Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Publication Tags

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Membranes Neoplasms Endosomal Sorting Complexes Required For Transport Tumors Mitochondria Autophagy Necrosis Neoplasm Metastasis Ion Channels Neutrophils Neuroblastoma Hypoxia Inducible Factor 1 Autophagosomes Protein Mitochondrial Degradation Mitophagy Proteins Therapeutics Growth Cells Endothelial Pas Domain Containing Protein 1 Barth Syndrome Extracellular Vesicles Closures Acyl Coa

Most Recent Publications

Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure

Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C. Bewley, Kouta Hamamoto, Xiaoming Liu, John M. Flanagan, Hong Gang Wang, Yoshinori Takahashi, Fang Tian, 2024, Communications Biology

Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis

Carson A. Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Zhenqiu Liu, Vladimir S. Spiegelman, Jeffrey Sundstrom, Hong Gang Wang, 2024, Genes and Diseases

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis

Tatsuya Hattori, Kevin A. Fundora, Kouta Hamamoto, David M. Opozda, Xinwen Liang, Xiaoming Liu, Jiawen Zhang, Yasin Uzun, Yoshinori Takahashi, Hong Gang Wang, 2024, Autophagy on p. 349-364

What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy

Yansheng Ye, Maria C. Bewley, Hong Gang Wang, Fang Tian, John M. Flanagan, 2024, Autophagy on p. 709-711

Iron inhibits glioblastoma cell migration and polarization

Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong Gang Wang, Amir Sheikhi, James R. Connor, 2023, FASEB Journal

Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy

Yansheng Ye, Erin R. Tyndall, Van Bui, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong Gang Wang, Fang Tian, 2023, Nature Communications

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, Su Fern Tan, Todd E. Fox, Jeremy J.P. Shaw, Maansi Taori, Bethany J. Horton, Upendarrao Golla, Arati Sharma, Zdzislaw M. Szulc, Hong-Gang Wang, Charles E. Chalfant, Myles C. Cabot, David F. Claxton, Thomas P. Loughran, David J. Feith, 2023, Cancers

Extracellular vesicles from retinal pigment epithelial cells expressing R345W-Fibulin-3 induce epithelial-mesenchymal transition in recipient cells

M Zhou, Yuanjun Zhao, S Weber, C Gates, N Carruthers, Han Chen, X Liu, Hong Gang Wang, M Ford, Matthew Swulius, Alistair J. Barber, Stephanie L. Grillo, Jeffrey M. Sundstrom, 2023, Journal of Extracellular Vesicles on p. e12373

IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis

Mayura R. Dhamdhere, Chethana P. Gowda, Vikash Singh, Zhenqiu Liu, Nicholas Carruthers, Christa Grant, Arati Sharma, Sinisa Dovat, Jeffrey M. Sundstrom, Hong Gang Wang, Vladimir S. Spiegelman, 2023, Oncogene on p. 1558-1571

Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

Katya Nacheva, Sameer S. Kulkarni, Mintesinot Kassu, David Flanigan, Andrii Monastyrskyi, Iredia D. Iyamu, Kenichiro Doi, Megan Barber, Niranjan Namelikonda, Jeremiah D. Tipton, Prakash Parvatkar, Hong Gang Wang, Roman Manetsch, 2023, Journal of Medicinal Chemistry on p. 5196-5207

Most-Cited Papers

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature Communications

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia P. Yee, Yiju Wei, Soo Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong Gang Wang, Wei Li, 2020, Nature Communications

Mechanisms and context underlying the role of autophagy in cancer metastasis

Christopher M. Dower, Carson A. Wills, Steven M. Frisch, Hong Gang Wang, 2018, Autophagy on p. 1110-1128

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Shu Jen Chen, Nicholas E. Hoffman, Santhanam Shanmughapriy, Lei Bao, Kerry Keefer, Kathleen Conrad, Salim Merali, Yoshinori Takahashi, Thomas Abraham, Iwona Hirschler-Laszkiewicz, Ju Fang Wang, Xue Qian Zhang, Jianliang Song, Carlos Barrero, Yuguang Shi, Yuka Imamura Kawasawa, Michael Bayerl, Tianyu Sun, Mustafa Barbour, Hong Gang Wang, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller, 2014, Journal of Biological Chemistry on p. 36284-36302

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Paul Hsu, Xiaolei Liu, Jun Zhang, Hong Gang Wang, Ji Ming Ye, Yuguang Shi, 2015, Autophagy on p. 643-652

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Zhenyuan Tang, Yoshinori Takahashi, Haiyan He, Tatsuya Hattori, C. Chen, Xinwen Liang, Han Chen, Megan M. Young, Hong Gang Wang, 2019, Cell Reports on p. 1744-1757.e5

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222

VPS37A directs ESCRT recruitment for phagophore closure

Yoshinori Takahashi, Xinwen Liang, Tatsuya Hattori, Zhenyuan Tang, Haiyan He, Han Chen, Xiaoming Liu, Thomas Abraham, Yuka Imamura-Kawasawa, Nicholas J. Buchkovich, Megan M. Young, Hong Gang Wang, 2019, Journal of Cell Biology on p. 3336-3354