Hong-Gang Wang
Professor of Pharmacology

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Hershey Med Ctr
Hershey, - huw11@psu.edu
Most Recent Publications
Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
Kouta Hamamoto, Xinwen Liang, Ayako Ito, Matthew Lanza, Van Bui, Jiawen Zhang, David M. Opozda, Tatsuya Hattori, Longgui Chen, David Haddock, Fumiaki Imamura, Hong Gang Wang, Yoshinori Takahashi, 2024, Cell Reports
Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure
Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C. Bewley, Kouta Hamamoto, Xiaoming Liu, John Flanagan, Hong-Gang Wang, Yoshinori Takahashi, Fang Tian, 2024, Communications Biology
Identification of Contactin-1 as a Potential Biomarker and Therapeutic Target in Neuroblastoma
Christa Grant, Carson A. Wills, Xiaoming Liu, Longgui Chen, Zhenqiu Liu, Hong Gang Wang, 2024, Biomedicines
Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
Zaineb Javed, Dong Hui Shin, Weihua Pan, Sierra R. White, Amal Taher Elhaw, Yeon Soo Kim, Shriya Kamlapurkar, Ya Yun Cheng, J. Cory Benson, Ahmed Emam Abdelnaby, Rebecca Phaeton, Hong Gang Wang, Shengyu Yang, Mara L.G. Sullivan, Claudette M. St.Croix, Simon C. Watkins, Steven J. Mullett, Stacy L. Gelhaus, Nam Lee, Lan G. Coffman, Katherine Aird, Mohamed Trebak, Karthikeyan Mythreye, Vonn Walter, Nadine Hempel, 2024, EMBO Reports on p. 4281-4310
Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis
Carson A. Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Zhenqiu Liu, Vladimir S. Spiegelman, Jeffrey Sundstrom, Hong Gang Wang, 2024, Genes and Diseases
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Tatsuya Hattori, Kevin A. Fundora, Kouta Hamamoto, David M. Opozda, Xinwen Liang, Xiaoming Liu, Jiawen Zhang, Yasin Uzun, Yoshinori Takahashi, Hong Gang Wang, 2024, Autophagy on p. 349-364
What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy
Yansheng Ye, Maria C. Bewley, Hong Gang Wang, Fang Tian, John M. Flanagan, 2024, Autophagy on p. 709-711
LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma
Tong Lu, Patricia Yee, Stephen Chih, Miaolu Tang, Han Chen, Dawit Aregawi, Michael J. Glantz, Brad E. Zacharia, Hong-Gang Wang, Wei Li, 2024, EMBO Journal on p. 2582-2605
Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy
Yansheng Ye, Erin R. Tyndall, Van Bui, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong Gang Wang, Fang Tian, 2023, Nature Communications
Iron inhibits glioblastoma cell migration and polarization
G Shenoy, S Kheirabadi, Z Ataie, A Sahu, K Palsa, Q Wade, C Khunsriraksakul, V Khristov, B Slagle-Webb, J Lathia, Hong Gang Wang, Amir Sheikhi, James Connor, 2023, FASEB Journal on p. e23307
Most-Cited Papers
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Patricia Yee, Yiju Wei, Soo Kim, Tong Lu, Stephen Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong Gang Wang, Wei Li, 2020, Nature Communications on p. 5424
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong Gang Wang, 2018, Nature Communications
Mechanisms and context underlying the role of autophagy in cancer metastasis
Christopher M. Dower, Carson A. Wills, Steven M. Frisch, Hong Gang Wang, 2018, Autophagy on p. 1110-1128
Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy
Paul Hsu, Xiaolei Liu, Jun Zhang, Hong Gang Wang, Ji Ming Ye, Yuguang Shi, 2015, Autophagy on p. 643-652
TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion
Zhenyuan Tang, Yoshinori Takahashi, Haiyan He, Tatsuya Hattori, C. Chen, Xinwen Liang, Han Chen, Megan M. Young, Hong Gang Wang, 2019, Cell Reports on p. 1744-1757.e5
VPS37A directs ESCRT recruitment for phagophore closure
Yoshinori Takahashi, Xinwen Liang, Tatsuya Hattori, Zhenyuan Tang, Haiyan He, Han Chen, Xiaoming Liu, Thomas Abraham, Yuka Imamura-Kawasawa, Nicholas J. Buchkovich, Megan M. Young, Hong Gang Wang, 2019, Journal of Cell Biology on p. 3336-3354
Acid ceramidase is upregulated in AML and represents a novel therapeutic target
Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Ying Liu, Haiyan He, Nikolaos Tsotakos, Jacob M. Serfass, Melat T. Gebru, Han Chen, Megan M. Young, Hong Gang Wang, 2017, Cell Death and Differentiation on p. 2127-2138