Greg Shearer

Associate Professor of Nutritional Sciences

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Graduate Students

Huck Affiliations

Publication Tags

Omega 3 Fatty Acids Lipoproteins Oxylipins Esters Apolipoprotein A I Fatty Acids Cholesterol Cardiovascular Diseases Hdl Lipoproteins Lipids Triglycerides Therapeutics Eicosapentaenoic Acid Atherosclerosis Nonesterified Fatty Acids Sleep Docosahexaenoic Acids Chemical Analysis Aspirin Hdl Cholesterol Plasmas Niacin Hydroxymethylglutaryl Coa Reductase Inhibitors Collagen Lysophosphatidic Acid

Most Recent Papers

Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop

Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, thrombosis, and vascular biology on p. 2457-2467

Predicting the effects of supplemental EPA and DHA on the omega-3 index

Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, S. Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Anne-Marie Chang, Orfeu M. Buxton, Gregory C. Shearer, 2019, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R697-R703

Walnuts change lipoprotein composition suppressing TNFα-stimulated cytokine production by diabetic adipocyte

Kamil Borkowski, Sun J. Yim, Roberta R. Holt, Robert M. Hackman, Carl L. Keen, John W. Newman, Gregory C. Shearer, 2019, Journal of Nutritional Biochemistry on p. 51-58

Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Margeaux M. Schade, Anne Marie Chang, Gregory C. Shearer, Orfeu M. Buxton, 2019, Journal of Lipid Research on p. 1935-1945

Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids

Gregory C. Shearer, Kamil Borkowski, Susan L. Puumala, William S. Harris, Theresa L. Pedersen, John W. Newman, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 1-10

Subcellular compartmentalization of proximal G<sub>q</sub>-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes

Erika F. Dahl, Steven C. Wu, Chastity L. Healy, Brian A. Harsch, Gregory C. Shearer, Timothy D. O’Connell, 2018, Journal of Biological Chemistry on p. 8734-8749

Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease

Mark S. Borja, Bradley Hammerson, Chongren Tang, Olga V. Savinova, Gregory C. Shearer, Michael N. Oda, 2017, PloS one

Smell and taste dysfunction is associated with higher serum total cholesterol concentrations in Chinese adults

Zhe Huang, Shue Huang, Hongliang Cong, Zheng Li, Junjuan Li, Kathleen L. Keller, Gregory C. Shearer, Penny M. Kris-Etherton, Shouling Wu, Xiang Gao, 2017, Journal of Nutrition on p. 1546-1551

Most-Cited Papers

Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers

Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman, 2012, Journal of Lipid Research on p. 1662-1669

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

HDL-apoA-I Exchange

Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PloS one

Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome

Gregory C. Shearer, James V. Pottala, Susan N. Hansen, Verdayne Brandenburg, William S. Harris, 2012, Journal of Lipid Research on p. 2429-2435

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

Longitudinal study of alcohol consumption and HDL concentrations

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin

R. C. Block, R. Duff, P. Lawrence, L. Kakinami, J. T. Brenna, Gregory C. Shearer, N. Meednu, S. Mousa, A. Friedman, W. S. Harris, Mark Larson, S. Georas, 2010, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 87-95

Omega-3 fatty acids modulate collagen signaling in human platelets

M. K. Larson, G. C. Shearer, J. H. Ashmore, J. M. Anderson-Daniels, E. L. Graslie, J. T. Tholen, J. L. Vogelaar, A. J. Korth, V. Nareddy, M. Sprehe, W. S. Harris, 2011, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 93-98

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure

Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell, 2015, Journal of Lipid Research on p. 2297-2308

Effect of omega-3 fatty acid ethyl esters on the oxylipin composition of lipoproteins in hypertriglyceridemic, statin-treated subjects

John W. Newman, Theresa L. Pedersen, Verdayne R. Brandenburg, William S. Harris, Gregory C. Shearer, 2014, PloS one