Istvan Albert
Research Professor of Bioinformatics

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W237 Millennium Science Complex
University Park, PA 16802 - iua1@psu.edu
- 814-865-2281
Research Summary
Bioinformatics, large scale biological data analysis, microarrays and sequence analysis. Scientific programming, algorithm development. Database-driven web development.
Huck Affiliations
- Center for Infectious Disease Dynamics
- Bioinformatics and Genomics
- One Health Microbiome Center
- Insect Biodiversity Center
Links
Most Recent Publications
Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections
Lauren N. McKinley, McCauley O. Meyer, Aswathy Sebastian, Benjamin K. Chang, Kyle J. Messina, Istvan Albert, Philip C. Bevilacqua, 2024, Nucleic Acids Research on p. 14133-14153
Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice
Laurel R. Seemiller, Lisa R. Goldberg, Aswathy Sebastian, Sue Rutherford Siegel, Craig Praul, Dana Zeid, Istvan Albert, Jacob Beierle, Camron D. Bryant, Thomas J. Gould, 2024, Alcohol, Clinical and Experimental Research on p. 2022-2034
CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling
Huiqing Zeng, Shimaa Ali, Aswathy Sebastian, Adriana Sophia Ramos-Medero, Istvan Albert, Charlotte Dean, Aimin Liu, 2024, Developmental Biology on p. 92-101
Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL
Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, 2023, Journal of Biological Chemistry
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
Lauren Bellfy, Chad Smies, Alicia Bernhardt, Kasuni Bodinayake, Aswathy Sebastian, Emily Stuart, Destiny S. Wright, Chen-Yu Lo, Chen Yu Lo, Shoko Murakami, Hannah Boyd, Shoko Murakami, Hannah M. Boyd, Megan von Abo, Megan J. von Abo, Istvan Albert, Istvan Albert, Janine Kwapis, 2023, Neuropsychopharmacology on p. 1789-1797
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Sougat Misra, Tai-Jung Lee, Molly Hall, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, A Patterson, Randall Rossi, Molly Hall, Istvan Albert, others, K Prabhu, 2023, Redox Biology on p. 102571
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
J Okombo, S Mok, T Qahash, T Yeo, J Bath, L Orchard, E Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, D Fidock, 2022, PLoS Pathogens on p. e1010926
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Scott Lindner, K Swearingen, M Shears, A Sebastian, M Walker, E Vrana, K Hart, A Minns, Istvan Albert, P Sinnis, R Moritz, Stefan H.I. Kappe, Kappe SHI, 2022, Nature Communications on p. 283
Transcriptional Profiling of the Small Intestine and the Colon Reveals Modulation of Gut Infection with Citrobacter rodentium According to the Vitamin A Status
Zhi Chai, Yafei Lyu, Q Chen, Cheng-Hsin Wei, Lindsay Snyder, I.M. Snyder, Veronika Weaver, Aswathy Sebastian, Albert, Istv\'an, István Albert, Qunhua Li, Margherita Cantorna, A Ross, Catharine Ross, others, 2022, Nutrients on p. 1563
Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development (Nature Communications, (2018), 9, 1, (2656), 10.1038/s41467-018-04966-3)
H Painter, Neo Chung, Aswathy Sebastian, Istvan Albert, John Storey, Llin\'as, Manuel, Manuel Llinás, 2022, Nature Communications on p. 1--1
Most-Cited Papers
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688
Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes
Yuan Wan, Gong Cheng, Xin Liu, Si Jie Hao, Merisa Nisic, Chuan Dong Zhu, Yi Qiu Xia, Wen Qing Li, Zhi Gang Wang, Wen Long Zhang, Shawn J. Rice, Aswathy Sebastian, Istvan Albert, Chandra P. Belani, Si Yang Zheng, 2017, Nature Biomedical Engineering
A rapid and label-free platform for virus capture and identification from clinical samples
Yin Ting Yeh, Kristen Gulino, Yu He Zhang, YuHe Zhanga, Aswathy Sabestien, Tsui-Wen Chou, Bin Zhou, Zhong Lin, Istvan Albert, Huaguang Lu, Venkataraman Swaminathan, Elodie Ghedin, Mauricio Terrones Maldonado, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 895-901
Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation
Charissa de Bekker, Robin A. Ohm, Raquel G. Loreto, Aswathy Sebastian, Istvan Albert, Martha Merrow, Andreas Brachmann, David P. Hughes, 2015, BMC Genomics
Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays
Yin Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones, Si Yang Zheng, 2016, Science advances on p. e1601026
NusA-dependent transcription termination prevents misregulation of global gene expression
Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology
Molecular tandem repeat strategy for elucidating mechanical properties of high-strength proteins
Huihun Jung, Abdon Pena-Francesch, Alham Saadat, Aswathy Sebastian, Dong Hwan Kim, Reginald F. Hamilton, Istvan Albert, Benjamin D. Allen, Melik C. Demirel, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6478-83
Testing the kinship theory of intragenomic conflict in honey bees (Apis mellifera)
David A. Galbraith, Sarah D. Kocher, Tom Glenn, Istvan Albert, Greg J. Hunt, Joan E. Strassmann, David C. Queller, Christina M. Grozinger, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 1020-1025
Selection on Aedes aegypti alters Wolbachia-mediated dengue virus blocking and fitness
Suzanne A. Ford, Scott L. Allen, Johanna R. Ohm, Leah T. Sigle, Aswathy Sebastian, Istvan Albert, Stephen F. Chenoweth, Elizabeth A. McGraw, 2019, Nature Microbiology on p. 1832-1839
News Articles Featuring Istvan Albert
Nov 05, 2024
Testing thousands of RNA enzymes helps find first ‘twister ribozyme’ in mammals
A new method, developed by Penn State researchers, can test the activity of thousands of predicted ribozymes in a single experiment.
Full Article
Aug 26, 2019
Research predicts stability of mosquito-borne disease prevention
More than half of the people in the world, including in the United States, live alongside Aedes aegypti — the mosquito that transmits dengue, Zika and other often deadly viruses. Dengue virus, alone, infects nearly 400 million people worldwide each year.
Full Article