Hong-Gang Wang

Professor of Pharmacology

Hong-Gang Wang

Most Recent Publications

DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice

Kevin A. Fundora, Yan Zhuang, Kouta Hamamoto, Guifang Wang, Longgui Chen, Tatsuya Hattori, Xinwen Liang, Lei Bao, Venugopal Vangala, Fang Tian, Yoshinori Takahashi, Hong-Gang Wang, 2025, Journal of Pharmacology and Experimental Therapeutics

Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

Van Bui, Xinwen Liang, Yansheng Ye, William Giang, Fang Tian, Yoshinori Takahashi, Hong Gang Wang, 2025, Autophagy on p. 1059-1074

Physiological insights into ESCRT-mediated phagophore closure: potential cytoprotective roles for ATG8ylated membranes

Kouta Hamamoto, Xinwen Liang, David M. Opozda, Hong-Gang Wang, Yoshinori Takahashi, 2025, Autophagy

Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

Kouta Hamamoto, Xinwen Liang, Ayako Ito, Matthew Lanza, Van Bui, Jiawen Zhang, David M. Opozda, Tatsuya Hattori, Longgui Chen, David Haddock, Fumiaki Imamura, Hong Gang Wang, Yoshinori Takahashi, 2024, Cell Reports

Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure

Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C. Bewley, Kouta Hamamoto, Xiaoming Liu, John Flanagan, Hong-Gang Wang, Yoshinori Takahashi, Fang Tian, 2024, Communications Biology

Identification of Contactin-1 as a Potential Biomarker and Therapeutic Target in Neuroblastoma

Christa Grant, Carson A. Wills, Xiaoming Liu, Longgui Chen, Zhenqiu Liu, Hong Gang Wang, 2024, Biomedicines

Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression

Zaineb Javed, Dong Hui Shin, Weihua Pan, Sierra R. White, Amal Taher Elhaw, Yeon Soo Kim, Shriya Kamlapurkar, Ya Yun Cheng, J. Cory Benson, Ahmed Emam Abdelnaby, Rebecca Phaeton, Hong Gang Wang, Shengyu Yang, Mara L.G. Sullivan, Claudette M. St.Croix, Simon C. Watkins, Steven J. Mullett, Stacy L. Gelhaus, Nam Lee, Lan G. Coffman, Katherine Aird, Mohamed Trebak, Karthikeyan Mythreye, Vonn Walter, Nadine Hempel, 2024, EMBO Reports on p. 4281-4310

Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis

Carson A. Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Zhenqiu Liu, Vladimir S. Spiegelman, Jeffrey Sundstrom, Hong Gang Wang, 2024, Genes and Diseases

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis

Tatsuya Hattori, Kevin A. Fundora, Kouta Hamamoto, David M. Opozda, Xinwen Liang, Xiaoming Liu, Jiawen Zhang, Yasin Uzun, Yoshinori Takahashi, Hong Gang Wang, 2024, Autophagy on p. 349-364

What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy

Yansheng Ye, Maria C. Bewley, Hong Gang Wang, Fang Tian, John M. Flanagan, 2024, Autophagy on p. 709-711

Most-Cited Papers

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Patricia Yee, Yiju Wei, Soo Kim, Tong Lu, Stephen Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong Gang Wang, Wei Li, 2020, Nature Communications on p. 5424

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature Communications

Mechanisms and context underlying the role of autophagy in cancer metastasis

Christopher M. Dower, Carson A. Wills, Steven M. Frisch, Hong Gang Wang, 2018, Autophagy on p. 1110-1128

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Paul Hsu, Xiaolei Liu, Jun Zhang, Hong Gang Wang, Ji Ming Ye, Yuguang Shi, 2015, Autophagy on p. 643-652

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Zhenyuan Tang, Yoshinori Takahashi, Haiyan He, Tatsuya Hattori, C. Chen, Xinwen Liang, Han Chen, Megan M. Young, Hong Gang Wang, 2019, Cell Reports on p. 1744-1757.e5

VPS37A directs ESCRT recruitment for phagophore closure

Yoshinori Takahashi, Xinwen Liang, Tatsuya Hattori, Zhenyuan Tang, Haiyan He, Han Chen, Xiaoming Liu, Thomas Abraham, Yuka Imamura-Kawasawa, Nicholas J. Buchkovich, Megan M. Young, Hong Gang Wang, 2019, Journal of Cell Biology on p. 3336-3354

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Ying Liu, Haiyan He, Nikolaos Tsotakos, Jacob M. Serfass, Melat T. Gebru, Han Chen, Megan M. Young, Hong Gang Wang, 2017, Cell Death and Differentiation on p. 2127-2138