Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Publication Tags

Proteins Membranes Autophagy Apoptosis Peptides Phosphorylation Autophagosomes Pharmaceutical Preparations Therapeutics Marinopyrrole A Endosomal Sorting Complexes Required For Transport Acute Myeloid Leukemia Cells Mitochondria Neoplasms Mutation Lung Neoplasms Death Domain Receptor Signaling Adaptor Proteins Acid Ceramidase Ceramides Amp Activated Protein Kinases Caspase 8 P Glycoprotein Abt 737 Beclin 1

Most Recent Papers

VPS37A directs ESCRT recruitment for phagophore closure

Yoshinori Takahashi, Xinwen Liang, Tatsuya Hattori, Zhenyuan Tang, Haiyan He, Han Chen, Xiaoming Liu, Thomas Abraham, Yuka Imamura-Kawasawa, Nicholas J. Buchkovich, Megan M. Young, Hong Gang Wang, 2019, The Journal of cell biology on p. 3336-3354

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. Viny, David J. Feith, Ross L. Levine, Hong Gang Wang, Thomas P. Loughran, Arati Sharma, Mark Kester, David F. Claxton, 2019, Blood Advances on p. 2598-2603

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Samy A.F. Morad, Matthew R. MacDougall, Noha Abdelmageed, Li Pin Kao, David J. Feith, Su Fern Tan, Mark Kester, Thomas P. Loughran, Hong Gang Wang, Myles C. Cabot, 2019, Experimental Cell Research on p. 256-264

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Zhenyuan Tang, Yoshinori Takahashi, Haiyan He, Tatsuya Hattori, C. Chen, Xinwen Liang, Han Chen, Megan M. Young, Hong Gang Wang, 2019, Cell Reports on p. 1744-1757.e5

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Sung Gyu Cho, Xiao Xiao, Shixuan Wang, Hua Gao, Ruslan Rafikov, Stephen Black, Shang Huang, Han Fei Ding, Yisang Yoon, Robert A. Kirken, Xiao Ming Yin, Hong Gang Wang, Zheng Dong, 2019, Journal of the American Society of Nephrology on p. 1174-1191

EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer

Shawn J. Rice, Xin Liu, Hong Gang Wang, Chandra P. Belani, 2019, PloS one

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Zhijun Liu, Yiju Wei, Lei Zhang, Patricia P. Yee, Martin Johnson, Xuexin Zhang, Melissa Gulley, Jennifer M. Atkinson, Mohamed Trebak, Hong-Gang Wang, Wei Li, 2019, Oncogene on p. 120-139

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Su Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, 2019, Journal of Lipid Research on p. 1078-1086

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

Jennifer M. Atkinson, Yansheng Ye, Melat T. Gebru, Qiang Liu, Shouhao Zhou, Megan M. Young, Yoshinori Takahashi, Qing Lin, Fang Tian, Hong Gang Wang, 2019, Journal of Biological Chemistry on p. 14033-14042

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan Marie Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong-Gang Wang, 2018, Nature communications

Most-Cited Papers

The association of AMPK with ULK1 regulates autophagy

Jong Woo Lee, Sungman Park, Yoshinori Takahashi, Hong Gang Wang, 2010, PloS one

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors

Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Eric J. Drake, Andrew M. Gulick, Hong Gang Wang, Qing Lin, 2012, Journal of the American Chemical Society on p. 14734-14737

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yonghua Yang, Warren Fiskus, Bao Yong, Peter Atadja, Yoshinori Takahashi, Tej K. Pandita, Hong Gang Wang, Kapil N. Bhalla, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 6841-6846

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Yoshinori Takahashi, Cheryl L. Meyerkord, Tsukasa Hori, Kristin Runkle, Todd E. Fox, Mark Kester, Thomas P. Loughran, Hong Gang Wang, 2011, Autophagy on p. 61-73

The BH3 α-helical mimic BH3-M6 disrupts Bcl-X<sub>L</sub>, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M. Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D. Hamilton, Hong Gang Wang, Saïd M. Sebti, 2011, Journal of Biological Chemistry on p. 9382-9392

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

S. Wei, X. Chen, K. McGraw, L. Zhang, R. Komrokji, J. Clark, G. Caceres, D. Billingsley, L. Sokol, J. Lancet, N. Fortenbery, J. Zhou, E. A. Eksioglu, D. Sallman, H. Wang, P. K. Epling-Burnette, J. Djeu, M. Sekeres, J. P. Maciejewski, A. List, 2013, Oncogene on p. 1110-1120

GSK-3β promotes cell survival by modulating Bif-1-dependent autophagy and cell death

Jun Yang, Yoshinori Takahashi, Erdong Cheng, Jihong Liu, Paul F. Terranova, Bin Zhao, J. Brantley Thrasher, Hong Gang Wang, Benyi Li, 2010, Journal of Cell Science on p. 861-870

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

Shanshan He, Duojiao Ni, Binyun Ma, Joo Hyung Lee, Tian Zhang, Irene Ghozalli, Sara Dolatshahi Pirooz, Zhen Zhao, Nagakumar Bharatham, Baihong Li, Soohwan Oh, Wen Hwa Lee, Yoshinori Takahashi, Hong-Gang Wang, Arlet Minassian, Pinghui Feng, Vojo Deretic, Rainer Pepperkok, Mitsuo Tagaya, Ho Sup Yoon, Chengyu Liang, 2013, Nature Cell Biology on p. 1206-1219