Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Publication Tags

Membranes Proteins Apoptosis Autophagy Autophagosomes Peptides Ion Channels Neoplasms Abt 737 Death Domain Receptor Signaling Adaptor Proteins Endosomal Sorting Complexes Required For Transport Marinopyrrole A Beclin 1 Hypoxia Inducible Factor 1 Caspase 8 Cells Cell Death Apoptosis Regulatory Proteins Tumors Chemical Activation Cell Survival Transient Receptor Potential Channels Acute Myeloid Leukemia Sumoylation Myelodysplastic Syndromes

Most Recent Papers

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong Gang Wang, 2020, Blood on p. 1067-1079

Computational identification of gene networks as a biomarker of neuroblastoma risk

Lidan Sun, Libo Jiang, Christa N. Grant, Hong Gang Wang, Claudia Gragnoli, Zhenqiu Liu, Rongling Wu, 2020, Cancers on p. 1-17

Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

Mi Zhou, Sarah R. Weber, Yuanjun Zhao, Han Chen, Alistair J. Barber, Stephanie L. Grillo, Carson A. Wills, Hong Gang Wang, John D. Hulleman, Jeffrey M. Sundstrom, 2020, Frontiers in Cell and Developmental Biology

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

Thomas G. Flower, Yoshinori Takahashi, Arpa Hudait, Kevin Rose, Nicholas Tjahjono, Alexander J. Pak, Adam L. Yokom, Xinwen Liang, Hong Gang Wang, Fadila Bouamr, Gregory A. Voth, James H. Hurley, 2020, Nature Structural and Molecular Biology on p. 570-580

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen, Lei Bao, Kerry Keefer, Santhanam Shanmughapriya, Longgui Chen, John Lee, Ju Fang Wang, Xue Qian Zhang, Iwona Hirschler-Laszkiewicz, Salim Merali, Carmen Merali, Yuka Imamura, Sinisa Dovat, Muniswamy Madesh, Joseph Y. Cheung, Hong Gang Wang, Barbara A. Miller, 2020, Cell Death and Disease

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes

Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang, Hong-Gang Wang, 2020, Cell Death and Differentiation

Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

Jennifer M. Pearson, Su Fern Tan, Arati Sharma, Charyguly Annageldiyev, Todd E. Fox, Jose Luis Abad, Gemma Fabrias, Dhimant Desai, Shantu Amin, Hong Gang Wang, Myles C. Cabot, David F. Claxton, Mark Kester, David J. Feith, Thomas P. Loughran, 2020, Molecular Cancer Research on p. 352-363

Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma

Zhenqiu Liu, Christa N. Grant, Lidan Sun, Barbara A. Miller, Vladimir S. Spiegelman, Hong Gang Wang, 2020, Cancers on p. 1-16

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Lei Bao, Fernanda Festa, Christopher S. Freet, John P. Lee, Iwona M. Hirschler-Laszkiewicz, Shu jen Chen, Kerry A. Keefer, Hong Gang Wang, Andrew D. Patterson, Joseph Y. Cheung, Barbara A. Miller, 2019, Scientific reports

FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

Megan M. Young, Van Bui, Chong Chen, Hong Gang Wang, 2019, Cell Death and Disease

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yonghua Yang, Warren Fiskus, Bao Yong, Peter Atadja, Yoshinori Takahashi, Tej K. Pandita, Hong Gang Wang, Kapil N. Bhalla, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 6841-6846

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors

Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Eric J. Drake, Andrew M. Gulick, Hong Gang Wang, Qing Lin, 2012, Journal of the American Chemical Society on p. 14734-14737

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Yoshinori Takahashi, Cheryl L. Meyerkord, Tsukasa Hori, Kristin Runkle, Todd E. Fox, Mark Kester, Thomas P. Loughran, Hong Gang Wang, 2011, Autophagy on p. 61-73

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

The BH3 α-helical mimic BH3-M6 disrupts Bcl-X<sub>L</sub>, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M. Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D. Hamilton, Hong Gang Wang, Saïd M. Sebti, 2011, Journal of Biological Chemistry on p. 9382-9392

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

S. Wei, X. Chen, K. McGraw, L. Zhang, R. Komrokji, J. Clark, G. Caceres, D. Billingsley, L. Sokol, J. Lancet, N. Fortenbery, J. Zhou, E. A. Eksioglu, D. Sallman, H. Wang, P. K. Epling-Burnette, J. Djeu, M. Sekeres, J. P. Maciejewski, A. List, 2013, Oncogene on p. 1110-1120

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature communications

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

Shanshan He, Duojiao Ni, Binyun Ma, Joo Hyung Lee, Tian Zhang, Irene Ghozalli, Sara Dolatshahi Pirooz, Zhen Zhao, Nagakumar Bharatham, Baihong Li, Soohwan Oh, Wen Hwa Lee, Yoshinori Takahashi, Hong-Gang Wang, Arlet Minassian, Pinghui Feng, Vojo Deretic, Rainer Pepperkok, Mitsuo Tagaya, Ho Sup Yoon, Chengyu Liang, 2013, Nature Cell Biology on p. 1206-1219

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Shu Jen Chen, Nicholas E. Hoffman, Santhanam Shanmughapriy, Lei Bao, Kerry Keefer, Kathleen Conrad, Salim Merali, Yoshinori Takahashi, Thomas Abraham, Iwona Hirschler-Laszkiewicz, Ju Fang Wang, Xue Qian Zhang, Jianliang Song, Carlos Barrero, Yuguang Shi, Yuka Imamura Kawasawa, Michael Bayerl, Tianyu Sun, Mustafa Barbour, Hong Gang Wang, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2014, Journal of Biological Chemistry on p. 36284-36302