Hyunwook Lee

Postdoctoral Researcher

hyl5126@psu.edu

Bio & Links
Publications

Huck Affiliations

Center for Infectious Disease Dynamics

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Capsid Viruses Enterovirus Epitopes Proteins Antibodies Cryoelectron Microscopy Neutralizing Antibodies Cryo Electron Microscopy Canine Parvovirus Human Papillomavirus 16 Receptors Carnivore Protoparvovirus 1 Immunoglobulin Fragments Picornaviridae Genome Capsid Proteins Monoclonal Antibodies Microvirus Ribonucleoproteins Virion Ribonucleases Asoxime Chloride Coat Proteins Dogs

Most Recent Publications

Cryo-EM Structure of Gokushovirus UEC6098 Reveals a Novel Capsid Architecture for a Single-Scaffolding Protein, Microvirus Assembly System

Hyunwook Lee, Alexis J. Baxter, Carol M. Bator, Bentley A. Fane, Susan L. Hafenstein, 2022, Journal of Virology

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Anna Perederina, Di Li, Hyunwook Lee, Carol Bator, Igor Berezin, Susan L. Hafenstein, Andrey S. Krasilnikov, 2020, Nature Communications

Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

Ian E.H. Voorhees, Hyunwook Lee, Andrew B. Allison, Robert Lopez-Astacio, Laura B. Goodman, Oyebola O. Oyesola, Olutayo Omobowale, Olusegun Fagbohun, Edward J. Dubovi, Susan L. Hafenstein, Edward C. Holmes, Colin R. Parrish, 2020, Journal of Virology

A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS

Belén Martínez-Gualda, Liang Sun, Olaia Martí-Marí, Sam Noppen, Rana Abdelnabi, Carol Bator, Ernesto Quesada, Leen Delang, Carmen Mirabelli, Hyunwook Lee, Dominique Schols, Johan Neyts, S Hafenstein, María-José Camarasa, Federico Gago, Ana San-Felix, 2019, Journal of Medicinal Chemistry on p. acs.jmedchem.9b01737

Transferrin receptor binds virus capsid with dynamic motion

Hyunwook Lee, Heather M. Callaway, Javier O. Cifuente, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 20462-20471

Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

Ian Voorhees, Hyunwook Lee, Andrew Allison, Robert Lopez-Astacio, Laura Goodman, Oyebola Oyesola, Olutayo Omobowale, Olusegun Fagbohun, Edward Dubovi, S Hafenstein, Edward Holmes, Colin Parrish, 2019, Journal of Virology on p. JVI.01162--19, jvi;JVI.01162--19v1

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid

Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Felix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts, 2019, PLoS Pathogens

CryoEM reconstruction approaches to resolve asymmetric features

Daniel Goetschius, Hyunwook Lee, Susan Hafenstein, 2019, Advances in virus research on p. 73--91

Activated protein c attenuates severe inflammation by targeting VLA-3high neutrophil subpopulation in mice

Pranita P. Sarangi, Hyun Wook Lee, Yelena V. Lerman, Alissa Trzeciak, Eric J. Harrower, Alireza R. Rezaie, Minsoo Kim, 2017, Journal of Immunology on p. 2930-2936

MOPS and coxsackievirus B3 stability

Steven D. Carson, Susan Hafenstein, Hyunwook Lee, 2017, Virology on p. 183-187

Most-Cited Papers

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

Yorihiro Nishimura, Hyunwook Lee, Susan Hafenstein, Chikako Kataoka, Takaji Wakita, Jeffrey M. Bergelson, Hiroyuki Shimizu, 2013, PLoS Pathogens on p. e1003511

Optogenetic control of chemokine receptor signal and T-cell migration

Yuexin Xu, Young Min Hyun, Kihong Lim, Hyunwook Lee, Ryan J. Cummings, Scott A. Gerber, Seyeon Bae, Thomas Yoonsang Cho, Edith M. Lord, Minsoo Kim, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 6371-6376

A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment

Hyunwook Lee, Sarah A. Brendle, Stephanie M. Bywaters, Jian Guan, Robert E. Ashley, Joshua D. Yoder, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2015, Journal of Virology on p. 1428-1438

A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody

Hyunwook Lee, Javier O. Cifuente, Robert E. Ashley, James F. Conway, Alexander M. Makhov, Yoshio Tano, Hiroyuki Shimizu, Yorihiro Nishimura, Susan Hafenstein, 2013, Journal of Virology on p. 11363-11370

Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization

Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Virology on p. 253-263

Hyunwook Lee

Postdoctoral Researcher

Huck Affiliations

Publication Tags

Most Recent Publications

Cryo-EM Structure of Gokushovirus UEC6098 Reveals a Novel Capsid Architecture for a Single-Scaffolding Protein, Microvirus Assembly System

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS

Transferrin receptor binds virus capsid with dynamic motion

Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid

CryoEM reconstruction approaches to resolve asymmetric features

Activated protein c attenuates severe inflammation by targeting VLA-3high neutrophil subpopulation in mice

MOPS and coxsackievirus B3 stability

Most-Cited Papers

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

Optogenetic control of chemokine receptor signal and T-cell migration

A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment

A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody

Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization

The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

Structures of the procapsid and mature virion of enterovirus 71 strain 1095

The U4 antibody epitope on human papillomavirus 16 identified by cryo-electron microscopy

Near-atomic resolution structure of a highly neutralizing fab bound to canine parvovirus