Idan Shalev

Assistant Professor of Biobehavioral Health

Idan Shalev

Research Summary

Interdisciplinary approach to identify mechanisms underpinning the biological embedding of stress across the lifespan with a special focus on biological aging.

Huck Graduate Students

Huck Affiliations

Publication Tags

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Telomere Health Leukocytes Caloric Restriction Psychiatry Mental Disorders Therapeutics Prospective Studies Longevity Biomarkers Research Confidence Intervals Oxytocin Receptors Sex Offenses Psychological Stress Anxiety Disorders Oxytocin Receptor Early Life Stress Mental Disorder Post Traumatic Stress Disorders Vasopressin V1a Receptor Childhood Parturition Genes Puberty

Most Recent Publications

Cross-tissue comparison of telomere length and metrics of DNA integrity, quality, and quantity among individuals aged 8 to 70 years

Sarah Wolf, Waylon Hastings, Qiaofeng Ye, Laura Etzel, Abner Apsley, Christopher Chiaro, Christine Heim, Thomas Heller, Jennie Noll, Hannah Schreier, Chad Shenk, Idan Shalev, PLOS One

A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming

Audrie Lin, Andrew N. Mertens, Md Ziaur Rahman, Sophia T. Tan, Dora Il’yasova, Ivan Spasojevic, Shahjahan Ali, Christine P. Stewart, Lia C.H. Fernald, Lisa Kim, Liying Yan, Ann Meyer, Md Rabiul Karim, Sunny Shahriar, Gabrielle Shuman, Benjamin F. Arnold, Alan E. Hubbard, Syeda L. Famida, Salma Akther, Md Saheen Hossen, Palash Mutsuddi, Abul K. Shoab, Idan Shalev, Mahbubur Rahman, Leanne Unicomb, Christopher D. Heaney, Patricia Kariger, John M. Colford, Stephen P. Luby, Douglas A. Granger, 2024, Nature Communications

Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor

Laura Etzel, Abner T. Apsley, Waylon J. Hastings, Qiaofeng Ye, Idan Shalev, 2024, Brain, Behavior, and Immunity on p. 724-733

Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis

Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. MacIsaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev, 2024, Aging Cell

Stress biomarkers and child development in young children in Bangladesh

Zachary Butzin-Dozier, Andrew N. Mertens, Sophia T. Tan, Douglas A. Granger, Helen O. Pitchik, Dora Il'yasova, Fahmida Tofail, Md Ziaur Rahman, Ivan Spasojevic, Idan Shalev, Shahjahan Ali, Mohammed Rabiul Karim, Sunny Shahriar, Syeda Luthfa Famida, Gabrielle Shuman, Abul K. Shoab, Salma Akther, Md Saheen Hossen, Palash Mutsuddi, Mahbubur Rahman, Leanne Unicomb, Kishor K. Das, Liying Yan, Ann Meyer, Christine P. Stewart, Alan E. Hubbard, Ruchira Tabassum Naved, Kausar Parvin, Md Mahfuz Al Mamun, Stephen P. Luby, John M. Colford, Lia C.H. Fernald, Audrie Lin, 2024, Psychoneuroendocrinology

Cross-tissue comparison of telomere length and quality metrics of DNA among individuals aged 8 to 70 years

Sarah E. Wolf, Waylon J. Hastings, Qiaofeng Ye, Laura Etzel, Abner T. Apsley, Christopher Chiaro, Christine C. Heim, Thomas Heller, Jennie G. Noll, Hannah M.C. Schreier, Chad E. Shenk, Idan Shalev, 2024, PLoS One

Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study

Abner T. Apsley, Sun Ah Lee, Aarti C. Bhat, Jonathan Rush, David M. Almeida, Steven W. Cole, Idan Shalev, 2024, Brain, Behavior, and Immunity on p. 80-88

Early origins of health and disease risk: The case for investigating adverse exposures and biological aging in utero, across childhood, and into adolescence

Laura Etzel, Patricia Garrett-Petters, Idan Shalev, 2023, Child Development Perspectives on p. 149-156

The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging

Sarah E. Wolf, Idan Shalev, 2023, Neuroscience and Biobehavioral Reviews

Telomere length and chronological age across the human lifespan: A systematic review and meta-analysis of 414 study samples including 743,019 individuals

Qiaofeng Ye, Abner T. Apsley, Laura Etzel, Waylon J. Hastings, John T. Kozlosky, Cade Walker, Sarah E. Wolf, Idan Shalev, 2023, Ageing Research Reviews

Most-Cited Papers

The p factor: One general psychopathology factor in the structure of psychiatric disorders?

Avshalom Caspi, Renate M. Houts, Daniel W. Belsky, Sidra J. Goldman-Mellor, Honalee Harrington, Salomon Israel, Madeline H. Meier, Sandhya Ramrakha, Idan Shalev, Richie Poulton, Terrie E. Moffitt, 2014, Clinical Psychological Science on p. 119-137

Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-Traumatic stress disorder

I. Shalev, T. E. Moffitt, A. W. Braithwaite, A. Danese, N. I. Fleming, S. Goldman-Mellor, H. L. Harrington, R. M. Houts, S. Israel, R. Poulton, S. P. Robertson, K. Sugden, B. Williams, A. Caspi, 2014, Molecular Psychiatry on p. 1163-1170

Change in the rate of biological aging in response to caloric restriction: Calerie Biobank analysis

Daniel W. Belsky, Kim M. Huffman, Carl F. Pieper, Idan Shalev, William E. Kraus, Rozalyn Anderson, 2018, Journals of Gerontology - Series A Biological Sciences and Medical Sciences on p. 4-10

Oxytocin receptor and vasopressin receptor 1a genes are respectively associated with emotional and cognitive empathy

F. Uzefovsky, I. Shalev, S. Israel, S. Edelman, Y. Raz, D. Mankuta, A. Knafo-Noam, R. P. Ebstein, 2015, Hormones and Behavior on p. 60-65

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999–2002

Waylon J. Hastings, Idan Shalev, Daniel W. Belsky, 2019, Psychoneuroendocrinology on p. 171-178

Childhood Sexual Abuse and Early Timing of Puberty

Jennie G. Noll, P Trickett, J Long, S Negriff, E Susman, Idan Shalev, J Li, F Putnam, 2017, Journal of Adolescent Health on p. 65-71

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, M. Kothari, G. H. Graf, V. B. Kraus, W. E. Kraus, D. T.S. Lin, C. F. Pieper, M. E. Ramaker, M. Bhapkar, S. K. Das, L. Ferrucci, W. J. Hastings, M. Kebbe, D. C. Parker, S. B. Racette, I. Shalev, B. Schilling, D. W. Belsky, 2023, Nature Aging

Is chronic asthma associated with shorter leukocyte telomere length at midlife?

Daniel W. Belsky, Idan Shalev, Malcolm R. Sears, Robert J. Hancox, Hona Lee Harrington, Renate Houts, Terrie E. Moffitt, Karen Sugden, Benjamin Williams, Richie Poulton, Avshalom Caspi, 2014, American Review of Respiratory Disease on p. 384-391

Perinatal complications and aging indicators by midlife

Idan Shalev, Avshalom Caspi, Antony Ambler, Daniel W. Belsky, Simon Chapple, Harvey Jay Cohen, Salomon Israel, Richie Poulton, Sandhya Ramrakha, Christine D. Rivera, Karen Sugden, Benjamin Williams, Dieter Wolke, Terrie E. Moffitt, 2014, Pediatrics on p. e1315-e1323

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Idan Shalev, Jay Belsky, 2016, Medical Hypotheses on p. 41-47