cans, 2019, ACS Chemical Neuroscience on p. 1744-1752

Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism

Devesh Mishra, Jennifer E. Richard, Ivana Maric, Begona Porteiro, Martin Häring, Sander Kooijman, Saliha Musovic, Kim Eerola, Lorena López-Ferreras, Eduard Peris, Katarzyna Grycel, Olesya T. Shevchouk, Peter Micallef, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm, Harvey J. Grill, Ruben Nogueiras, Karolina P. Skibicka, 2019, Cell Reports on p. 3011-3026.e5

GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner

Lorena López-Ferreras, Kim Eerola, Devesh Mishra, Olesya T. Shevchouk, Jennifer E. Richard, Fredrik H. Nilsson, Matthew R. Hayes, Karolina P. Skibicka, 2019, Molecular Metabolism on p. 178-193

Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight

L. López-Ferreras, J. E. Richard, E. E. Noble, K. Eerola, R. H. Anderberg, K. Olandersson, L. Taing, S. E. Kanoski, M. R. Hayes, K. P. Skibicka, 2018, Molecular Psychiatry on p. 1157-1168

CNS β<sub>3</sub>-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight

Jennifer E. Richard, Lorena López-Ferreras, Belén Chanclón, Kim Eerola, Peter Micallef, Karolina P. Skibicka, Ingrid Wernstedt Asterholm, 2017, American Journal of Physiology - Endocrinology and Metabolism on p. E344-E358

Ghrelin's control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic

Lorena López-Ferreras, Jennifer E. Richard, Rozita H. Anderberg, Fredrik H. Nilsson, Kajsa Olandersson, Scott E. Kanoski, Karolina Skibicka, 2017, Physiology and Behavior on p. 40-49

Estradiol is a critical regulator of food-reward behavior

Jennifer E. Richard, Lorena López-Ferreras, Rozita H. Anderberg, Kajsa Olandersson, Karolina P. Skibicka, 2017, Psychoneuroendocrinology on p. 193-202

Most-Cited Papers

Ghrelin increases intake of rewarding food in rodents

Emil Egecioglu, Elisabet Jerlhag, Nicolas Salomé, Karolina P. Skibicka, David Haage, Mohammad Bohlooly-Y, Daniel Andersson, Mikael Bjursell, Daniel Perrissoud, Jörgen A. Engel, Suzanne L. Dickson, 2010, Addiction Biology on p. 304-311

Ghrelin directly targets the ventral tegmental area to increase food motivation

K. P. Skibicka, C. Hansson, M. Alvarez-Crespo, P. A. Friberg, S. L. Dickson, 2011, Neuroscience on p. 129-137

The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food

Suzanne L. Dickson, Rozita H. Shirazi, Caroline Hansson, Filip Bergquist, Hans Nissbrandt, Karolina P. Skibicka, 2012, Journal of Neuroscience on p. 4812-4820

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

Matthew R. Hayes, Karolina P. Skibicka, Theresa M. Leichner, Douglas J. Guarnieri, Ralph J. DiLeone, Kendra K. Bence, Harvey J. Grill, 2010, Cell Metabolism on p. 77-83

Role of ghrelin in food reward

Karolina Skibicka, Caroline Hansson, Emil Egecioglu, Suzanne L. Dickson, 2012, Addiction Biology on p. 95-107

Hedonic and incentive signals for body weight control

Emil Egecioglu, Karolina P. Skibicka, Caroline Hansson, Mayte Alvarez-Crespo, P. Anders Friberg, Elisabet Jerlhag, Jörgen A. Engel, Suzanne L. Dickson, 2011, Reviews in Endocrine and Metabolic Disorders on p. 141-151

The Amygdala as a Neurobiological Target for Ghrelin in Rats

Mayte Alvarez-Crespo, Karolina P. Skibicka, Imre Farkas, Csilla S. Molnár, Emil Egecioglu, Erik Hrabovszky, Zsolt Liposits, Suzanne L. Dickson, 2012, PloS one

Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6

Rozita Shirazi, Vilborg Palsdottir, Jim Collander, Fredrik Anesten, Heike Vogel, Fanny Langlet, Alexander Jaschke, Annette Schürmann, Vincent Prévot, Ruijin Shao, John Olov Jansson, Karolina Patrycja Skibicka, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 16199-16204

Divergent circuitry underlying food reward and intake effects of ghrelin

Karolina Skibicka, Rozita H. Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L. Dickson, 2013, Neuropharmacology on p. 274-283

Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward

Karolina Skibicka, Rozita H. Shirazi, Caroline Hansson, Suzanne L. Dickson, 2012, Endocrinology on p. 1194-1205