Greg Shearer
Chair, Intercollege Graduate Degree Program in Integrative and Biomedical Physiology; Professor of Nutrition and Physiology
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Chandlee Lab
University Park, - gcs13@psu.edu
- 814-867-3040
Research Summary
We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease
Huck Affiliations
Publication Tags
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Oxylipins Fatty Acids Inflammation Nonesterified Fatty Acids Oxylipin Fatty Acid Longitudinal Studies Metabolic Syndrome Oleic Acid Omega 3 Fatty Acids Unsaturated Fatty Acids Apolipoprotein A I Cardiovascular Diseases Liver Hdl Lipoproteins Heart Failure Atherosclerosis Microbiota Aspirin Esters Oleoylethanolamide Eicosapentaenoic Acid Triglycerides Cholesterol HeartMost Recent Publications
Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study
Jason Westra, Carmen Annevelink, Tonya Orchard, Lifang Hou, William S. Harris, Timothy D. O'Connell, Gregory Shearer, Nathan Tintle, 2023, Prostaglandins Leukotrienes and Essential Fatty Acids
FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome
Naixin Zhang, Brian Harsch, Michael J. Zhang, Dylan J. Gyberg, Jackie A. Stevens, Brandon M. Wagner, Jenna Mendelson, Michael T. Patterson, Devin A. Orchard, Chastity L. Healy, Jesse W. Williams, De Wayne Townsend, Gregory C. Shearer, Katherine A. Murphy, Timothy D. O'Connell, 2023, Journal of Lipid Research
Effect of omega-3 ethyl esters on the triglyceride-rich lipoprotein response to endotoxin challenge in healthy young men
Rachel E. Walker, Chesney K. Richter, Ann C. Skulas-Ray, Michael R. Flock, Brian A. Harsch, Carmen E. Annevelink, Penny M. Kris-Etherton, Gordon L. Jensen, Gregory C. Shearer, 2023, Journal of Lipid Research
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease
Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer, 2022, Physiology on p. 311-322
Esterified Oxylipins: Do They Matter?
Carmen E. Annevelink, Rachel E. Walker, Gregory C. Shearer, 2022, Metabolites
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload
Katherine A. Murphy, Brian A. Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon M. Wagner, Katherine M. Ernste, Wei Huang, Robert C. Block, Casey D. Wright, Nathan Tintle, Brian C. Jensen, Quinn S. Wells, Gregory C. Shearer, Timothy D. O'Connell, 2022, Cardiovascular Research on p. 1061-1073
Soybean oil lowers circulating cholesterol levels and coronary heart disease risk, and has no effect on markers of inflammation and oxidation
Mark Messina, Gregory Shearer, Kristina Petersen, 2021, Nutrition
Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study
Robert C. Block, Gregory C. Shearer, Ashley Holub, Xin M. Tu, Shaker Mousa, J. Thomas Brenna, William S. Harris, Nathan Tintle, 2021, Prostaglandins Leukotrienes and Essential Fatty Acids
Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers
Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer, 2021, Physiological Reports
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia
Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American Journal of Physiology on p. E392-E404
Most-Cited Papers
Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation
Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996
Longitudinal study of alcohol consumption and HDL concentrations: A community-based study
Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912
Oleic acid-derived oleoylethanolamide: A nutritional science perspective
Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15
A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study
N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72
An overview of the biologic effects of omega-6 oxylipins in humans
Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38
Predicting the effects of supplemental EPA and DHA on the omega-3 index
R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040
ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4
Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92
Omega-6 fatty acids and cardiovascular disease friend, not foe?
William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564
HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis
Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PLoS One on p. e71541