Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Publication Tags

Membranes Autophagy Apoptosis Neoplasms Proteins Neuroblastoma Therapeutics Peptides Caspase 8 Endosomal Sorting Complexes Required For Transport Death Domain Receptor Signaling Adaptor Proteins Autophagosomes Acute Myeloid Leukemia Marinopyrrole A Sphingolipids Extracellular Vesicles Neoplasm Metastasis Abt 737 Cell Death Pharmaceutical Preparations Cell Survival Protein Leukemia Transient Receptor Potential Channels Chemical Activation

Most Recent Publications

The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1

Iwona Hirschler-Laszkiewicz, Fernanda Festa, Suming Huang, George Lucian Moldovan, Claudia Nicolae, Ashna Dhoonmoon, Lei Bao, Kerry Keefer, Shu jen Chen, Hong Gang Wang, Joseph Y. Cheung, Barbara A. Miller, 2022, Scientific Reports

Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis

Zhenqiu Liu, Vladimir S. Spiegelman, Hong Gang Wang, 2022, Cancer Reports

Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

Shouhao Zhou, Xinyi Liu, Xinying Fang, Vernon M. Chinchilli, Michael Wang, Hong Gang Wang, Nikolay V. Dokholyan, Chan Shen, J. Jack Lee, 2022, eLife

Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy

Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey M. Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong Gang Wang, 2022, Journal for ImmunoTherapy of Cancer

Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma

Christa N. Grant, Carson A. Wills, Xiaoming Liu, Vladimir S. Spiegelman, Hong Gang Wang, 2022, In Vivo on p. 49-56

PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression

Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu, 2021, Scientific Reports

NMR resonance assignments of human Atg3 in aqueous solution and bicelles

Yansheng Ye, Guifang Wang, Maria C. Bewley, Hong-Gang Wang, Fang Tian, 2021, Biomolecular NMR Assignments on p. 421-425

Data-driven math model of FLT3-ITD acute myeloid leukemia reveals potential therapeutic targets

David J. Wooten, Melat Gebru, Hong Gang Wang, Réka Albert, 2021, Journal of Personalized Medicine

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes

Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang, Hong Gang Wang, 2021, Cell Death and Differentiation on p. 657-670

Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

Carson A. Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Christopher M. Dower, Jeffrey Sundstrom, Hong Gang Wang, 2021, Cancer Research on p. 452-463

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Sphingolipids: Regulators of crosstalk between apoptosis and autophagy

Megan M. Young, Mark Kester, Hong Gang Wang, 2013, Journal of Lipid Research on p. 5-19

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature Communications

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yonghua Yang, Warren Fiskus, Bao Yong, Peter Atadja, Yoshinori Takahashi, Tej K. Pandita, Hong Gang Wang, Kapil N. Bhalla, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 6841-6846

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors

Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Eric J. Drake, Andrew M. Gulick, Hong Gang Wang, Qing Lin, 2012, Journal of the American Chemical Society on p. 14734-14737

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Mechanisms and context underlying the role of autophagy in cancer metastasis

Christopher M. Dower, Carson A. Wills, Steven M. Frisch, Hong Gang Wang, 2018, Autophagy on p. 1110-1128