Girish Kirimanjeswara
Emphasis Area Representative, Immunology and Infectious Disease; Associate Professor of Veterinary and Biomedical Science

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W205 Millennium Science Complex
University Park, PA 16802 - gsk125@psu.edu
- 814-863-5250
Research Summary
Establishing the Virulence Factors
Huck Affiliations
Publication Tags
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Vaccines Francisella Tularensis Selenoproteins Bacteria Selenium Infections Infection Lung Water Macrophages Mammals Lungs Mice Tularemia Heparin Phosphates Caspase 1 Immunity Coatings Peptides Reactive Oxygen Species Bordetella Pertussis Live Vaccines Osmotic Pressure Vitamin DMost Recent Publications
DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice
Gry Persson, Katherine H. Restori, Julie Hincheli Emdrup, Sophie Schussek, Michael Schantz Klausen, McKayla J. Nicol, Bhuvana Katkere, Birgitte Rønø, Girish Kirimanjeswara, Anders Bundgaard Sørensen, 2023, Frontiers in Immunology
The role of selenoproteins in neutrophils during inflammation
Tai Jung Lee, Shaneice K. Nettleford, Allison McGlynn, Bradley A. Carlson, Girish S. Kirimanjeswara, K. Sandeep Prabhu, 2022, Archives of Biochemistry and Biophysics
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation
Atip Lawanprasert, Atip Lawanprasert^, Andrew W. Simonson, Andrew Simonson^, Sarah Sumner, McKayla Nicol, Sopida Pimcharoen, Sopida Pimcharoen^, Girish S. Kirimanjeswara, Scott Medina*, 2022, Biomacromolecules on p. 1158-1168
Vitamin D and the Ability to Produce 1,25(OH)<sub>2</sub>D Are Critical for Protection from Viral Infection of the Lungs
Juhi Arora, Devanshi Patel, McKayla Nicol, Cassandra Field, Katherine Restori, Jinpeng Wang, Nicole Froelich, Bhuvana Katkere, Josey Terwilliger, Veronika Weaver, others, Erin Luley, Kathleen Kelly, Girish S. Kirimanjeswara, Troy Sutton, Margherita T. Cantorna, 2022, Nutrients on p. 3061
Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation
Atip Lawanprasert, Sopida Pimcharoen, Sarah E. Sumner, Connor T. Watson, Keefe B. Manning, Girish S. Kirimanjeswara, Scott H. Medina, 2022, Small
Differential immune response following intranasal and intradermal infection with francisella tularensis: Implications for vaccine development
McKayla J. Nicol, David R. Williamson, David E. Place, Girish S. Kirimanjeswara, 2021, Microorganisms
Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity
Rachel Markley, Katherine Restori, Bhuvana Katkere, Sarah Sumner, McKayla Nicol, Anastasia Tyryshkina, Shaneice Nettleford, David Williamson, David Place, Kalyan Dewan, Ashley Shay, others, Bradley Carlson, Santhosh Girirajan, K. Sandeep Prabhu, Girish S. Kirimanjeswara, 2021, Frontiers in Immunology on p. 701341
Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species
M Nicol, T Brubaker, B Honish, 2nd, Brian J. Honish, A Simmons, A Kazemi, M Geissel, C Whalen, Christopher Siedlecki, S Bilen, Sven G. Bilén, S Knecht, Girish S. Kirimanjeswara, 2020, Scientific Reports on p. 3066
Influence of Dielectric Coatings on Pin-to-Rod Nanosecond-Pulsed Discharges in Phosphate-Buffered Saline
Timothy Brubacker, Timothy Brubaker, McKayla Nicol, Girish Soorapp Kirimanjeswara, Christopher Siedlecki, Ali Kazemi, Philip Snyder, Philip Synder, S Bilen, Sven Bilén, Sean Knetch, Sean Knecht, 2020, IEEE Transactions on Radiation and Plasma Medical Sciences on p. 655-662
Role of Selenoproteins in Bacterial Pathogenesis
Sarah E. Sumner, Rachel L. Markley, Girish S. Kirimanjeswara, 2019, Biological Trace Element Research on p. 69-82
Most-Cited Papers
Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species
M Nicol, T Brubaker, B Honish, 2nd, Brian J. Honish, A Simmons, A Kazemi, M Geissel, C Whalen, Christopher Siedlecki, S Bilen, Sven G. Bilén, S Knecht, Girish S. Kirimanjeswara, 2020, Scientific Reports on p. 3066
A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes
Tyler D.P. Goralski, Girish S. Kirimanjeswara, Kenneth C. Keiler, 2018, mBio
Differing effects of interleukin-10 on cutaneous and pulmonary francisella tularensis live vaccine strain infection
Dennis W. Metzger, Sharon L. Salmon, Girish Kirimanjeswara, 2013, Infection and Immunity on p. 2022-2027
Role of Selenoproteins in Bacterial Pathogenesis
Sarah E. Sumner, Rachel L. Markley, Girish S. Kirimanjeswara, 2019, Biological Trace Element Research on p. 69-82
Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate
J Gyorfi, C Otteni, K Brown, A Patel, K Lehman, B Phillips, K Dewan, Girish Kirimanjeswara, Jay D. Raman, 2014, World Journal of Urology on p. 905-909
The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages
P Saha, Xia Xiao, Beng Yeoh, Q Chen, Bhuvana Katkere, Girish Soorappa Kirimanjeswara, Matam Vijay-Kumar, 2019, Gut Microbes on p. 412--423
Increased susceptibility of IgA-deficient mice to pulmonary francisella tularensis live vaccine strain infection
Yoichi Furuya, Girish S. Kirimanjeswara, Sean Roberts, Dennis W. Metzger, 2013, Infection and Immunity on p. 3434-3441
Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication
Tyler Goralski, Kalyan Dewan, John N. Alumasa, Victoria Avanzato, David Place, Rachel Markley, Bhuvana Katkere, Seham Rabadi, Chandra Bakshi, Kenneth C. Keiler, Girish S. Kirimanjeswara, others, 2016, Antimicrobial Agents and Chemotherapy on p. 3276--3282
Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity
David E. Place, Sarah J. Muse, Girish S. Kirimanjeswara, Eric T. Harvill, 2014, PLoS One on p. e107188
A single mechanosensitive channel protects Francisella tularensis subsp. holarctica from hypoosmotic shock and promotes survival in the aquatic environment
David R. Williamson, Kalyan K. Dewan, Tanmay Patel, Catherine M. Wastella, Gang Ning, Girish S. Kirimanjeswara, 2018, Applied and Environmental Microbiology
News Articles Featuring Girish Kirimanjeswara
Apr 13, 2023
T-cell vaccine for COVID-19 may last longer than current vaccines
The current COVID-19 vaccines are designed to trigger an antibody response to the SARS-CoV-2 spike protein, which is vulnerable to mutations that could make the vaccine less effective over time.
Full Article
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Full Article
Mar 17, 2022
Inhalable aerogel triggers immunity to COVID-19 in mice, may block transmission
An inhalable "aerogel" loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.
Full Article
May 06, 2020
Plasma medicine research highlights antibacterial effects and potential uses
As interest in the application of plasma medicine — the use of low-temperature plasma (LTP) created by an electrical discharge to address medical problems — continues to grow, so does the need for research advancements proving its capabilities and potential impacts on the health care industry.
Full Article