Greg Shearer

Associate Professor of Nutritional Sciences

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Graduate Students

Huck Affiliations

Publication Tags

Omega 3 Fatty Acids Fatty Acids Hdl Lipoproteins Lipoproteins Lipids Apolipoproteins Nonesterified Fatty Acids Therapeutics Eicosapentaenoic Acid Atherosclerosis Glycosylation Microbiota Sleep Triglycerides Oxylipins Esters Docosahexaenoic Acids Apolipoprotein A I Collagen Oxidized Low Density Lipoprotein Cardiovascular Diseases Inflammation Fibrosis Colitis Pressure

Most Recent Papers

Oleic acid-derived oleoylethanolamide: A nutritional science perspective.

K Bowen, Penny Kris-Etherton, Gregory Shearer, Sheila West, Lavanya Reddivari, Peter Jones, Progress in Lipid Research on p. 1-15

Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

Gregory Shearer, Timothy O'Connell, Richard Mason, Matthew Budoff, Anne Marie Navar, 2020, European Heart Journal on p. J3-J20

Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia

Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American journal of physiology. Endocrinology and metabolism on p. E392-E404

Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop

Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, thrombosis, and vascular biology on p. 2457-2467

Predicting the effects of supplemental EPA and DHA on the omega-3 index

Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, S. Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Anne-Marie Chang, Orfeu M. Buxton, Gregory C. Shearer, 2019, American Journal of Physiology - Regulatory Integrative and Comparative Physiology on p. R697-R703

Walnuts change lipoprotein composition suppressing TNFα-stimulated cytokine production by diabetic adipocyte

Kamil Borkowski, Sun J. Yim, Roberta R. Holt, Robert M. Hackman, Carl L. Keen, John W. Newman, Gregory C. Shearer, 2019, Journal of Nutritional Biochemistry on p. 51-58

Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Margeaux M. Schade, Anne Marie Chang, Gregory C. Shearer, Orfeu M. Buxton, 2019, Journal of Lipid Research on p. 1935-1945

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D. Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew David Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2019, Gut

Most-Cited Papers

Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase g signaling in cardiac fibroblasts

Jinghai Chen, Gregory C. Shearer, Quanhai Chen, Chastity L. Healy, April J. Beyer, Vijaya B. Nareddy, A. Martin Gerdes, William S. Harris, Timothy D. O'Connell, Dajun Wang, 2011, Circulation on p. 584-593

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers

Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman, 2012, Journal of Lipid Research on p. 1662-1669

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

HDL-apoA-I Exchange

Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PloS one on p. e71541

Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome

Gregory C. Shearer, James V. Pottala, Susan N. Hansen, Verdayne Brandenburg, William S. Harris, 2012, Journal of Lipid Research on p. 2429-2435

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D. Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew David Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2019, Gut

Omega-3 fatty acids modulate collagen signaling in human platelets

M. K. Larson, G. C. Shearer, J. H. Ashmore, J. M. Anderson-Daniels, E. L. Graslie, J. T. Tholen, J. L. Vogelaar, A. J. Korth, V. Nareddy, M. Sprehe, W. S. Harris, 2011, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 93-98

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure

Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell, 2015, Journal of Lipid Research on p. 2297-2308

Reduced apolipoprotein glycosylation in patients with the metabolic syndrome

Olga V. Savinova, Kristi Fillaus, Linhong Jing, William S. Harris, Gregory C. Shearer, 2014, PloS one