Girish Kirimanjeswara

Emphasis Area Representative, Immunology and Infectious Disease; Associate Professor of Veterinary and Biomedical Science

W205 Millennium Science Complex
University Park, PA 16802
gsk125@psu.edu
814-863-5250

Research Summary

Establishing the Virulence Factors

Huck Affiliations

Center for Infectious Disease Dynamics

Molecular, Cellular, and Integrative Biosciences

Integrative and Biomedical Physiology

One Health Microbiome Center

Publication Tags

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Vaccines Bacteria Francisella Tularensis Water Vitamin D Selenoproteins Infections Macrophages Infection Mammals Selenium Lung Heparin Caspase 1 Povidone Iodine Phosphates Tularemia Biopsy Immunity Inflammation Lungs Mice Coatings Peptides Reactive Oxygen Species

Most Recent Publications

Cold Atmospheric Plasma Medicine: Applications, Challenges, and Opportunities for Predictive Control

McKayla Nicol, Ali Kazemi, Mckayla Nicol, Ali Kazemi, Sven G. Bilén, Girish S. Kirimanjeswara, S Bilén, Sean D. Knecht, G Kirimanjeswara, 2024, Plasma on p. 233-257

DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice

Gry Persson, Katherine H. Restori, Julie Hincheli Emdrup, Sophie Schussek, Michael Schantz Klausen, McKayla J. Nicol, Bhuvana Katkere, Birgitte Rønø, Girish Kirimanjeswara, Anders Bundgaard Sørensen, 2023, Frontiers in Immunology

The role of selenoproteins in neutrophils during inflammation

Tai Jung Lee, Shaneice K. Nettleford, Allison McGlynn, Bradley A. Carlson, Girish S. Kirimanjeswara, K. Sandeep Prabhu, 2022, Archives of Biochemistry and Biophysics

Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation

Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168

Vitamin D and the Ability to Produce 1,25(OH)<sub>2</sub>D Are Critical for Protection from Viral Infection of the Lungs

Juhi Arora, Devanshi Patel, McKayla Nicol, Cassandra Field, Katherine Restori, Jinpeng Wang, Nicole Froelich, Bhuvana Katkere, Josey Terwilliger, Veronika Weaver, others, Erin Luley, Kathleen Kelly, Girish S. Kirimanjeswara, Troy Sutton, Margherita T. Cantorna, 2022, Nutrients on p. 3061

Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation

Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small

Differential immune response following intranasal and intradermal infection with francisella tularensis: Implications for vaccine development

McKayla J. Nicol, David R. Williamson, David E. Place, Girish S. Kirimanjeswara, 2021, Microorganisms

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Rachel Markley, Katherine Restori, Bhuvana Katkere, Sarah Sumner, McKayla Nicol, Anastasia Tyryshkina, Shaneice Nettleford, David Williamson, David Place, Kalyan Dewan, Ashley Shay, others, Bradley Carlson, Santhosh Girirajan, K. Sandeep Prabhu, Girish S. Kirimanjeswara, 2021, Frontiers in Immunology on p. 701341

Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species

M Nicol, T Brubaker, B Honish, 2nd, Brian J. Honish, A Simmons, A Kazemi, M Geissel, C Whalen, Christopher Siedlecki, S Bilen, Sven G. Bilén, S Knecht, Girish S. Kirimanjeswara, 2020, Scientific Reports on p. 3066

Influence of Dielectric Coatings on Pin-to-Rod Nanosecond-Pulsed Discharges in Phosphate-Buffered Saline

Timothy Brubacker, Timothy Brubaker, McKayla Nicol, Girish Soorapp Kirimanjeswara, Christopher Siedlecki, Ali Kazemi, Philip Snyder, Philip Synder, S Bilen, Sven Bilén, Sean Knetch, Sean Knecht, 2020, IEEE Transactions on Radiation and Plasma Medical Sciences on p. 655-662

Most-Cited Papers

Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species

Role of Selenoproteins in Bacterial Pathogenesis

Sarah E. Sumner, Rachel L. Markley, Girish S. Kirimanjeswara, 2019, Biological Trace Element Research on p. 69-82

The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages

P Saha, Xia Xiao, Beng Yeoh, Q Chen, Bhuvana Katkere, Girish Soorappa Kirimanjeswara, Matam Vijay-Kumar, 2019, Gut Microbes on p. 412--423

A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes

Tyler D.P. Goralski, Girish S. Kirimanjeswara, Kenneth C. Keiler, 2018, mBio

Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate

J Gyorfi, C Otteni, K Brown, A Patel, K Lehman, B Phillips, K Dewan, Girish Kirimanjeswara, Jay D. Raman, 2014, World Journal of Urology on p. 905-909

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication

Tyler Goralski, Kalyan Dewan, John N. Alumasa, Victoria Avanzato, David Place, Rachel Markley, Bhuvana Katkere, Seham Rabadi, Chandra Bakshi, Kenneth C. Keiler, Girish S. Kirimanjeswara, others, 2016, Antimicrobial Agents and Chemotherapy on p. 3276--3282

Vitamin D and the Ability to Produce 1,25(OH)<sub>2</sub>D Are Critical for Protection from Viral Infection of the Lungs

Povidone iodine rectal preparation at time of prostate needle biopsy is a simple and reproducible means to reduce risk of procedural infection

Jay Raman, K Lehman, K Dewan, Girish Kirimanjeswara, 2015, Journal of Visualized Experiments

A single mechanosensitive channel protects Francisella tularensis subsp. holarctica from hypoosmotic shock and promotes survival in the aquatic environment

David R. Williamson, Kalyan K. Dewan, Tanmay Patel, Catherine M. Wastella, Gang Ning, Girish S. Kirimanjeswara, 2018, Applied and Environmental Microbiology

Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity

David E. Place, Sarah J. Muse, Girish S. Kirimanjeswara, Eric T. Harvill, 2014, PLoS One on p. e107188

News Articles Featuring Girish Kirimanjeswara

Apr 13, 2023

T-cell vaccine for COVID-19 may last longer than current vaccines

The current COVID-19 vaccines are designed to trigger an antibody response to the SARS-CoV-2 spike protein, which is vulnerable to mutations that could make the vaccine less effective over time.

Full Article

Jan 05, 2023

Controlled, localized delivery of blood thinner may improve blood clot treatment

Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.

Full Article

Mar 17, 2022

Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission

An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.

Full Article

May 06, 2020

Plasma medicine research highlights antibacterial effects and potential uses

As interest in the application of plasma medicine — the use of low-temperature plasma (LTP) created by an electrical discharge to address medical problems — continues to grow, so does the need for research advancements proving its capabilities and potential impacts on the health care industry.

Full Article