Greg Shearer
Associate Professor of Nutritional Sciences

-
Chandlee Lab
University Park, - gcs13@psu.edu
- 814-867-3040
Research Summary
We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease
Huck Graduate Students
Huck Affiliations
Publication Tags
Fatty Acids Oxylipins Inflammation Nonesterified Fatty Acids Omega 3 Fatty Acids Cardiovascular Diseases Unsaturated Fatty Acids Hdl Lipoproteins Longitudinal Studies Fatty Acid Oleic Acid Apolipoprotein A I Eicosapentaenoic Acid Liver Lipids Microbiota Atherosclerosis Aspirin Oleoylethanolamide Esters Oxylipin Metabolic Syndrome Triglycerides Cholesterol Docosahexaenoic AcidsMost Recent Publications
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease
Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer, 2022, Physiology on p. 311-322
Esterified Oxylipins: Do They Matter?
Carmen E. Annevelink, Rachel E. Walker, Gregory C. Shearer, 2022, Metabolites
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload
Katherine A. Murphy, Brian A. Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon M. Wagner, Katherine M. Ernste, Wei Huang, Robert C. Block, Casey D. Wright, Nathan Tintle, Brian C. Jensen, Quinn S. Wells, Gregory C. Shearer, Timothy D. O'Connell, 2022, Cardiovascular Research on p. 1061-1073
Soybean oil lowers circulating cholesterol levels and coronary heart disease risk, and has no effect on markers of inflammation and oxidation
Mark Messina, Gregory Shearer, Kristina Petersen, 2021, Nutrition
Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study
Robert C. Block, Gregory C. Shearer, Ashley Holub, Xin M. Tu, Shaker Mousa, J. Thomas Brenna, William S. Harris, Nathan Tintle, 2021, Prostaglandins Leukotrienes and Essential Fatty Acids
Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers
Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer, 2021, Physiological Reports
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia
Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American Journal of Physiology on p. E392-E404
Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites
Timothy D. O'Connell, Richard Preston Mason, Matthew J. Budoff, Ann Marie Navar, Gregory C. Shearer, 2020, European Heart Journal, Supplement on p. J3-J20
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease
Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins Da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, Thrombosis, and Vascular Biology on p. 2457-2467
Predicting the effects of supplemental EPA and DHA on the omega-3 index
R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040
Most-Cited Papers
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996
Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation
Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812
Longitudinal study of alcohol consumption and HDL concentrations: A community-based study
Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912
Oleic acid-derived oleoylethanolamide: A nutritional science perspective
Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15
A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study
N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72
Omega-6 fatty acids and cardiovascular disease friend, not foe?
William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564
An overview of the biologic effects of omega-6 oxylipins in humans
Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38
ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4
Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92
Predicting the effects of supplemental EPA and DHA on the omega-3 index
R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040
HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis
Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PLoS One on p. e71541