Gregory Yochum
Assoc. Professor, Biochemistry
-
Hershey Med Ctr
Hershey, - gsy3@psu.edu
Huck Affiliations
Publication Tags
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Bilirubin Diverticulitis Colorectal Neoplasms Neoplasms Liver Catenins Ulcerative Colitis Therapeutics Carcinogenesis Colitis Growth Diverticular Diseases Reactive Oxygen Metabolite Messenger Rna Stellate Crystal Cascades Permeability Leukotriene B4 Extrusion Exome Occludin Hepatic Stellate Cells Neoplasm Metastasis Up Regulation PouchitisMost Recent Publications
Mucin MUC5B levels are reduced in the colonic epithelia of ulcerative colitis patients
W Ding, W Koltun, Gregory Yochum, bioRxiv : the preprint server for biology
The microbiome of diverticulitis
N Jeganathan, E Davenport, Gregory Yochum, W Koltun, Current Opinion Physiology
The Wnt/beta-catenin pathway is activated by miR-1246 in liver cancer stem cells
Melanie Eshelman, Gregory Yochum, Translational cancer research on p. S1457-S1460
AXIN2: Oncogene or tumor suppressor in colorectal carcinoma?
Gregory Yochum, Journal of Cancer Science and Therapy
Increased activity of MAPKAPK2 within mesenchymal cells as a target for inflammation associated fibrosis in Crohn's Disease.
M Chulkina, C Rohmer, S McAninch, R Panganiban, R Villéger, A Portolese, J Ciocirlan, W Yang, C Cohen, W Koltun, J Valentine, Y Cong, Gregory Yochum, E Beswick, I Pinchuk, 2024, Journal of Crohn's & colitis
Disease Severity Impairs Generation of Intestinal Organoid Cultures From Inflammatory Bowel Disease Patients
Wei Ding, Olivia M. Marx, Marc M. Mankarious, Walter A. Koltun, Gregory S. Yochum, 2024, Journal of Surgical Research on p. 187-195
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis
Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione, Hidekazu Tsukamoto, 2023, Nature Communications
Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
Lan Xiao, Bridgette Warner, Caroline G. Mallard, Hee K. Chung, Amol Shetty, Christine A. Brantner, Jaladanki N. Rao, Gregory S. Yochum, Walter A. Koltun, Kathleen B. To, Douglas J. Turner, Myriam Gorospe, Jian Ying Wang, 2023, Life Science Alliance
Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway.
T Pathak, J Benson, M Johnson, P Xin, A Abdelnaby, V Walter, W Koltun, Gregory Yochum, N Hempel, M Trebak, 2023, bioRxiv : the preprint server for biology
Creating a Surgical Biobank: The Hershey Medical Center Experience
Marc M. Mankarious, Tara M. Connelly, Leonard Harris, Sue Deiling, Gregory S. Yochum, Walter A. Koltun, 2023, Diseases of the Colon and Rectum on p. 1174-1184
Most-Cited Papers
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA
M Rawat, K Rawat, Walter Koltun, Meghali Nighot, G Yochum, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389
The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients
Kathleen M. Schieffer, Kate Sabey, Justin R. Wright, David R. Toole, Rebecca Drucker, Vasily Tokarev, Leonard R. Harris, Sue Deiling, Melanie A. Eshelman, John P. Hegarty, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, David B. Stewart, 2017, Scientific Reports
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia
C. Song, X. Pan, Z. Ge, C. Gowda, Y. Ding, H. Li, Z. Li, G. Yochum, M. Muschen, Q. Li, K. J. Payne, S. Dovat, 2016, Leukemia on p. 1436-1440
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells
Meera Shah, Sherri Rennoll, Wesley Raup-Konsavage, Gregory Yochum, 2015, Cell Cycle on p. 323-332
Review article: the pathogenesis of pouchitis
K Schieffer, Emmanuelle Williams, G. S. Yochum, W. A. Koltun, 2016, Alimentary Pharmacology and Therapeutics on p. 817-835
Pathophysiology of diverticular disease
Kathleen Schieffer, Bryan Kline, Gregory Yochum, Walter Koltun, 2018, Expert Review of Gastroenterology and Hepatology on p. 683-692
Dichotomous role of the human mitochondrial na<sup>+</sup> /ca2<sup>+</sup> /li<sup>+</sup> exchanger nclx in colorectal cancer growth and metastasis
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin Johnson, Xuexin Zhang, Ping Xin, Ryan Yoast, Scott Emrich, Gregory S. Yochum, Israel Sekler, Walter Koltun, Donald L. Gill, N Hempel, M Trebak, 2020, eLife on p. 1-41
Reduced total serum bilirubin levels are associated with ulcerative colitis
Kathleen M. Schieffer, Shannon M. Bruffy, Richard Rauscher, Walter A. Koltun, Gregory S. Yochum, Carla J. Gallagher, 2017, PLoS One
Synthetic cannabinoid activity against colorectal cancer cells
Wesley Raup-Konsavage, Megan Johnson, Christopher Legare, Gregory Yochum, D Morgan, Kent E. Vrana, 2018, Cannabis and Cannabinoid Research on p. 272-281
Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing
Joel L. Coble, Feng Yue, Tarik J. Salameh, Leonard R. Harris, Sue Deiling, Francesca M. Ruggiero, Melanie A. Eshelman, Gregory S. Yochum, Walter A. Koltun, Glenn S. Gerhard, James R. Broach, 2017, Human Molecular Genetics on p. 3212-3220