Greg Shearer

Chair, Intercollege Graduate Degree Program in Integrative and Biomedical Physiology; Professor of Nutrition and Physiology

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Graduate Students

Huck Affiliations

Most Recent Publications

The Effect of Fatty Acid Desaturase on Cardiovascular Lipid Biomarkers Depends on Circulating ω-3 and ω-6 Polyunsaturated Fatty Acids in the UK Biobank

Carmen E. Arrington, Jason Westra, Nathan L. Tintle, Gregory C. Shearer, 2025, Nutrients

A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury.

S Puccini, C Healy, B Harsch, A Ahmed, Gregory Shearer, T O'Connell, 2025, bioRxiv : the preprint server for biology

ABCA1 and apoA-I dependent 12-hydroxyeicosatetraenoic acid efflux regulates macrophage inflammatory signaling.

B Harsch, K Borkowski, R Walker, T Pedersen, J Newman, Gregory Shearer, 2024, bioRxiv : the preprint server for biology

Eicosapentaenoic acid and Arachidonic acid Protection Against Left Ventricle Pathology: the Multi-Ethnic Study of Atherosclerosis.

Gregory Shearer, R Block, S Huang, L Liu, D Herrington, M Tsai, N Tintle, T O'Connell, 2024, medRxiv : the preprint server for health sciences

A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort

Carmen E. Annevelink, Jason Westra, Aleix Sala-Vila, William S. Harris, Nathan L. Tintle, Gregory C. Shearer, 2024, Journal of Nutrition on p. 1640-1651

Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy.

M Zhang, S Karachenets, D Gyberg, S Puccini, C Healy, S Wu, Gregory Shearer, T O'Connell, 2024, bioRxiv : the preprint server for biology

Effects of niacin and omega-3 fatty acids on HDL-apolipoprotein A-I exchange in subjects with metabolic syndrome

Mark S. Borja, Bradley Hammerson, Chongren Tang, Litzy Juarez-Serrano, Olga V. Savinova, William S. Harris, Michael N. Oda, Gregory C. Shearer, 2024, PLoS One

Sex differences in the central and peripheral omega 3 oxylipin response to acute systemic inflammation

Karolina Skibicka, J Kelliher, I Maric, Christopher Engeland, Gregory Shearer, K Skibicka, 2024, American Journal of Physiology on p. R341-R351

Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders

N Liang, B Harsch, S Zhou, A Borkowska, Gregory Shearer, R Kaddurah-Daouk, J Newman, K Borkowski, 2024, Progress in Lipid Research on p. 101265

Metabolomics and Risk of Dementia: A Systematic Review of Prospective Studies

A Flores, X Zhang, P Kris-Etherton, Martin J. Sliwinski, Gregory Shearer, Xiang Gao, Muzi Na, 2024, Journal of Nutrition on p. 826-845

Most-Cited Papers

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Longitudinal study of alcohol consumption and HDL concentrations: A community-based study

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

An overview of the biologic effects of omega-6 oxylipins in humans

Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38

Predicting the effects of supplemental EPA and DHA on the omega-3 index

R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4

Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids: From MESA

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: Potential role of free fatty acid receptor 4

Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell, 2015, Journal of Lipid Research on p. 2297-2308