J. Martin Bollinger

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

J. Martin Bollinger

Research Summary

Mechanisms of metalloenzymes and metallofactor assembly

Huck Affiliations

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Publication Tags

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Enzymes Oxygenases Iron Substrates Hydrogen Carbon Proteins Oxygen Arginine Glutarates Protein Electrons Hydroxylation Peroxides Ketoglutaric Acids Carbon Atom Deuterium X Rays Ethylene Dioxygen Aldehydes Beta Lactams Oxidation Decarboxylation Ligands

Most Recent Publications

Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH

Anastasia C. Manesis, Jeffrey W. Slater, Kenny Cantave, J. Martin Bollinger, Carsten Krebs, Amy C. Rosenzweig, 2023, Biochemistry on p. 1082-1092

Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily

Molly J. McBride, Sarah R. Pope, Mrutyunjay A. Nair, Debangsu Sil, Xavier E. Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154

Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)- and 2-Oxoglutarate-dependent Oxygenases

J. M. Bollinger, Carsten Krebs, Amie K. Boal, Alexey Silakov, John C. Price, Megan L. Matthews, Wei Chen Chang, Ryan J. Martinie, Juan Pan, Noah P. Dunham, Eliott S. Wenger, Rachelle A. Copeland, Chi Yun Lin, 2022, FASEB Journal

Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Chi-Yun Lin, Angel L. Muñoz Hernández, Angel Hernández, Tatiana N. Laremore, Alexey Silakov, Carsten Krebs, Amie K. Boal, Joseph Bollinger, 2022, ACS Catalysis on p. 6968-6979

Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro- l -Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, M Neugebauer, Jeffrey W. Slater, Monica E. Neugebauer, M Chng, A Boal, Michelle C.Y. Chang, C Krebs, Amie Boal, Carsten Krebs, J. Martin Bollinger, 2022, Biochemistry on p. 689-702

A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Yun Ji Park, Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana A. Montaser, Paul M. Thomas, William B. Dowdle, Anahi Ruiz, Neil L. Kelleher, Joseph Bollinger, Carsten Krebs, Brian M. Hoffman, Amy C. Rosenzweig, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2123566119

Synthesis of 6,6- and 7,7-Difluoro-1-acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO

Nabin Panth, Eliott S. Wenger, Carsten Krebs, Joseph Bollinger, Robert B. Grossman, 2022, ChemBioChem on p. e202200081

An Iron(IV)-Oxo Intermediate Initiating l -Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme

Rachelle Copeland, Katherine Davis, Tokufu Shoda, Elizabeth Blaesi, A Boal, Carsten Krebs, J. Bollinger, 2021, Journal of the American Chemical Society on p. 2293-2303

Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF

M McBride, S Pope, K Hu, C. Denise Okafor, C Denise Okafor, E Balskus, J Bollinger, J. Martin Bollinger, Amie K. Boal, 2021, Proceedings of the National Academy of Sciences of the United States of America

Hybrid radical-polar pathway for excision of ethylene from 2-oxoglutarate by an iron oxygenase

R Copeland, S Zhou, Irene Schaperdoth, Tokufu Kent C. Shoda, K Tokufu, Joseph Bollinger, Carsten Krebs, 2021, Science on p. 1489-1493

Most-Cited Papers

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2013, Nature on p. 320-323

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836

The biosynthesis of methanobactin

Grace E. Kenney, Laura M.K. Dassama, Maria Eirini Pandelia, Anthony S. Gizzi, Ryan J. Martinie, Peng Gao, Caroline J. DeHart, Luis F. Schachner, Owen S. Skinner, Soo Y. Ro, Xiao Zhu, Monica Sadek, Paul M. Thomas, Steven C. Almo, J. Martin Bollinger, Carsten Krebs, Neil L. Kelleher, Amy C. Rosenzweig, 2018, Science on p. 1411-1416

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Ryan J. Martinie, Jovan Livada, Wei Chen Chang, Michael T. Green, Carsten Krebs, J. Martin Bollinger, Alexey Silakov, 2015, Journal of the American Chemical Society on p. 6912-6919

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate

Maria E. Pandelia, Ning Li, H. Norgaard, Hanne Nørgaard, Douglas M. Warui, Lauren J. Rajakovich, Wei Chen Chang, Squire J. Booker, Carsten Krebs, J. Martin Bollinger, J. Bollinger, Jr., 2013, Journal of the American Chemical Society on p. 15801-15812