Greg Shearer

Associate Professor of Nutritional Sciences

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Graduate Students

Huck Affiliations

Publication Tags

Omega 3 Fatty Acids Fatty Acids Oxylipins Inflammation Cardiovascular Diseases Liver Eicosapentaenoic Acid Longitudinal Studies Microbiota Atherosclerosis Hdl Lipoproteins Oleic Acid Lipids Apolipoprotein A I Docosahexaenoic Acids Insulin Resistance Colitis Oleoylethanolamide Cytokines Fermentation Aspirin Lipoproteins Dietary Fiber Esters Triglycerides

Most Recent Papers

Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study

Robert C. Block, Gregory C. Shearer, Ashley Holub, Xin M. Tu, Shaker Mousa, J. Thomas Brenna, William S. Harris, Nathan Tintle, 2021, Prostaglandins Leukotrienes and Essential Fatty Acids

Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers

Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer, 2021, Physiological Reports

Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia

Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American Journal of Physiology on p. E392-E404

Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

Timothy D. O'Connell, Richard Preston Mason, Matthew J. Budoff, Ann Marie Navar, Gregory C. Shearer, 2020, European Heart Journal, Supplement on p. J3-J20

Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop

Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, Thrombosis, and Vascular Biology on p. 2457-2467

Predicting the effects of supplemental EPA and DHA on the omega-3 index

Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, S. Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.

Vishal Singh, B Yeoh, Ronald Walker, X Xiao, Piu Saha, R Golonka, J Cai, Bretin ACA, X Cheng, Q Liu, M Flythe, B Chassaing, Gregory Shearer, Andrew Patterson, A Gewirtz, M Vijay-Kumar, 2019, Gut on p. 1801-1812

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

Walnuts change lipoprotein composition suppressing TNFα-stimulated cytokine production by diabetic adipocyte

Kamil Borkowski, Sun J. Yim, Roberta R. Holt, Robert M. Hackman, Carl L. Keen, John W. Newman, Gregory C. Shearer, 2019, Nutrition Reports International on p. 51-58

Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Anne-Marie Chang, Orfeu M. Buxton, Gregory C. Shearer, 2019, American Journal of Physiology on p. R697-R703

Most-Cited Papers

Fish oil - How does it reduce plasma triglycerides?

Gregory C. Shearer, Olga V. Savinova, William S. Harris, 2012, BBA - Specialised Section On Lipids and Related Subjects on p. 843-851

Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase g signaling in cardiac fibroblasts

Jinghai Chen, Gregory C. Shearer, Quanhai Chen, Chastity L. Healy, April J. Beyer, Vijaya B. Nareddy, A. Martin Gerdes, William S. Harris, Timothy D. O'Connell, Dajun Wang, 2011, Circulation on p. 584-593

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers

Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman, 2012, Journal of Lipid Research on p. 1662-1669

Longitudinal study of alcohol consumption and HDL concentrations

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

Omega-6 fatty acids and cardiovascular disease friend, not foe?

William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.

Vishal Singh, B Yeoh, Ronald Walker, X Xiao, Piu Saha, R Golonka, J Cai, Bretin ACA, X Cheng, Q Liu, M Flythe, B Chassaing, Gregory Shearer, Andrew Patterson, A Gewirtz, M Vijay-Kumar, 2019, Gut on p. 1801-1812

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

HDL-apoA-I Exchange

Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PLoS One on p. e71541