Gregory Yochum

Assoc. Professor, Biochemistry

Gregory Yochum

Huck Affiliations

Publication Tags

Crohn Disease Diverticulitis Proteins Catenins Tight Junctions Bilirubin Permeability Ulcerative Colitis Genes Single Nucleotide Polymorphism Messenger Rna Gene Expression Diverticular Diseases Interleukin 1beta Up Regulation Protein Occludin Beta Catenin Microbiota Colitis Colon Therapeutics Inflammatory Bowel Diseases Recurrence Mucous Membrane

Most Recent Publications

BRD4-MK2 signaling

Marina Chulkina, Steven McAninch, Yi Li, Walter Koltun, Gregory Yochum, Bing Tian, Jia Zhou, Ellen J. Beswick, Allan R. Brasier, Irina V. Pinchuk, 2022, FASEB Journal

PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression

Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu, 2021, Scientific Reports

Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease

Bryan P. Kline, Taelor Weaver, David L. Brinton, Leonard Harris, Gregory S. Yochum, Arthur S. Berg, Walter A. Koltun, 2021, Annals of Surgery on p. 346-351

Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease

Carl Grim, Robert Noble, Gabriela Uribe, Kamil Khanipov, Paul Johnson, Walter A. Koltun, Tammara Watts, Yuriy Fofanov, Gregory S. Yochum, Don W. Powell, Ellen J. Beswick, Irina V. Pinchuk, 2021, Journal of Crohn's and Colitis on p. 1362-1375

COLQ and ARHGAP15 are associated with diverticular disease and are expressed in the colon

Bryan Kline, Gregory Yochum, D Brinton, Kathleen Schieffer, Taelor Weaver, Leonard Harris, Sue Deiling, Arthur S. Berg, Walter A. Koltun, 2021, Journal of Surgical Research on p. 397-403

The microbiome of diverticulitis

Nimlan Arjun Jeganathan, Emily R. Davenport, Gregory S. Yochum, Walter A. Koltun, 2021, Current Opinion in Physiology

AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability

A Ganapathy, K Saha, E Suchanec, V Singh, A Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot, 2021, Autophagy on p. 1-18

IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.

M Rawat, Meghali Nighot, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389

Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy

Bryan P. Kline, Taelor Weaver, David L. Brinton, Sue Deiling, Gregory S. Yochum, Arthur S. Berg, Walter A. Koltun, 2020, Diseases of the Colon and Rectum on p. 357-364

Transcriptomic analysis of ileal tissue from Crohn's disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis

Melanie Eshelman, Leonard Harris, Sue Deiling, Walter A. Koltun, N Jeganathan, Gregory Yochum, 2020, Physiological Genomics on p. 478-484

Most-Cited Papers

Wnt/β-catenin signaling regulates yes-associated protein (YAP) gene expression in colorectal carcinoma cells

Wesley M. Konsavage, Sydney L. Kyler, Sherri A. Rennoll, Ge Jin, Gregory S. Yochum, 2012, Journal of Biological Chemistry on p. 11730-11739

Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways

Wesley M. Konsavage, Gregory S. Yochum, 2013, Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica on p. 71-79

IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.

M Rawat, Meghali Nighot, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

C. Song, X. Pan, Z. Ge, C. Gowda, Y. Ding, H. Li, Z. Li, G. Yochum, M. Muschen, Q. Li, K. J. Payne, S. Dovat, 2016, Leukemia on p. 1436-1440

Review article

K. M. Schieffer, E. D. Williams, G. S. Yochum, W. A. Koltun, 2016, Alimentary Pharmacology and Therapeutics on p. 817-835

The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

Kathleen M. Schieffer, Kate Sabey, Justin R. Wright, David R. Toole, Rebecca Drucker, Vasily Tokarev, Leonard R. Harris, Sue Deiling, Melanie A. Eshelman, John P. Hegarty, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, David B. Stewart, 2017, Scientific Reports

Pathophysiology of diverticular disease

Kathleen M. Schieffer, Bryan P. Kline, Gregory Yochum, Walter Koltun, 2018, Expert Review of Gastroenterology and Hepatology on p. 683-692

Reduced total serum bilirubin levels are associated with ulcerative colitis

Kathleen M. Schieffer, Shannon M. Bruffy, Richard Rauscher, Walter A. Koltun, Gregory S. Yochum, Carla J. Gallagher, 2017, PLoS One

Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing

Joel L. Coble, Feng Yue, Tarik J. Salameh, Leonard R. Harris, Sue Deiling, Francesca M. Ruggiero, Melanie A. Eshelman, Gregory S. Yochum, Walter A. Koltun, Glenn S. Gerhard, James R. Broach, 2017, Human Molecular Genetics on p. 3212-3220

RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis

Kathleen M. Schieffer, Christine S. Choi, Scott Emrich, Leonard Harris, Sue Deiling, Dipti M. Karamchandani, Anna Salzberg, Yuka I. Kawasawa, Gregory S. Yochum, Walter A. Koltun, 2017, American Journal of Physiology on p. G277-G284