Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Publication Tags

Membranes Apoptosis Autophagy Proteins Endosomal Sorting Complexes Required For Transport Neoplasms Pharmaceutical Preparations Autophagosomes Tumors Therapeutics Acute Myeloid Leukemia Caspase 8 Peptides Death Domain Receptor Signaling Adaptor Proteins Biomarkers Cells Genes Cell Death Chemical Activation Clustered Regularly Interspaced Short Palindromic Repeats Necrosis Neutrophils Abt 737 Poly(Adp Ribose) Polymerase Inhibitors Gamma Glutamyl Hydrolase

Most Recent Papers

Data-driven math model of FLT3-ITD acute myeloid leukemia reveals potential therapeutic targets

David J. Wooten, Melat Gebru, Hong-Gang Wang, Réka Albert, 2021, Journal of Personalized Medicine

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes

Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang, Hong Gang Wang, 2021, Cell Death and Differentiation on p. 657-670

Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

Carson Wills, X Liu, Longgui Chen, Y Zhao, Christopher Dower, Jeffrey Sundstrom, Hong Wang, 2021, Cancer Research on p. 452-463

An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy

Yansheng Ye, 2021, Nature Communications on p. 1-11

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia P. Yee, Yiju Wei, Soo Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong Gang Wang, Wei Li, 2020, Nature Communications

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong Gang Wang, Subhajyoti De, George Lucian Moldovan, 2020, Nature Communications

Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia

Melat T. Gebru, Hong Gang Wang, 2020, Journal of Hematology and Oncology

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong Gang Wang, 2020, Blood on p. 1067-1079

Computational identification of gene networks as a biomarker of neuroblastoma risk

Lidan Sun, Libo Jiang, Christa N. Grant, Hong Gang Wang, Claudia Gragnoli, Zhenqiu Liu, Rongling Wu, 2020, Cancers on p. 1-17

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

Thomas G. Flower, Yoshinori Takahashi, Arpa Hudait, Kevin Rose, Nicholas Tjahjono, Alexander J. Pak, Adam L. Yokom, Xinwen Liang, Hong Gang Wang, Fadila Bouamr, Gregory A. Voth, James H. Hurley, 2020, Nature Structural and Molecular Biology on p. 570-580

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Sphingolipids

Megan M. Young, Mark Kester, Hong Gang Wang, 2013, Journal of Lipid Research on p. 5-19

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yonghua Yang, Warren Fiskus, Bao Yong, Peter Atadja, Yoshinori Takahashi, Tej K. Pandita, Hong Gang Wang, Kapil N. Bhalla, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 6841-6846

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors

Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Eric J. Drake, Andrew M. Gulick, Hong Gang Wang, Qing Lin, 2012, Journal of the American Chemical Society on p. 14734-14737

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Kenichiro Doi, Rongshi Li, Shen Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P. Loughran, Said Sebti, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 10224-10235

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Yoshinori Takahashi, Cheryl L. Meyerkord, Tsukasa Hori, Kristin Runkle, Todd E. Fox, Mark Kester, Thomas P. Loughran, Hong Gang Wang, 2011, Autophagy on p. 61-73

The BH3 α-helical mimic BH3-M6 disrupts Bcl-X<sub>L</sub>, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M. Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D. Hamilton, Hong Gang Wang, Saïd M. Sebti, 2011, Journal of Biological Chemistry on p. 9382-9392

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature Communications