Hyunwook Lee
Postdoctoral Researcher
Huck Affiliations
Publication Tags
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Capsid Viruses Enterovirus Epitopes Proteins Antibodies Cryoelectron Microscopy Neutralizing Antibodies Receptors Human Papillomavirus 16 Cryo Electron Microscopy Canine Parvovirus Picornaviridae Immunoglobulin Fragments Genome Capsid Proteins Virion Microvirus Ribonucleoproteins Asoxime Chloride Enterovirus A Dendrimers Carnivore Protoparvovirus 1 Ribonucleases TryptophanMost Recent Publications
The Structures and Functions of Parvovirus Capsids and Missing Pieces: the Viral DNA and Its Packaging, Asymmetrical Features, Nonprotein Components, and Receptor or Antibody Binding and Interactions
Robert A. López-Astacio, Oluwafemi F. Adu, Hyunwook Lee, Susan L. Hafenstein, Colin R. Parrish, 2023, Journal of Virology
Viral Capsid, Antibody, and Receptor Interactions: Experimental Analysis of the Antibody Escape Evolution of Canine Parvovirus
Robert A. López-Astacio, Oluwafemi F. Adu, Daniel J. Goetschius, Hyunwook Lee, Wendy S. Weichert, Brian R. Wasik, Simon P. Frueh, Brynn K. Alford, Ian E.H. Voorhees, Joseph F. Flint, Sarah Saddoris, Laura B. Goodman, Edward C. Holmes, Susan L. Hafenstein, Colin R. Parrish, 2023, Journal of Virology on p. e0009023
Cryo-EM Structure of Gokushovirus UEC6098 Reveals a Novel Capsid Architecture for a Single-Scaffolding Protein, Microvirus Assembly System
Hyunwook Lee, Alexis Baxter, Carol Bator, Bentley Fane, Susan L. Hafenstein, 2022, Journal of Virology
Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
Anna Perederina, Di Li, Hyunwook Lee, Carol Bator, Igor Berezin, Susan L. Hafenstein, Andrey S. Krasilnikov, 2020, Nature Communications
Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread
Ian E.H. Voorhees, Hyunwook Lee, Andrew B. Allison, Robert Lopez-Astacio, Laura B. Goodman, Oyebola O. Oyesola, Olutayo Omobowale, Olusegun Fagbohun, Edward J. Dubovi, Susan L. Hafenstein, Edward C. Holmes, Colin R. Parrish, 2020, Journal of Virology
A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS
Belén Martínez-Gualda, Liang Sun, Olaia Martí-Marí, Sam Noppen, Rana Abdelnabi, Carol Bator, Ernesto Quesada, Leen Delang, Carmen Mirabelli, Hyunwook Lee, Dominique Schols, Johan Neyts, S Hafenstein, María-José Camarasa, Federico Gago, Ana San-Felix, 2019, Journal of Medicinal Chemistry on p. acs.jmedchem.9b01737
Transferrin receptor binds virus capsid with dynamic motion
Hyunwook Lee, Heather M. Callaway, Javier O. Cifuente, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 20462-20471
Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread
Ian Voorhees, Hyunwook Lee, Andrew Allison, Robert Lopez-Astacio, Laura Goodman, Oyebola Oyesola, Olutayo Omobowale, Olusegun Fagbohun, Edward Dubovi, S Hafenstein, Edward Holmes, Colin Parrish, 2019, Journal of Virology on p. JVI.01162--19, jvi;JVI.01162--19v1
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid
Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Felix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts, 2019, PLoS Pathogens
CryoEM reconstruction approaches to resolve asymmetric features
Daniel Goetschius, Hyunwook Lee, Susan Hafenstein, 2019, Advances in virus research on p. 73--91
Most-Cited Papers
Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction
Yorihiro Nishimura, Hyunwook Lee, Susan Hafenstein, Chikako Kataoka, Takaji Wakita, Jeffrey M. Bergelson, Hiroyuki Shimizu, 2013, PLoS Pathogens on p. e1003511
Optogenetic control of chemokine receptor signal and T-cell migration
Yuexin Xu, Young Min Hyun, Kihong Lim, Hyunwook Lee, Ryan J. Cummings, Scott A. Gerber, Seyeon Bae, Thomas Yoonsang Cho, Edith M. Lord, Minsoo Kim, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 6371-6376
A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody
Hyunwook Lee, Javier O. Cifuente, Robert E. Ashley, James F. Conway, Alexander M. Makhov, Yoshio Tano, Hiroyuki Shimizu, Yorihiro Nishimura, Susan Hafenstein, 2013, Journal of Virology on p. 11363-11370
A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment
Hyunwook Lee, Sarah A. Brendle, Stephanie M. Bywaters, Jian Guan, Robert E. Ashley, Joshua D. Yoder, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2015, Journal of Virology on p. 1428-1438
Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Virology on p. 253-263
The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs
Hyunwook Lee, Kristin L. Shingler, Lindsey J. Organtini, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein, 2016, Science advances
Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread
Ian E.H. Voorhees, Hyunwook Lee, Andrew B. Allison, Robert Lopez-Astacio, Laura B. Goodman, Oyebola O. Oyesola, Olutayo Omobowale, Olusegun Fagbohun, Edward J. Dubovi, Susan L. Hafenstein, Edward C. Holmes, Colin R. Parrish, 2020, Journal of Virology
Structures of the procapsid and mature virion of enterovirus 71 strain 1095
Javier O. Cifuente, Hyunwook Lee, Joshua D. Yoder, Kristin L. Shingler, Michael S. Carnegie, Jennifer L. Yoder, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein, 2013, Journal of Virology on p. 7637-7645
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid
Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Felix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts, 2019, PLoS Pathogens
The U4 antibody epitope on human papillomavirus 16 identified by cryo-electron microscopy
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Neil D. Christensen, Susan Hafenstein, 2015, Journal of Virology on p. 12108-12117