Istvan Albert

Research Professor of Bioinformatics

Huck Co-hire with Eberly College of Science

Istvan Albert

Research Summary

Bioinformatics, large scale biological data analysis, microarrays and sequence analysis. Scientific programming, algorithm development. Database-driven web development.

Huck Affiliations

Links

Most Recent Publications

Epigenetic Modifiers to Treat Retinal Degenerative Diseases

Evgenya Popova, Lisa Schneper, Aswathy Sebastian, Istvan Albert, Joyce Tombran-Tink, Colin J. Barnstable, 2025, Cells

Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice

Laurel R. Seemiller, Lisa R. Goldberg, Aswathy Sebastian, Sue Rutherford Siegel, Craig Praul, Dana Zeid, Istvan Albert, Jacob Beierle, Camron D. Bryant, Thomas J. Gould, 2024, Alcohol, Clinical and Experimental Research on p. 2022-2034

CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling

Huiqing Zeng, Shimaa Ali, Aswathy Sebastian, Adriana Ramos-Medero, Istvan Albert, Charlotte Dean, Aimin Liu, 2024, Developmental Biology on p. 92--101

Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections

Lauren McKinley, McCauley Meyer, Aswathy Sebastian, Benjamin Chang, Kyle Messina, Istvan Albert, Philip C. Bevilacqua, 2024, Nucleic Acids Research on p. 14133--14153

Human CCR4-NOT is a global regulator of gene expression and is a novel silencer of retrotransposon activation

S Kulkarni, Alexis Morrissey, Aswathy Sebastian, B Giardine, C Keller, C Smith, Belinda Giardine, Courtney Smith, O Akinniyi, Oluwasegun Akinniyi, Cheryl Keller, Alexei Arnaoutov, Istvan Albert, S Mahony, others, J Reese, 2024, bioRxiv : the preprint server for biology on p. 2024--09

GeneScape: A Python package for gene ontology visualization

Istvan Albert, 2024, Journal of Open Source Software on p. 6624

Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL

Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, 2023, Journal of Biological Chemistry

The clock gene Per1 may exert diurnal control over hippocampal memory consolidation

Lauren Bellfy, Chad Smies, Alicia Bernhardt, Kasuni Bodinayake, Aswathy Sebastian, Emily Stuart, Destiny S. Wright, Chen-Yu Lo, Chen Yu Lo, Shoko Murakami, Hannah Boyd, Shoko Murakami, Hannah M. Boyd, Megan von Abo, Megan J. von Abo, Istvan Albert, Istvan Albert, Janine Kwapis, 2023, Neuropsychopharmacology on p. 1789-1797

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Sougat Misra, Tai-Jung Lee, Molly Hall, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, A Patterson, Randall Rossi, Molly Hall, Istvan Albert, others, K Prabhu, 2023, Redox Biology on p. 102571

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

J Okombo, S Mok, T Qahash, T Yeo, J Bath, L Orchard, E Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, D Fidock, 2022, PLoS Pathogens on p. e1010926

Most-Cited Papers

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

Yuan Wan, Gong Cheng, Xin Liu, Si Jie Hao, Merisa Nisic, Chuan Dong Zhu, Yi Qiu Xia, Wen Qing Li, Zhi Gang Wang, Wen Long Zhang, Shawn J. Rice, Aswathy Sebastian, Istvan Albert, Chandra P. Belani, Si Yang Zheng, 2017, Nature Biomedical Engineering

A rapid and label-free platform for virus capture and identification from clinical samples

Yin Ting Yeh, Kristen Gulino, Yu He Zhang, YuHe Zhanga, Aswathy Sabestien, Tsui-Wen Chou, Bin Zhou, Zhong Lin, Istvan Albert, Huaguang Lu, Venkataraman Swaminathan, Elodie Ghedin, Mauricio Terrones Maldonado, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 895-901

Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation

Charissa de Bekker, Robin A. Ohm, Raquel G. Loreto, Aswathy Sebastian, Istvan Albert, Martha Merrow, Andreas Brachmann, David P. Hughes, 2015, BMC Genomics

Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays

Yin Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones, Si Yang Zheng, 2016, Science advances on p. e1601026

NusA-dependent transcription termination prevents misregulation of global gene expression

Smarajit Mondal, Alexander V. Yakhnin, Aswathy Sebastian, Istvan Albert, Paul Babitzke, 2016, Nature Microbiology

Molecular tandem repeat strategy for elucidating mechanical properties of high-strength proteins

Huihun Jung, Abdon Pena-Francesch, Alham Saadat, Aswathy Sebastian, Dong Hwan Kim, Reginald F. Hamilton, Istvan Albert, Benjamin D. Allen, Melik C. Demirel, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6478-83

Selection on Aedes aegypti alters Wolbachia-mediated dengue virus blocking and fitness

Suzanne A. Ford, Scott L. Allen, Johanna R. Ohm, Leah T. Sigle, Aswathy Sebastian, Istvan Albert, Stephen F. Chenoweth, Elizabeth A. McGraw, 2019, Nature Microbiology on p. 1832-1839

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Heather J. Painter, Neo Christopher Chung, Aswathy Sebastian, Istvan Albert, John D. Storey, Manuel Llinás, 2018, Nature Communications

News Articles Featuring Istvan Albert

May 18, 2026

$3M NIH grant to support research on memory and exaggerated fear responses

Experiencing a traumatic event sometimes produces long-lasting biological changes that can lead to an exaggerated fear response to future stressful events, such as what occurs in individuals with post-traumatic stress disorder. To better understand the regulatory mechanisms in the brain that produce this biological memory and exaggerated fear response, a team of researchers from Penn State and the University of Wisconsin-Milwaukee has been awarded a grant from the U.S. National Institutes of Health’s National Institute of Mental Health.

Full Article

Sep 23, 2025

Gene editing, traditional crossbreeding produce disease-resistant cacao plants

Novel approach could revolutionize sustainable chocolate production while addressing global food security, researchers report.

Full Article

Nov 05, 2024

Testing thousands of RNA enzymes helps find first ‘twister ribozyme’ in mammals

A new method, developed by Penn State researchers, can test the activity of thousands of predicted ribozymes in a single experiment.

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Aug 26, 2019

Research predicts stability of mosquito-borne disease prevention

More than half of the people in the world, including in the United States, live alongside Aedes aegypti — the mosquito that transmits dengue, Zika and other often deadly viruses. Dengue virus, alone, infects nearly 400 million people worldwide each year.

Full Article