Jordan Bisanz
Assistant Professor of Biochemistry and Molecular Biology
Research Summary
The interface of microbiology and bioinformatics, with approaches including genomics and metabolomics to investigate the interplay of diet, drugs, and the gut microbiome.
Huck Affiliations
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Microbiota Gastrointestinal Microbiome Diet Biotechnology Microorganisms Meta Analysis Cardiovascular Diseases Microbiome Data Science High Fat Diet Digestive System Caloric Restriction Bile Acids And Salts Health Amino Acids Genes B Lymphocytes Bacteria Pharmaceutical Preparations Guidelines Metabolism Levodopa Poisons Weights And Measures Immunoglobulin AMost Recent Publications
Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors
Than S. Kyaw, Chen Zhang, Moriah Sandy, Kai Trepka, Shenwei Zhang, Luis A. Ramirez Hernandez, Lorenzo Ramirez, Janice J.N. Goh, Kristie Yu, Vincent Dimassa, Elizabeth N. Bess, Jacob G. Brockert, Darren S. Dumlao, Jordan E. Bisanz, Peter J. Turnbaugh, 2024, iScience
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
Megan D. McCurry, Gabriel D. D'Agostino, Jasmine T. Walsh, Jordan E. Bisanz, Ines Zalosnik, Xueyang Dong, David J. Morris, Joshua R. Korzenik, Andrea G. Edlow, Emily P. Balskus, Peter J. Turnbaugh, Jun R. Huh, A. Sloan Devlin, 2024, Cell on p. 2952-2968.e13
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Bipin Rimal, Stephanie Collins, Ceylan Tanes, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Tingting Yan, Emily Gentry, Jordan Bisanz, Imhoi Koo, Erin Reilly, Kristopher Krausz, Fuhua Hao, Dhimant Desai, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Min Kim, Yatrik Shah, Frank Gonzalez, Kyle Bittinger, Joseph Zackular, John Vanden Heuvel, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Emily E. Weinert, Andrew Patterson, 2024, Nature on p. 859-863
Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Vaibhav Upadhyay, Rahul K. Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, Renuka G. Kumar, Victoria Wong Murray, Cecilia Noecker, Jordan E. Bisanz, Yulin Hswen, Connie W.Y. Ha, Bharath Sreekumar, Irene P. Chen, Susan V. Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh, 2023, mBio on p. e0088923
Roles of the gut microbiome in weight management
Rachel N. Carmody, Jordan E. Bisanz, 2023, Nature Reviews Microbiology on p. 535-550
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta
Cecilia Noecker, Juan Sanchez, Jordan E. Bisanz, Veronica Escalante, Margaret Alexander, Kai Trepka, Almut Heinken, Yuanyuan Liu, Dylan Dodd, Ines Thiele, Brian C. DeFelice, Peter J. Turnbaugh, 2023, PLoS Biology
Meta-organismal metabolism in cardiovascular disease
Min Soo Kim, Jordan E. Bisanz, 2023, Cell Host and Microbe on p. 1-2
Challenges and opportunities of strain diversity in gut microbiome research
Benjamin D. Anderson, Jordan E. Bisanz, 2023, Frontiers in Microbiology
Effects of caloric restriction on the gut microbiome are linked with immune senescence
Julia Sbierski-Kind, Sophia Grenkowitz, Stephan Schlickeiser, Arvid Sandforth, Marie Friedrich, Désirée Kunkel, Rainer Glauben, Sebastian Brachs, Knut Mai, Andrea Thürmer, Aleksandar Radonić, Oliver Drechsel, Peter J. Turnbaugh, Jordan E. Bisanz, Hans Dieter Volk, Joachim Spranger, Reiner Jumpertz von Schwartzenberg, 2022, Microbiome
Making gut microbiomes from scratch
Shuchang Tian, Jordan E. Bisanz, 2022, Cell Host and Microbe on p. 1508-1509
Most-Cited Papers
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
