Gregory Yochum
Assoc. Professor, Biochemistry
-
Hershey Med Ctr
Hershey, - gsy3@psu.edu
Huck Affiliations
Most Recent Publications
Mucin MUC5B levels are reduced in the colonic epithelia of ulcerative colitis patients
W Ding, W Koltun, Gregory Yochum, bioRxiv : the preprint server for biology
The Wnt/beta-catenin pathway is activated by miR-1246 in liver cancer stem cells
Melanie Eshelman, Gregory Yochum, Translational cancer research on p. S1457-S1460
AXIN2: Oncogene or tumor suppressor in colorectal carcinoma?
Gregory Yochum, Journal of Cancer Science and Therapy
The microbiome of diverticulitis
N Jeganathan, E Davenport, Gregory Yochum, W Koltun, Current Opinion Physiology
Interferon-γ/Janus Kinase 1/STAT1 Signaling Represses Forkhead Box A1 and Drives a Basal Transcriptional State in Muscle-Invasive Bladder Cancer
Shamara S. Lawrence, Hironobu Yamashita, Lauren Shuman, Jay D. Raman, Monika Joshi, Gregory S. Yochum, Xue Ru Wu, Hikmat A. Al-Ahmadie, Joshua I. Warrick, Vonn Walter, David Degraff, 2025, American Journal of Pathology on p. 1013-1030
Orally Bioavailable BRD4 BD1 Inhibitor ZL0516 Effectively Suppresses Colonic Inflammation in Animal Models of Inflammatory Bowel Disease
Zonghui Ma, Steven McAninch, Zhiqing Liu, Cun Zhang, Haiying Chen, Jing He, Wenjing Yang, Ronaldo P. Panganiban, Yingzi Cong, Gregory Yochum, Allan R. Brasier, Irina V. Pinchuk, Bing Tian, Jia Zhou, 2025, ACS Pharmacology and Translational Science on p. 1152-1167
Multiomic Sequencing Reveals Distinctive Gene Expression and Epigenetic Alterations Associated With Primary Sclerosing Cholangitis Development in Treatment-Naïve Pediatric Ulcerative Colitis
Alejandra Rodriguez-Sosa, Ololade Lawal, Ciaran McDonnell, Luke Grant, John O'Brien, Muhammad Ali, Ian Stephens, Grainne Kirwan, Flavia Genua, Alexander Kel, Anna Dominik, Roisin Stack, Gregory Yochum, Michael McDermot, Glen Doherty, Seamus Hussey, Sudipto Das, 2025, Gastro Hep Advances
TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression
Carli M. King, Wei Ding, Melanie A. Eshelman, Gregory S. Yochum, 2024, Scientific Reports
SOX2 represses c-MYC transcription by altering the co-activator landscape of the c-MYC super-enhancer and promoter regions
Briana D. Ormsbee Golden, Daisy V. Gonzalez, Gregory S. Yochum, Donald W. Coulter, Angie Rizzino, 2024, Journal of Biological Chemistry
Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids
Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K. Thanki, Walter Koltun, Gregory S. Yochum, Irina V. Pinchuk, Celia Chao, Mark R. Hellmich, Katalin Módis, 2024, Antioxidants
Most-Cited Papers
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA
M Rawat, K Rawat, Walter Koltun, Meghali Nighot, G Yochum, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389
AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability
A Ganapathy, K Saha, E Suchanec, V Singh, A Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot, 2021, Autophagy on p. 1-18
Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, H Yang, Yanbo Yu, Anthony Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Pinchuk, Iryna, V, Hongjie Zhang, Yingzi Cong, 2022, Gastroenterology on p. 89-102
Review article: the pathogenesis of pouchitis
K Schieffer, Emmanuelle Williams, G. S. Yochum, W. A. Koltun, 2016, Alimentary Pharmacology and Therapeutics on p. 817-835
The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients
Kathleen M. Schieffer, Kate Sabey, Justin R. Wright, David R. Toole, Rebecca Drucker, Vasily Tokarev, Leonard R. Harris, Sue Deiling, Melanie A. Eshelman, John P. Hegarty, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, David B. Stewart, 2017, Scientific Reports
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia
C. Song, X. Pan, Z. Ge, C. Gowda, Y. Ding, H. Li, Z. Li, G. Yochum, M. Muschen, Q. Li, K. J. Payne, S. Dovat, 2016, Leukemia on p. 1436-1440
Dichotomous role of the human mitochondrial na<sup>+</sup> /ca2<sup>+</sup> /li<sup>+</sup> exchanger nclx in colorectal cancer growth and metastasis
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin Johnson, Xuexin Zhang, Ping Xin, Ryan Yoast, Scott Emrich, Gregory S. Yochum, Israel Sekler, Walter Koltun, Donald L. Gill, N Hempel, M Trebak, 2020, eLife on p. 1-41
The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression
V Singh, C Gowda, Vishal Singh, A Ganapathy, Dipti M. Karamchandani, M Eshelman, Gregory Yochum, Prashant Nighot, Vladimir S. Spiegelman, 2020, Journal of Biological Chemistry on p. 8602-8612
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells
Meera Shah, Sherri Rennoll, Wesley Raup-Konsavage, Gregory Yochum, 2015, Cell Cycle on p. 323-332
Pathophysiology of diverticular disease
Kathleen Schieffer, Bryan Kline, Gregory Yochum, Walter Koltun, 2018, Expert Review of Gastroenterology and Hepatology on p. 683-692