Joseph Cotruvo
Associate Professor of Chemistry
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220 Chemistry
University Park, PA 16802 - juc96@psu.edu
- 814-863-4869
Research Summary
Biochemistry and chemical biology to uncover and understand new metal and redox biology. We are particularly interested in applications to infectious disease, bioenergy, and cancer biology.
Huck Affiliations
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Publication Tags
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Proteins Metals Lanthanoid Series Elements Rare Earth Elements Lanthanoid Atom Protein Bacteria Carrier Proteins Metal Metal Ion Enzymes Copper Ions Iron Sensors Americium Fluorescent Probe Actinoid Atom Superoxides Riboswitch Ribonucleotide Reductases Biochemistry Curium Fluorescent Dyes TyrosineMost Recent Publications
The czcD (NiCo) riboswitch responds to iron(II)
Jiansong Xu, Joseph Cotruvo, Biochemistry on p. 1508-1516
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
Joseph A. Mattocks, Jonathan J. Jung, Chi Yun Lin, Ziye Dong, Neela H. Yennawar, Emily R. Featherston, Christina S. Kang-Yun, Timothy A. Hamilton, Dan M. Park, Amie K. Boal, Joseph A. Cotruvo, 2023, Nature on p. 87-93
Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes
Kirsten E. Martin, Joseph A. Mattocks, Dariusz Śmiłowicz, Eduardo Aluicio-Sarduy, Jennifer N. Whetter, Jonathan W. Engle, Joseph A. Cotruvo, Eszter Boros, 2023, RSC Chemical Biology on p. 414-421
Erratum: Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes (RSC Chemical Biology (2023) DOI: 10.1039/D3CB00020F)
Kirsten E. Martin, Joseph A. Mattocks, Dariusz Śmiłowicz, Eduardo Aluicio-Sarduy, Jennifer N. Whetter, Jonathan W. Engle, Joseph A. Cotruvo, Eszter Boros, 2023, RSC Chemical Biology
Erratum: Characterization of Americium and Curium Complexes with the Protein Lanmodulin: A Potential Macromolecular Mechanism for Actinide Mobility in the Environment (J. Am. Chem. Soc. (2021) 143 (38) (15769-15783) DOI: 10.1021/jacs.1c07103)
Gauthier J.P. Deblonde, Joseph A. Mattocks, Huan Wang, Eric M. Gale, Annie B. Kersting, Mavrik Zavarin, Joseph A. Cotruvo, 2022, Journal of the American Chemical Society on p. 23708
A genetically encoded fluorescent sensor for manganese(II), engineered from lanmodulin
Jennifer Park, Michael B. Cleary, Danyang Li, Joseph A. Mattocks, Jiansong Xu, Huan Wang, Somshuvra Mukhopadhyay, Eric M. Gale, Joseph A. Cotruvo, 2022, Proceedings of the National Academy of Sciences of the United States of America
Reconsidering the czcD (NiCo) Riboswitch as an Iron Riboswitch
Jiansong Xu, Joseph A. Cotruvo, 2022, ACS Bio and Med Chem Au on p. 376-385
Iron-responsive riboswitches
Jiansong Xu, Joseph A. Cotruvo, 2022, Current Opinion in Chemical Biology
Fluorescent biosensors for manganese(II) and iron(II)
Jennifer Park, Jiansong Xu, Joseph Cotruvo, 2022, on p. 87-118
Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions
Joseph A. Mattocks, Joseph A. Cotruvo, Gauthier J.P. Deblonde, 2022, Chemical Science on p. 6054-6066
Most-Cited Papers
Synthetic fluorescent probes for studying copper in biological systems
Joseph A. Cotruvo, Allegra T. Aron, Karla M. Ramos-Torres, Christopher J. Chang, 2015, Chemical Society Reviews on p. 4400-4414
Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems
Allegra T. Aron, Karla M. Ramos-Torres, Joseph A. Cotruvo, Christopher J. Chang, 2015, Accounts of Chemical Research on p. 2434-2442
The Chemistry of Lanthanides in Biology: Recent Discoveries, Emerging Principles, and Technological Applications
Joseph A. Cotruvo, 2019, ACS Central Science on p. 1496-1506
Copper regulates cyclic-AMP-dependent lipolysis
Lakshmi Krishnamoorthy, Joseph A. Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S. Pendyala, Shang Jia, Allegra T. Aron, Cheri M. Ackerman, Mark N.Vander Wal, Timothy Guan, Lukas P. Smaga, Samouil L. Farhi, Elizabeth J. New, Svetlana Lutsenko, Christopher J. Chang, 2016, Nature Chemical Biology on p. 586-592
Lanmodulin: A Highly Selective Lanthanide-Binding Protein from a Lanthanide-Utilizing Bacterium
Joseph Alfred Cotruvo, Jr., Emily R. Featherston, Joseph A. Mattocks, Jackson V. Ho, Tatiana Nikolaevna Laremore, 2018, Journal of the American Chemical Society on p. 15056-15061
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate
Joseph A. Cotruvo, Troy A. Stich, R. David Britt, Joanne Stubbe, 2013, Journal of the American Chemical Society on p. 4027-4039
A Selective, Protein-Based Fluorescent Sensor with Picomolar Affinity for Rare Earth Elements
Joseph A. Mattocks, Jackson V. Ho, Joseph A. Cotruvo, 2019, Journal of the American Chemical Society
Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin
Erik C. Cook, Emily R. Featherston, Scott A. Showalter, Joseph A. Cotruvo, 2019, Biochemistry on p. 120-125
Selective and Efficient Biomacromolecular Extraction of Rare-Earth Elements using Lanmodulin
Gauthier J.P. Deblonde, Joseph A. Mattocks, Dan M. Park, David W. Reed, Joseph A. Cotruvo, Yongqin Jiao, 2020, Inorganic Chemistry on p. 11855-11867
Bridging Hydrometallurgy and Biochemistry: A Protein-Based Process for Recovery and Separation of Rare Earth Elements
Ziye Dong, Joseph A. Mattocks, Gauthier J.P. Deblonde, Dehong Hu, Yongqin Jiao, Joseph A. Cotruvo, Dan M. Park, 2021, ACS Central Science on p. 1798-1808
News Articles Featuring Joseph Cotruvo
Jun 01, 2023
Protein can sort rare earth elements better than current mining practices
The device you’re currently reading this story on needs tiny chunks of metals like neodymium and dysprosium to work. So do wind turbines, electric vehicles and lasers. These rare earth elements are vital to modern technology, but they’re hard to mine and recycle because they’re tricky to distinguish from each other.
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May 31, 2023
Bacterial protein outperforms humans in separating rare earth elements
Rare earth elements like neodymium and dysprosium are popular in the mining industry because they are used in smartphones and hard drives but they are hard to separate from each other and the earth’s crust they were formed in.
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May 31, 2023
A protein mines, sorts rare earths better than humans, paving way for green tech
Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth’s crust and from one another.
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Mar 09, 2023
New biosensor reveals activity of elusive metal that’s essential for life
A new biosensor engineered by Penn State researchers offers scientists the first dynamic glimpses of manganese, an elusive metal ion that is essential for life.
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Oct 20, 2021
Radioactive metals for medicine get a boost from recently discovered protein
A protein can be used to recover and purify radioactive metals such as actinium that could be beneficial for next-generation drugs used in cancer therapies and medical imaging, according to new research from Penn State and Lawrence Livermore National Laboratory (LLNL).
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Oct 08, 2021
New, environmentally friendly method to extract and separate rare earth elements
A new method improves the extraction and separation of rare earth elements — a group of 17 chemical elements critical for technologies such as smart phones and electric car batteries — from unconventional sources.
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Aug 25, 2021
New sensor can detect valuable rare earth element in non-traditional sources
A new luminescent sensor can detect terbium, a valuable rare earth element, from complex environmental samples like acid mine waste. The sensor, developed by researchers at Penn State, takes advantage of a protein that very specifically binds to rare earth elements and could be harnessed to help develop a domestic supply of these metals, which are used in technologies such as smart phones, electric car batteries, and energy efficient lighting.
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Feb 16, 2021
Three from Eberly College of Science awarded 2021 Sloan Research Fellowships
Three faculty members from the Eberly College of Science have been honored with 2021 Alfred P. Sloan Research Fellowships in recognition of their research accomplishments. The new Sloan fellows include Maria del Carmen Carmona Benitez, assistant professor of physics; Joseph Cotruvo Jr., Louis Martarano Career Development Professor of Chemistry; and Elizabeth Elacqua, assistant professor of chemistry.
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Apr 23, 2019
New sensor detects rare metals used in smartphones
A more efficient and cost-effective way to detect lanthanides, the rare earth metals used in smartphones and other technologies, could be possible with a new protein-based sensor that changes its fluorescence when it binds to these metals. A team of researchers from Penn State developed the sensor from a protein they recently described and subsequently used it to explore the biology of bacteria that use lanthanides. A study describing the sensor appears online in the Journal of the American Chemical Society.
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