Greg Shearer

Chair, Intercollege Graduate Degree Program in Integrative and Biomedical Physiology; Professor of Nutrition and Physiology

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Affiliations

Publication Tags

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Oxylipins Nonesterified Fatty Acids Fatty Acids Oxylipin Heart Failure Inflammation Oleic Acid Fatty Acid Unsaturated Fatty Acids Metabolic Syndrome Oleoylethanolamide Microbiota Esters Longitudinal Studies Triglycerides Diet Acid Lipoproteins Erythrocytes Metabolic Lipids Fibrosis Genes Liver Therapeutics

Most Recent Publications

Mark S. Borja, Bradley Hammerson, Chongren Tang, Litzy Juarez-Serrano, Olga V. Savinova, William S. Harris, Michael N. Oda, Gregory C. Shearer, 2024, PLoS One

Nuanyi Liang, Brian A. Harsch, Sitong Zhou, Alison Borkowska, Gregory C. Shearer, Rima Kaddurah-Daouk, John W. Newman, Kamil Borkowski, 2024, Progress in Lipid Research

Metabolomics and Risk of Dementia: A Systematic Review of Prospective Studies

Ashley C. Flores, Xinyuan Zhang, Penny M. Kris-Etherton, Martin J. Sliwinski, Greg C. Shearer, Xiang Gao, Muzi Na, 2024, Journal of Nutrition on p. 826-845

A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort

Carmen E. Annevelink, Jason Westra, Aleix Sala-Vila, William S. Harris, Nathan L. Tintle, Gregory C. Shearer, 2024, Journal of Nutrition

Carmen E. Annevelink, Philip A. Sapp, Kristina Petersen, Greg C. Shearer, Penny M. Kris-Etherton, 2023, Journal of Clinical Lipidology on p. 577-586

Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study

Jason Westra, Carmen Annevelink, Tonya Orchard, Lifang Hou, William S. Harris, Timothy D. O'Connell, Gregory Shearer, Nathan Tintle, 2023, Prostaglandins Leukotrienes and Essential Fatty Acids

Naixin Zhang, Brian Harsch, Michael J. Zhang, Dylan J. Gyberg, Jackie A. Stevens, Brandon M. Wagner, Jenna Mendelson, Michael T. Patterson, Devin A. Orchard, Chastity L. Healy, Jesse W. Williams, De Wayne Townsend, Gregory C. Shearer, Katherine A. Murphy, Timothy D. O'Connell, 2023, Journal of Lipid Research

Rachel E. Walker, Chesney K. Richter, Ann C. Skulas-Ray, Michael R. Flock, Brian A. Harsch, Carmen E. Annevelink, Penny M. Kris-Etherton, Gordon L. Jensen, Gregory C. Shearer, 2023, Journal of Lipid Research

Carmen E. Annevelink, Rachel E. Walker, Gregory C. Shearer, 2022, Metabolites

Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer, 2022, Physiology on p. 311-322

Most-Cited Papers

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

An overview of the biologic effects of omega-6 oxylipins in humans

Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92

Omega-6 fatty acids and cardiovascular disease friend, not foe?

William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564

Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell, 2015, Journal of Lipid Research on p. 2297-2308