Howard Salis
Associate Professor of Chemical Engineering; Associate Professor of Agricultural and Biological Engineering
-
224 Ag Engineering
University Park, PA - hms17@psu.edu
- 814-863-1931
Research Summary
Engineering microorganisms for applications in synthetic biology and metabolic engineering.
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Center for Biorenewables
Links
Publication Tags
Proteins Kinetics Gene Expression Messenger Rna Genes Rna Dna Machine Learning Bacteria Escherichia Coli Genome Enzymes Protein Ribosomes Synthetic Biology Application Transcription Biosynthesis Plasmids Guide Rna Methane Metabolic Ultrafiltration Biofuels RiboswitchMost Recent Papers
Tuning Cell-Free Composition Controls the Time Delay, Dynamics, and Productivity of TX-TL Expression
Grace E. Vezeau, Howard M. Salis, 2021, ACS Synthetic Biology on p. 2508-2519
Systematic Quantification of Sequence and Structural Determinants Controlling mRNA stability in Bacterial Operons
Daniel P. Cetnar, Howard M. Salis, 2021, ACS Synthetic Biology on p. 318-332
Purification of Cas9-RNA complexes by ultrafiltration
Ivan Manzano, Neil Taylor, Matthew Csordas, Grace E. Vezeau, Howard M. Salis, Andrew L. Zydney, 2020, Biotechnology Progress
Automated design of thousands of nonrepetitive parts for engineering stable genetic systems
Ayaan Hossain, Eriberto Lopez, Sean M. Halper, Daniel P. Cetnar, Alexander C. Reis, Devin Strickland, Eric Klavins, Howard M. Salis, 2020, Nature Biotechnology on p. 1466-1475
An automated model test system for systematic development and improvement of gene expression models
Alexander C. Reis, Howard M. Salis, 2020, ACS Synthetic Biology on p. 3145-3156
Synthesis Success Calculator
Sean M. Halper, Ayaan Hossain, Howard M. Salis, 2020, ACS Synthetic Biology on p. 1563-1571
RNA size and 3-dimensional structure determine ultrafiltration behavior of small RNA molecules
Ivan Manzano, Grace Vezeau, Howard Salis, Andrew L. Zydney, 2020, Separations Technology
Convolutional neural net learns promoter sequence features driving transcription strength
Nicholas Leiby, Ayaan Hossain, Howard M. Salis, 2020, EPiC Series in Computing on p. 163-172
Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays
Alexander C. Reis, Sean M. Halper, Grace E. Vezeau, Daniel P. Cetnar, Ayaan Hossain, Phillip R. Clauer, Howard M. Salis, 2019, Nature Biotechnology on p. 1294-1301
Controlling Heterogeneity and Increasing Titer from Riboswitch-Regulated Bacillus subtilis Spores for Time-Delayed Protein Expression Applications
Denis Tamiev, Alyssa Lantz, Grace Vezeau, Howard Salis, Nigel F. Reuel, 2019, ACS Synthetic Biology on p. 2336-2346
Most-Cited Papers
Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites
Amin Espah Borujeni, Anirudh S. Channarasappa, Howard M. Salis, 2014, Nucleic Acids Research on p. 2646-2659
Efficient search, mapping, and optimization of multi-protein genetic systems in diverse bacteria
Iman Farasat, Manish Kushwaha, Jason Collens, Michael Easterbrook, Matthew Guido, Howard M. Salis, 2014, Molecular Systems Biology
Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration
Chiam Yu Ng, Iman Farasat, Costas D. Maranas, Howard M. Salis, 2015, Metabolic Engineering on p. 86-96
Automated physics-based design of synthetic riboswitches from diverse RNA aptamers
Amin Espah Borujeni, Dennis M. Mishler, Jingzhi Wang, Walker Huso, Howard M. Salis, 2016, Nucleic Acids Research on p. 1-13
Reversing methanogenesis to capture methane for liquid biofuel precursors
Valerie W.C. Soo, Michael J. McAnulty, Arti Tripathi, Fayin Zhu, Limin Zhang, Emmanuel Hatzakis, Philip B. Smith, Saumya Agrawal, Hadi Nazem-Bokaee, Saratram Gopalakrishnan, Howard M. Salis, James G. Ferry, Costas D. Maranas, Andrew D. Patterson, Thomas K. Wood, 2016, Microbial Cell Factories on p. 11
A portable expression resource for engineering cross-species genetic circuits and pathways
Manish Kushwaha, Howard M. Salis, 2015, Nature Communications
Translation Initiation is Controlled by RNA Folding Kinetics via a Ribosome Drafting Mechanism
Amin Espah Borujeni, Howard M. Salis, 2016, Journal of the American Chemical Society on p. 7016-7023
A predictive biophysical model of translationalcoupling to coordinate and control protein expressionin bacterial operons
Tian Tian, Howard M. Salis, 2015, Nucleic Acids Research on p. 7137-7151
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation
Iman Farasat, Howard M. Salis, 2016, PLoS Computational Biology on p. e1004724
Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences
Amin Espah Borujeni, Daniel Cetnar, Iman Farasat, Ashlee Smith, Natasha Lundgren, Howard M. Salis, 2017, Nucleic Acids Research on p. 5437-5448
News Articles Featuring Howard Salis
Jul 21, 2020
Researchers offer solution for one of synthetic biology's biggest problems
A team of Penn State and University of Washington researchers recently developed a new algorithm to help prevent the failure of engineered genetic systems, or organisms engineered to have new capabilities.
Full Article