Justin Pritchard
Huck Early Career Entrepreneurial Professorship; Associate Professor of Biomedical Engineering;
-
212 Wartik Lab
University Park, PA - jrp94@psu.edu
- 814-865-7906
Research Summary
Using systems and synthetic biology approaches to understand and control drug resistance.
Huck Graduate Students
Huck Affiliations
- Center for Mathematical Biology
- Molecular, Cellular, and Integrative Biosciences
- Center for Structural Oncology
- Integrative and Biomedical Physiology
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Pharmaceutical Preparations Genome Neoplasms Mutation Growth Therapeutics Genes Resistance Drug Resistance Drug Tumors Clustered Regularly Interspaced Short Palindromic Repeats Platinum Population Mycobacterium Cisplatin Oxaliplatin Drug Combinations Vibrio Cholerae Cells Mutant Mycobacterium Tuberculosis Datasets Biomarkers MutantsMost Recent Publications
The risks of perpetuating an evolutionary arms race in drug discovery
Scott Leighow*, Justin Pritchard, Evolution, Medicine, and Public Health
Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to
Haider Inam*, Ivan Sokirniy*, Yiyun Rao*, Anushka Shah*, Farnaz Naeemikia*, Edward O'Brien, Cheng Dong, Justin Pritchard, iScience on p. 21
Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions
Atip Lawanprasert, Janna N. Sloand, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Michael A. Miller, Sopida Pimcharoen, Jian Wang, Scott M. Leighow, Justin R. Pritchard, Nikolay V. Dokholyan, Scott H. Medina, 2023, ChemBioChem
An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity
J. A. Reynolds, Y. L. Vishweshwaraiah, V. R. Chirasani, J. R. Pritchard, N. V. Dokholyan, 2023, Journal of Biological Chemistry
The role of migration in mutant dynamics in fragmented populations
Jesse Kreger, Donovan Brown, Natalia L. Komarova, Dominik Wodarz, Justin Pritchard, 2023, Journal of Evolutionary Biology on p. 444-460
Vascularized pancreas-on-a-chip device produced using a printable simulated extracellular matrix
Monika Hospodiuk-Karwowski, Kai Chi, Justin Pritchard, Jeffrey M. Catchmark, 2022, Biomedical Materials (Bristol)
Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes
Scott M. Leighow, Ben Landry, Michael J. Lee, Shelly R. Peyton, Justin R. Pritchard, 2022, Cellular and Molecular Bioengineering on p. 521-533
SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021
T Tran, N Wikle, F Yang, H Inam, S Leighow, B Gentilesco, P Chan, E Albert, E Strong, Justin R. Pritchard, W Hanage, Ephraim Hanks, F Crawford, Maciej F. Boni, 2022, JAMA network open on p. e2214171
Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers
Suzanne George, Margaret von Mehren, Jonathan A. Fletcher, Jichao Sun, Sen Zhang, Justin R. Pritchard, John Graeme Hodgson, David Kerstein, Victor M. Rivera, Frank G. Haluska, Michael C. Heinrich, 2022, Clinical Cancer Research on p. 1268-1276
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments
B Zhao, Y Rao, S Leighow, Edward P. O’Brien, L Gilbert, Justin R. Pritchard, 2022, Nature Communications on p. 625
Most-Cited Papers
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann, 2017, Nature Medicine on p. 461-471
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Sarah M. Fortune, 2017, Nature Microbiology
Defining principles of combination drug mechanisms of action
Justin R. Pritchard, Peter M. Bruno, Luke A. Gilberta, Kelsey L. Caprona, Douglas A. Lauffenburger, Michael T. Hemann, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. E170-E179
ARTIST: High-Resolution Genome-Wide Assessment of Fitness Using Transposon-Insertion Sequencing
Justin R. Pritchard, Michael C. Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia J. Zhang, Eric J. Rubin, Matthew K. Waldor, 2014, PLoS Genetics on p. e1004782
High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data
Michael C. Chao, Justin R. Pritchard, Yanjia J. Zhang, Eric J. Rubin, Jonathan Livny, Brigid M. Davis, Matthew K. Waldor, 2013, Nucleic Acids Research on p. 9033-9048
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
Peter M. Bruno, Mengrou Lu, Kady A. Dennis, Haider Inam, Connor J. Moore, John Sheehe, Stephen J. Elledge, Michael T. Hemann, Justin R. Pritchard, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 4053-4060
Addressing genetic tumor heterogeneity through computationally predictive combination therapy
Boyang Zhao, Justin R. Pritchard, Douglas A. Lauffenburger, Michael T. Hemann, 2014, Cancer Discovery on p. 166-174
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne Laure Roux, Jean Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J. Rubin, Roland Brosch, Laurent Kremer, Jean Louis Herrmann, Fabienne Girard-Misguich, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E1002-E1011
Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
Boyang Zhao, Joseph C. Sedlak, Raja Srinivas, Pau Creixell, Justin R. Pritchard, Bruce Tidor, Douglas A. Lauffenburger, Michael T. Hemann, 2016, Cell on p. 234-246
Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors
Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M. Rivera, Andrew Garner, Francois Gonzalvez, 2015, Oncotarget on p. 32646-32655
News Articles Featuring Justin Pritchard
Jun 12, 2023
Penn State announces tenure-line faculty promotions, effective July 1, 2023
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.
Full Article
Feb 10, 2021
Researchers awarded $1.5M to create stem cell predictive model
Stem cells are the building blocks of the body, according to Penn State researchers. Though similar to one another at their origins, stem cells take on unique characteristics as they mature, becoming specialized cells throughout the body — such as bone, muscle, ligament, tissue or other organ cells.
Full Article
Mar 24, 2020
Engineers model mutations causing drug resistance
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed. Now, a team of Penn State engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.
Full Article