Justin Pritchard

Huck Early Career Entrepreneurial Professorship; Assistant Professor of Biomedical Engineering;

Justin Pritchard

Research Summary

Using systems and synthetic biology approaches to understand and control drug resistance.

Huck Graduate Students

Huck Affiliations


Publication Tags

Neoplasms Genome Pharmaceutical Preparations Therapeutics Genes Growth Platinum Clustered Regularly Interspaced Short Palindromic Repeats Sars Virus Mycobacterium Cisplatin Oxaliplatin Drug Combinations Mutation Vibrio Cholerae Infections Datasets Mycobacterium Tuberculosis Synthetic Lethal Mutations Combination Drug Therapy Lymphoma Epidemics Drug Resistance Infection Carboplatin

Most Recent Papers

The risks of perpetuating an evolutionary arms race in drug discovery

Scott Leighow, Justin Pritchard, Evolution, Medicine, and Public Health

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P. O’Brien, Luke Gilbert, Justin R. Pritchard, 2022, Nature Communications

Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors

Suzanne George, Margaret von Mehren, Jonathan A. Fletcher, Jichao Sun, Sen Zhang, Justin R. Pritchard, John Graeme Hodgson, David Kerstein, Victor M. Rivera, Frank G. Haluska, Michael C. Heinrich, 2022, Clinical Cancer Research on p. 1268-1276

Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity

Mickaël Marloye, Haider Inam, Connor J. Moore, Tyler R. Mertens, Aude Ingels, Marilin Koch, Michal O. Nowicki, Véronique Mathieu, Justin R. Pritchard, Samuel G. Awuah, Sean E. Lawler, Franck Meyer, François Dufrasne, Gilles Berger, 2022, Inorganic Chemistry Frontiers

SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics

Nathan B. Wikle, Thu Nguyen-Anh Tran, Bethany Gentilesco, Scott M. Leighow, Emmy Albert, Emily R. Strong, Karel Brinda, Haider Inam, Fuhan Yang, Sajid Hossain, Philip Chan, William P. Hanage, Maria Messick, Justin R. Pritchard, Ephraim M. Hanks, Maciej F. Boni, 2022, Science advances

Materials-driven approaches to understand extrinsic drug resistance in cancer

Justin R. Pritchard, Michael J. Lee, Shelly R. Peyton, 2022, Soft Matter

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

Thu Nguyen Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks, Maciej F. Boni, 2021, BMC Medicine

A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy

Christopher Yogodzinski, Abolfazl Arab, Justin R. Pritchard, Hani Goodarzi, Luke A. Gilbert, 2021, Genome Medicine

Genomic and experimental evidence that ALK<sup>ATI</sup> does not predict single agent sensitivity to ALK inhibitors

Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward O'Brien, Cheng Dong, David M. McCandlish, Justin R. Pritchard, 2021, iScience

Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes

Mickaël Marloye, Haider Inam, Connor J. Moore, Vinciane Debaille, Justin R. Pritchard, Michel Gelbcke, Franck Meyer, François Dufrasne, Gilles Berger, 2021, Journal of Biological Inorganic Chemistry on p. 535-549

Most-Cited Papers

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann, 2017, Nature Medicine on p. 461-471

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Sarah M. Fortune, 2017, Nature Microbiology

Defining principles of combination drug mechanisms of action

Justin R. Pritchard, Peter M. Bruno, Luke A. Gilberta, Kelsey L. Caprona, Douglas A. Lauffenburger, Michael T. Hemann, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. E170-E179


Justin R. Pritchard, Michael C. Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia J. Zhang, Eric J. Rubin, Matthew K. Waldor, 2014, PLoS Genetics on p. e1004782

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data

Michael C. Chao, Justin R. Pritchard, Yanjia J. Zhang, Eric J. Rubin, Jonathan Livny, Brigid M. Davis, Matthew K. Waldor, 2013, Nucleic Acids Research on p. 9033-9048

Addressing genetic tumor heterogeneity through computationally predictive combination therapy

Boyang Zhao, Justin R. Pritchard, Douglas A. Lauffenburger, Michael T. Hemann, 2014, Cancer Discovery on p. 166-174

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Boyang Zhao, Joseph C. Sedlak, Raja Srinivas, Pau Creixell, Justin R. Pritchard, Bruce Tidor, Douglas A. Lauffenburger, Michael T. Hemann, 2016, Cell on p. 234-246

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne Laure Roux, Jean Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J. Rubin, Roland Brosch, Laurent Kremer, Jean Louis Herrmann, Fabienne Girard-Misguich, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E1002-E1011

Understanding resistance to combination chemotherapy

Justin R. Pritchard, Douglas A. Lauffenburger, Michael T. Hemann, 2012, Drug Resistance Updates on p. 249-257

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M. Rivera, Andrew Garner, Francois Gonzalvez, 2015, Oncotarget on p. 32646-32655