E Bolyen, J Rideout, M Dillon, N Bokulich, C Abnet, G Al-Ghalith, H Alexander, E Alm, M Arumugam, F Asnicar, Y Bai, Jordan E. Bisanz, K Bittinger, A Brejnrod, C Brislawn, C Brown, B Callahan, A Caraballo-Rodríguez, J Chase, E Cope, R Da Silva, C Diener, P Dorrestein, G Douglas, D Durall, C Duvallet, C Edwardson, M Ernst, M Estaki, J Fouquier, J Gauglitz, S Gibbons, D Gibson, A Gonzalez, K Gorlick, J Guo, B Hillmann, S Holmes, H Holste, C Huttenhower, G Huttley, S Janssen, A Jarmusch, L Jiang, B Kaehler, K Kang, C Keefe, P Keim, S Kelley, D Knights, I Koester, T Kosciolek, J Kreps, Langille MGI, Morgan G.I. Langille, J Lee, R Ley, Y Liu, E Loftfield, C Lozupone, M Maher, C Marotz, B Martin, D McDonald, L McIver, A Melnik, J Metcalf, S Morgan, J Morton, A Naimey, J Navas-Molina, L Nothias, S Orchanian, T Pearson, S Peoples, D Petras, M Preuss, E Pruesse, L Rasmussen, A Rivers, M Robeson, 2nd, Michael S. Robeson, P Rosenthal, N Segata, M Shaffer, A Shiffer, R Sinha, S Song, J Spear, A Swafford, L Thompson, P Torres, P Trinh, A Tripathi, P Turnbaugh, S Ul-Hasan, van der Hooft JJJ, Justin J.J. van der Hooft, F Vargas, Y Vázquez-Baeza, E Vogtmann, M von Hippel, W Walters, Y Wan, M Wang, J Warren, K Weber, Williamson CHD, Charles H.D. Williamson, A Willis, Z Xu, J Zaneveld, Y Zhang, Q Zhu, R Knight, J Caporaso, 2019, Nature Biotechnology on p. 852-857
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Vayu Maini Rekdal, V Maini Rekdal, E Bess, Jordan Bisanz, P Turnbaugh, E Balskus, 2019, Science
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 (Nature Biotechnology, (2019), 37, 8, (852-857), 10.1038/s41587-019-0209-9)
Evan Bolyen, Jai Ram Rideout, Matthew R. Dillon, Nicholas A. Bokulich, Christian C. Abnet, Gabriel A. Al-Ghalith, Harriet Alexander, Eric J. Alm, Manimozhiyan Arumugam, Francesco Asnicar, Yang Bai, Jordan E. Bisanz, Kyle Bittinger, Asker Brejnrod, Colin J. Brislawn, C. Titus Brown, Benjamin J. Callahan, Andrés Mauricio Caraballo-Rodríguez, John Chase, Emily K. Cope, Ricardo Da Silva, Christian Diener, Pieter C. Dorrestein, Gavin M. Douglas, Daniel M. Durall, Claire Duvallet, Christian F. Edwardson, Madeleine Ernst, Mehrbod Estaki, Jennifer Fouquier, Julia M. Gauglitz, Sean M. Gibbons, Deanna L. Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin Hillmann, Susan Holmes, Hannes Holste, Curtis Huttenhower, Gavin A. Huttley, Stefan Janssen, Alan K. Jarmusch, Lingjing Jiang, Benjamin D. Kaehler, Kyo Bin Kang, Christopher R. Keefe, Paul Keim, Scott T. Kelley, Dan Knights, Irina Koester, Tomasz Kosciolek, Jorden Kreps, Morgan G.I. Langille, Joslynn Lee, Ruth Ley, Yong Xin Liu, Erikka Loftfield, Catherine Lozupone, Massoud Maher, Clarisse Marotz, Bryan D. Martin, Daniel McDonald, Lauren J. McIver, Alexey V. Melnik, Jessica L. Metcalf, Sydney C. Morgan, Jamie T. Morton, Ahmad Turan Naimey, Jose A. Navas-Molina, Louis Felix Nothias, Stephanie B. Orchanian, Talima Pearson, Samuel L. Peoples, Daniel Petras, Mary Lai Preuss, Elmar Pruesse, Lasse Buur Rasmussen, Adam Rivers, Michael S. Robeson, Patrick Rosenthal, Nicola Segata, Michael Shaffer, Arron Shiffer, Rashmi Sinha, Se Jin Song, John R. Spear, Austin D. Swafford, Luke R. Thompson, Pedro J. Torres, Pauline Trinh, Anupriya Tripathi, Peter J. Turnbaugh, Sabah Ul-Hasan, Justin J.J. van der Hooft, Fernando Vargas, Yoshiki Vázquez-Baeza, Emily Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C. Weber, Charles H.D. Williamson, Amy D. Willis, Zhenjiang Zech Xu, Jesse R. Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, J. Gregory Caporaso, 2019, Nature Biotechnology on p. 1091
Human gut bacteria produce Τ<sub>Η</sub>17-modulating bile acid metabolites
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin, 2022, Nature on p. 907-912
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
S Collins, Jonathan Stine, Jordan E. Bisanz, C. Denise Okafor, D Okafor, Andrew Patterson, 2022, Nature Reviews Microbiology on p. 236-247
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Jordan Bisanz, V Upadhyay, J Turnbaugh, K Ly, P Turnbaugh, 2019, Cell Host and Microbe on p. 265-272.e4
Reporting guidelines for human microbiome research: the STORMS checklist
