Gregory Yochum
Assoc. Professor, Biochemistry

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Hershey Med Ctr
Hershey, - gsy3@psu.edu
Huck Affiliations
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Colorectal Neoplasms Diverticulitis Crohn Disease Colitis Bilirubin Tight Junctions Proteins Catenins Neoplasms Protein Occludin Fibrosis Microbiota Carcinogenesis Dna Ulcerative Colitis Permeability Therapeutics Growth Mucous Membrane Diverticular Diseases Serum Tcf Transcription Factors Bacteria Sigmoid ColonMost Recent Publications
The Microbiome of Complicated Diverticulitis: An Imbalance of Sulfur-Metabolizing Bacteria
Austin C. Portolese, Brittney N. McMullen, Samantha K. Baker, Jeremy R. Chen See, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, Nimalan A. Jeganathan, 2023, Diseases of the Colon and Rectum on p. 707-715
TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells
Carli M. King, Olivia M. Marx, Wei Ding, Walter A. Koltun, Gregory S. Yochum, 2023, Genes
Transcriptome Analyses Identify Deregulated MYC in Early Onset Colorectal Cancer
Olivia M. Marx, Marc M. Mankarious, Melanie A. Eshelman, Wei Ding, Walter A. Koltun, Gregory S. Yochum, 2022, Biomolecules
BRD4-MK2 signaling
Marina Chulkina, Steven McAninch, Yi Li, Walter Koltun, Gregory Yochum, Bing Tian, Jia Zhou, Ellen J. Beswick, Allan R. Brasier, Irina V. Pinchuk, 2022, FASEB Journal
Long-Term Use of Proton Pump Inhibitors Disrupts Intestinal Tight Junction Barrier and Exaggerates Experimental Colitis
Meghali Nighot, Pei-Luan Liao, Nathan Morris, Dennis Mccarthy, Viszwapriya Dharmaprakash, Inam Ullah Khan, Ullah Khan, Inam, Inamullah Khan, Shannon Dalessio, Kushal Saha, Prashant Nighot, Thomas Ma, Ashwinkumar Ganapathy, Alexandra Wang, W Ding, Gregory Yochum, Walter Koltun, P Nighot, T Ma, 2022, Journal of Crohn's and Colitis on p. 565-579
Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, H Yang, Yanbo Yu, Anthony Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Pinchuk, Iryna, V, Hongjie Zhang, Yingzi Cong, 2022, Gastroenterology on p. 89-102
Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Ashwinkumar Ganapathy, Alexandra Wang, Nathan Morris, Nathan Michael Morris, Eric Suchanec, Wei Ding, Gregory Yochum, Walter Koltun, M Nighot, T Ma, Prashant Nighot, 2022, Journal of Crohn's and Colitis on p. 433-449
PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu, 2021, Scientific Reports
CD163L1<sup>+</sup>CXCL10<sup>+</sup> Macrophages are Enriched Within Colonic Lamina Propria of Diverticulitis Patients
Kathleen Schieffer, Scott Emrich, Gregory S. Yochum, Walter A. Koltun, 2021, Journal of Surgical Research on p. 527-535
Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease
Bryan Kline, Taelor Weaver, Brinton, David L., Jr., David L. Brinton, Leonard Harris, Gregory S. Yochum, Arthur S. Berg, Walter Koltun, 2021, Annals of Surgery on p. 346-351
Most-Cited Papers
Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways
Konsavage, Wesley M., Jr., Wesley M. Konsavage, Gregory Yochum, 2013, Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica on p. 71-79
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA
M Rawat, K Rawat, Walter Koltun, Meghali Nighot, G Yochum, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia
C. Song, X. Pan, Z. Ge, C. Gowda, Y. Ding, H. Li, Z. Li, G. Yochum, M. Muschen, Q. Li, K. J. Payne, S. Dovat, 2016, Leukemia on p. 1436-1440
The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients
Kathleen M. Schieffer, Kate Sabey, Justin R. Wright, David R. Toole, Rebecca Drucker, Vasily Tokarev, Leonard R. Harris, Sue Deiling, Melanie A. Eshelman, John P. Hegarty, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, David B. Stewart, 2017, Scientific Reports
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells
Meera Shah, Sherri Rennoll, Wesley Raup-Konsavage, Gregory Yochum, 2015, Cell Cycle on p. 323-332
Review article: the pathogenesis of pouchitis
K. M. Schieffer, E. D. Williams, G. S. Yochum, W. A. Koltun, 2016, Alimentary Pharmacology and Therapeutics on p. 817-835
Reduced total serum bilirubin levels are associated with ulcerative colitis
Kathleen M. Schieffer, Shannon M. Bruffy, Richard Rauscher, Walter A. Koltun, Gregory S. Yochum, Carla J. Gallagher, 2017, PLoS One
Pathophysiology of diverticular disease
Kathleen Schieffer, Bryan Kline, Gregory Yochum, Walter Koltun, 2018, Expert Review of Gastroenterology and Hepatology on p. 683-692
Dichotomous role of the human mitochondrial na<sup>+</sup> /ca2<sup>+</sup> /li<sup>+</sup> exchanger nclx in colorectal cancer growth and metastasis
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin Johnson, Xuexin Zhang, Ping Xin, Ryan Yoast, Scott Emrich, Gregory S. Yochum, Israel Sekler, Walter Koltun, Donald L. Gill, N Hempel, M Trebak, 2020, eLife on p. 1-41
Synthetic cannabinoid activity against colorectal cancer cells
Wesley Raup-Konsavage, Megan Johnson, Christopher Legare, Gregory Yochum, D Morgan, Kent E. Vrana, 2018, Cannabis and Cannabinoid Research on p. 272-281