J. Martin Bollinger
Professor of Chemistry; Professor of Biochemistry and Molecular Biology

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330 Chemistry
University Park, PA - jmb21@psu.edu
- (814) 863-1464
Research Summary
Mechanisms of metalloenzymes and metallofactor assembly
Huck Affiliations
Links
Publication Tags
Iron Oxygenases Enzymes Substrates Hydrogen Carbon Proteins Oxygen Arginine Glutarates Protein Hydroxylation Electrons Peroxides Ketoglutaric Acids Carbon Atom Biosynthesis Deuterium Sulfur Ethylene X Rays Dioxygen Beta Lactams Aldehydes HemeMost Recent Publications
Synthesis of 6,6- and 7,7-Difluoro-1-acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO
Nabin Panth, Eliott S. Wenger, Carsten Krebs, J. Martin Bollinger, Robert B. Grossman, 2022, ChemBioChem
Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)
Chi Yun Lin, Angel L. Muñoz Hernández, Tatiana N. Laremore, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2022, ACS Catalysis on p. 6968-6979
Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)- and 2-Oxoglutarate-dependent Oxygenases
J. M. Bollinger, Carsten Krebs, Amie K. Boal, Alexey Silakov, John C. Price, Megan L. Matthews, Wei Chen Chang, Ryan J. Martinie, Juan Pan, Noah P. Dunham, Eliott S. Wenger, Rachelle A. Copeland, Chi Yun Lin, 2022, FASEB Journal
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro- l -Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica E. Neugebauer, Michelle C.Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2022, Biochemistry on p. 689-702
A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis
Yun Ji Park, Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana A. Montaser, Paul M. Thomas, William B. Dowdle, Anahi Ruiz, Neil L. Kelleher, J. Martin Bollinger, Carsten Krebs, Brian M. Hoffman, Amy C. Rosenzweig, 2022, Proceedings of the National Academy of Sciences of the United States of America
An Iron(IV)-Oxo Intermediate Initiating l -Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme
Rachelle Copeland, Katherine Davis, Tokufu Shoda, Elizabeth Blaesi, A Boal, Carsten Krebs, J. Bollinger, 2021, Journal of the American Chemical Society on p. 2293-2303
Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF
M McBride, S Pope, K Hu, C. Denise Okafor, C Denise Okafor, E Balskus, J Bollinger, J. Martin Bollinger, Amie K. Boal, 2021, Proceedings of the National Academy of Sciences of the United States of America
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
N Maio, Bernard A.P. Lafont, A Lafont, D Sil, Y Li, J. Martin Bollinger, Joseph Bollinger, Carsten Krebs, T Pierson, W. Marston Linehan, M Linehan, Tracey A. Rouault, 2021, Science on p. 236-241
Hybrid radical-polar pathway for excision of ethylene from 2-oxoglutarate by an iron oxygenase
R Copeland, S Zhou, Irene Schaperdoth, Tokufu Kent C. Shoda, K Tokufu, Joseph Bollinger, Carsten Krebs, 2021, Science on p. 1489-1493
Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
Gang Liu, Debangsu Sil, Nunziata Maio, Wing Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault, 2020, Nature Communications
Most-Cited Papers
Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2
Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2013, Nature on p. 320-323
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics
Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144
Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase
Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126
The biosynthesis of methanobactin
Grace E. Kenney, Laura M.K. Dassama, Maria Eirini Pandelia, Anthony S. Gizzi, Ryan J. Martinie, Peng Gao, Caroline J. DeHart, Luis F. Schachner, Owen S. Skinner, Soo Y. Ro, Xiao Zhu, Monica Sadek, Paul M. Thomas, Steven C. Almo, J. Martin Bollinger, Carsten Krebs, Neil L. Kelleher, Amy C. Rosenzweig, 2018, Science on p. 1411-1416
Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate
Maria E. Pandelia, Ning Li, Hanne Nørgaard, Douglas M. Warui, Lauren J. Rajakovich, Wei Chen Chang, Squire J. Booker, Carsten Krebs, J. Martin Bollinger, 2013, Journal of the American Chemical Society on p. 15801-15812
Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2
Ryan J. Martinie, Jovan Livada, Wei Chen Chang, Michael T. Green, Carsten Krebs, J. Martin Bollinger, Alexey Silakov, 2015, Journal of the American Chemical Society on p. 6912-6919
News Articles Featuring J. Martin Bollinger
Oct 29, 2018
Germs Dodge Immune Defenses With DNA-Building Enzymes
Some bacteria, including those that cause strep throat and pneumonia, use a certain type of enzyme to replicate their DNA without the usually required metal ions, according to new research.
Full Article