Gustavo Nader
Dorothy Foher and J. Lloyd Huck Chair in Molecular, Cellular and Integrative Physiology, Professor of Kinesiology
-
101 Noll Lab
University Park, PA - gan11@psu.edu
- 814-867-6153
Research Summary
Ribosome biogenesis and cellular growth control. Transcription and epigenetic regulation of ribosomal RNA genes.
Huck Graduate Students
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
Links
Most Recent Publications
MECHANISMS OF MECHANICAL OVERLOAD-INDUCED SKELETAL MUSCLE HYPERTROPHY: CURRENT UNDERSTANDING AND FUTURE DIRECTIONS
Michael D. Roberts, John J. McCarthy, Troy A. Hornberger, Stuart M. Phillips, Abigail L. Mackey, Gustavo A. Nader, Marni D. Boppart, Andreas N. Kavazis, Paul T. Reidy, Riki Ogasawara, Cleiton A. Libardi, Carlos Ugrinowitsch, Frank W. Booth, Karyn A. Esser, 2023, Physiological Reviews on p. 2679-2757
LP07 and LLC preclinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
Daniel J. Belcher, Maria Guitart, Brian Hain, Hyo Gun Kim, David Waning, Esther Barreiro, Gustavo A. Nader, 2022, Journal of Applied Physiology on p. 1260-1272
Metastatic or xenograft colorectal cancer models induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting in a tumor-type-dependent manner
Hyo Gun Kim, Joshua R. Huot, Fabrizio Pin, Daniel J. Belcher, Andrea Bonetto, Gustavo A. Nader, 2022, Journal of Applied Physiology on p. 1273-1283
The LP07 and LLC pre-clinical models of lung cancer present divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
Daniel J. Belcher, Maria de la Rosa Guitart, Brian Hain, Hyo Gun Kim, David Waning, Esther Barreiro, Gustavo A. Nader, 2022, FASEB Journal
Divergent Anabolic Deficits and Pro-inflammatory Effectors of Muscle Wasting in Xenograft and Metastatic Tumor Models of Colorectal Cancer
Hyo Gun Kim, Joshua Huot, Fabrizio Pin, Daniel Belcher, Andrea Bonetto, Gustavo A. Nader, 2022, FASEB Journal
Chemotherapy agents reduce protein synthesis and ribosomal capacity in myotubes independent of oxidative stress
Bin Guo, Devasier Bennet, Daniel J. Belcher, Hyo Gun Kim, Gustavo A. Nader, 2021, American Journal of Physiology on p. C1000-C1009
Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia
Hyo Gun Kim, Joshua R. Huot, Fabrizio Pin, Bin Guo, Andrea Bonetto, Gustavo A. Nader, 2021, FASEB Journal
Elevated CO<sub>2</sub> regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Masahiko Shigemura, Emilia Lecuona, Martín Angulo, Laura A. Dada, Melanie B. Edwards, Lynn C. Welch, S. Marina Casalino-Matsuda, Peter H.S. Sporn, István Vadász, Iiro Taneli Helenius, Gustavo A. Nader, Yosef Gruenbaum, Kfir Sharabi, Eoin Cummins, Cormac Taylor, Ankit Bharat, Cara J. Gottardi, Greg J. Beitel, Naftali Kaminski, G. R.Scott Budinger, Sergejs Berdnikovs, Jacob I. Sznajder, 2019, Scientific Reports
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease
Chang Liu, Eva Karin Gidlund, Anna Witasp, Abdul Rashid Qureshi, Magnus Söderberg, Anders Thorell, Gustavo A. Nader, Peter Barany, Peter Stenvinkel, Ferdinand von Walden, 2019, American Journal of Physiology - Renal Physiology on p. F1122-F1131
Regulation of Ribosome Biogenesis during Skeletal Muscle Hypertrophy
Hyo Gun Kim, Bin Guo, Gustavo A. Nader, 2019, Exercise and Sport Sciences Reviews on p. 91-97
Most-Cited Papers
Muscle wasting in end-stage renal disease promulgates premature death: Established, emerging and potential novel treatment strategies
Peter Stenvinkel, Juan Jesus Carrero, Ferdinand Von Walden, T. Alp Ikizler, Gustavo A. Nader, 2016, Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress on p. 1070-1077
High CO<sub>2</sub> levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific ring finger protein 1 (MuRF1)
Ariel Jaitovich, Martín Angulo, Emilia Lecuona, Laura A. Dada, Lynn C. Welch, Yuan Cheng, Galina Gusarova, Ermelinda Ceco, Chang Liu, Masahiko Shigemura, Esther Barreiro, Cam Patterson, Gustavo A. Nader, Jacob I. Sznajder, 2015, Journal of Biological Chemistry on p. 9183-9194
Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy
G. A. Nader, F. Von Walden, C. Liu, J. Lindvall, L. Gutmann, E. E. Pistilli, P. M. Gordon, 2014, Journal of Applied Physiology on p. 693-702
mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling
Ferdinand von Walden, Chang Liu, Nicole Aurigemma, Gustavo A. Nader, 2016, American Journal of Physiology on p. C663-C672
Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro-inflammatory gene expression, and reduced rRNA synthesis
Ferdinand von Walden, Stefan Gantelius, Chang Liu, Henrik Borgström, Lars Björk, Ola Gremark, Ola Grenmark, Per Stål, Gustavo A. Nader, Eva Ponten, Eva PontéN, 2018, Muscle and Nerve on p. 277-285
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease
Chang Liu, Eva Karin Gidlund, Anna Witasp, Abdul Rashid Qureshi, Magnus Söderberg, Anders Thorell, Gustavo A. Nader, Peter Barany, Peter Stenvinkel, Ferdinand von Walden, 2019, American Journal of Physiology - Renal Physiology on p. F1122-F1131
Turning terminally differentiated skeletal muscle cells into regenerative progenitors
Heng Wang, Sara Lööf, Paula Borg, Gustavo A. Nader, Helen M. Blau, András Simon, 2015, Nature Communications
MECHANISMS OF MECHANICAL OVERLOAD-INDUCED SKELETAL MUSCLE HYPERTROPHY: CURRENT UNDERSTANDING AND FUTURE DIRECTIONS
Michael D. Roberts, John J. McCarthy, Troy A. Hornberger, Stuart M. Phillips, Abigail L. Mackey, Gustavo A. Nader, Marni D. Boppart, Andreas N. Kavazis, Paul T. Reidy, Riki Ogasawara, Cleiton A. Libardi, Carlos Ugrinowitsch, Frank W. Booth, Karyn A. Esser, 2023, Physiological Reviews on p. 2679-2757
Muscle dysfunction in patients with lung diseases a growing epidemic
Esther Barreiro, Jacob I. Sznajder, Gustavo A. Nader, G. R.Scott Budinger, 2015, American Review of Respiratory Disease on p. 616-619
News Articles Featuring Gustavo Nader
Jun 12, 2023
Penn State announces tenure-line faculty promotions, effective July 1, 2023
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.
Full Article
Nov 29, 2022
Muscle wasting severity linked to type, size and location of tumor in mice
About 80% of people with cancer suffer from significant muscle wasting, or loss of muscle tissue, and 30% of these patients die from this condition. New research in mice finds that the severity of muscle wasting is related to the type, size and location of the tumor.
Full Article