Karolina Skibicka
Huck Chair of Metabolic Physiology; Associate Professor of Nutritional Sciences
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110 Chandlee
University Park, PA - kps5783@psu.edu
Research Summary
Utilizing rodent models to discover novel neural substrates that control fundamental homeostatic and reward controls of food intake, and their failures in the case of obesity and infection-induced anorexia; How food and feeding behavior affect neural circuits controlling sociability and emotionality.
Huck Affiliations
Publication Tags
Glucagon Like Peptide 1 Glucagon Like Peptide 1 Receptor Food Eating Anxiety Reward Body Weight Exenatide Peptides Obesity Brain Parabrachial Nucleus Interleukin 6 Ghrelin Sex Characteristics Alcohols Rhombencephalon Rodentia Diet Neurons Lateral Hypothalamic Area Motivation Feeding Behavior Solitary Nucleus Weight LossMost Recent Publications
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery
Huiyuan Zheng, Lorena López-Ferreras, Jean Phillipe Krieger, Stephen Fasul, Valentina Cea Salazar, Natalia Valderrama Pena, Karolina P. Skibicka, Linda Rinaman, 2022, Molecular Metabolism
Hindbrain insulin controls feeding behavior
Kim Eerola, Francesco Longo, Thomas M. Reinbothe, Jennifer E. Richard, Olesya T. Shevchouk, Lorena López-Ferreras, Devesh Mishra, Mohammed Asker, Johan Tolö, Caroline Miranda, Saliha Musovic, Charlotta S. Olofsson, Patrik Rorsman, Karolina P. Skibicka, 2022, Molecular Metabolism
Neural Pathway for Gut Feelings: Vagal Interoceptive Feedback From the Gastrointestinal Tract Is a Critical Modulator of Anxiety-like Behavior
Jean Philippe Krieger, Mohammed Asker, Pauline van der Velden, Stina Börchers, Jennifer E. Richard, Ivana Maric, Francesco Longo, Arashdeep Singh, Guillaume de Lartigue, Karolina P. Skibicka, 2022, Biological Psychiatry on p. 709-721
Commonly-used rodent tests of anxiety-like behavior lack predictive validity for human sex differences
Stina Börchers, Jean Philippe Krieger, Mohammed Asker, Ivana Maric, Karolina P. Skibicka, 2022, Psychoneuroendocrinology
From an Empty Stomach to Anxiolysis: Molecular and Behavioral Assessment of Sex Differences in the Ghrelin Axis of Rats
Stina Börchers, Jean Philippe Krieger, Ivana Maric, Jil Carl, Maral Abraham, Francesco Longo, Mohammed Asker, Jennifer E. Richard, Karolina P. Skibicka, 2022, Frontiers in Endocrinology
Sex and Species Differences in the Development of Diet-Induced Obesity and Metabolic Disturbances in Rodents
Ivana Maric, Jean Philippe Krieger, Pauline van der Velden, Stina Börchers, Mohammed Asker, Milica Vujicic, Ingrid Wernstedt Asterholm, Karolina P. Skibicka, 2022, Frontiers in Nutrition
Key role for hypothalamic interleukin-6 in food-motivated behavior and body weight regulation
L López-Ferreras, F Longo, J Richard, K Eerola, O Shevchouk, M Tuzinovic, Karolina Skibicka, 2021, Psychoneuroendocrinology on p. 105284
The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R
L. López-Ferreras, K. Eerola, O. T. Shevchouk, J. E. Richard, F. H. Nilsson, L. E. Jansson, M. R. Hayes, K. P. Skibicka, 2020, Psychoneuroendocrinology
Ghrelin Receptor Stimulation of the Lateral Parabrachial Nucleus in Rats Increases Food Intake but not Food Motivation
Tina Bake, Marie V. Le May, Christian E. Edvardsson, Heike Vogel, Ulrika Bergström, Marjorie Nicholson Albers, Karolina P. Skibicka, Imre Farkas, Zsolt Liposits, Suzanne L. Dickson, 2020, Obesity on p. 1503-1511
Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus
Fredrik Anesten, Devesh Mishra, Adrià Dalmau Gasull, Linda Engström-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P. Skibicka, Matti Poutanen, John Olov Jansson, 2019, Neuroendocrinology on p. 310-321
Most-Cited Papers
GLP-1 and weight loss: Unraveling the diverse neural circuitry
Scott E. Kanoski, Matthew R. Hayes, Karolina P. Skibicka, 2016, American Journal of Physiology on p. R885-R895
Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
Rozita Shirazi, Vilborg Palsdottir, Jim Collander, Fredrik Anesten, Heike Vogel, Fanny Langlet, Alexander Jaschke, Annette Schürmann, Vincent Prévot, Ruijin Shao, John Olov Jansson, Karolina Patrycja Skibicka, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 16199-16204
The central GLP-1: Implications for food and drug reward
Karolina P. Skibicka, 2013, Frontiers in Neuroscience
Gut Peptide GLP-1 and Its Analogue, Exendin-4, Decrease Alcohol Intake and Reward
Rozita H. Shirazi, Suzanne L. Dickson, Karolina P. Skibicka, 2013, PLoS One
Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system
Jennifer E. Richard, Rozita H. Anderberg, Andreas Göteson, Fiona M. Gribble, Frank Reimann, Karolina P. Skibicka, 2015, PLoS One
Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake
Karolina P. Skibicka, Rozita H. Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L. Dickson, 2013, Neuropharmacology on p. 274-283
Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Min Hu, Jennifer Elise Richard, Manuel Maliqueo, Milana Kokosar, Romina Fornes, Anna Benrick, Thomas Jansson, Claes Ohlsson, Xiaoke Wu, Karolina Patrycja Skibicka, Elisabet Stener-Victorin, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 14348-14353
GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality
Rozita H. Anderberg, Jennifer E. Richard, Caroline Hansson, Hans Nissbrandt, Filip Bergquist, Karolina P. Skibicka, 2016, Psychoneuroendocrinology on p. 54-66
GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: Neuroanatomical, electrophysiological, and behavioral evidence
Jennifer E. Richard, Imre Farkas, Fredrik Anesten, Rozita H. Anderberg, Suzanne L. Dickson, Fiona M. Gribble, Frank Reimann, John Olov Jansson, Zsolt Liposits, Karolina P. Skibicka, 2014, Endocrinology on p. 4356-4367
Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight
L. López-Ferreras, J. E. Richard, E. E. Noble, K. Eerola, R. H. Anderberg, K. Olandersson, L. Taing, S. E. Kanoski, M. R. Hayes, K. P. Skibicka, 2018, Molecular Psychiatry on p. 1157-1168