C Mirzayi, A Renson, Cesare Furlanello, F Zohra, Susanna Assunta Sansone, S Elsafoury, Fatima Zohra, L Geistlinger, Shaimaa Elsafoury, L Kasselman, Ludwig Geistlinger, K Eckenrode, J van de Wijgert, Lora J. Kasselman, A Loughman, Kelly Eckenrode, F Marques, Janneke van de Wijgert, D MacIntyre, Amy Loughman, M Arumugam, Francine Z. Marques, David A. MacIntyre, R Azhar, Manimozhiyan Arumugam, F Beghini, K Bergstrom, Rimsha Azhar, A Bhatt, Francesco Beghini, Kirk Bergstrom, J Braun, Ami Bhatt, H Bravo, Jordan E. Bisanz, G Buck, Jonathan Braun, Hector Corrada Bravo, F Bushman, Gregory A. Buck, D Casero, Frederic Bushman, G Clarke, M Collado, David Casero, Gerard Clarke, P Cotter, Maria Carmen Collado, J Cryan, R Demmer, Paul D. Cotter, S Devkota, John F. Cryan, Ryan T. Demmer, E Elinav, Suzanne Devkota, J Escobar, J Fettweis, Eran Elinav, Juan S. Escobar, R Finn, A Fodor, Jennifer Fettweis, Robert D. Finn, S Forslund, A Franke, Anthony A. Fodor, Sofia Forslund, C Furlanello, Andre Franke, J Gilbert, Cesare Furlanello, E Grice, B Haibe-Kains, Jack Gilbert, Elizabeth Grice, S Handley, P Herd, Benjamin Haibe-Kains, S Holmes, Scott Handley, Pamela Herd, J Jacobs, Susan Holmes, L Karstens, R Knight, Jonathan P. Jacobs, Lisa Karstens, D Knights, Rob Knight, O Koren, D Kwon, Dan Knights, M Langille, Omry Koren, B Lindsay, Douglas S. Kwon, D McGovern, A McHardy, S McWeeney, N Mueller, L Nezi, M Olm, N Palm, E Pasolli, J Raes, M Redinbo, M Rühlemann, R Balfour Sartor, P Schloss, L Schriml, E Segal, M Shardell, T Sharpton, E Smirnova, H Sokol, J Sonnenburg, S Srinivasan, L Thingholm, P Turnbaugh, V Upadhyay, R Walls, P Wilmes, T Yamada, G Zeller, M Zhang, N Zhao, L Zhao, W Bao, A Culhane, V Devanarayan, J Dopazo, X Fan, M Fischer, W Jones, R Kusko, C Mason, T Mercer, S Sansone, A Scherer, L Shi, S Thakkar, W Tong, R Wolfinger, C Hunter, N Segata, C Huttenhower, J Dowd, H Jones, L Waldron, 2021, Nature Medicine on p. 1885-1892
Randomized Open-Label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children
Jordan E. Bisanz, M Enos, J Mwanga, J Changalucha, J Burton, G Gloor, G Reid, 2014, mBio on p. e01580-14
Gut microbiota–specific iga<sup>+</sup> B cells traffic to the CNS in active multiple sclerosis
A Pröbstel, X Zhou, R Baumann, S Wischnewski, M Kutza, O Rojas, K Sellrie, A Bischof, K Kim, A Ramesh, R Dandekar, A Greenfield, R Schubert, Jordan Bisanz, S Vistnes, K Khaleghi, J Landefeld, G Kirkish, F Liesche-Starnecker, V Ramaglia, S Singh, E Tran, P Barba, K Zorn, J Oechtering, K Forsberg, L Shiow, R Henry, J Graves, Cree BAC, Bruce A.C. Cree, S Hauser, J Kuhle, J Gelfand, P Andersen, J Schlegel, P Turnbaugh, P Seeberger, J Gommerman, M Wilson, L Schirmer, S Baranzini, 2020, Science immunology
Caloric restriction disrupts the microbiota and colonization resistance
R von Schwartzenberg, Jordan Bisanz, S Lyalina, P Spanogiannopoulos, Q Ang, J Cai, S Dickmann, M Friedrich, S Liu, S Collins, D Ingebrigtsen, S Miller, J Turnbaugh, Andrew D. Patterson, K Pollard, K Mai, J Spranger, P Turnbaugh, 2021, Nature on p. 272-277
News Articles Featuring Jordan Bisanz
Aug 14, 2024
Early life exposure to common chemical permanently disrupts gut microbiome
Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.
Full Article
Jun 13, 2024
Bisanz named Huck Early Career Chair in Host-Microbiome Interactions
Jordan Bisanz, assistant professor of biochemistry and molecular biology in the Eberly College of Science at Penn State, has been awarded a Dorothy Foehr Huck and J. Lloyd Huck Early Career Chair in Host-Microbiome Interactions.
Full Article
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article
Feb 05, 2024
$1.9M NIH grant to support research on impacts of the microbiome on human health
To help understand how complex communities of microbes impact human health, the National Institutes of Health’s National Institute of General Medical Science has awarded a five-year, $1.9 million Maximizing Investigator’s Research Award to Jordan Bisanz
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Feb 15, 2023
Free film and panel discussion reveals 'invisible' crisis of the microbial world
At 6 p.m. Thursday, March 2, Penn State’s Microbiome Center will present "The Invisible Extinction" — a movie that spotlights the trailblazing work and charismatic personalities of renowned scientists who aim to save the vanishing microbes that are essential for our survival.
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