Jan McAllister

Professor of Cellular and Molecular Physiology

Hershey Med Ctr
Hershey,
jxm63@psu.edu

Bio & Links
Publications

Huck Affiliations

Publication Tags

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Androgens Polycystic Ovary Syndrome Theca Cells Genes Messenger Rna Proteins Androgen Alternative Splicing Genome Wide Association Study Metabolic Ovary Disorder Fertility Ovaries Interleukin 10 Cell And Tissue Based Therapy Mesenchymal Stem Cells Micrornas Stromal Cells Mice Protein Isoforms Therapeutics Biosynthesis Introns Amino Acids

Most Recent Publications

Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome

R. Alan Harris, Kellie J. Archer, Mark O. Goodarzi, Timothy P. York, Jeffrey Rogers, Andrea Dunaif, Jan M. McAllister, Jerome F. Strauss, 2023, Gene

The PCOS GWAS Candidate Gene ZNF217 Influences Theca Cell Expression of DENND1A.V2, CYP17A1, and Androgen Production

Jamaia S. Waterbury, Maria E. Teves, Alison Gaynor, Angela X. Han, Grace Mavodza, Jordan Newell, Jerome F. Strauss, Jan M. McAllister, 2022, Journal of the Endocrine Society

Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10

Rishi Man Chugh, Hang soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister, Ayman Al-Hendy, 2021, Stem Cell Research and Therapy

Human dennd1a.V2 drives cyp17a1 expression and androgen production in mouse ovaries and adrenals

Maria E. Teves, Bhavi P. Modi, Rewa Kulkarni, Angela X. Han, Jamaia S. Marks, Mark A. Subler, Jolene Windle, Jordan M. Newall, Jan M. McAllister, Jerome F. Strauss, 2020, International Journal of Molecular Sciences

Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways

Rewa Kulkarni, Maria E. Teves, Angela X. Han, Jan M. McAllister, Jerome F. Strauss, 2019, Journal of the Endocrine Society on p. 2204-2223

MiRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis

Jan M. Mcallister, Angela X. Han, Bhavi P. Modi, Maria E. Teves, Grace R. Mavodza, Zachary L. Anderson, Tsaiwei Shen, Lane K. Christenson, Kellie J. Archer, Jerome F. Strauss, 2019, Endocrinology on p. 1964-1981

VCAM1 is induced in ovarian theca and stromal cells in a mouse model of androgen excess

Nicholes R. Candelaria, Achuth Padmanabhan, Fabio Stossi, M. Cecilia Ljungberg, Katharine E. Shelly, Braden K. Pew, Minerva Solis, Ayane M. Rossano, Jan M. McAllister, Sheng Wu, Jo Anne S. Richards, 2019, Endocrinology on p. 1377-1393

The Genetics of Polycystic Ovary Syndrome: From Genome-Wide Association to Molecular Mechanisms

Jerome Strauss, Bhavi Modi, Janette McAllister, 2018, on p. 25-33

Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2

Meng Kian Tee, Mart Speek, Balázs Legeza, Bhavi Modi, Maria Eugenia Teves, Janette M. McAllister, Jerome F. Strauss, Walter L. Miller, 2016, Molecular and Cellular Endocrinology on p. 25-35

Functional genomics of PCOS: From GWAS to molecular mechanisms

Jan M. McAllister, Richard S. Legro, Bhavi P. Modi, Jerome F. Strauss, 2015, Obstetrical and Gynecological Survey on p. 573-574

Most-Cited Papers

Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

Jan M. McAllister, Bhavi Modi, Bruce A. Miller, Jessica Biegler, Richard Bruggeman, Richard S. Legro, Jerome F. Strauss, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. E1519-E1527

Functional genomics of PCOS: From GWAS to molecular mechanisms

J McAllister, R Legro, B Modi, J Strauss, 3rd, 2015, Trends in Endocrinology and Metabolism on p. 118-24

Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls

Douglas Heimark, Jan McAllister, Joseph Larner, 2014, Endocrine Journal on p. 111-117

MiRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis

Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2

Meng Kian Tee, Mart Speek, Balázs Legeza, Bhavi Modi, Maria Eugenia Teves, Janette M. McAllister, Jerome F. Strauss, Walter L. Miller, 2016, Molecular and Cellular Endocrinology on p. 25-35