Gregory Yochum

Assoc. Professor, Biochemistry

Gregory Yochum

Huck Affiliations

Publication Tags

Catenins Gene Expression Beta Catenin Genes Diverticulitis Proteins Chromatin Epithelial Cells Colorectal Neoplasms Single Nucleotide Polymorphism Dna Transcription Factors Regeneration Alleles Rna Epithelium Crohn Disease Imatinib Mesylate Immune System Tcf Transcription Factors Therapeutics Cells Colonic Neoplasms Sigmoid Colon Transcription Factor 7 Like 2 Protein

Most Recent Papers

The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.

Vishal Singh, Chandrika Gowda, Vishal Singh, A Ganapathy, Dipti Karamchandani, M Eshelman, Gregory Yochum, Prashant Nighot, Vladimir Spiegelman, 2020, The Journal of biological chemistry on p. 8602-8612

Tristetraprolin targets Nos2 expression in the colonic epithelium

Melanie A. Eshelman, Stephen M. Matthews, Emily M. Schleicher, Rebecca M. Fleeman, Yuka Imamura Kawasawa, Deborah J. Stumpo, Perry J. Blackshear, Walter A. Koltun, Faoud T. Ishmael, Gregory S. Yochum, 2019, Scientific reports

Multifocal Versus Conventional Unifocal Diverticulitis

Bryan P. Kline, Kathleen M. Schieffer, Christine S. Choi, Tara Connelly, Jeffrey Chen, Leonard Harris, Sue Deiling, Gregory S. Yochum, Walter A. Koltun, 2019, Digestive Diseases and Sciences on p. 3143-3151

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

Stephen M. Matthews, Melanie A. Eshelman, Arthur S. Berg, Walter A. Koltun, Gregory S. Yochum, 2019, PloS one

A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients

Kathleen M. Schieffer, Bryan P. Kline, Leonard R. Harris, Sue Deiling, Walter Koltun, Gregory Yochum, 2018, Journal of Gastrointestinal and Liver Diseases on p. 249-255

Synthetic cannabinoid activity against colorectal cancer cells

Wesley M. Raup-Konsavage, Megan Johnson, Christopher A. Legare, Gregory S. Yochum, Daniel J. Morgan, Kent E. Vrana, 2018, Cannabis and Cannabinoid Research on p. 272-281

The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

Kathleen M. Schieffer, Kate Sabey, Justin R. Wright, David R. Toole, Rebecca Drucker, Vasily Tokarev, Leonard R. Harris, Sue Deiling, Melanie A. Eshelman, John P. Hegarty, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, David B. Stewart, 2017, Scientific reports

NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis

Kathleen M. Schieffer, Justin R. Wright, Leonard R. Harris, Sue Deiling, Zhaohai Yang, Regina Lamendellab, Gregory S. Yochum, Walter A. Koltun, 2017, Journal of Crohn's and Colitis on p. 1393-1397

Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia

Kathleen M. Schieffer, Lisa S. Poritz, Gregory S. Yochum, Walter A. Koltun, 2017, Journal of Surgical Research on p. 217-225

RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis

Kathleen M. Schieffer, Christine S. Choi, Scott Emrich, Leonard Harris, Sue Deiling, Dipti M. Karamchandani, Anna Salzberg, Yuka I. Kawasawa, Gregory S. Yochum, Walter A. Koltun, 2017, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. G277-G284

Most-Cited Papers

Wnt/β-catenin signaling regulates yes-associated protein (YAP) gene expression in colorectal carcinoma cells

Wesley M. Konsavage, Sydney L. Kyler, Sherri A. Rennoll, Ge Jin, Gregory S. Yochum, 2012, Journal of Biological Chemistry on p. 11730-11739

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

Daniel Bottomly, Sydney L. Kyler, Shannon K. McWeeney, Gregory S. Yochum, 2010, Nucleic acids research on p. 5735-5745

A gene expression signature of CD34<sup>+</sup> cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

Shannon K. McWeeney, Lucy C. Pemberton, Marc M. Loriaux, Kristina Vartanian, Stephanie G. Willis, Gregory Yochum, Beth Wilmot, Yaron Turpaz, Raji Pillai, Brian J. Druker, Jennifer L. Snead, Mary MacPartlin, Stephen G. O'Brien, Junia V. Melo, Thoralf Lange, Christina A. Harrington, Michael W.N. Deininger, 2010, Blood on p. 315-325

A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers

Gregory S. Yochum, Colette M. Sherrick, Mary MacPartlin, Richard H. Goodman, 2010, Proceedings of the National Academy of Sciences of the United States of America on p. 145-150

Multiple wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops

Gregory S. Yochum, 2011, PloS one

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells

Meera Shah, Sherri A. Rennoll, Wesley M. Raup-Konsavage, Gregory Yochum, 2015, Cell Cycle on p. 232-332

The Myc 3'wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract

Wesley M. Konsavage, Ge Jin, Gregory S. Yochum, 2012, Molecular and cellular biology on p. 3891-3902

Nuclear AXIN2 represses MYC gene expression

Sherri A. Rennoll, Wesley M. Konsavage, Gregory S. Yochum, 2014, Biochemical and Biophysical Research Communications on p. 217-222

A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice

Wesley M. Raup-Konsavage, Timothy K. Cooper, Gregory S. Yochum, 2016, Digestive Diseases and Sciences on p. 410-422

RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis

Kathleen M. Schieffer, Christine S. Choi, Scott Emrich, Leonard Harris, Sue Deiling, Dipti M. Karamchandani, Anna Salzberg, Yuka I. Kawasawa, Gregory S. Yochum, Walter A. Koltun, 2017, American Journal of Physiology - Gastrointestinal and Liver Physiology on p. G277-G284